DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB1 and LAMB3

DIOPT Version :9

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_000219.2 Gene:LAMB3 / 3914 HGNCID:6490 Length:1172 Species:Homo sapiens


Alignment Length:1785 Identity:373/1785 - (20%)
Similarity:595/1785 - (33%) Gaps:681/1785 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 CERSSCYPATGNLLIGRENRLTASSTCGLHSPERFCILSHLQDKKCFLCDTREETKHDPYKNHRI 113
            |.|.:|||..|:||:||...|.|||||||..||.:|........||..||:|:  .|: |.:||:
Human    21 CSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEWQMKCCKCDSRQ--PHN-YYSHRV 82

  Fly   114 GQIIYKTKPGTNIPTWWQSENGKENATIQLDLEAEFHFTHLIITFTTFRPAAMYIERSFDFGQTW 178
            ..:...:.|    ..||||:|.....::||||:..|....:::.|....||.|.||||.|||:||
Human    83 ENVASSSGP----MRWWQSQNDVNPVSLQLDLDRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTW 143

  Fly   179 HIYRYFAYDCKESFP----GVPTVLENITDVMCTSRYSNVEPSRNGEVIFRVLPPNINVTD---- 235
            .:|:|.|.||..:||    |.|   ::..||.|.|.........||..:      .:|:.|    
Human   144 RVYQYLAADCTSTFPRVRQGRP---QSWQDVRCQSLPQRPNARLNGGKV------QLNLMDLVSG 199

  Fly   236 ---PYAEHVQNQLKMTNLRIQMTKLHKLGDNLLDSRLENEEKYYYGISNMVVRGSCSCYGHASQC 297
               ..::.:|...::||||:..|:|..     :..|..:....||.:|.:.::|||.|:|||.:|
Human   200 IPATQSQKIQEVGEITNLRVNFTRLAP-----VPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRC 259

  Fly   298 LPLDPAFSQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAV 362
            .| .|..|...:....||..|.|.|||.|.|||.|..|:|:.||:||.|:..:.|::|:||.|:.
Human   260 AP-KPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSE 323

  Fly   363 SCHFDEAVFTASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSSD 427
            :||||.|||.||....|||||||..:|.|::||.|..:::|:.....:.:..|..|:|||     
Human   324 TCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDP----- 383

  Fly   428 DGICDSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTLNNSGCV 492
                       :|||.||                                 .|:|:         
Human   384 -----------DGAVPGA---------------------------------PCDPV--------- 395

  Fly   493 MRTGECKCKKYVTGKDCNQCMPETYGLSESPEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTGR 557
              ||:|.||::|.|:.|:.|.|                                           
Human   396 --TGQCVCKEHVQGERCDLCKP------------------------------------------- 415

  Fly   558 SCSQPKQNYFIPLLPEVHEAEVVDECISYGANGNCSLVAETPDGSFTGIGFTRVPENSELVFTVG 622
                                                        .|||:                
Human   416 --------------------------------------------GFTGL---------------- 420

  Fly   623 DIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGGCGELAAATSSETRIPFSLPDRSRQV 687
                                                                             
Human   421 ----------------------------------------------------------------- 420

  Fly   688 VALNEVCLEAGKVYKFRIYFERKRHDVDSPTATILVDSLTLIPRIDVTPIFQGSVLADIRKKDYE 752
                                                                             
Human   421 ----------------------------------------------------------------- 420

  Fly   753 KYNCKSSLYDMNYKSDPKCQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGYCQCKPNVVGR 817
                                                                             
Human   421 ----------------------------------------------------------------- 420

  Fly   818 QCDQCAPGTYGFGPEGCKACDCNSIGSKDKYCDLITGQCQCVPNTYGRECNQCQPGYWNFPECRV 882
                    ||. .|:||..||||.:||:.                             :.|    
Human   421 --------TYA-NPQGCHRCDCNILGSRR-----------------------------DMP---- 443

  Fly   883 CQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGSEIGCRPCRCPETVASGLAHAD 947
                                                                             
Human   444 ----------------------------------------------------------------- 443

  Fly   948 GCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNPDNGGTCSKCECSNNVDLYDTGNCDRQTGAC 1012
                                                                     ||.::|.|
Human   444 ---------------------------------------------------------CDEESGRC 451

  Fly  1013 LKCLYQTTGDHCELCKDGFFGDALQQNCQQCECDFLGTNNTIAHCDRFTGQCPCLPNVQGVRCDQ 1077
            |                                                    |||||.|.:|||
Human   452 L----------------------------------------------------CLPNVVGPKCDQ 464

  Fly  1078 CAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACN-----QCQAHYWGNPNE 1137
            ||..|||:|||:|||.|.|||..:|..|||.:||||.|:.||||..|:     ||....:|:...
Human   465 CAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVAT 529

  Fly  1138 KCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGECFNNWD----- 1197
            .|:.|:||..|.....||:.:|.|:|..|:.|.:|::|.|||..::|.|..|..||..:|     
Human   530 GCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLRE 594

  Fly  1198 --LILSALEDATTATILRAKEIKQVGATGAYTSEFSELDKKLQHIRNLLQNTSVSLVDIEKLDYE 1260
              |....|.:| ||::.....::..|    ..|...:...|::.||.:|.:.:|:..::.::...
Human   595 QALRFGRLRNA-TASLWSGPGLEDRG----LASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASA 654

  Fly  1261 TQSLRDQLQASHGRLSETEQNLDDIYNSLSLSGVELESLQNHSRLVQQLSKELKENGIQLQESNI 1325
            ..|||..||.....|...|:       :|||.. :||||......:..:.:..:|...::..::.
Human   655 ILSLRRTLQGLQLDLPLEEE-------TLSLPR-DLESLDRSFNGLLTMYQRKREQFEKISSADP 711

  Fly  1326 EGALNLTRHAYE-------RVSNLSTLKDEANELASNTDRNCKRVENLSNKIQAEADDLANNNKL 1383
            .||..:...|||       :||:.|.|.|:..:.....:|..:         ||.......:.||
Human   712 SGAFRMLSTAYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVR---------QAGGGGGTGSPKL 767

  Fly  1384 IEDYRAELTSLTSQIPELNNQVCGK-----------PGDPCDSLCGGAGCG-HCGGFLSCEHGAK 1436
            :. .|.|::||....|.. |::||.           ||:.|.. ..|..|| .|.|.|....|| 
Human   768 VA-LRLEMSSLPDLTPTF-NKLCGNSRQMACTPISCPGELCPQ-DNGTACGSRCRGVLPRAGGA- 828

  Fly  1437 THSEEALKVAKDAE--TAITSKKDQADQTIRALTQAKLNASEAYEKAKRGFEQSERYLNQTNANI 1499
                 .|...:.||  ....::..:..|.|||   |:.:||:....|:|...|.....:|...::
Human   829 -----FLMAGQVAEQLRGFNAQLQRTRQMIRA---AEESASQIQSSAQRLETQVSASRSQMEEDV 885

  Fly  1500 KLAENLFIALNNFQENKTASPSESKELAQKTLDLDLKLEPEEIETLGDQINRAVSSLKNVEAIIY 1564
            :....|...:.:|..:.....:..:|:::..|.|.|..:...:....::|....:.|.||:.::.
Human   886 RRTRLLIQQVRDFLTDPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLS 950

  Fly  1565 RTKPDLDRVNNLQSIANATKEKADKILDSANSVVESLAAADESQGKAKDAIQQANSNIELAGQDL 1629
            :||.|:.|...||:.|...:.:|..:......||.:|.....:..:|:|.:|..:.::.|....:
Human   951 QTKQDIARARRLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRV 1015

  Fly  1630 EKIDEETYSAEAPANNTAQQVEKLAKKVQKLQNNIMKNDRDAKEITKEAGSVKLEAMRARGEANN 1694
            .::.:....||....:..:|:.....::::|::...:...:|.:..:.|.....:|:.|:.....
Human  1016 AEVQQVLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER 1080

  Fly  1695 LQSATSATNQTLTDRASRSENARE---RAKQLLQRASKLTVDTNAKLKDLNDLQTVYLNKNQQLL 1756
            ::...:    .|.||..:|....|   |.:.:...|.:|..:|...:..:.|::...|..:|.::
Human  1081 IKQKYA----ELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAIM 1141

  Fly  1757 RLQAEIGPLNKELNEHLIHIKERGSHYRQC 1786
            ...|::..|.|.:.:...||..|..:|..|
Human  1142 LRSADLTGLEKRVEQIRDHINGRVLYYATC 1171

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 63..286 CDD:278484 74/233 (32%)
EGF_Lam 287..343 CDD:238012 26/55 (47%)
Laminin_EGF 355..415 CDD:278482 26/59 (44%)
Laminin_EGF 418..475 CDD:278482 9/56 (16%)
EGF_Lam 477..526 CDD:238012 12/48 (25%)
EGF_Lam 529..567 CDD:214543 0/37 (0%)
EGF_Lam 789..834 CDD:214543 3/44 (7%)
Laminin_EGF 837..885 CDD:278482 7/47 (15%)
Laminin_EGF 883..930 CDD:278482 0/46 (0%)
Laminin_EGF 933..988 CDD:278482 0/54 (0%)
Laminin_EGF 991..1043 CDD:278482 5/51 (10%)
Laminin_EGF 1043..1091 CDD:278482 17/47 (36%)
Laminin_EGF 1094..1142 CDD:278482 22/52 (42%)
Laminin_EGF 1142..1190 CDD:278482 18/47 (38%)
COG6 1212..>1398 CDD:303003 41/192 (21%)
TelA 1439..1782 CDD:226371 65/347 (19%)
ApoLp-III_like 1545..1702 CDD:304399 27/156 (17%)
LAMB3NP_000219.2 LamNT 20..248 CDD:214532 82/247 (33%)
EGF_Lam 249..304 CDD:238012 26/55 (47%)
EGF_Lam 315..369 CDD:238012 26/53 (49%)
Laminin_EGF 379..428 CDD:278482 27/415 (7%)
Laminin_EGF 431..478 CDD:278482 29/253 (11%)
Laminin_EGF 481..534 CDD:278482 22/52 (42%)
EGF_Lam 534..576 CDD:214543 16/41 (39%)
Domain II 579..785 51/229 (22%)
Domain alpha 786..816 7/30 (23%)
Domain I 817..1170 71/365 (19%)
MA 844..1071 CDD:214599 42/229 (18%)
MCP_signal 862..1076 CDD:304920 37/213 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 59 1.000 Domainoid score I10659
eggNOG 1 0.900 - - E1_KOG0994
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10574
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.910

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