DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanB1 and si:ch211-241e1.3

DIOPT Version :9

Sequence 1:	NP_476618.1	Gene:	LanB1 / 34068	FlyBaseID:	FBgn0261800	Length:	1788	Species:	Drosophila melanogaster
Sequence 2:	XP_696031.6	Gene:	si:ch211-241e1.3 / 567640	ZFINID:	ZDB-GENE-030131-230	Length:	1368	Species:	Danio rerio

Alignment Length:	1037	Identity:	210/1037 - (20%)
Similarity:	350/1037 - (33%)	Gaps:	354/1037 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   869 QCQPGYW-----NFPECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGSEI 928
            :|..|::     .||.|..|.||||:..|:...|.|::|.|:|.|..|:.|.:|:|.:.   :..
Zfish   107 RCPAGHYLDRSGLFPRCVPCSCNGHSNECEENTGRCLNCADNTAGQRCELCKEGFYWSE---ARR 168

  Fly   929 GCRPCRCPETVASGLAHAD-----GCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNP-DNGGT 987
            .|..|.||      |.:.|     ||: :|: :.:.|.|:.|::|.|||.||..::|:| ..||.
Zfish   169 KCTACPCP------LGNQDNNFAVGCT-ETQ-SRIQCVCKTGHAGERCERCASGYYGDPLVYGGG 225

  Fly   988 CSKCECSNNVDLYDTGNCDRQTGACLKCL-YQTTGDHCELCKDGFFGDALQQNCQQCECDFLGTN 1051
            |..|.|:.|:       ||.:||||...| .|.|...                 :|||
Zfish   226 CRPCRCAGNL-------CDSKTGACRNSLELQDTNTE-----------------EQCE------- 259

  Fly  1052 NTIAHCDRFTGQCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCK 1116
                                  .||.||:.             ..:.:..|..:.....||
Zfish   260 ----------------------ECDNCAQT-------------LLNDLEKLEMELRRIKGQ---- 285

  Fly  1117 PGFGGRACNQCQAHYWGNPNEKCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIG 1181
                                             |||...|.:...
Zfish   286 ---------------------------------ADFDSLRPSSKA-------------------- 297

  Fly  1182 QFPHCSPCGECFNNWDLILSALEDATTATILRAKEIKQVGATGAY--TSEFSELDKKLQHIRNLL 1244
                             :|..||||.|||       |.:..|.::  .|:..::.:..|.:.||.
Zfish   298 -----------------LLKQLEDAITAT-------KNLVNTFSFAVNSQMPKIVQLEQDVINLA 338

  Fly  1245 QNTSVSLVDIEKLDYETQSLRDQLQASHGRLSETE---QNL------------DDIYNSLSLSGV 1294
            .:......::.|...::|......:.||.|..:.:   |||            |...:..||...
Zfish   339 DDMDSLKEEVRKRSGDSQKALANAENSHQRAKDLDTETQNLLTKIRELLKQLMDAKSDGSSLPSA 403

  Fly  1295 ELESLQNHSRLVQQLSKELKENGIQLQ---------ESN--IEGALNLTR------HAYERV--- 1339
            :|..|...|   :.:.|::::.....|         |:|  :|...|:.:      .|.:||
Zfish   404 DLAKLLEKS---ENMVKDMEKRSFTTQKDAAKKEQAEANKFLEDVKNIVKQCDQNEEASKRVDGL 465

  Fly  1340 -SNLSTLKDEANELASNTDRNCKRVENLS--------------NKIQAEAD-------------- 1375
             ||..|...|..:|....:...|:.:||:              |.:|.|.|
Zfish   466 LSNYETKLKELEDLLKQAENMVKKAKNLNDVNAQGLKDILKRVNDLQRERDVVRDQIVLATDQLK 530

  Fly  1376 DLANNNKLIEDYRAELTSLTSQIPELNNQVCGKPGDPCDSLCGGAGCGHCGGFLSCEHGAKT--- 1437
            |..:..|:..|.:.|...|.:|:                                  :||||
Zfish   531 DTQDLLKMFNDGKTEYEQLAAQL----------------------------------NGAKTDLK 561

  Fly  1438 ---------------------HSEEALKVAKDAETAITSKKDQAD--------QTIRALTQAKLN 1473
                                 |:|...|:||:.:.|:.:...::.        :..:.:|.| :|
Zfish   562 KKLQTVSQAAAKEKLVQQAEEHAENMYKLAKELQDAVQNVSGRSGVQDALSGIEAYKNITDA-VN 625

  Fly  1474 ASEAYEKAKRGFEQSERYLNQTNAN--IKLAENLFIALNNFQENKTASPSESKELAQKTLDLDLK 1536
            |:|  |.||:..|.:::.||..:..  |..|::|  ..|.....|||. :.:|:|...|.||.
Zfish   626 AAE--EAAKKAKEAADKALNDVSQGDLINRAQDL--KTNGSNLLKTAK-NTAKDLKGATKDLT-- 683

  Fly  1537 LEPEEIETLGDQINRAVSSLKNVEAIIYRTKPDLDRVNNLQSIANATKEKADKILDSANSVVESL 1601
                      :|.||...:.|..:|:........|.:..:|      ::...||:|:|.   ::.
Zfish   684 ----------EQKNRLQDAEKKKKALEEELLKIQDGLKGIQ------RDDIAKIIDAAK---KTA 729

  Fly  1602 AAADESQGKAKDAIQQANSNIELAG--QDLEKIDEETYSAEAPANNTAQQVEKLAKKVQKLQNNI 1664
            |||:.|.....|.:....:.::...  ..:..:|....:.:....|.:..:..|..|:.:|.|.|
Zfish   730 AAANRSTSDTMDQLNDIKAEVKKISITPTVSNMDNVLNNVDMTVKNVSGSIPSLLDKIDELNNQI 794

  Fly  1665 MKNDRDAKEITKEAGSVKLEAMRARGEANNL---QSATSATNQTLTDRASRSENARERAKQL-LQ 1725
            ...:..:..|.|    :|....:||..||.:   ...|...:..|...|..::.....|..| ||
Zfish   795 NYGNNVSDNINK----IKELIEQARDAANRVVVPMKFTGVGHVELRPPADLADMRAFTALSLSLQ 855

  Fly  1726 RASKLTV--DTNAKLKDLNDLQTVYLNKNQQLLRLQAEIGPLNKELNEHLIHI--KERGSHY 1783
            |..|...  |.....:|.:||..:||.|.      .|....:...|.::::|.  |..|..|
Zfish   856 RPEKPPARGDDAVVQQDEDDLFVMYLGKK------NASGDYIGMVLRKNVLHFIYKLNGREY 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB1	NP_476618.1	Laminin_N	63..286	CDD:278484
		EGF_Lam	287..343	CDD:238012
		Laminin_EGF	355..415	CDD:278482
		Laminin_EGF	418..475	CDD:278482
		EGF_Lam	477..526	CDD:238012
		EGF_Lam	529..567	CDD:214543
		EGF_Lam	789..834	CDD:214543
		Laminin_EGF	837..885	CDD:278482	6/20 (30%)
		Laminin_EGF	883..930	CDD:278482	16/46 (35%)
		Laminin_EGF	933..988	CDD:278482	21/60 (35%)
		Laminin_EGF	991..1043	CDD:278482	12/52 (23%)
		Laminin_EGF	1043..1091	CDD:278482	6/47 (13%)
		Laminin_EGF	1094..1142	CDD:278482	3/47 (6%)
		Laminin_EGF	1142..1190	CDD:278482	4/47 (9%)
		COG6	1212..>1398	CDD:303003	46/251 (18%)
		TelA	1439..1782	CDD:226371	79/362 (22%)
		ApoLp-III_like	1545..1702	CDD:304399	31/161 (19%)
si:ch211-241e1.3	XP_696031.6	EGF_Lam	125..>162	CDD:238012	15/36 (42%)
		TNFRSF	142..>263	CDD:328932	48/184 (26%)
		Laminin_EGF	<196..226	CDD:278482	13/29 (45%)
		Laminin_I	293..541	CDD:310534	51/294 (17%)
		OmpH	520..>599	CDD:332039	16/112 (14%)
		Laminin_II	733..850	CDD:283628	19/120 (16%)
		LamG	873..1011	CDD:214598	11/45 (24%)
		LamG	1043..1186	CDD:238058
		LamG	1215..1340	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010