DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB1 and LanA

DIOPT Version :9

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster


Alignment Length:2852 Identity:576/2852 - (20%)
Similarity:868/2852 - (30%) Gaps:1271/2852 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 PATGNLLIGRENRLTASSTCG--LHSPERFCIL------------SHLQDKKCFLCDTREETKHD 106
            |...||..||  ::.|::|||  ...||.:|.|            |.:|.:.|..||.....::.
  Fly    26 PPYFNLATGR--KIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYCDPTVPERNH 88

  Fly   107 PYKNHRIGQIIYKTKPGTNIPTWWQS---ENGKE--NATIQLDLEAEFHFTHLIITF-TTFRPAA 165
            |.:|         ...||.  .||||   ..|.:  ...:.::.|.|||..:|.|.. .:.||..
  Fly    89 PPEN---------AIDGTE--AWWQSPPLSRGMKFNEVNLTINFEQEFHVAYLFIRMGNSPRPGL 142

  Fly   166 MYIERSFDFGQTWHIYRYFA---YDCKESFPGVPTVLENIT---DVMCTSRYSNVEPSRNGEVIF 224
            ..:|:|.|:|:||..:::|:   .|| |::.|..| .:.||   ||:||:.||.:.|..|||:..
  Fly   143 WTLEKSTDYGKTWTPWQHFSDTPADC-ETYFGKDT-YKPITRDDDVICTTEYSKIVPLENGEIPV 205

  Fly   225 RVLPPNINVTDPYAEHV-QNQLKMTNLRIQMTKLHKLGDNLLDSRLEN---EEKYYYGISNMVVR 285
            .:|....:.|:.:...| |...:.||:||::.:...|..:|:....::   ..:|:|.|.::.:.
  Fly   206 MLLNERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYFYSIKDISIG 270

  Fly   286 GSCSCYGHASQCLPLDPAFSQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTN 350
            |.|.|.|||..|...||       :..:....|.|.|:|.|:.|.||...|....|:    :.||
  Fly   271 GRCMCNGHADTCDVKDP-------KSPVRILACRCQHHTCGIQCNECCPGFEQKKWR----QNTN 324

  Fly   351 A----CKKCECNDHAVSCHFDEAVFTASG--------FVSGGVCDNCLHNTRGQHCEECMPYFYR 403
            |    |:.|.|:.|:..|.:||.| ...|        :..||||.||.|||.|.:|.:|.|.:||
  Fly   325 ARPFNCEPCNCHGHSNECKYDEEV-NRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYR 388

  Fly   404 DP-----EQDITS---------------------------------------------------- 411
            ..     |.|:.|                                                    
  Fly   389 PKGKHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPPSCDSCAYGYYGYPNCRECECNLN 453

  Fly   412 ----------------------------------------------------------------- 411
                                                                             
  Fly   454 GTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPECKACECNKIGSITNDCNVTTGECKCLT 518

  Fly   412 -------ER---------VCQPCDCDPQGSSDD-------------------------------- 428
                   ||         .|..||||.||:..:                                
  Fly   519 NFGGDNCERCKHGYFNYPTCSYCDCDNQGTESEICNKQSGQCICREGFGGPRCDQCLPGFYNYPD 583

  Fly   429 -------------------GICDSLNEL------------------------------------- 437
                               |.|:.||..                                     
  Fly   584 CKPCNCSSTGSSAITCDNTGKCNCLNNFAGKQCTLCTAGYYSYPDCLPCHCDSHGSQGVSCNSDG 648

  Fly   438 ----------------EEG---------------------------AVAGACHCKAFVTGRRCNQ 459
                            :||                           .|...|.||..||||.||:
  Fly   649 QCLCQPNFDGRQCDSCKEGFYNFPSCEDCNCDPAGVIDKFAGCGSVPVGELCKCKERVTGRICNE 713

  Fly   460 CKDGYWNLQSDNPEGCEPCTCNPLGTLNN-SGCVMRTGECKCKKYVTGKDCNQCMPETYGL-SES 522
            ||..||||...|.||||.|.|...||::. ..|..::|:|.||.:..|:.|.:|...|:.| |.|
  Fly   714 CKPLYWNLNISNTEGCEICDCWTDGTISALDTCTSKSGQCPCKPHTQGRRCQECRDGTFDLDSAS 778

  Fly   523 PEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQPKQNYFIPLLPEVH------------ 575
            ..||..|:||.|||:.:.||.|||||:|.|.:||.:|:||...:|.|.|.:..            
  Fly   779 LFGCKDCSCDVGGSWQSVCDKISGQCKCHPRITGLACTQPLTTHFFPTLHQFQYEYEDGSLPSGT 843

  Fly   576 --------------------------------------------------EAEVVDECISYGANG 590
                                                              .||.|...||..::.
  Fly   844 QVRYDYDEAAFPGFSSKGYVVFNAIQNDVRNEVNVFKSSLYRIVLRYVNPNAENVTATISVTSDN 908

  Fly   591 NCS-------LVAETPDGSFTGIG------------------FTRV------------------- 611
            ...       |:..|.:..|..:.                  ||..                   
  Fly   909 PLEVDQHVKVLLQPTSEPQFVTVAGPLGVKPSAIVLDPGRYVFTTKANKNVMLDYFVLLPAAYYE 973

  Fly   612 -------------------------------------------------------PENSELVFTV 621
                                                                   ||:.::|..|
  Fly   974 AGILTRHISNPCELGNMELCRHYKYASVEVFSPAATPFVIGENSKPTNPVETYTDPEHLQIVSHV 1038

  Fly   622 GDI----------------PRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGG-------- 662
            |||                |||..|..||.|.| .|...::.:|.|...|..|.|..        
  Fly  1039 GDIPVLSGSQNELHYIVDVPRSGRYIFVIDYIS-DRNFPDSYYINLKLKDNPDSETSVLLYPCLY 1102

  Fly   663 ---CGE----------------------LAAATSSETRIPF----SLPDRSRQVVALN--EVCL- 695
               |..                      ::|.....:|.|.    ::|.....:..:|  .||: 
  Fly  1103 STICRTSVNEDGMEKSFYINKEDLQPVIISADIEDGSRFPIISVTAIPVDQWSIDYINPSPVCVI 1167

  Fly   696 --EAGKVYKFR-------IYFERKRHD--------------------VDSPT-ATILVDSLTLIP 730
              :.....|||       |.||....|                    :||.. |||:::|     
  Fly  1168 HDQQCATPKFRSVPDSKKIEFETDHEDRIATNKPPYASLDERVKLVHLDSQNEATIVIES----- 1227

  Fly   731 RIDVT----------------------------------------------------PIFQGSVL 743
            ::|.|                                                    |..:||..
  Fly  1228 KVDATKPNLFVILVKYYQPSHPKYQVYYTLTAGKNQYDGKFDIQHCPSSSGCRGVIRPAGEGSFE 1292

  Fly   744 ADIRKK-------------DY------EKY------------------NCKSSLYDMNYKSDPKC 771
            .|...|             ||      ::|                  ||....:.:.:.:...|
  Fly  1293 IDDEFKFTITTDRSQSVWLDYLVVVPLKQYNDDLLVEETFDQTKEFIQNCGHDHFHITHNASDFC 1357

  Fly   772 QNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGYCQCK------------------------- 811
            :.....|:...:.||..|||:..||.|..|...||.||||                         
  Fly  1358 KKSVFSLTADYNSGALPCNCDYAGSTSFECHPFGGQCQCKPNVIERTCGACRSRYYGFPDCKPCK 1422

  Fly   812 -----------------PNVVGRQCDQCAPGTYGFGPE-GCKACDCNSIG--SKDKYCDLITGQC 856
                             |||:|..|::|||.||||... ||:.|.||.:|  :.:..|||..|.|
  Fly  1423 CPNSAMCEPTTGECMCPPNVIGDLCEKCAPNTYGFHQVIGCEECACNPMGIANGNSQCDLFNGTC 1487

  Fly   857 QCVPNTYGRECNQCQPGYWNFPEC----------------------------------------- 880
            :|..|..||.|:.|..||:|||.|                                         
  Fly  1488 ECRQNIEGRACDVCSNGYFNFPHCEQCSCHKPGTELEVCDKIDGACFCKKNVVGRDCDQCVDGTY 1552

  Fly   881 ----------------------------------------------------------------- 880
                                                                             
  Fly  1553 NLQESNPDGCTTCFCFGKTSRCDSAYLRVYNVSLLKHVSITTPEFHEESIKFDMWPVPADEILLN 1617

  Fly   881 ----------------------------------------------------------------- 880
                                                                             
  Fly  1618 ETTLKADFTLREVNDERPAYFGVLDYLLNQNNHISAYGGDLAYTLHFTSGFDGKYIVAPDVILFS 1682

  Fly   881 ---------------------RV------------------------------------------ 882
                                 ||                                          
  Fly  1683 EHNALVHTSYEQPSRNEPFTNRVNIVESNFQTISGKPVSRADFMMVLRDLKVIFIRANYWEQTLV 1747

  Fly   883 -------------------------------------------------------------CQCN 886
                                                                         |:||
  Fly  1748 THLSDVYLTLADEDADGTGEYQFLAVERCSCPPGYSGHSCEDCAPGYYRDPSGPYGGYCIPCECN 1812

  Fly   887 GHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGSEIGCRPCRCPETVASGLAHADGCSL 951
            ||:.|||...|.|..||..|.|..|:.|:.|||||...|:...|..|.||....|. ..|..|.:
  Fly  1813 GHSETCDCATGICSKCQHGTEGDHCERCVSGYYGNATNGTPGDCMICACPLPFDSN-NFATSCEI 1876

  Fly   952 DTRNNNMLCHCQEGYSGSRCEICADNFFGNPDN-GGTCSKCECSNNVDLYDTGNCDRQTGACLKC 1015
            ....:.:.|.|:.||:|.|||.||:.|:|.|:: |..|..||||.|::..|.|:||.:||.||:|
  Fly  1877 SESGDQIHCECKPGYTGPRCESCANGFYGEPESIGQVCKPCECSGNINPEDQGSCDTRTGECLRC 1941

  Fly  1016 LYQTTGDHCELCKDGFFGDALQ-QNCQQCECDFLGTNNTIAHCDRFTGQCPCLPNVQGVRCDQCA 1079
            |..|.|..|.||..||:|||:: :|||.|:||.|||..    ||.|.|.|.|..||.|.|||:|.
  Fly  1942 LNNTFGAACNLCAPGFYGDAIKLKNCQSCDCDDLGTQT----CDPFVGVCTCHENVIGDRCDRCK 2002

  Fly  1080 ENHWKIASGEGCESCNCDPIGALHE--QCNSYTGQCQCKPGFGGRACNQCQAHYWGNPNEKCQPC 1142
            .:|:...||.||.:|:|   ||...  ||:.:||.|.||.|..||.|::|...:|....:.|.||
  Fly  2003 PDHYGFESGVGCRACDC---GAASNSTQCDPHTGHCACKSGVTGRQCDRCAVDHWKYEKDGCTPC 2064

  Fly  1143 ECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYI-----GQFPHCSPCGECFNNWDLIL-- 1200
            .|:|..:..|.|:..||.|.|..|:.|.:|:.|...::     |       |.||.|....:|  
  Fly  2065 NCNQGYSRGFGCNPNTGKCQCLPGVIGDRCDACPNRWVLIKDEG-------CQECNNCHHALLDV 2122

  Fly  1201 ---------SALEDATTATILRAKEIKQVGATGAYTSE----FSELDKKLQHIRNLLQNTSVSLV 1252
                     |.|||..:.|:            ..:||:    :.:|..:|:....||...||.|.
  Fly  2123 TDRMRYQIDSVLEDFNSVTL------------AFFTSQKLNYYDQLADELEPKVKLLDPNSVDLS 2175

  Fly  1253 DIEKLDYETQSLRDQLQASHGRLSETEQNLDDI--YNSLSLSGVEL---ESLQNHSRL------V 1306
            ..:|.:.|.:|   ..::...::::|..|..||  .:|.:|..:.:   |::::..:.      |
  Fly  2176 PSKKANSELES---DAKSYAKQVNQTLANAFDIRERSSTTLGNITVAYDEAVKSADQAKEAIASV 2237

  Fly  1307 QQLSKELKE--------------------NGIQLQESNIEGALNLTRHAYERVS----------- 1340
            :.|||.|:.                    ||..::.:..|..|...|..||.|:           
  Fly  2238 EALSKNLEAAASTKIDAALEQAQHILGQINGTSIELTPNEQVLEKARKLYEEVNTLVLPIKAQNK 2302

  Fly  1341 NLSTLKDEANELASNTD------------------RNCKRVENLSN---------KIQAE----- 1373
            :|:.||::..|.:.:.:                  ||....:...|         |:|||     
  Fly  2303 SLNALKNDIGEFSDHLEDLFNWSEASQAKSADVERRNVANQKAFDNSKFDTVSEQKLQAEKNIKD 2367

  Fly  1374 -ADDLANNNKLIEDYRAELTSLTSQIPELNNQVCGKPGDPCDSLCGGAGCGHCGGFLSCEHGAKT 1437
             .:.|.|.:..:.....:|.:|...:.|||:                               ...
  Fly  2368 AGNFLINGDLTLNQINQKLDNLRDALNELNS-------------------------------FNK 2401

  Fly  1438 HSEEALKVAKDAETAITSKKDQADQ-----------------TIRALTQAKLNASEAYEKAKRGF 1485
            :.:|.|.|.:|......:..|||:|                 .:.|..:..:.|:.||.......
  Fly  2402 NVDEELPVREDQHKEADALTDQAEQKAAELAIKAQDLAAQYTDMTASAEPAIKAATAYSGIVEAV 2466

  Fly  1486 EQSERYLNQTNANIKLAENLFIALNNFQENKTASPSESKELAQKTLDLDLKLEPEEIETLGDQIN 1550
            |.::          ||:::...|..| ..:||....|...||. |...||             :.
  Fly  2467 EAAQ----------KLSQDAISAAGN-ATDKTDGIEERAHLAD-TGSTDL-------------LQ 2506

  Fly  1551 RAVSSLKNVEAIIY-RTKPDLDRVNNLQSIANATKEKADKILDSANSVVESLAAADE------SQ 1608
            ||..||:.|:..:. |......:|..:.::.|||:.:    |...|.:::.|.|..:      |.
  Fly  2507 RARQSLQKVQDDLEPRLNASAGKVQKISAVNNATEHQ----LKDINKLIDQLPAESQRDMWKNSN 2567

  Fly  1609 GKAKDAIQ--------------QANSNIELA---GQDLEKIDEETYSAEAPANNTAQQVEKLAKK 1656
            ..|.||::              |....:|.|   .:||:..:::...|....::....|.||::.
  Fly  2568 ANASDALEILKNVLEILEPVSVQTPKELEKAHGINRDLDLTNKDVSQANKQLDDVEGSVSKLSEL 2632

  Fly  1657 VQKLQNNIMKNDRDAKEITKEAGSVKLEAMRARGEANNLQSATSATNQTLTDRASRSENARERAK 1721
            .:.::....:....::::.:|..::|.:...||..||:::...:....|:.:.     ...|:.|
  Fly  2633 AEDIEEQQHRVGSQSRQLGQEIENLKAQVEAARQLANSIKVGVNFKPSTILEL-----KTPEKTK 2692

  Fly  1722 QLLQRASKLTV--------------DTNAKLKDLNDLQTVYLNKNQQLLRLQAEIGP 1764
            .|..|.:..|.              :.|...:..||...|.:.....:|.:....||
  Fly  2693 LLATRTNLSTYFRTTEPSGFLLYLGNDNKTAQKNNDFVAVEIVNGYPILTIDLGNGP 2749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 63..286 CDD:278484 69/252 (27%)
EGF_Lam 287..343 CDD:238012 18/55 (33%)
Laminin_EGF 355..415 CDD:278482 28/205 (14%)
Laminin_EGF 418..475 CDD:278482 30/187 (16%)
EGF_Lam 477..526 CDD:238012 16/50 (32%)
EGF_Lam 529..567 CDD:214543 20/37 (54%)
EGF_Lam 789..834 CDD:214543 25/87 (29%)
Laminin_EGF 837..885 CDD:278482 24/344 (7%)
Laminin_EGF 883..930 CDD:278482 22/46 (48%)
Laminin_EGF 933..988 CDD:278482 20/55 (36%)
Laminin_EGF 991..1043 CDD:278482 28/52 (54%)
Laminin_EGF 1043..1091 CDD:278482 22/47 (47%)
Laminin_EGF 1094..1142 CDD:278482 18/49 (37%)
Laminin_EGF 1142..1190 CDD:278482 14/52 (27%)
COG6 1212..>1398 CDD:303003 47/264 (18%)
TelA 1439..1782 CDD:226371 71/381 (19%)
ApoLp-III_like 1545..1702 CDD:304399 33/180 (18%)
LanANP_476617.1 LamNT 18..271 CDD:214532 72/259 (28%)
EGF_Lam 272..>314 CDD:238012 16/48 (33%)
EGF_Lam 332..389 CDD:238012 22/57 (39%)
EGF_Lam 402..443 CDD:238012 0/40 (0%)
EGF_Lam 448..491 CDD:238012 0/42 (0%)
Laminin_EGF 495..543 CDD:278482 4/47 (9%)
Laminin_EGF 541..589 CDD:278482 6/47 (13%)
Laminin_EGF 587..634 CDD:278482 4/46 (9%)
EGF_Lam 631..673 CDD:238012 2/41 (5%)
Laminin_EGF 677..729 CDD:278482 18/51 (35%)
Laminin_EGF 732..782 CDD:278482 16/49 (33%)
EGF_Lam 785..828 CDD:238012 22/42 (52%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 10/134 (7%)
Laminin_EGF 1375..1423 CDD:278482 13/47 (28%)
EGF_Lam 1420..1457 CDD:238012 10/36 (28%)
Laminin_EGF 1466..1516 CDD:278482 21/49 (43%)
Laminin_EGF 1514..1562 CDD:278482 0/47 (0%)
LamB 1632..1760 CDD:214597 2/127 (2%)
Laminin_EGF <1775..1801 CDD:278482 0/25 (0%)
EGF_Lam 1808..1851 CDD:238012 21/42 (50%)
EGF_Lam 1859..1907 CDD:214543 18/48 (38%)
EGF_Lam 1916..1968 CDD:238012 26/51 (51%)
EGF_Lam 1969..2015 CDD:238012 23/49 (47%)
EGF_Lam 2016..>2054 CDD:238012 16/40 (40%)
EGF_Lam 2063..>2097 CDD:238012 13/33 (39%)
Laminin_I 2129..2385 CDD:283627 50/270 (19%)
Tar 2278..2662 CDD:223910 77/443 (17%)
Laminin_II 2566..2700 CDD:283628 24/138 (17%)
LamG 2674..2843 CDD:238058 13/81 (16%)
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45445159
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR10574
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.940

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