Protein Alignment LanB1 and lama5

DIOPT Version :10

• Sequence 1: NP_476618.1
• Gene: LanB1 / 34068
• FlyBaseID: FBgn0261800
• Length: 1788
• Species: Drosophila melanogaster
• Sequence 2: NP_001428968.1
• Gene: lama5 / 321243
• ZFINID: ZDB-GENE-030131-9823
• Length: 3665
• Species: Danio rerio
• Alignment Length: 2922
• Identity: 587/2922 - (20%)
• Similarity: 899/2922 - (30%)
• Gaps: 1304/2922 - (44%)

  Fly     6 LIVVIVLALLSWQWDPVDSQRPPQHGRRDRPKYPPNKFIKTHPCERSSCYPATGNLLIGRENRLT 70
            ::|.:.|.||:   ..:.:|..|.:|        .|.|         |.:|...||..|  .::|
Zfish    14 VLVFLPLLLLT---GTLTAQELPVNG--------VNGF---------SLHPPYFNLAEG--TKIT 56

  Fly    71 ASSTCGLHSPER-----FCIL----------SHLQDKKCFLCDTREETKHDPYKNHRIGQIIYKT 120
            |::|||:...|:     :|.|          ..:|.:.|.:|.:::..:..|..|         .
Zfish    57 ATATCGVDENEQPIQDLYCKLVGGPVSGDPSQTIQGQYCDICSSQDTNRAHPISN---------A 112

  Fly   121 KPGTNIPTWWQ----SENGKEN-ATIQLDLEAEFHFTHLIITFTTF-RPAAMYIERSFDFGQTWH 179
            ..||.  .|||    |.:.|.| ..:.|||...||..:::|.|... ||....:|||.|||:|:.
Zfish   113 IDGTE--RWWQSPPLSRSAKHNQVNVTLDLGQLFHVAYVLIKFANSPRPDLWVLERSIDFGKTYQ 175

  Fly   180 IYRYFA---YDCKESFPGVPTVLENI---TDVMCTSRYSNVEPSRNGEVIFRVL---PPNINVTD 235
            .:::||   .||.|.| |..|: |.|   .||:||:.||.:.|..|||::..::   |..:|.:
Zfish   176 PWQFFASSKRDCIERF-GQRTI-ERIYHDDDVICTTEYSRIVPLENGEIVVSLVNGRPGAMNFS- 237

  Fly   236 PYAEHVQNQLKMTNLRIQMTKLHKLGDNLLDSRLEN---EEKYYYGISNMVVRGSCSCYGHASQC 297
             |:..::...|.||:|::..:.:.|..:|:...|.:   ..:|||.|.::.:.|.|.|.|||..|
Zfish   238 -YSPVLREFTKATNIRLRFLRTNTLLGHLMGKTLRDPTVTRRYYYSIKDISIGGRCVCNGHAEAC 301

  Fly   298 LPLDPAFSQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAV 362
            ...||      |:...:  :|:|.|||.|.:|:.|...||..|||||.....|.|:.|.|:.|:.
Zfish   302 NAQDP------NDPYKL--QCDCQHNTCGTSCDRCCPGFNQFPWKPATTYSANECEPCNCHRHSS 358

  Fly   363 SCHFDEAV------FTASG-FVSGGVCDNCLHNTRGQHCEECMPYFYRDPE-------------- 406
            .|::|..:      ....| :..||||..|.|:|.|.:||.|:|.:||.|:
Zfish   359 ECYYDPEIDQRRSSLDMQGEYNGGGVCVECQHHTTGVNCERCIPGYYRSPDHPLESPFACSKCQC 423

  Fly   407 ---------QDITSERVCQP--------------------------------------CDCDPQG 424
                     :|.|....|:|                                      |:|:..|
Zfish   424 ESEFTEGTCEDRTGRCYCKPNYTGENCDQCAEGYEHFPECYQVLINGEVRPAGENIIDCECNAAG 488

  Fly   425 SSD----------------------------------------------DGICD----------- 432
            :..                                              ||.||
Zfish   489 TEGNSCRPDPRTNTCVCKPEFTGEHCDTCSHGYFSINCQRCQCSGQGCLDGSCDAVTGQCVCRSG 553

  Fly   433 ----------------------------------------------------------------- 432
                                                                             
Zfish   554 FQGYSCEQCAPGYFNYPLCQYCGCSVVGSIPEMCDPAGRCLCRPEFTGPRCDQCQSGFHSYPNCQ 618

  Fly   433 ------------SLNELEE---------------------------------------------- 439
                        |.:||::
Zfish   619 VCTCDPRTSLDSSCSELDQCNCRPNYSGPRCQQCAPGYYSYPSCTPCDCSVEGSRSSSCDPVSGQ 683

  Fly   440 ---------------------------------GAV-------AGACHCKAFVTGRRCNQCKDGY 464
                                             |:|       .|:|.|:.:|.|..|.:||..|
Zfish   684 CVCLPNIEGQRCDSCSPGSYGFPLCQLGTCNPAGSVHNDILPTVGSCVCRPYVEGVACERCKPLY 748

  Fly   465 WNLQSDNPEGCEPCTCNPLGTLNN-SGCVMRTGECKCKKYVTGKDCNQCMPETYGL-SESPEGCS 527
            |||..|...||..|.||..|||:. :.|..|||:|.||..|....||.|....:.| .:|..||.
Zfish   749 WNLSPDTIYGCSTCDCNTAGTLSEVAECTQRTGQCFCKPNVCSGTCNVCKDGFFNLQKDSYFGCQ 813

  Fly   528 LCNCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQPKQNYFIPLLP----EVHEAEVVD-ECISYG 587
            .|.||.|||....||...|:|||||::.|..|.||:.:::.|.|.    ||.:...:| ..:.:|
Zfish   814 GCQCDIGGSVGQACDERYGRCRCRPNVEGPKCKQPRPDHYFPDLHHMKFEVEDGTTMDGRPVRFG 878

  Fly   588 AN--------------------------------------------------------------- 589
            .|
Zfish   879 YNPLEFESFSWRGYAQMSPIQPRVLVEVVVGSPDLFHVVLHYVNRGGVDVTGQVSVIEDGRHVLC 943

  Fly   590 GNCS----LVAETPDGSFTGIGFTRVPENSEL--------VFTV--------------------- 621
            ||||    .:...|....|   |..||:||.:        .:||
Zfish   944 GNCSEQSKQIVFAPSSEPT---FVNVPQNSFVEPFVLNPGTWTVIIEAEGILLDYLVLLPSAYYE 1005

  Fly   622 ----------------------------------------------------------------- 621
                                                                             
Zfish  1006 APILQLQVTEPCSYSHTQDASQNCLQYMYLSLDEFPSISSNDASCRSDNHLPRPCHTEKITPRHP 1070

  Fly   622 ---------------GDIPRSMPYDAVIRYQS------------TSRGD---------------- 643
                           |.:|....|..|:.|.|            :|.|:
Zfish  1071 SMAICSGNDISVGLRGRVPVPGEYVLVVEYASEDQAPQNLTVSVSSAGESTHQEQITLLHCKYSF 1135

  Fly   644 ------------------WENAFITLV-------------------------------------R 653
                              ..||.|.|:                                     .
Zfish  1136 LCRSVSVDDMKRVALFTISANAEIQLIAERSSFFLHKVFLIPRAQFTMEYLKPRVHCISTHGHFA 1200

  Fly   654 PD---------QVDPEGGCGELAAATSSETRIPFSLPDRS------------------------- 684
            ||         |..|:....:...|:|....|..|.||.|
Zfish  1201 PDSGSCIPSRFQNPPQSLVLKEGQASSVAEPILASAPDPSLYADRPMTSTPPTATDNTEHVLLDT 1265

  Fly   685 ---------------RQVVALN-----------EVCLEAGKVY---------------------K 702
                           |.|..|:           :|.:..|:::                     :
Zfish  1266 SQNAVVYSTRVHALGRYVFILHYHQPLHPTYNVQVFINGGRIWQGNVNASFCPHGYGCRSVVMSE 1330

  Fly   703 FRIYFERKRHDV-----DSPTATILVDSLTLIPRIDVTPIFQGSVLADIRKKDYEKY-NC-KSSL 760
            .:|..:...|:|     .....|:.:|.:.::|....:..|....|.|   |.|:.. || ::|.
Zfish  1331 NQIILDVTDHEVILTLRVPDRKTLWLDYVLVVPEGSYSSSFLSEELLD---KSYDFISNCGQNSF 1392

  Fly   761 YDMNYKSDPKCQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGYCQCKPNVVGRQCDQCAPG 825
            |.....:...|.:....||.|.::||..|.|:..|:.|..|||.||.|:|:|||:||.|.|||.|
Zfish  1393 YINPSSASAFCLSSAVSLSSFFNNGAVPCGCHEVGAESDTCESFGGQCRCRPNVIGRDCSQCATG 1457

  Fly   826 TYGF----------------------------------GPE--------GCKACDCNSIG--SKD 846
            .|||                                  .|:        ||:.|:|:..|  |.|
Zfish  1458 YYGFPNCRPCNCGSRLCEPVTGECICPPRTLQPDCVTCEPQTFGCHPLVGCEMCNCSRPGVTSMD 1522

  Fly   847 KYCDLITGQCQCVPNTYGRECNQCQPGYWNFPECR------------------------------ 881
            ..||...|||:|..|..||:|::|.||::.:|.||
Zfish  1523 ISCDTNNGQCRCRNNIVGRQCDRCSPGFYGYPNCRPCNCNEAGTEMNVCDSFTGRCLCKENVEGP 1587

  Fly   882 ----------------------------------------------------------------- 881
                                                                             
Zfish  1588 RCDQCKLGTFHLDPTNAKGCTKCFCFGATDRCHSSDKRRSEIMDMAGWVLLRSDRQEVPVSTYLD 1652

  Fly   882 ----------------------------------------------------------------- 881
                                                                             
Zfish  1653 QDLVEADLSDVPDVSQDLHWHAPQAYLGDKVSSYGGYLRYRLHTQTMRGDAFLMVETIRPDVILK 1717

  Fly   882 ----------------------------------------------------------------- 881
                                                                             
Zfish  1718 GNQMTLVYMEREYPSPEDPHEGIVHLVEESFRHAQTGNSVSREELMMVLVALESLQIRALHSQSA 1782

  Fly   882 -----------------------------------------------------------VCQCNG 887
                                                                       .|.|||
Zfish  1783 QSVSLRAAVLEVAENMPSGRHANNVEICLCPGNYLGDSCQQCAPGYYRDNKGLFLGKCVPCNCNG 1847

  Fly   888 HAATCDPIQGTCIDCQDSTTGYSCDSCLDGY-YGNPLFGSEIGCRPCRCPETVASGLAHADGCSL 951
            |:..|....|.|::|:.:|.|..|:.||.|: :.|.:.|..:.|..|.||..|||. ..|..|.
Zfish  1848 HSDQCLDGSGICVNCRHNTAGNHCEKCLGGFHHNNTVDGHSVSCSSCPCPLQVASN-NFAIRCV- 1910

  Fly   952 DTRNNNMLCHCQEGYSGSRCEICADNFFGNP-DNGGTCSKCECSNNVD---LYDTGNCDRQTGAC 1012
             .:.|||.|.|..||:||:||.||..::||| ..|.||..|.|:.|.|   |:  .:|...||.|
Zfish  1911 -EKPNNMRCLCMPGYAGSKCERCAPGYYGNPVVIGSTCQPCNCNGNSDPNMLF--SDCHPLTGEC 1972

  Fly  1013 LKCLYQTTGDHCELCKDGFFGDAL-QQNCQQCECDFLGTNNTIAHCDRFTGQCPCLPNVQGVRCD 1076
            ..|::.|.|.|||:|..||:|||: .:||.:|.|...||    ||||..||||.|.|.|.|.:||
Zfish  1973 QSCMHNTAGPHCEICAPGFYGDAITAKNCTRCNCSPCGT----AHCDSHTGQCHCKPGVVGAQCD 2033

  Fly  1077 QCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACNQCQAHYWGNPNEKCQP 1141
            :|....:...|..||..|:||...||.:.|:...|.|.|:||..|..|:||...:|...:..|:.
Zfish  2034 RCEHGTFGFDSCTGCRKCDCDASAALVQACDPVNGACACQPGVNGPNCHQCAPGHWNYSSNGCRK 2098

  Fly  1142 CECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYI-----GQFPHCSPCGECFNNWDLILS 1201
            |||.  |.   :||..||.|.|..|:.|.:|:.|...:.     |...||.||..|      ::.
Zfish  2099 CECK--GG---RCDPRTGECRCTTGLTGKQCDTCLSQHSVPVQNGADMHCQPCDSC------VMV 2152

  Fly  1202 ALED-----------ATTATILRAK-----EIKQVGAT-----GAYTSEFSELDK---KLQHIRN 1242
            .|||           |...|.|.|.     ::.::.|:     .|.|:..|.|||   :...:..
Zfish  2153 LLEDLDRISHFYESVANQLTSLNASTFAWTQLNRLNASIADIANAITNYNSTLDKSRNRASVLEG 2217

  Fly  1243 LLQNTSVSLVDIEKLDYETQ----SLRDQLQASHGRLSE-------TEQNLDDIYNSLSLSGVEL 1296
            .|:.....:.|:||....||    :|.|.:.::|.|..|       ..:::.||...::
Zfish  2218 ELEIIDSDIKDLEKKASVTQKKKDALEDNINSTHTRAQELFGFIKGIMRDVKDIIQQVN------ 2276

  Fly  1297 ESLQNHSRL------------VQQLSKELKENGIQLQESNIEGALNLTRHAYERVSN-------- 1341
            .:.||.:::            |:.:.::::..|...|::..:..|:...:..:||.|
Zfish  2277 RTAQNETQVMDEKDLARKIAEVESMLRDMRFRGFDYQKNKAKNELDQANNLVDRVINEIANRTWN 2341

  Fly  1342 ------------------LSTLKDEANELASNTDR-------NCKRVENLSNKI----------- 1370
                              |..|:|..||..:||.:       |.|.:|:|..|:
Zfish  2342 NEAVAENIRNKLKQFNEQLMDLRDAMNEAVNNTAQTVEANNINQKHLEDLQKKVNSLHEKYKEVV 2406

  Fly  1371 ---QAEADDLANNNKL---IEDYRAELTSLTSQIPELNNQVCGK-----PGDPCDSLCGGAGCGH 1424
               |...||:...|.|   ::|.:.:...|.:|:......:..|     |
Zfish  2407 SQLQMAEDDVTQVNDLLSMLQDSKEDYEHLAAQLDGARQPLAEKVQKYAP--------------- 2456

  Fly  1425 CGGFLSCEHGAKTHSEEALKVAKDAETAIT-SKKDQADQTIRALTQAKLNASEAYEKAKRGFEQS 1488
            ....:.....|:.|:|...::|.:..:.|: |.:|.       ..|..||||.||........::
Zfish  2457 AANKIPLVEAAEKHAEMLEQLANNLSSLISGSNQDN-------FIQRALNASRAYTNIINSVLEA 2514

  Fly  1489 ERYLNQTNANIKLAENLFIALNNFQENKTASPSESKEL-AQKTLDLDLKLEPEEIETLGDQINRA 1552
            |     |.| :|..|...:||.|.::         |:| ||...   ||.:..|:....:::|.:
Zfish  2515 E-----TTA-LKANETASMALENIRD---------KDLPAQAAA---LKNQSTELLKSAEELNNS 2561

  Fly  1553 VSSLKNVEAIIYRTKPDLDRVNNLQSIANATKEKADKILD----------SANSVVESLAAADES 1607
            ..||          ||.:|.:.  .|:.:|.|:|...:.|          |.:.:|.|::|
Zfish  2562 SQSL----------KPRVDTIK--MSLLDAEKKKEKMLQDLKDIQNKLNVSRDDIVNSISA---- 2610

  Fly  1608 QGKAKDAIQQANSNI-ELAG--QDLEKIDEETYSAEAPANNTAQQVE------------------ 1651
               ||.|::|||:.: .::|  ..::|..||.......:|.|::.:.
Zfish  2611 ---AKSAVEQANNTVANVSGVLAPIQKQLEEWQKQYGDSNATSEDINKALNDANTSVAALSDTLP 2672

  Fly  1652 KLAKKVQKLQNNIMKNDRDAKEITKEAGSVKLEAMRARGEANNLQSATSATNQTLTDRASRSENA 1716
            ||.||:.:|.|...:....:..|.:    ::....:||..||.:..:.....::.....:.|..|
Zfish  2673 KLIKKLDRLHNTTFQPSNISDSIQR----IRQLIEQARNAANKVSVSMQFNGKSGVQVRTPSNVA 2733

  Fly  1717 RERAKQLLQRASKL---TVDTNAKLKDLNDLQTVYLNK------------NQQLLRLQAEIG 1763
            ...|...||...||   |:....:.:..|....:||..            |.:.||....:|
Zfish  2734 DLAAYSSLQMYIKLPSPTIKKKRQTEATNPQFVLYLGNRDSSKEYMAVTLNGKKLRWHFNVG 2795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LanB1	NP_476618.1	Laminin_N	54..286	CDD:459653	75/264 (28%)
		EGF_Lam	287..343	CDD:238012	21/55 (38%)
		Laminin_EGF	355..415	CDD:395007	23/89 (26%)
		Laminin_EGF	418..475	CDD:395007	25/276 (9%)
		EGF_Lam	477..526	CDD:238012	19/50 (38%)
		EGF_Lam	529..567	CDD:214543	18/37 (49%)
		EGF_Lam	789..834	CDD:214543	25/86 (29%)
		Laminin_EGF	837..885	CDD:395007	22/333 (7%)
		Laminin_EGF	883..930	CDD:395007	17/47 (36%)
		Laminin_EGF	933..988	CDD:395007	25/55 (45%)
		Laminin_EGF	991..1035	CDD:395007	19/46 (41%)
		Laminin_EGF	1043..1091	CDD:395007	20/47 (43%)
		Laminin_EGF	1094..1142	CDD:395007	17/47 (36%)
		Laminin_EGF	1142..1190	CDD:395007	18/52 (35%)
		Mplasa_alph_rch	1228..>1771	CDD:275316	130/665 (20%)
		cc_DmLAMB1-like_C	1717..1786	CDD:411973	13/62 (21%)
lama5	NP_001428968.1	None