DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LanB1 and Lama3

DIOPT Version :9

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_001380677.1 Gene:Lama3 / 307582 RGDID:628776 Length:3333 Species:Rattus norvegicus


Alignment Length:2644 Identity:562/2644 - (21%)
Similarity:852/2644 - (32%) Gaps:1153/2644 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LIVVIVLALLSWQWDPVDSQRPPQHGRRDRPKYPPNKFIKTHPCERSSCYPATGNLLIGRENRLT 70
            |:::::|..:|..|..| :|.|                    |..|.|.:|...||  .:..::.
  Rat    16 LVLLLLLLRMSPCWSVV-AQDP--------------------PAARLSLHPPYFNL--AQAAKIW 57

  Fly    71 ASSTCGLHS-------PERFCIL---------SH-LQDKKCFLCDTREETKHDPYKNHRIGQIIY 118
            |::|||...       ||.||.|         .| :|.:.|..|::.:..|..| ..|.|     
  Rat    58 ATATCGERGLDVSRPRPELFCKLVGGPTAPGSGHTIQGQFCDYCNSEDSRKAHP-AIHAI----- 116

  Fly   119 KTKPGTNIPTWWQS-------ENGKENATIQLDLEAEFHFTHLIITFTTF-RPAAMYIERSFDFG 175
               .|:.  .||||       :..|.|.|  |||...||..:::|.|... ||....:|||.|||
  Rat   117 ---DGSE--RWWQSPPLSSGTQYNKVNLT--LDLGQLFHVAYILIKFANSPRPDLWVLERSVDFG 174

  Fly   176 QTWHIYRYFAY---DCKESFPGVPTVLENITD-VMCTSRYSNVEPSRNGEVIFRVLPPNINVTDP 236
            .|:..::|||:   ||.:.|.....:.....| |:|.:.||.:.|..|||::..::...     |
  Rat   175 NTYSPWQYFAHSRGDCLQQFGQEANMAVTRDDQVLCVTEYSRIVPLENGEIVVSLINGR-----P 234

  Fly   237 YAEH------VQNQLKMTNLRIQMTKLHKLGDNLLDSRLENE----EKYYYGISNMVVRGSCSCY 291
            .|:|      ::...|.||:|::..:.:.|..:|: |:.|.:    .:|||.|.::.|.|.|.|.
  Rat   235 GAKHFAFSDTLREFTKATNIRLRFLRTNTLLGHLI-SKAERDPTVTRRYYYSIKDISVGGRCVCN 298

  Fly   292 GHASQCLPLDPAFSQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCE 356
            |||..|        .|||.:...  ||:|.|:|.|..|..|...:|..||:||...:.|.|:.|.
  Rat   299 GHAEAC--------SADNPEKQF--RCKCQHHTCGDTCNRCCAGYNQRPWRPAAQDQHNECEACN 353

  Fly   357 CNDHAVSCHFDEAV------FTASG-FVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERV 414
            |:.|||.|::||||      ..:.| :..||||.:|.|||.|.:||:|...::|.....:.:...
  Rat   354 CHGHAVDCYYDEAVSRQQASLNSKGVYTGGGVCIDCQHNTAGVNCEKCAKGYFRPHGVPVEALHG 418

  Fly   415 CQPCDCDP-------QGSS----------------DDG--------------------------- 429
            |.||.|||       |||.                .||                           
  Rat   419 CIPCSCDPDRADECDQGSGRCHCKPNFSGDFCETCADGYYNFPFCLRIPVFPDYTLNPEDPMAGN 483

  Fly   430 --------------ICDS--------------LNELEEGAVA----------------------- 443
                          |||.              .:....|:.:                       
  Rat   484 IKGCDCNLEGVLPEICDDRGRCLCRPGVEGPRCDSCRSGSYSFPICQACQCSTSGSYPVPCDPET 548

  Fly   444 GACHCKAFVTGRRCNQCKDG--------------------------------------------Y 464
            |.|.|...||||||::|..|                                            |
  Rat   549 GQCECLPGVTGRRCDRCLSGAYDFPYCQGSSSVCDPAGTMDSSLGYCQCKLHVTSPTCSVCKPLY 613

  Fly   465 WNLQSDNPEGCEPCTCNPLGTLNNSG-CVMRTGECKCKKYVTGKDCNQCMPETYGLSESPE-GCS 527
            |:|..:||.||..|.|:..||::..| |....|:|.||.:|||..|:.|....:.|.:|.. ||.
  Rat   614 WDLAKENPRGCSECQCHEAGTVSGIGECGQEDGDCSCKAHVTGDACDTCADGYFSLEKSNYFGCQ 678

  Fly   528 LCNCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQPKQN-YFIPLLPEVHEAEVVDECISYGANGN 591
            .|.||.||:....|...||:|:||.|:.|:.|.:|:.| ||    |::|..:...|. ..|.||.
  Rat   679 GCQCDIGGALTTMCSGPSGECQCREHIEGKQCQRPESNCYF----PDLHHMKYEVEG-GTGPNGR 738

  Fly   592 CSLVA----ETPDGSFTG-IGFTRVPENSELVFTVGDIPRSMPYDAVIRYQS------------- 638
            .....    |.|:.|:.| :..|.|....::..||.....|: :..::||.:             
  Rat   739 DLRFGFDPLEFPEFSWRGYVPMTSVQNEVKVRLTVRKSSLSL-FRIILRYINPGMEEVSGRITVY 802

  Fly   639 TSRG--------------DWENAFITL----------VRPD------QVD--------------- 658
            :|||              ..|.||:|:          :.|.      ||:               
  Rat   803 SSRGKSDASQSKEITFPPSKEPAFVTVPGNGFADPFSITPGTWIACIQVEGVLLDYLVLLPRDYY 867

  Fly   659 ------------------PEGGC-------------------------GE---LA---------- 667
                              |:..|                         ||   ||          
  Rat   868 EAFALQVPVTEPCAHTGSPQDNCLLYQHLPLTRFSCTLACEATHFLIDGERRPLAVRQPMPTHPA 932

  Fly   668 ----AATSSETRIPFSLPDRSRQVVALN-----------EVCLE------AGKV----YKFRI-- 705
                :.|..|..:...:|.....||.|.           :|.|:      ||:|    .|:.|  
  Rat   933 MVDLSGTEVELHLRLRVPQIGHYVVMLEYATEVDQLFVVDVNLKSPESALAGQVNIYSCKYSILC 997

  Fly   706 -----------------------------------------------YFERKRHDVDS------- 716
                                                           |...:.|.:.|       
  Rat   998 RSVVIDSLSRTAVYELLADADVQLKVHAARFLLHHICVIPAEEFSTEYLRPQVHCIASYGQSANP 1062

  Fly   717 ------------PTATIL---------------------VDSLTL-IPRIDVT------------ 735
                        |||.||                     .:.:|| .|:..||            
  Rat  1063 SASCVSVTHETPPTALILDATSGGHFSPLPHEPSSPADVTNGVTLKAPQNQVTLRGLIPHLGRHV 1127

  Fly   736 -------------------------------------------PIFQGSVLADIRKKDY------ 751
                                                       .|.:|.|..||.:.|.      
  Rat  1128 FVVHFYQAEHPGFPTEVVVDGGRRWSGSFRASFCPHLLGCQDQVISEGQVEFDISEADVAVTVKI 1192

  Fly   752 ----------------EKYNC---------KSSLY------DMNYKSDPK-----CQNLDNILSV 780
                            |.|:.         |||.:      |..| .||:     |:|....|..
  Rat  1193 PDGKSLTLVRVLVVPAEDYDYHILHRTSVDKSSEFISSCGGDSFY-IDPQAASGFCKNSARSLVA 1256

  Fly   781 FVHDGASMCNCNPTGSLSKVCESNGGYCQCKPNVVGRQCDQCAPGTYGF---------------- 829
            |.|:||..|.|:|.|:....|...||.|.|:|||:||||.:||.|.|||                
  Rat  1257 FYHNGAVPCECHPAGAAVHHCSPEGGQCPCRPNVIGRQCTRCATGYYGFPHCKPCNCGRRLCEEV 1321

  Fly   830 -----------GPE---------------GCKACDCNSIGSKD---KYCDLITGQCQCVPNTYGR 865
                       .|:               ||:.|:|:..|:.:   ..||..:|||:|.|...|:
  Rat  1322 TGKCLCPPNTVRPQCEVCEMNSFNFHPVAGCEVCNCSRKGTVEAAVSECDRDSGQCRCKPRVTGQ 1386

  Fly   866 ECNQCQPGYWNFPECRVCQCN---GHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYY----GNPL 923
            :|::|.||:::||||..|.||   .....|||..|.|: |:::..|..|..|.:|.:    .|| 
  Rat  1387 QCDKCAPGFYHFPECVPCSCNRDGTEPGVCDPGTGACM-CKENVEGPQCQFCREGSFYLDSANP- 1449

  Fly   924 FGSEIGCRPCRC---------------------------------------------------PE 937
                .||..|.|                                                   |.
  Rat  1450 ----EGCTRCFCFGVNTDCRSSHKRRAKFVDMMGWRLETADGVDVPVSFNPSSNSVVADLQELPS 1510

  Fly   938 TVAS----------------------------GL------------------------------- 943
            :|.|                            ||                               
  Rat  1511 SVHSASWVAPPSYLGDKVSSYGGYLTYQAKSFGLPGDMVLLEKQPDVQLIGQHMSIIHAEPSDPR 1575

  Fly   944 ----------------AHADGCSLDTRNNNM---------------------------------- 958
                            .||...:..:|...|                                  
  Rat  1576 PDRPHHGRVQVVEGNFRHAGNSAPVSREELMAVLSSLEGLHIRGLHFTETQRLTLGEVGLEEASD 1640

  Fly   959 -----------LCHCQEGYSGSRCEICADNFFGNPDN--GGTCSKCECSNNVDLYDTGNCDRQTG 1010
                       :|.|...|:|..|:.|...::.:..:  .|.|..|.|:.:     :..|...:|
  Rat  1641 TGSGPRAHLVEMCTCPPDYTGDSCQGCRPGYYRDIKSFPAGRCVPCNCNGH-----SNRCQDGSG 1700

  Fly  1011 ACLKCLYQTTGDHCELCKDGFFGDALQQNCQQCECDFLGTNNTIAHCDRFTGQCPCLPNVQGVRC 1075
            .|:.|.:.|.|:|||.|::|::|.|:..:|:.|.|         .|.:.|...|.    |.|   
  Rat  1701 VCINCQHNTAGEHCERCQEGYYGSAIHGSCRVCPC---------PHTNSFATGCA----VDG--- 1749

  Fly  1076 DQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACNQCQAHYWGNPNE--- 1137
                                    ||:         :|.||||:.|..|.:|...|:|||.:   
  Rat  1750 ------------------------GAV---------RCACKPGYTGAQCERCAPGYFGNPQKFGG 1781

  Fly  1138 KCQPCECD---QFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPC---------- 1189
            .||||.|:   |||.    ||..||:||..|...|....||        ..|..|          
  Rat  1782 SCQPCNCNSNGQFGT----CDPLTGDCVSQEPKDGSPAEEC--------DDCDSCVMTLLNDLVS 1834

  Fly  1190 -GECFNNWDLILSALEDATTAT---------ILRAKEIKQ--VGATGAYTSEFSELD---KKLQH 1239
             ||   ...|:.|.|:..:.:|         .::||:::.  :|...|.:|..|::|   |:|.|
  Rat  1835 MGE---ELRLVKSRLQGLSVSTGALEQIRHVEMQAKDLRNQLLGFRSAISSHGSKMDGLEKELSH 1896

  Fly  1240 IRNLLQNTSVSLVDIEKLDYETQSLRDQLQASHGRLSETEQNLDD-IYNSLSLSGVELESLQNHS 1303
                             |:.|.::|:::.|.:..:......|:|. |.|:..|.......:||..
  Rat  1897 -----------------LNQEFETLQEKAQVNSRKAQTLYNNIDQTIQNAKELDMKIKNIIQNVH 1944

  Fly  1304 RLVQQL---------------SKELKENGIQLQE---------------SNIEGALNLTR----- 1333
            .|::|:               |:||.|....|:|               ..:|..|.|.|     
  Rat  1945 ILLKQIARPGGEGMDLPVGDWSRELAEAQRMLRELRGRDFKKHLQEAEAQKMEAQLLLNRIRTWL 2009

  Fly  1334 --HAYERVSNLSTLKDEANELASN-------------------------------TDRNCKRVEN 1365
              |..|....|..::|..|:..:.                               ..|..|.:::
  Rat  2010 ESHQVENNGLLKNIRDSLNDYEAKLQDLRSVLQEAAAQGKQATGLNHENEGVLGAIQRQMKEMDS 2074

  Fly  1366 LSNKIQ---AEAD-DLANNNKLIE-------DYRAELTSLTSQIPELNNQVCGKPGDPCDSLCGG 1419
            |.|.:.   |.|| .|...|.|::       :|.:...:|.....|||:||              
  Rat  2075 LKNDLTEHLATADASLLQTNSLLQRMDTSQKEYESLAAALNGARQELNDQV-------------- 2125

  Fly  1420 AGCGHCGGFLSCEHGAKTHSEEALKVAKDAETAITSKKDQADQTIRALTQAKLNASEAYEKAKRG 1484
            ......||.......|:.|::...::||..|.  ..:....|:.:|    ..::|:.|||..   
  Rat  2126 RELSRSGGKAPLVAEAEKHAQSLQELAKQLEE--IKRNTSGDELVR----CAVDAATAYESI--- 2181

  Fly  1485 FEQSERYLNQTNANIKLAENLFIALNNFQENKTASPSES-------KELAQ--KTLDLDLKLEPE 1540
                      .|| |:.||:        ...|.||.|||       ::|.:  |||..|    .|
  Rat  2182 ----------LNA-IRAAED--------AAGKAASASESAFQTVIKEDLPRRAKTLSSD----SE 2223

  Fly  1541 EI--------ETLGDQINRAVSSLKN-----------VEAIIYRTKPDLDRV--NNLQSIANATK 1584
            |:        :.|..:||.|::||:.           ::|.:...:.||..:  .::.|:.:..|
  Rat  2224 ELLNEAKMTRKRLQQEINPALNSLQQTLKTVSVQKDLLDANVTAVRNDLRGIQRGDIDSVVSGAK 2288

  Fly  1585 EKADKILDSANSVVESLAAADESQGKAKDAIQQANSNIELAGQDLEKIDEETYSAEAPANNTAQQ 1649
            ....|.....:.|::.|:......|:.||:......      :|..|       |...|||:   
  Rat  2289 SMVRKANGITSEVLDGLSPIQTDLGRIKDSYGSTRH------EDFNK-------ALIDANNS--- 2337

  Fly  1650 VEKLAKKVQKLQNNIMKNDRDAKEITKEAGSVKLEAMRARGEANNLQSATSATNQTLTDRASRSE 1714
            |:||.||:..|                   .||:|::                ||.|....:.|:
  Rat  2338 VKKLTKKLPDL-------------------FVKIESI----------------NQQLLPLGNISD 2367

  Fly  1715 NARERAKQLLQR----ASKLTVDT--NAKL-------KDLNDLQ 1745
            |. :|.::|:|:    |:|:.:..  |.|.       .||.||:
  Rat  2368 NV-DRIRELIQQARDAANKVAIPMRFNGKSGVEVRLPNDLEDLK 2410

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 63..286 CDD:278484 72/261 (28%)
EGF_Lam 287..343 CDD:238012 20/55 (36%)
Laminin_EGF 355..415 CDD:278482 24/66 (36%)
Laminin_EGF 418..475 CDD:278482 29/201 (14%)
EGF_Lam 477..526 CDD:238012 17/50 (34%)
EGF_Lam 529..567 CDD:214543 16/38 (42%)
EGF_Lam 789..834 CDD:214543 23/86 (27%)
Laminin_EGF 837..885 CDD:278482 20/50 (40%)
Laminin_EGF 883..930 CDD:278482 15/53 (28%)
Laminin_EGF 933..988 CDD:278482 18/227 (8%)
Laminin_EGF 991..1043 CDD:278482 16/51 (31%)
Laminin_EGF 1043..1091 CDD:278482 7/47 (15%)
Laminin_EGF 1094..1142 CDD:278482 16/50 (32%)
Laminin_EGF 1142..1190 CDD:278482 17/61 (28%)
COG6 1212..>1398 CDD:303003 50/270 (19%)
TelA 1439..1782 CDD:226371 75/350 (21%)
ApoLp-III_like 1545..1702 CDD:304399 32/169 (19%)
Lama3NP_001380677.1 LamNT 42..293 CDD:214532 76/271 (28%)
EGF_Lam 294..340 CDD:238012 20/55 (36%)
EGF_Lam 351..419 CDD:238012 24/67 (36%)
EGF_Lam 421..461 CDD:238012 10/39 (26%)
Laminin_EGF 487..534 CDD:395007 4/46 (9%)
EGF_Lam 531..573 CDD:238012 11/41 (27%)
Laminin_EGF 627..677 CDD:395007 17/49 (35%)
EGF_Lam 680..723 CDD:238012 19/46 (41%)
Laminin_EGF 1265..1313 CDD:395007 22/47 (47%)
EGF_Lam 1310..1353 CDD:238012 2/42 (5%)
EGF_Lam 1355..1400 CDD:238012 16/44 (36%)
EGF_Lam 1403..1453 CDD:238012 16/55 (29%)
Laminin_B 1517..1651 CDD:395006 6/133 (5%)
EGF_Lam 1685..1731 CDD:238012 15/50 (30%)
EGF_Lam 1733..1784 CDD:238012 21/99 (21%)
Laminin_I 1846..2103 CDD:310534 50/273 (18%)
SMC_prok_B 2031..>2387 CDD:274008 90/453 (20%)
Laminin_II 2287..2415 CDD:368703 38/176 (22%)
LamG 2434..2569 CDD:214598
LamG 2601..2741 CDD:238058
LamG 2768..2900 CDD:238058
LamG 2992..3134 CDD:238058
LamG 3158..3309 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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