DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LanB1 and Lama2

DIOPT Version :9

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:XP_038954896.1 Gene:Lama2 / 309368 RGDID:1308889 Length:3121 Species:Rattus norvegicus


Alignment Length:2368 Identity:564/2368 - (23%)
Similarity:858/2368 - (36%) Gaps:838/2368 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LIVVIVLALLSWQWDPVDSQRPPQHGRRDRPKYPPNKFIKTHPCERSSCYPATGNLLIGRENRL- 69
            ::::::|.:|    :...:|||.|  ||..|.:           ::...:||..||   ..|.| 
  Rat     7 ILLLLLLGIL----EGSQTQRPQQ--RRQSPAH-----------QQRGLFPAVLNL---ASNALI 51

  Fly    70 TASSTCGLHSPERFC-ILSH-----LQDKKCFLCDTREETKHDPYKNHRIGQIIYKTKPGTNIPT 128
            |.::|||...||.:| ::.|     :::.:|.:|:  :.:.| ||:.|.|...|    .|.|  |
  Rat    52 TTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICN--QNSSH-PYQRHPITNAI----DGKN--T 107

  Fly   129 WWQS---ENGKE--NATIQLDLEAEFHFTHLII-TFTTFRPAAMYIERSFDFGQTWHIYRYFAYD 187
            ||||   :||.|  ..||.|||:..|...::|: ...:.||....:|||.| .:.:..::|.|..
  Rat   108 WWQSPSIKNGVEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLD-DEEYKPWQYHAVT 171

  Fly   188 CKES------FP--GVPTVLENITDVMCTSRYSNVEPSRNGEVIFRVLPPNINVTDPYAEHVQNQ 244
            ..|.      :|  |.|:..:: .:|:|||.||.:.|..|||:...::....:..||..|    .
  Rat   172 DTECLTLYNIYPRTGPPSYAKD-DEVICTSFYSKIHPLENGEIHISLINGRPSADDPSPE----L 231

  Fly   245 LKMTN---LRIQMTKLHKLGDNLL-----DSRLEN---EEKYYYGISNMVVRGSCSCYGHASQCL 298
            |:.|:   :|::..::..|..:|:     |.|..:   ..:|||.:.::.|.|.|.|||||..| 
  Rat   232 LEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARAC- 295

  Fly   299 PLDPAFSQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKP-AFGKKTNACKKCECNDHAV 362
            |||||.:::         ||||.|||.|.:|:.|...|:..||:. .|..||. |:.|.|:..|.
  Rat   296 PLDPATNKS---------RCECEHNTCGESCDRCCPGFHQKPWRAGTFLTKTE-CEACNCHGKAE 350

  Fly   363 SCHFDEAVFTAS-------GFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDC 420
            .|::||.|.:.:       .::.||||.||.|||.|.:||.|:..|:|......:..|.||||.|
  Rat   351 ECYYDETVASRNLSLNIHGKYIGGGVCINCTHNTAGINCETCIDGFFRPKGVSPSYPRPCQPCHC 415

  Fly   421 DPQGSSDDGICDSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGT 485
            ||.||..:...........|...|:|:||....|..|::|..||    ...|: |:||.|:.||:
  Rat   416 DPAGSLSEVCIKDEKHTRRGLKPGSCYCKPGFGGMNCDRCVRGY----RGYPD-CQPCNCSGLGS 475

  Fly   486 LNNSGCVMRTGECKCKKYVTGKDCNQCMPETYGL-SESPEGCSLCNCDAGGSYDNYCDVISGQCR 549
            .|...|:   |.|.||:.|.|:||:.|....:.| .|:.:||..|          :|..:|.:|:
  Rat   476 TNQDPCI---GPCSCKENVEGEDCSHCKFGFFNLQEENQKGCEEC----------FCSGVSDRCQ 527

  Fly   550 CRPHMTGRSCSQPKQNYFIPLLPEVHEAEVVDECISYGANGNCSLVAETPDGSFTGIGFTRVPEN 614
            .                                  ||...||                       
  Rat   528 S----------------------------------SYWTYGN----------------------- 535

  Fly   615 SELVFTVGDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGGCGELAAATSSETRIPFS 679
                  :.|:......|...|.|...:.|..:|      |.|:          :.::||.|  .|
  Rat   536 ------IQDMHGWYLTDLSGRIQVAPQLDNPDA------PQQI----------SVSNSEAR--RS 576

  Fly   680 LPDR---SRQVVALNEVCLEAGKVYKFRIYFERKRHDVDSPTATILVDSLTLI---PRIDVTPIF 738
            |||.   |.....|.......|....|.|.::.:..:.|  |..||  .|.:|   ..:.::..:
  Rat   577 LPDSYYWSAPAPYLRNKLPAVGGQLSFTISYDLEEEEDD--TEKIL--QLMIILEGNNLRISTAY 637

  Fly   739 QGSVLADIRKKDYEKYNCKSSLYDMNYKSDPKCQ--------NLDNILSVFVHD-------GASM 788
            : .|..:..::..|:.:.|...:.::..:.|..:        ||:.:|....::       ..|.
  Rat   638 K-EVHLEPSEEHVEELSLKEESFTIHGTNLPVSRKDFMILLTNLERVLIQTTYNLGMDVIFRLSS 701

  Fly   789 CNCN-----PTG-SLSKVCESNGGYCQCKPNVVGRQCDQCAP------GTYGFGPEGCKACDCNS 841
            .|..     ||. |::...|    .|||.|...|..|:.|.|      ||. ||           
  Rat   702 VNLESAVPYPTDRSIASAVE----VCQCPPGYSGSSCEACWPRHRRVNGTI-FG----------- 750

  Fly   842 IGSKDKYCDLITGQCQCVPNTYGRECNQCQPGYWNFPECRVCQCNGHAATCDPIQGTCIDCQDST 906
                                      ..|:|          |||.|||..|:.:.|.|:.|:|.|
  Rat   751 --------------------------GLCEP----------CQCFGHAEACNDVTGECLSCKDHT 779

  Fly   907 TGYSCDSCLDGYYGNPLFGSEIGCRPCRCPETVASGLAHADGCSLDTRNNNMLC-HCQEGYSGSR 970
            .|..|:.||.|:||:|..|:...|:||.||..:.|. ..:..|.|| |:..::| .|..||:|.|
  Rat   780 GGPYCNECLPGFYGDPTRGTSEDCQPCACPLNIPSN-NFSPTCHLD-RSLGLICDECPVGYTGPR 842

  Fly   971 CEICADNFFGNPD-NGGTCSKCECSNNVDLYDTGNCDRQTGACLKCLYQTTGDHCELCKDGFFGD 1034
            ||.||:.:||.|. .||:|..|.|::|:|....|:||..:|:||.|...|||..||||.||:|||
  Rat   843 CERCAEGYFGQPSIPGGSCQPCLCNDNLDFSIPGSCDSLSGSCLICKPGTTGRFCELCADGYFGD 907

  Fly  1035 ALQ-QNCQQCECDFLGTNNTIAHCDRFTGQCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDP 1098
            |:. :|||.|.|:..|:.:.|  |.|.||||.|.|||||.|||:|....:.:..|.||..|||:.
  Rat   908 AVDAKNCQPCRCNVNGSFSEI--CHRKTGQCECRPNVQGQRCDECKPETFGLQLGRGCIPCNCNS 970

  Fly  1099 IGALHEQCNSYTGQCQCKPGFGGRACNQCQAHYW---------------GN------------PN 1136
            .|:....|.: :|||.|:||..|:.|::|...|:               ||            ||
  Rat   971 FGSKSFDCEA-SGQCWCQPGVAGKKCDRCAHGYFNFQEGGCTACDCSHLGNNCNPKTGQCICPPN 1034

  Fly  1137 ---EK----------------CQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQ 1182
               ||                |:.|.|...|:...||:..||.|.||....|.||:||.||: ..
  Rat  1035 TIGEKCSECLPNTWGHSIVTGCKVCNCSTVGSLSSQCNINTGQCSCHPKFSGMKCSECNRGH-WN 1098

  Fly  1183 FPHCSPCGECFNNWDLILSALEDATTATI----------------------------------LR 1213
            :|.||.| :||      |.. .||||...                                  |.
  Rat  1099 YPLCSLC-DCF------LPG-TDATTCDSETRKCSCSDQTGQCTCKVNVEGVHCDRCRPGKFGLE 1155

  Fly  1214 AKEIKQVGATGAY----TSEFSE--------------------LDKKLQHIRN---LLQNTSVSL 1251
            ||  ..:|.:..|    ||:.||                    :|:.|||...   ..||..:  
  Rat  1156 AK--NPLGCSSCYCFGVTSQCSEAKGLVRTWVTLRDEQTILPLVDEALQHTTTKGIAFQNPEI-- 1216

  Fly  1252 VDIEKLDYETQSLR--------------DQLQASHGRLSET-------EQNLDDIYNSLSLSGVE 1295
              :.|:|...|.|.              .:|.|..|:|..|       |.........:.:.|  
  Rat  1217 --VAKMDEVRQDLHLEPFYWKLPEQFEGKKLMAYGGKLKYTIYFEARDETGFATYKPQVIIRG-- 1277

  Fly  1296 LESLQNHSRL-----------------VQQLSKELKENG-------------------------- 1317
              ....|:|:                 ::...||.|..|                          
  Rat  1278 --GTPTHARIITRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPRISRTVTREDFLDILYDIHYILI 1340

  Fly  1318 ----------IQLQESNIEGALNLTRHAYERVSNL------------------------------ 1342
                      .::.|.::|||......|...::||                              
  Rat  1341 KATYGNVVRQSRISEISMEGAEPGQVSAASPLANLIERCDCPPGYSGLSCETCAPGFYRVHSEPG 1405

  Fly  1343 -------------------STLKDEANELASNTDRN-----CKR--------VENLSNKIQAEAD 1375
                               |:..|....:..|...:     |:|        |..|.|..|..|.
  Rat  1406 GRTPGPTLGTCVPCQCHGHSSQCDPETSVCQNCQHHTAGDFCERCALGYYGIVRGLPNDCQPCAC 1470

  Fly  1376 DL--ANNN-------KLIEDYRAELTSLTSQIPELNNQVC--------GKPGD------------ 1411
            .|  .:||       :.:||||.     |:.......|.|        |.|..            
  Rat  1471 PLISPSNNFSPSCVLEGLEDYRC-----TACPRGYEGQYCERCAPGYAGSPSSPGGSCQECECDP 1530

  Fly  1412 ------PCDSLCG------GAGCGHCGGFLSCEHGAKTHSEEAL--------------------- 1443
                  |||.:.|      ||....|.|   ||||......|.:                     
  Rat  1531 YGSLPVPCDPVTGLCTCRPGATGRKCDG---CEHGHAREGAECVFCGDECTGLLLGDLAHLEQMA 1592

  Fly  1444 -------------KVAKDAETAITSKK-----DQADQTIRALTQAKLNA-----SEAYEKAKR-- 1483
                         |:....|.|....|     .:|.:.:..|.:..:|.     :|...:|.:  
  Rat  1593 MNINLTGPLPAPYKILYGLENATQELKHLLSPQRAPERLLQLAEGNMNTLVMEMNELLTRATKVT 1657

  Fly  1484 -GFEQSERYLNQTNAN----------------------IKLAENL----FIALNNFQENKTASPS 1521
             ..||:.:...:||:.                      |||.|.|    ..|..|.||.:.....
  Rat  1658 ADGEQTGQDAERTNSRAQSLEEFIKGLVQHAEAVNEKAIKLNETLGSQDRTAERNLQELQKEIDR 1722

  Fly  1522 ESKELAQKTLDLDLKLEPEEIETLGDQINRAVSSLKNVEAII--------------------YRT 1566
            ..|||..|    ||:.:.|..|   |::..|...||.|..:.                    |:.
  Rat  1723 MLKELRSK----DLQTQKEVAE---DELVAAEGLLKRVNKLFGEPRAQNEEMEKDLREKLAEYQN 1780

  Fly  1567 K---------------PDLDRVN-------------------NLQSIANATKEKADKILDSANSV 1597
            |               .|.||::                   :.:.|.|..||..| |||.||.:
  Rat  1781 KLDDAWDLLREATKKTKDADRLSAANQKNMTILETKKEAIEGSKRQIENTLKEGND-ILDEANRL 1844

  Fly  1598 VESLAA----ADESQGKAKDAIQQANSNIELAGQDLE--KIDEETYSAEAPA------------- 1643
            ...:.:    .::.:.|.....::.:..|:...|:::  ::.|:.:.||:.|             
  Rat  1845 AGEITSVIDYVEDIKTKLPPMSEELSDKIDDLAQEIKDRRLAEKVFQAESHAAQLNDSSAVLDGI 1909

  Fly  1644 ---------NNTA------------QQVEKLAKKVQKL-------------------QNNIMKND 1668
                     |.||            .:.||:|::.::|                   :.::.|:.
  Rat  1910 LDEAKNISFNATAAFRAYSNIKDYIDEAEKVAREAKELAHEATKLATSPQGLLKEDAKGSLQKSF 1974

  Fly  1669 RDAKEITKEAGSVK-----LEAMRARGEANNLQSA--TSATNQTL-------TDRASRSENARER 1719
            |...|..|.|..||     |..::.|.|..:|:::  ..|.|.|:       .|.|::.:..:|:
  Rat  1975 RILNEAKKLANDVKENHNDLSGLKTRLETADLRNSGLLGALNDTMDKLSAIPNDTAAKLQAVKEK 2039

  Fly  1720 AKQ---------------------LLQRASKL---TVDTNAKLKD------LNDLQTVYLNKNQQ 1754
            |::                     |.|..:||   ...|||.:||      :.|......|..|:
  Rat  2040 AREANDTAKAVLAQVKDLHQNLDGLKQNYNKLADSVAKTNAVVKDPSKNKIIADAGATVRNLEQE 2104

  Fly  1755 LLRLQAEIGPLNKELNEHL----IHIKE 1778
            ..||..::.|: |||.::|    ..|||
  Rat  2105 ADRLIDKLKPI-KELEDNLKKNISEIKE 2131

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 63..286 CDD:278484 71/254 (28%)
EGF_Lam 287..343 CDD:238012 25/55 (45%)
Laminin_EGF 355..415 CDD:278482 23/66 (35%)
Laminin_EGF 418..475 CDD:278482 17/56 (30%)
EGF_Lam 477..526 CDD:238012 18/49 (37%)
EGF_Lam 529..567 CDD:214543 4/37 (11%)
EGF_Lam 789..834 CDD:214543 17/56 (30%)
Laminin_EGF 837..885 CDD:278482 3/47 (6%)
Laminin_EGF 883..930 CDD:278482 21/46 (46%)
Laminin_EGF 933..988 CDD:278482 23/56 (41%)
Laminin_EGF 991..1043 CDD:278482 27/52 (52%)
Laminin_EGF 1043..1091 CDD:278482 21/47 (45%)
Laminin_EGF 1094..1142 CDD:278482 22/93 (24%)
Laminin_EGF 1142..1190 CDD:278482 20/47 (43%)
COG6 1212..>1398 CDD:303003 57/357 (16%)
TelA 1439..1782 CDD:226371 105/574 (18%)
ApoLp-III_like 1545..1702 CDD:304399 45/276 (16%)
Lama2XP_038954896.1 Laminin_N 39..284 CDD:395009 75/262 (29%)
EGF_Lam 286..333 CDD:238012 25/56 (45%)
Laminin_EGF 413..470 CDD:395007 20/61 (33%)
Laminin_EGF 468..514 CDD:395007 17/48 (35%)
Laminin_B 582..721 CDD:395006 23/143 (16%)
EGF_Lam 755..804 CDD:238012 22/58 (38%)
EGF_Lam 805..862 CDD:238012 24/58 (41%)
EGF_Lam 863..915 CDD:238012 25/51 (49%)
EGF_Lam 916..963 CDD:238012 21/48 (44%)
EGF_Lam 966..1010 CDD:214543 15/44 (34%)
EGF_Lam 1012..1057 CDD:238012 6/44 (14%)
Laminin_EGF 1059..1107 CDD:395007 21/49 (43%)
Laminin_EGF 1105..1162 CDD:395007 11/66 (17%)
LamB 1228..1363 CDD:214597 17/138 (12%)
EGF_Lam <1378..1406 CDD:238012 0/27 (0%)
Laminin_EGF 1419..1465 CDD:395007 8/45 (18%)
Laminin_EGF 1468..1523 CDD:395007 13/59 (22%)
EGF_Lam 1526..>1563 CDD:238012 11/39 (28%)
Laminin_I 1593..1851 CDD:310534 50/265 (19%)
SMC_prok_B <1675..>2033 CDD:274008 67/365 (18%)
Laminin_II 2036..2171 CDD:368703 24/97 (25%)
Laminin_G_1 2173..2313 CDD:395008
Laminin_G_1 2367..2506 CDD:395008
LamG 2527..2689 CDD:238058
Laminin_G_1 2792..2920 CDD:395008
LamG 2940..3092 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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