DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LanB1 and LAMA3

DIOPT Version :9

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:XP_011524280.1 Gene:LAMA3 / 3909 HGNCID:6483 Length:3342 Species:Homo sapiens


Alignment Length:2616 Identity:537/2616 - (20%)
Similarity:849/2616 - (32%) Gaps:1100/2616 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 RPPQHGRRDRPKYPPNKF----IKTHP-CERS----------SCYPATGNLLIGRENRLTASSTC 75
            ||  .||...|..||...    ::..| |..:          |.:|...||  ....|:.|::||
Human     6 RP--RGRALGPVLPPTPLLLLVLRVLPACGATARDPGAAAGLSLHPTYFNL--AEAARIWATATC 66

  Fly    76 GLH-------SPERFCIL---------SH-LQDKKCFLCDTREETKHDPYKNHRIGQIIYKTKPG 123
            |..       .||.:|.|         .| :|.:.|..|::     .||.|.|          |.
Human    67 GERGPGEGRPQPELYCKLVGGPTAPGSGHTIQGQFCDYCNS-----EDPRKAH----------PV 116

  Fly   124 TNI----PTWWQS---ENGKE--NATIQLDLEAEFHFTHLIITFTTF-RPAAMYIERSFDFGQTW 178
            ||.    ..||||   .:|.:  ...:.|||...||..:::|.|... ||....:|||.|||.|:
Human   117 TNAIDGSERWWQSPPLSSGTQYNRVNLTLDLGQLFHVAYILIKFANSPRPDLWVLERSVDFGSTY 181

  Fly   179 HIYRYFAY---DCKESFPGVPTV-LENITDVMCTSRYSNVEPSRNGEVIFRVL---PPNINVTDP 236
            ..::|||:   ||.:.|.....: :....||:|.:.||.:.|..||||:..::   |...|.|  
Human   182 SPWQYFAHSKVDCLKEFGREANMAVTRDDDVLCVTEYSRIVPLENGEVVVSLINGRPGAKNFT-- 244

  Fly   237 YAEHVQNQLKMTNLRIQMTKLHKLGDNLLDSRLENE----EKYYYGISNMVVRGSCSCYGHASQC 297
            ::..::...|.||:|::..:.:.|..:|: |:.:.:    .:|||.|.::.:.|.|.|.|||..|
Human   245 FSHTLREFTKATNIRLRFLRTNTLLGHLI-SKAQRDPTVTRRYYYSIKDISIGGQCVCNGHAEVC 308

  Fly   298 LPLDPAFSQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAV 362
                    ..:|.:.:.  ||||.|:|.|..|:.|...:|...|:||..::::.|:.|.|:.||.
Human   309 --------NINNPEKLF--RCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNCHGHAS 363

  Fly   363 SCHFD------EAVFTASG-FVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDC 420
            :|::|      :|.....| :..||||.||.|||.|.:||:|...:||.....:.:...|.||.|
Human   364 NCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVDAPDGCIPCSC 428

  Fly   421 DP-------QG---------------------------------------SSDDGI--------- 430
            ||       ||                                       ||:|.:         
Human   429 DPEHADGCEQGSGRCHCKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDC 493

  Fly   431 --------------------------CDSLN--------------------ELEEGAVAGACHCK 449
                                      ||:..                    ::...:|.|.|.|:
Human   494 NLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSFPICQACWCSALGSYQMPCSSVTGQCECR 558

  Fly   450 AFVTGRRCNQCKDG--------------------------------------------YWNLQSD 470
            ..|||:||::|..|                                            ||||..:
Human   559 PGVTGQRCDRCLSGAYDFPHCQGSSSACDPAGTINSNLGYCQCKLHVEGPTCSRCKLLYWNLDKE 623

  Fly   471 NPEGCEPCTCNPLGTLNNSG-CVMRTGECKCKKYVTGKDCNQCMPETYGLSESPE-GCSLCNCDA 533
            ||.||..|.|:..||::.:| |....|:|.||.:|.|..|:.|....:.|.:|.. ||..|.||.
Human   624 NPSGCSECKCHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGYFALEKSNYFGCQGCQCDI 688

  Fly   534 GGSYDNYCDVISGQCRCRPHMTGRSCSQPKQNYFIPLLPEVH--EAEVVDECISYGANGNCSLVA 596
            ||:..:.|...||.|:||.|:.|:.|.:|:.||:   .|::|  :.|:.|              .
Human   689 GGALSSMCSGPSGVCQCREHVVGKVCQRPENNYY---FPDLHHMKYEIED--------------G 736

  Fly   597 ETPDGSFTGIGF----------------TRVPENSELVFTVGDIPRSMPYDAVIRYQS------- 638
            .||:|.....||                |.|..:..:...||....|: :..::||.:       
Human   737 STPNGRDLRFGFDPLAFPEFSWRGYAQMTSVQNDVRITLNVGKSSGSL-FRVILRYVNPGTEAVS 800

  Fly   639 ---TSRGDW-----------------ENAFITL-------------------------------- 651
               |....|                 |.||:|:                                
Human   801 GHITIYPSWGKARAAQSKEIIFLPSKEPAFVTVPGNGFADPFSITPGIWVACIKAEGVLLDYLVL 865

  Fly   652 ----------------------------------------------------------------- 651
                                                                             
Human   866 LPRDYYEASVLQLPVTEPCAYAGPPQEKSVWGRSCLLYQHLPVTRFPCTLACEARHFLLDGEPRP 930

  Fly   652 --------VRPDQVD--------------PEGG-------------------------------- 662
                    ..|..||              |:.|                                
Human   931 VAVRQPTPAHPVMVDLSGREVELHLRLRIPQVGHYVVVVEYSTEAAQLFVVDVNVKSSGSVLAGQ 995

  Fly   663 ----------------------------------------------------------------- 662
                                                                             
Human   996 VNIYSCNYSVLCRSAVIDHMSRIAMYELLADADIQLKGHMARFLLHQVCIIPIEEFSAEYVRPQV 1060

  Fly   663 ---------------CGELAAATSSETRI-------PF-SLPDRSRQVVAL----------NEVC 694
                           |..||..|.....|       || .||.:|...|.:          |:|.
Human  1061 HCIASYGRFVNQSATCVSLAHETPPTALILDVLSGRPFPHLPQQSSPSVDVLPGVTLKAPQNQVT 1125

  Fly   695 LEAGKV-----YKFRIYFERKRH------------------------------------------ 712
            |. |:|     |.|.|:|.:..|                                          
Human  1126 LR-GRVPHLGRYVFVIHFYQAAHPTFPAQVSVDGGWPRAGSFHASFCPHVLGCRDQVIAEGQIEF 1189

  Fly   713 DVDSP--TATILV---DSLTLIPRIDVTPI--FQGSVLADIRKKDYEK-----YNC-KSSLYDMN 764
            |:..|  .||:.|   .||.|: |:.|.|.  :...:|   .||..:|     .|| |:|.|   
Human  1190 DISEPEVAATVKVPEGKSLVLV-RVLVVPAENYDYQIL---HKKSMDKSLEFITNCGKNSFY--- 1247

  Fly   765 YKSDPK-----CQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGYCQCKPNVVGRQCDQCAP 824
              .||:     |:|....|..|.|.||..|.|:|||:....|...||.|.|:|||:||||.:||.
Human  1248 --LDPQTASRFCKNSARSLVAFYHKGALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCAT 1310

  Fly   825 GTYGF---------------------------GPE---------------GCKACDCNSIGSKD- 846
            |.|||                           .|:               ||:.|:|:..|:.: 
Human  1311 GHYGFPRCKPCSCGRRLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMAGCEGCNCSRRGTIEA 1375

  Fly   847 --KYCDLITGQCQCVPNTYGRECNQCQPGYWNFPECRVCQCN---GHAATCDPIQGTCIDCQDST 906
              ..||..:|||:|.|...||:|::|..|::.||||..|.||   .....|||..|.|: |:::.
Human  1376 AMPECDRDSGQCRCKPRITGRQCDRCASGFYRFPECVPCNCNRDGTEPGVCDPGTGACL-CKENV 1439

  Fly   907 TGYSCDSCLDG-YYGNPLFGSEIGCRPCRC----------------------------------- 935
            .|..|:.|.:| ::.:|  .:..||..|.|                                   
Human  1440 EGTECNVCREGSFHLDP--ANLKGCTSCFCFGVNNQCHSSHKRRTKFVDMLGWHLETADRVDIPV 1502

  Fly   936 ----------------PETVAS----------------------------GL------------- 943
                            |.|:.|                            ||             
Human  1503 SFNPGSNSMVADLQELPATIHSASWVAPTSYLGDKVSSYGGYLTYQAKSFGLPGDMVLLEKKPDV 1567

  Fly   944 ----------------------------------AHADGCSLDTRNNNM---------------- 958
                                              .||...:..:|...|                
Human  1568 QLTGQHMSIIYEETNTPRPDRLHHGRVHVVEGNFRHASSRAPVSREELMTVLSRLADVRIQGLYF 1632

  Fly   959 -----------------------------LCHCQEGYSGSRCEICADNFFGNPDN--GGTCSKCE 992
                                         :|.|...|:|..|:.|:..::.:...  .|.|..|.
Human  1633 TETQRLTLSEVGLEEASDTGSGRIALAVEICACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCN 1697

  Fly   993 CSNNVDLYDTGNCDRQTGACLKCLYQTTGDHCELCKDGFFGDALQQNCQQCECDFLGTNNTIAHC 1057
            |:.:     :..|...:|.|:.|.:.|.|:|||.|::|::|:|:..:|:.|.|         .|.
Human  1698 CNGH-----SNQCQDGSGICVNCQHNTAGEHCERCQEGYYGNAVHGSCRACPC---------PHT 1748

  Fly  1058 DRF-TGQCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGFGG 1121
            :.| ||   |:.|...||                                      |.||.|:.|
Human  1749 NSFATG---CVVNGGDVR--------------------------------------CSCKAGYTG 1772

  Fly  1122 RACNQCQAHYWGNPNE---KCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQF 1183
            ..|.:|...|:|||.:   .||||.|:..|... .|...||:|:..|........|         
Human  1773 TQCERCAPGYFGNPQKFGGSCQPCSCNSNGQLG-SCHPLTGDCINQEPKDSSPAEE--------- 1827

  Fly  1184 PHCSPCGECFNNWDLILSALEDATTATILRAKEIKQVGATGAYTSEFSELDKKLQHIRNLLQNTS 1248
              |..|..|      :::.|.|..|                        :.::|:.:::.||..|
Human  1828 --CDDCDSC------VMTLLNDLAT------------------------MGEQLRLVKSQLQGLS 1860

  Fly  1249 VSLVDIEKLDY-ETQS--LRDQLQASHGRLSETEQNLDDIYNSLSLSGVELESLQN----HSRLV 1306
            .|...:|::.: |||:  ||:||......:|.....::.:...|:....|.|:||.    :||..
Human  1861 ASAGLLEQMRHMETQAKDLRNQLLNYRSAISNHGSKIEGLERELTDLNQEFETLQEKAQVNSRKA 1925

  Fly  1307 QQLSKELKENGIQLQESNIEGALNLTRHAYERVSNLSTLKDEANELAS--------NTDRNCKRV 1363
            |.|:..:.......:|.::: ..|:.|:.:..:..:|....|.|.:.|        ...|..:.:
Human  1926 QTLNNNVNRATQSAKELDVK-IKNVIRNVHILLKQISGTDGEGNNVPSGDFSREWAEAQRMMREL 1989

  Fly  1364 EN-------------------LSNKI-------QAEADDLANN-NKLIEDYRAELTSLTSQIPEL 1401
            .|                   |.|:|       |.|.:.|||: ...:.:|.|:|:.|.:::.|.
Human  1990 RNRNFGKHLREAEADKRESQLLLNRIRTWQKTHQGENNGLANSIRDSLNEYEAKLSDLRARLQEA 2054

  Fly  1402 NNQVCGKPGDPCDSLCGGAGCGHCGGFLSCEHGAKTHSEEALKVAKDAETAITSKKDQADQTIRA 1466
            ..|.                        ...:|....:|.||...:.....|.|.  |:|.| :.
Human  2055 AAQA------------------------KQANGLNQENERALGAIQRQVKEINSL--QSDFT-KY 2092

  Fly  1467 LTQAKLN------ASEAYEKAKRGFEQSERYLNQTNANI--KLAENLFIALNNFQENKTASPSES 1523
            ||.|..:      |.:..||:::.:|:....||:....:  |:.|     |:. ...||:...|:
Human  2093 LTTADSSLLQTNIALQLMEKSQKEYEKLAASLNEARQELSDKVRE-----LSR-SAGKTSLVEEA 2151

  Fly  1524 KELAQKTLDLDLKLEPEEIETLGDQINRAVSSLKNVEAIIYRTKPDLDRVNNLQSIANATK---E 1585
            ::.|:...:|..:||..:....||::.|..                :|.....::|.||.|   :
Human  2152 EKHARSLQELAKQLEEIKRNASGDELVRCA----------------VDAATAYENILNAIKAAED 2200

  Fly  1586 KADKILDSANSVVESLAAADESQGKAKDAIQQANSNIELAGQDLEKIDEETYSAEAPANNTAQQV 1650
            .|::...::.|.::::...|..: |||.....::..:..|....:|:.:|.    :||.|..||.
Human  2201 AANRAASASESALQTVIKEDLPR-KAKTLSSNSDKLLNEAKMTQKKLKQEV----SPALNNLQQT 2260

  Fly  1651 EKLAKKVQK--LQNN----------IMKNDRD-----AKEITKEAGSVKLEAMRARGEANNLQSA 1698
            ..:. .|||  :..|          |.:.|.|     ||.:.::|..:..|.:..   .|.:|:.
Human  2261 LNIV-TVQKEVIDTNLTTLRDGLHGIQRGDIDAMISSAKSMVRKANDITDEVLDG---LNPIQTD 2321

  Fly  1699 TSATNQTLTDRASRSENARERAKQLLQRASKLTVDTNAKLKDL-NDLQTVYLNKNQQLLRLQAEI 1762
            .    :.:.|...|::|  |..|:.|..|.........||.|| ..::::    |||||      
Human  2322 V----ERIKDTYGRTQN--EDFKKALTDADNSVNKLTNKLPDLWRKIESI----NQQLL------ 2370

  Fly  1763 GPLNKELNEHLIHIKE 1778
             ||. .:::::..|:|
Human  2371 -PLG-NISDNMDRIRE 2384

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 63..286 CDD:278484 71/260 (27%)
EGF_Lam 287..343 CDD:238012 18/55 (33%)
Laminin_EGF 355..415 CDD:278482 23/66 (35%)
Laminin_EGF 418..475 CDD:278482 28/201 (14%)
EGF_Lam 477..526 CDD:238012 16/50 (32%)
EGF_Lam 529..567 CDD:214543 16/37 (43%)
EGF_Lam 789..834 CDD:214543 24/86 (28%)
Laminin_EGF 837..885 CDD:278482 20/50 (40%)
Laminin_EGF 883..930 CDD:278482 14/50 (28%)
Laminin_EGF 933..988 CDD:278482 18/227 (8%)
Laminin_EGF 991..1043 CDD:278482 16/51 (31%)
Laminin_EGF 1043..1091 CDD:278482 10/48 (21%)
Laminin_EGF 1094..1142 CDD:278482 13/50 (26%)
Laminin_EGF 1142..1190 CDD:278482 10/47 (21%)
COG6 1212..>1398 CDD:303003 44/227 (19%)
TelA 1439..1782 CDD:226371 82/369 (22%)
ApoLp-III_like 1545..1702 CDD:304399 35/176 (20%)
LAMA3XP_011524280.1 LamNT 46..297 CDD:214532 75/270 (28%)
EGF_Lam 299..344 CDD:238012 18/54 (33%)
Laminin_EGF 356..423 CDD:278482 23/66 (35%)
EGF_Lam 425..465 CDD:238012 7/39 (18%)
Laminin_EGF 491..538 CDD:278482 2/46 (4%)
EGF_Lam 535..577 CDD:238012 11/41 (27%)
Laminin_EGF 585..628 CDD:278482 6/42 (14%)
EGF_Lam 631..682 CDD:238012 17/50 (34%)
EGF_Lam 684..727 CDD:238012 18/45 (40%)
Laminin_EGF 1275..1323 CDD:278482 23/47 (49%)
EGF_Lam 1365..1410 CDD:238012 16/44 (36%)
EGF_Lam 1413..1463 CDD:238012 15/52 (29%)
LamB 1523..1650 CDD:214597 7/126 (6%)
EGF_Lam 1695..1741 CDD:238012 15/50 (30%)
Laminin_EGF 1743..1793 CDD:278482 21/99 (21%)
Laminin_I 1854..2113 CDD:283627 59/286 (21%)
Laminin_I 2071..2357 CDD:283627 70/325 (22%)
ApoLp-III_like 2101..2265 CDD:304399 38/191 (20%)
Laminin_II 2297..2425 CDD:283628 26/109 (24%)
LamG 2444..2579 CDD:214598
LamG 2611..2751 CDD:238058
LamG 2778..2910 CDD:238058
LamG 3003..3143 CDD:238058
LamG 3167..3318 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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