DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanB1 and Lamb1

DIOPT Version :9

Sequence 1:	NP_476618.1	Gene:	LanB1 / 34068	FlyBaseID:	FBgn0261800	Length:	1788	Species:	Drosophila melanogaster
Sequence 2:	XP_003750185.1	Gene:	Lamb1 / 298941	RGDID:	1306311	Length:	1834	Species:	Rattus norvegicus

Alignment Length:	1862	Identity:	764/1862 - (41%)
Similarity:	1087/1862 - (58%)	Gaps:	175/1862 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LELRLIVVIVLALLSWQWDPVDSQRPPQHGRRDRPKYPPNKFIKTHPCERSSCYPATGNLLIGRE 66
            |::.::.|....:|:.....|.:|.|              :|  ::.|...|||||||:|||||.
  Rat    47 LDMGVLQVFAFGVLALWGTRVCAQEP--------------EF--SYGCAEGSCYPATGDLLIGRA 95

  Fly    67 NRLTASSTCGLHSPERFCILSHLQ-DKKCFLCDTREETKHDPY------KNHRIGQIIYKTKPGT 124
            .:|:.:||||||.||.:||:|||| |||||:||:|     |||      .:|.|..::....| .
  Rat    96 QKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICDSR-----DPYHETLNPDSHLIENVVTTFAP-N 154

  Fly   125 NIPTWWQSENGKENATIQLDLEAEFHFTHLIITFTTFRPAAMYIERSFDFGQTWHIYRYFAYDCK 189
            .:..|||||||.||.|:||||||||||||||:||.|||||||.||||.|||:||.:||||||||:
  Rat   155 RLKIWWQSENGVENVTVQLDLEAEFHFTHLIMTFKTFRPAAMLIERSSDFGKTWGVYRYFAYDCE 219

  Fly   190 ESFPGVPT-VLENITDVMCTSRYSNVEPSRNGEVIFRVLPPNINVTDPYAEHVQNQLKMTNLRIQ 253
            .||||:.| .::.:.|::|.||||::|||..||||||.|.|...:.|||:..:||.||:|||||:
  Rat   220 SSFPGISTGPMKKVDDIICDSRYSDIEPSTEGEVIFRALDPAFKIEDPYSPRIQNLLKITNLRIK 284

  Fly   254 MTKLHKLGDNLLDSRLENEEKYYYGISNMVVRGSCSCYGHASQCLPLDPAFSQADNEDGMVHGRC 318
            ..|||.|||||||||:|..|||||.:.:|||||:|.||||||:|.|:| .|:  :..:|||||.|
  Rat   285 FVKLHTLGDNLLDSRMEIREKYYYAVYDMVVRGNCFCYGHASECAPVD-GFN--EEVEGMVHGHC 346

  Fly   319 ECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAVSCHFDEAVFTASGFVSGGVCD 383
            .|.|||||:|||.|.||::||||:||.|:.:||||||.||:|:.|||||.|||.|:|.|||||||
  Rat   347 MCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKCNCNEHSSSCHFDMAVFLATGNVSGGVCD 411

  Fly   384 NCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSSDDGICDSLNELEEGAVAGACHC 448
            ||.|||.|::||:|.|::::.||:||....:|:||.|||.||.:.||||...:...|.:||.|.|
  Rat   412 NCQHNTMGRNCEQCKPFYFQHPERDIRDPNLCEPCTCDPAGSENGGICDGYTDFSVGLIAGQCRC 476

  Fly   449 KAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTL-NNSGCVMRTGECKCKKYVTGKDCNQC 512
            |..|.|.||:.||:|:::|.:::|.||:.|.||||||: ..:.|...||.|.||:.|||:.|:||
  Rat   477 KLHVEGERCDVCKEGFYDLSAEDPFGCKSCACNPLGTIPGGNPCDSETGYCYCKRLVTGQRCDQC 541

  Fly   513 MPETYGLSESPEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQPKQNYFIPLLPE-VHE 576
            :|:.:|||...:||..|:||.||:.:|.|...||||.|.|||.||.|::.:..|:...|.. ::|
  Rat   542 LPQHWGLSNDLDGCRPCDCDLGGALNNSCSEDSGQCSCLPHMIGRQCNEVESGYYFTTLDHYIYE 606

  Fly   577 AEVVDECISYGAN-GNCSLVAE-------TPDGSFTGIGFTRVPENSELVFTVGDIPRSMPYDAV 633
            ||        .|| |...:|.|       .|  |:||.||.||||.:.|.|.:.:||.||.|:.:
  Rat   607 AE--------EANLGPGVVVVERRYIQDRIP--SWTGPGFVRVPEGAYLEFFIDNIPHSMEYEIL 661

  Fly   634 IRYQSTSRGDWENAFITLVRPDQVDPEGGCGELAAATSSETRIPFSLPDRSRQVVALNEVCLEAG 698
            |||:......||.|.||:.||.::.....||.......::.   .||...||.||....||.|.|
  Rat   662 IRYEPQLPDHWEKAVITVQRPGRIPTSSRCGNTVPDDDNQV---VSLSPGSRYVVLPRPVCFEKG 723

  Fly   699 KVYKFRI---YFERKRHDVDSPTATILVDSLTLIPRIDVTPIFQ--GSVLADIRK---KDYEKYN 755
            ..|..|:   .:.....||:||..  |:|||.|:|......||.  ||...::..   :.:::|.
  Rat   724 MNYTVRLELPQYTASGSDVESPYT--LIDSLVLMPYCKSLDIFTVGGSGDGEVTNSAWETFQRYR 786

  Fly   756 C--------KSSLYDMNYKSDPKCQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGYCQCKP 812
            |        |:.:.|:       |:|:...:|..:|.....|.|:|.||||.||:.|||.|||:|
  Rat   787 CLENSRSVVKTPMTDV-------CRNIIFSISALIHQAGLACECDPQGSLSSVCDPNGGQCQCRP 844

  Fly   813 NVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSKDKYCDLITGQCQCVPNTYGRECNQCQPGYWNF 877
            |||||.|::|||||:||||.|||.|||:..||...:||.:||||.|....|.|:|::|.||:|.|
  Rat   845 NVVGRTCNRCAPGTFGFGPNGCKPCDCHLQGSVSAFCDAVTGQCHCFQGIYARQCDRCLPGFWGF 909

  Fly   878 PECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGSEIGCRPCRCPETVASG 942
            |.|:.|||||||..||.:.|.|:.|||.|||::|:.||.||||:|:.||...||||.||:...||
  Rat   910 PSCQPCQCNGHAEDCDTVTGECLSCQDYTTGHNCERCLAGYYGDPIIGSGDHCRPCPCPDGPDSG 974

  Fly   943 LAHADGCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNP-DNGGTCSKCECSNNVDLYDTGNCD 1006
            ...|..|..|.....:.|.|..||.||||:.||..:|||| |.||:|..|:|.:|:|..|...||
  Rat   975 RQFARSCYQDPVTLQLACVCDPGYIGSRCDGCASGYFGNPSDFGGSCQPCQCHHNIDTTDPEACD 1039

  Fly  1007 RQTGACLKCLYQTTGDHCELCKDGFFGDALQQNCQQCECDFLGT-----NNTIAHCDRFTGQCPC 1066
            ::||.||||||.|.||||:.|:.|::||||:|:|::|.|::|||     |.:..|||:.||||.|
  Rat  1040 KETGRCLKCLYHTEGDHCQFCQHGYYGDALRQDCRKCVCNYLGTVREHCNGSDCHCDKTTGQCSC 1104

  Fly  1067 LPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACNQCQAHY 1131
            ||||.|..||:||.:.|::|||.|||.|||:.:.:....||.:||||||.||||||.|::||..:
  Rat  1105 LPNVIGQNCDRCAPHTWQLASGTGCEPCNCNAVHSFGPSCNEFTGQCQCMPGFGGRTCSECQELF 1169

  Fly  1132 WGNPNEKCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGECFNNW 1196
            ||:|:.:|:.|:||..|....|||:.||.|||.||:.|.:|::|.|||.|.||.|:||.:||..|
  Rat  1170 WGDPDVECRACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCDKCTRGYSGVFPDCTPCHQCFALW 1234

  Fly  1197 DLILSALEDATTATILRAKEIKQVGATGAYTSEFSELDKKLQHIRNL---------LQNTSVSLV 1252
            |:|:..|.:.|...:.:||.:|..|..|.|......::||:..||::         |:|..:...
  Rat  1235 DVIIGELTNRTHKFLEKAKALKISGVIGPYRETVDSVEKKVNEIRDILAQSPAAEPLKNIGILFE 1299

  Fly  1253 DIEKLDYETQSLRDQLQASHGRLSETEQNLDDIYNSLSLSGVELESLQNHSRLVQQLSKELKENG 1317
            :.|||   |:.:.:::.....:||:|..      .|.|.:| ||::||..:..:.:...||.|..
  Rat  1300 EAEKL---TKDVTEKMAQVEVKLSDTAS------RSNSTAG-ELDALQAEAGSLDKTVNELAEQL 1354

  Fly  1318 IQLQESNIEGAL-NLTRHAYERVSNLSTLKDEANELASNTDRNC---------KRVENL------ 1366
            ..::.|:|:||| ::|:  |.::|    |:.|....||.||.|.         .|||:|
  Rat  1355 EFIKNSDIQGALDSITK--YFQIS----LEAEKRVNASTTDPNSTVEQSALTRDRVEDLMLERES 1413

  Fly  1367 --SNKIQAEA---DDLANNNKLIE-DYRAELTSLTSQIPELNNQVCGKPG---DPCDSLCGGAGC 1422
              ..|.:.:|   |:||...:.:: ...||:|..|....:.:...||.|.   |..:..|||.|
  Rat  1414 QFKEKQEEQARLLDELAGKLQSLDLSAAAEMTCGTHPGADCSESECGGPNCRTDEGEKKCGGPG- 1477

  Fly  1423 GHCGGFLSCEHGAKTHSEEALKVAKDAETAITSKKDQADQTIRALTQAKLNASEAYEKAKRGFEQ 1487
              |||.::..|.|   .::|:...:|...|:.    :.:|..:.:::||:.|.||.:.|
  Rat  1478 --CGGLVTVAHSA---WQKAMDFDRDVLNALA----EVEQLSKMVSEAKVRADEAKQNA------ 1527

  Fly  1488 SERYLNQTNANIKLAE-------NLFIALNNFQENKTASPSESKELAQKTLDLDLKLEPEEIETL 1545
             :..|.:|||..:..:       ||...:.:|....:|.....:.:|.:.|.:::...|::::.|
  Rat  1528 -QDVLLKTNATREKVDRSNEDLRNLIKQIRDFLTEDSADLDSIEAVANEVLKMEMPSTPQQLQNL 1591

  Fly  1546 GDQINRAVSSLKNVEAIIYRTKPDLDRVNNLQSIANATKEKADKILDSANSVVESLAAADESQGK 1610
            .:.|...|.:|..||.|:.::..|:.|...|...|....:.|..:..:|:.|.|:|..|:::|..
  Rat  1592 TEDIRERVETLSQVEVILQQSAADIARAELLLEEAKRASKSATDVKVTADMVKEALEEAEKAQVA 1656

  Fly  1611 AKDAIQQANSNIELAGQDLEKIDEETYSAEAPANNTAQQVEKLAKKVQKLQNNIMKNDRDAKEIT 1675
            |:.||:||:.:|:.....|..|:.||.::|....|.:|::.||.:.|::|:....:|..:|..|.
  Rat  1657 AEKAIKQADEDIQGTQNLLTSIESETAASEETLTNASQRISKLERNVEELKRKAAQNSGEADYIE 1721

  Fly  1676 KEAGSVKLEAMRAR----GEANNLQSATSATNQTLTDRASRSENARERAKQLLQRASKLTVDTNA 1736
            |...|||..|...:    ||   |..........:..:...|.:||.:|:.|...|..|....|:
  Rat  1722 KVVYSVKQSADEVKKTLDGE---LDEKYKKVESLIAQKTEESADARRKAELLQNEAKTLLAQANS 1783

  Fly  1737 KLKDLNDLQTVY-------LNKNQQLLRLQAEIGPLNKELNE 1771
            ||:.|.||:..|       .:|.|:|:||:.|:..|.|:::|
  Rat  1784 KLQLLEDLERKYEDNQKYLEDKAQELVRLEGEVRSLLKDISE 1825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB1	NP_476618.1	Laminin_N	63..286	CDD:278484	137/230 (60%)
		EGF_Lam	287..343	CDD:238012	33/55 (60%)
		Laminin_EGF	355..415	CDD:278482	35/59 (59%)
		Laminin_EGF	418..475	CDD:278482	25/56 (45%)
		EGF_Lam	477..526	CDD:238012	23/49 (47%)
		EGF_Lam	529..567	CDD:214543	18/37 (49%)
		EGF_Lam	789..834	CDD:214543	31/44 (70%)
		Laminin_EGF	837..885	CDD:278482	23/47 (49%)
		Laminin_EGF	883..930	CDD:278482	27/46 (59%)
		Laminin_EGF	933..988	CDD:278482	25/55 (45%)
		Laminin_EGF	991..1043	CDD:278482	28/51 (55%)
		Laminin_EGF	1043..1091	CDD:278482	27/52 (52%)
		Laminin_EGF	1094..1142	CDD:278482	24/47 (51%)
		Laminin_EGF	1142..1190	CDD:278482	25/47 (53%)
		COG6	1212..>1398	CDD:303003	57/216 (26%)
		TelA	1439..1782	CDD:226371	90/351 (26%)
		ApoLp-III_like	1545..1702	CDD:304399	46/160 (29%)
Lamb1	XP_003750185.1	Laminin_N	92..317	CDD:278484	137/230 (60%)
		EGF_Lam	319..371	CDD:238012	33/54 (61%)
		EGF_Lam	383..435	CDD:238012	32/51 (63%)
		Laminin_EGF	446..503	CDD:278482	25/56 (45%)
		EGF_Lam	505..556	CDD:238012	24/50 (48%)
		EGF_Lam	557..>596	CDD:238012	18/38 (47%)
		EGF_Lam	821..866	CDD:214543	31/44 (70%)
		Laminin_EGF	869..917	CDD:278482	23/47 (49%)
		EGF_Lam	914..959	CDD:238012	26/44 (59%)
		Laminin_EGF	965..1021	CDD:278482	25/55 (45%)
		Laminin_EGF	1024..1068	CDD:278482	23/43 (53%)
		Laminin_EGF	1076..1129	CDD:278482	27/52 (52%)
		Laminin_EGF	1132..1180	CDD:278482	24/47 (51%)
		Laminin_EGF	1180..1230	CDD:278482	26/49 (53%)
		MA	1500..1739	CDD:214599	62/249 (25%)
		MCP_signal	1504..1706	CDD:304920	52/212 (25%)
		Prefoldin	1654..1768	CDD:298833	32/116 (28%)
		RILP-like	<1738..1826	CDD:304877	26/91 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	305	1.000	Domainoid score	I1319
eggNOG	1	0.900	-	-		E1_KOG0994
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1462	1.000	Inparanoid score	I103
OMA	1	1.010	-	-		QHG49316
OrthoDB	1	1.010	-	-		D42471at33208
OrthoFinder	1	1.000	-	-		FOG0002726
OrthoInspector	1	1.000	-	-		otm45315
orthoMCL	1	0.900	-	-		OOG6_100925
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1817
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840