DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanB1 and LAMB1

DIOPT Version :9

Sequence 1:	NP_476618.1	Gene:	LanB1 / 34068	FlyBaseID:	FBgn0261800	Length:	1788	Species:	Drosophila melanogaster
Sequence 2:	XP_016867690.1	Gene:	LAMB1 / 3912	HGNCID:	6486	Length:	1810	Species:	Homo sapiens

Alignment Length:	1832	Identity:	755/1832 - (41%)
Similarity:	1071/1832 - (58%)	Gaps:	166/1832 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 RRDRPKYPPNKFIKTHPCERSSCYPATGNLLIGRENRLTASSTCGLHSPERFCILSHLQ-DKKCF 95
            |...|::       ::.|...|||||||:|||||..:|:.:||||||.||.:||:|||| |||||
Human    44 RAQEPEF-------SYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCF 101

  Fly    96 LCDTREETKHDPY------KNHRIGQIIYKTKPGTNIPTWWQSENGKENATIQLDLEAEFHFTHL 154
            :|:::     |||      .:|.|..::....| ..:..|||||||.||.|||||||||||||||
Human   102 ICNSQ-----DPYHETLNPDSHLIENVVTTFAP-NRLKIWWQSENGVENVTIQLDLEAEFHFTHL 160

  Fly   155 IITFTTFRPAAMYIERSFDFGQTWHIYRYFAYDCKESFPGVPT-VLENITDVMCTSRYSNVEPSR 218
            |:||.|||||||.||||.|||:||.:||||||||:.||||:.| .::.:.|::|.||||::|||.
Human   161 IMTFKTFRPAAMLIERSSDFGKTWGVYRYFAYDCEASFPGISTGPMKKVDDIICDSRYSDIEPST 225

  Fly   219 NGEVIFRVLPPNINVTDPYAEHVQNQLKMTNLRIQMTKLHKLGDNLLDSRLENEEKYYYGISNMV 283
            .||||||.|.|...:.|||:..:||.||:|||||:..|||.|||||||||:|..|||||.:.:||
Human   226 EGEVIFRALDPAFKIEDPYSPRIQNLLKITNLRIKFVKLHTLGDNLLDSRMEIREKYYYAVYDMV 290

  Fly   284 VRGSCSCYGHASQCLPLDPAFSQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKK 348
            |||:|.||||||:|.|:| .|:  :..:|||||.|.|.|||||:|||.|.||::||||:||.|:.
Human   291 VRGNCFCYGHASECAPVD-GFN--EEVEGMVHGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRN 352

  Fly   349 TNACKKCECNDHAVSCHFDEAVFTASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSER 413
            :||||||.||:|::|||||.||:.|:|.|||||||:|.|||.|::||:|.|::|:.||:||....
Human   353 SNACKKCNCNEHSISCHFDMAVYLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPN 417

  Fly   414 VCQPCDCDPQGSSDDGICDSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPC 478
            .|:.|.|||.||.::|||||..:...|.:||.|.||..|.|..|:.||:|:::|.|::|.||:.|
Human   418 FCERCTCDPAGSQNEGICDSYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFGCKSC 482

  Fly   479 TCNPLGTL-NNSGCVMRTGECKCKKYVTGKDCNQCMPETYGLSESPEGCSLCNCDAGGSYDNYCD 542
            .||||||: ..:.|...||.|.||:.|||:.|:||:||.:|||...:||..|:||.||:.:|.|.
Human   483 ACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCDQCLPEHWGLSNDLDGCRPCDCDLGGALNNSCF 547

  Fly   543 VISGQCRCRPHMTGRSCSQPKQNYFIPLLPE-VHEAEVVDECISYGANGNCSLVA------ETPD 600
            ..||||.|||||.||.|::.:..|:...|.. ::|||..:      .....|:|.      ..|
Human   548 AESGQCSCRPHMIGRQCNEVEPGYYFATLDHYLYEAEEAN------LGPGVSIVERQYIQDRIP- 605

  Fly   601 GSFTGIGFTRVPENSELVFTVGDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGGCGE 665
             |:||.||.||||.:.|.|.:.:||.||.||.:|||:......||.|.||:.||.::.....||.
Human   606 -SWTGAGFVRVPEGAYLEFFIDNIPYSMEYDILIRYEPQLPDHWEKAVITVQRPGRIPTSSRCGN 669

  Fly   666 LAAATSSETRIPFSLPDRSRQVVALN----------EVCLEAGKVYKFRI---YFERKRHDVDSP 717
                         ::||...|||:|:          .||.|.|..|..|:   .:.....||:||
Human   670 -------------TIPDDDNQVVSLSPGSRYVVLPRPVCFEKGTNYTVRLELPQYTSSDSDVESP 721

  Fly   718 TATILVDSLTLIPRIDVTPIFQ--GS---VLADIRKKDYEKYNC--------KSSLYDMNYKSDP 769
            ..  |:|||.|:|......||.  ||   |:.:...:.:::|.|        |:.:.|:
Human   722 YT--LIDSLVLMPYCKSLDIFTVGGSGDGVVTNSAWETFQRYRCLENSRSVVKTPMTDV------ 778

  Fly   770 KCQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGYCQCKPNVVGRQCDQCAPGTYGFGPEGC 834
             |:|:...:|..:|.....|.|:|.||||.||:.|||.|||:||||||.|::|||||:||||.||
Human   779 -CRNIIFSISALLHQTGLACECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNRCAPGTFGFGPSGC 842

  Fly   835 KACDCNSIGSKDKYCDLITGQCQCVPNTYGRECNQCQPGYWNFPECRVCQCNGHAATCDPIQGTC 899
            |.|:|:..||.:.:|:.:||||.|....|.|:|::|.||:|.||.|:.|||||||..|||:.|.|
Human   843 KPCECHLQGSVNAFCNPVTGQCHCFQGVYARQCDRCLPGHWGFPSCQPCQCNGHADDCDPVTGEC 907

  Fly   900 IDCQDSTTGYSCDSCLDGYYGNPLFGSEIGCRPCRCPETVASGLAHADGCSLDTRNNNMLCHCQE 964
            ::|||.|.|::|:.||.||||:|:.||...||||.||:...||...|..|..|.....:.|.|..
Human   908 LNCQDYTMGHNCERCLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPVTLQLACVCDP 972

  Fly   965 GYSGSRCEICADNFFGNPDN-GGTCSKCECSNNVDLYDTGNCDRQTGACLKCLYQTTGDHCELCK 1028
            ||.||||:.||..:||||.. ||:|..|:|.||:|..|...||::||.||||||.|.|:||:.|:
Human   973 GYIGSRCDDCASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKETGRCLKCLYHTEGEHCQFCR 1037

  Fly  1029 DGFFGDALQQNCQQCECDFLGT-----NNTIAHCDRFTGQCPCLPNVQGVRCDQCAENHWKIASG 1088
            .|::||||||:|::|.|::|||     |.:...||:.||||.|||||.|..||:||.|.|::|||
Human  1038 FGYYGDALQQDCRKCVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQNCDRCAPNTWQLASG 1102

  Fly  1089 EGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACNQCQAHYWGNPNEKCQPCECDQFGAADFQ 1153
            .||:.|||:...:....||.:||||||.||||||.|::||..:||:|:.:|:.|:||..|....|
Human  1103 TGCDPCNCNAAHSFGPSCNEFTGQCQCMPGFGGRTCSECQELFWGDPDVECRACDCDPRGIETPQ 1167

  Fly  1154 CDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGECFNNWDLILSALEDATTATILRAKEIK 1218
            ||:.||.|||.||:.|.:|::|.|||.|.||.|:||.:||..||:|::.|.:.|...:.:||.:|
Human  1168 CDQSTGQCVCVEGVEGPRCDKCTRGYSGVFPDCTPCHQCFALWDVIIAELTNRTHRFLEKAKALK 1232

  Fly  1219 QVGATGAYTSEFSELDKKLQHIRNLLQNTSVS--LVDIEKLDYETQSL-RDQLQASHGRLSETEQ 1280
            ..|..|.|......:::|:..|:::|..:..:  |.:|..|..|.:.| :|..:    .:::.|.
Human  1233 ISGVIGPYRETVDSVERKVSEIKDILAQSPAAEPLKNIGNLFEEAEKLIKDVTE----MMAQVEV 1293

  Fly  1281 NLDDIYNSLSLSGVELESLQNHSRLVQQLSKELKENGIQLQESNIEGAL-NLTRH------AYER 1338
            .|.|..:..:.:..||:|||..:..:....|||.|....::.|:|.||| ::|::      |.||
Human  1294 KLSDTTSQSNSTAKELDSLQTEAESLDNTVKELAEQLEFIKNSDIRGALDSITKYFQMSLEAEER 1358

  Fly  1339 VSNLSTLKDEANELASNTDRNCKRVENL--------SNKIQAEA---DDLANNNKLIE-DYRAEL 1391
            | |.||  .|.|.....:.....|||::        ..|.:.:|   |:||...:.:: ...||:
Human  1359 V-NAST--TEPNSTVEQSALMRDRVEDVMMERESQFKEKQEEQARLLDELAGKLQSLDLSAAAEM 1420

  Fly  1392 TSLTSQIPELNNQVCGKPG---DPCDSLCGGAGCGHCGGFLSCEHGAKTHSEEALKVAKDAETAI 1453
            |..|......:...||.|.   |..:..|||.|||          |..|.:..|.:.|.|.:..:
Human  1421 TCGTPPGASCSETECGGPNCRTDEGERKCGGPGCG----------GLVTVAHNAWQKAMDLDQDV 1475

  Fly  1454 TSKKDQADQTIRALTQAKLNASEAYEKAKRGFEQSERYLNQTNA--------NIKLAENLFIALN 1510
            .|...:.:|..:.:::|||.|.||.:.|       |..|.:|||        |.:| .||...:.
Human  1476 LSALAEVEQLSKMVSEAKLRADEAKQSA-------EDILLKTNATKEKMDKSNEEL-RNLIKQIR 1532

  Fly  1511 NFQENKTASPSESKELAQKTLDLDLKLEPEEIETLGDQINRAVSSLKNVEAIIYRTKPDLDRVNN 1575
            ||....:|.....:.:|.:.|.:::...|::::.|.:.|...|.||..||.|:..:..|:.|...
Human  1533 NFLTQDSADLDSIEAVANEVLKMEMPSTPQQLQNLTEDIRERVESLSQVEVILQHSAADIARAEM 1597

  Fly  1576 LQSIANATKEKADKILDSANSVVESLAAADESQGKAKDAIQQANSNIELAGQDLEKIDEETYSAE 1640
            |...|....:.|..:..:|:.|.|:|..|:::|..|:.||:||:.:|:.....|..|:.||.::|
Human  1598 LLEEAKRASKSATDVKVTADMVKEALEEAEKAQVAAEKAIKQADEDIQGTQNLLTSIESETAASE 1662

  Fly  1641 APANNTAQQVEKLAKKVQKLQNNIMKNDRDAKEITKEAGSVKLEAMRAR----GEANNLQSATSA 1701
            ....|.:|::.:|.:.|::|:....:|..:|:.|.|...:||..|...:    ||   |......
Human  1663 ETLFNASQRISELERNVEELKRKAAQNSGEAEYIEKVVYTVKQSAEDVKKTLDGE---LDEKYKK 1724

  Fly  1702 TNQTLTDRASRSENARERAKQLLQRASKLTVDTNAKLKDLNDLQTVY-------LNKNQQLLRLQ 1759
            ....:..:...|.:||.:|:.|...|..|....|:||:.|.||:..|       .:|.|:|.||:
Human  1725 VENLIAKKTEESADARRKAEMLQNEAKTLLAQANSKLQLLKDLERKYEDNQRYLEDKAQELARLE 1789

  Fly  1760 AEIGPLNKELNE 1771
            .|:..|.|::::
Human  1790 GEVRSLLKDISQ 1801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB1	NP_476618.1	Laminin_N	63..286	CDD:278484	136/230 (59%)
		EGF_Lam	287..343	CDD:238012	33/55 (60%)
		Laminin_EGF	355..415	CDD:278482	34/59 (58%)
		Laminin_EGF	418..475	CDD:278482	26/56 (46%)
		EGF_Lam	477..526	CDD:238012	24/49 (49%)
		EGF_Lam	529..567	CDD:214543	19/37 (51%)
		EGF_Lam	789..834	CDD:214543	31/44 (70%)
		Laminin_EGF	837..885	CDD:278482	21/47 (45%)
		Laminin_EGF	883..930	CDD:278482	27/46 (59%)
		Laminin_EGF	933..988	CDD:278482	24/55 (44%)
		Laminin_EGF	991..1043	CDD:278482	29/51 (57%)
		Laminin_EGF	1043..1091	CDD:278482	27/52 (52%)
		Laminin_EGF	1094..1142	CDD:278482	24/47 (51%)
		Laminin_EGF	1142..1190	CDD:278482	25/47 (53%)
		COG6	1212..>1398	CDD:303003	54/207 (26%)
		TelA	1439..1782	CDD:226371	94/352 (27%)
		ApoLp-III_like	1545..1702	CDD:304399	45/160 (28%)
LAMB1	XP_016867690.1	Laminin_N	68..293	CDD:278484	136/230 (59%)
		EGF_Lam	295..347	CDD:238012	33/54 (61%)
		EGF_Lam	359..411	CDD:238012	31/51 (61%)
		Laminin_EGF	422..479	CDD:278482	26/56 (46%)
		Laminin_EGF	482..536	CDD:278482	27/53 (51%)
		EGF_Lam	533..>572	CDD:238012	19/38 (50%)
		EGF_Lam	797..842	CDD:214543	31/44 (70%)
		Laminin_EGF	845..893	CDD:278482	21/47 (45%)
		Laminin_EGF	891..938	CDD:278482	27/46 (59%)
		Laminin_EGF	941..997	CDD:278482	24/55 (44%)
		Laminin_EGF	1000..1044	CDD:278482	23/43 (53%)
		Laminin_EGF	1052..1106	CDD:278482	28/53 (53%)
		Laminin_EGF	1108..1156	CDD:278482	24/47 (51%)
		Laminin_EGF	1156..1206	CDD:278482	26/49 (53%)
		PhaP_Bmeg	<1275..1404	CDD:299060	35/135 (26%)
		Mt_ATP_synt	1496..1712	CDD:292332	61/223 (27%)
		GARP	1562..1750	CDD:293336	50/190 (26%)
		Prefoldin	1673..1790	CDD:298833	32/119 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	302	1.000	Domainoid score	I1401
eggNOG	1	0.900	-	-		E1_KOG0994
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1452	1.000	Inparanoid score	I112
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49316
OrthoDB	1	1.010	-	-		D42471at33208
OrthoFinder	1	1.000	-	-		FOG0002726
OrthoInspector	1	1.000	-	-		otm41175
orthoMCL	1	0.900	-	-		OOG6_100925
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3531
SonicParanoid	1	1.000	-	-		X1817
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870