DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LanB1 and si:ch211-158d24.2

DIOPT Version :9

Sequence 1:	NP_476618.1	Gene:	LanB1 / 34068	FlyBaseID:	FBgn0261800	Length:	1788	Species:	Drosophila melanogaster
Sequence 2:	XP_689297.6	Gene:	si:ch211-158d24.2 / 560805	ZFINID:	ZDB-GENE-081105-115	Length:	548	Species:	Danio rerio

Alignment Length:	306	Identity:	105/306 - (34%)
Similarity:	147/306 - (48%)	Gaps:	23/306 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   788 MCNCNPTG-SLSKVCESNGGYCQCKPNVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSKDKYCDL 851
            :|||:..| |....|:...|.|.|.|...|.||::|....:..|..||..|.|:|.|:....||
Zfish   151 VCNCSGEGVSDPDECDRKTGQCDCMPGYTGLQCEECEEDHFTNGTIGCLPCACDSFGAHGTSCD- 214

  Fly   852 ITGQCQCVPNTYGRECNQCQPGYWNFPE--CRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSC 914
            .:|.|.|....||.:|:.|.||:::|..  |:.||||.|:..|.|..|.|:||||:|.|::|:.|
Zfish   215 SSGMCTCKMGVYGPKCDDCHPGFFHFSSTGCQPCQCNNHSTYCHPQSGICLDCQDNTQGHNCEEC 279

  Fly   915 LDGYYGNPLFGSEIGCRPCRCPETVASGLAHADGCSLDTRNNNMLCHCQEGYSGSRCEICADNFF 979
            |..:|.....||...|.||.|....:||:     |.||:....:...|:.|::|..|:.|.|..|
Zfish   280 LPSFYRRGGEGSADVCLPCPCSSETSSGI-----CHLDSSGRPVCAECKPGFTGPTCDSCTDGLF 339

  Fly   980 GNPDNGGTCSKCECSNNVDLYDTGN-CDRQTGACLKCLYQTTGDHCELCKDGFFGDALQQNCQQC 1043
               .:.|||..|:|:.|.|...... |..:||.|.:|:..|||.|||:|..|:.|||.:.||...
Zfish   340 ---KSAGTCIPCDCNGNADPRSVPQICHPETGHCHRCVNHTTGAHCEICARGYTGDARRHNCTLR 401

  Fly  1044 ECDFLGTNNT--------IAHCDRFTGQCPCLPNVQGVRCDQCAEN 1081
            ....|.|.:.        :......|.  |.||.:|....|....|
Zfish   402 AVKVLPTTSVSSTPSSRLLTSSSPTTN--PSLPTLQSGTGDSAGHN 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB1	NP_476618.1	Laminin_N	63..286	CDD:278484
		EGF_Lam	287..343	CDD:238012
		Laminin_EGF	355..415	CDD:278482
		Laminin_EGF	418..475	CDD:278482
		EGF_Lam	477..526	CDD:238012
		EGF_Lam	529..567	CDD:214543
		EGF_Lam	789..834	CDD:214543	15/45 (33%)
		Laminin_EGF	837..885	CDD:278482	18/49 (37%)
		Laminin_EGF	883..930	CDD:278482	21/46 (46%)
		Laminin_EGF	933..988	CDD:278482	15/54 (28%)
		Laminin_EGF	991..1043	CDD:278482	22/52 (42%)
		Laminin_EGF	1043..1091	CDD:278482	9/47 (19%)
		Laminin_EGF	1094..1142	CDD:278482
		Laminin_EGF	1142..1190	CDD:278482
		COG6	1212..>1398	CDD:303003
		TelA	1439..1782	CDD:226371
		ApoLp-III_like	1545..1702	CDD:304399
si:ch211-158d24.2	XP_689297.6	EGF_Lam	152..>191	CDD:238012	14/38 (37%)
		EGF_Lam	201..245	CDD:214543	16/44 (36%)
		EGF_Lam	247..286	CDD:238012	19/38 (50%)
		EGF_Lam	347..397	CDD:238012	20/49 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0994
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810