DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB1 and LAMA1

DIOPT Version :9

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_005550.2 Gene:LAMA1 / 284217 HGNCID:6481 Length:3075 Species:Homo sapiens


Alignment Length:2274 Identity:537/2274 - (23%)
Similarity:840/2274 - (36%) Gaps:789/2274 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 CERSSCYPATGNLLIGRENRLTASSTCGLHSPERFC-ILSH-----LQDKKCFLCDTREETKHDP 107
            |.:...:||..||  .....::.::|||...||.|| ::.|     :::.:|.:||....   :|
Human    17 CRQRGLFPAILNL--ASNAHISTNATCGEKGPEMFCKLVEHVPGRPVRNPQCRICDGNSA---NP 76

  Fly   108 YKNHRIGQIIYKTKPGTNIPTWWQS---ENGKEN--ATIQLDLEAEFHFTHLIITFTTF-RPAAM 166
            .:.|.|...|    .|||  .||||   :||:|.  .||.|||...|...::||..... ||...
Human    77 RERHPISHAI----DGTN--NWWQSPSIQNGREYHWVTITLDLRQVFQVAYVIIKAANAPRPGNW 135

  Fly   167 YIERSFDFGQTWHIYRYFAYDCKESFP--------GVPTVLENITDVMCTSRYSNVEPSRNGEVI 223
            .:|||.| |.|:..::|:|....|...        |.||...: .:|:|||.||.:.|..:||:.
Human   136 ILERSLD-GTTFSPWQYYAVSDSECLSRYNITPRRGPPTYRAD-DEVICTSYYSRLVPLEHGEIH 198

  Fly   224 FRVL--PPNINVTDPYAEHVQNQLKMTN---LRIQMTKLHKLGDNLLD-SRLENEE-------KY 275
            ..::  .|:.:...|      ..|:.|:   :|:::.::..|..:|:. |..|.:|       :|
Human   199 TSLINGRPSADDLSP------KLLEFTSARYIRLRLQRIRTLNADLMTLSHREPKELDPIVTRRY 257

  Fly   276 YYGISNMVVRGSCSCYGHASQCLPLDPAFSQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLP 340
            ||.|.::.|.|.|.||||||.| |.|....:.         :|:|.|||.|.:|..|...::..|
Human   258 YYSIKDISVGGMCICYGHASSC-PWDETTKKL---------QCQCEHNTCGESCNRCCPGYHQQP 312

  Fly   341 WKPAFGKKTNACKKCECNDHAVSCHFDEAVF-------TASGFVSGGVCDNCLHNTRGQHCEECM 398
            |:|......|.|:.|.|::.|..|::||:|.       ||..|..||||.|||.||.|.:||.|:
Human   313 WRPGTVSSGNTCEACNCHNKAKDCYYDESVAKQKKSLNTAGQFRGGGVCINCLQNTMGINCETCI 377

  Fly   399 PYFYRDPEQDITSERVCQPCDCDPQGSSDDGIC---DSLNELEEGAVAGACHCKAFVTGRRCNQC 460
            ..:||..:.....:..|:||:|||.||. ..:|   |..::|..|...|.|.||...||.:|::|
Human   378 DGYYRPHKVSPYEDEPCRPCNCDPVGSL-SSVCIKDDLHSDLHNGKQPGQCPCKEGYTGEKCDRC 441

  Fly   461 KDGYWNLQSDNPEGCEPCTCNPLGTLNNSGCVMRTGECKCKKYVTGKDCNQCMPETYGLSE-SPE 524
            :.||    .|.|. |..|.|||:|:.::..|   ||.|.||:.|.||.|::|.|..|.|.| :|.
Human   442 QLGY----KDYPT-CVSCGCNPVGSASDEPC---TGPCVCKENVEGKACDRCKPGFYNLKEKNPR 498

  Fly   525 GCSLCNCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQPKQNYFIPLLPEVHEAEVVDECISYGAN 589
            |||                                                      ||..:|.:
Human   499 GCS------------------------------------------------------ECFCFGVS 509

  Fly   590 GNCSLVAETPDGSFTGIGFTRVPENSELVFTVGDI--PRSMPYDAVIRYQSTSRGDWENAFITLV 652
            ..||.:: .|.|..          ||...:.|.|:  ||.:                        
Human   510 DVCSSLS-WPVGQV----------NSMSGWLVTDLISPRKI------------------------ 539

  Fly   653 RPDQVDPEGGCGELAAATSSETRIPFSLPDRSRQVVALNEVCLE---AGKVY----------KFR 704
             |.|.|..||                      |..|::|...:.   |.|.|          |..
Human   540 -PSQQDALGG----------------------RHQVSINNTAVMQRLAPKYYWAAPEAYLGNKLT 581

  Fly   705 IY--FERKRHDVDSPTATILVDSLTLIPRIDVTPIFQGSVLA------DIRKKDYEKYNCKSSLY 761
            .:  |.:.....|.|..|  ||| .|:...||  |.:|:.|.      .:..:.||:|.....|.
Human   582 AFGGFLKYTVSYDIPVET--VDS-NLMSHADV--IIKGNGLTLSTQAEGLSLQPYEEYLNVVRLV 641

  Fly   762 DMNYKSDPKCQNLD---------NILSVFV---HDGASMC---------NCNPTGSLSKVCESNG 805
            ..|::.....:.:|         |:..:.:   ::.|.|.         :...:.::..|..::.
Human   642 PENFQDFHSKRQIDRDQLMTVLANVTHLLIRANYNSAKMALYRLESVSLDIASSNAIDLVVAADV 706

  Fly   806 GYCQCKPNVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSKDKYCDLITGQCQCVPNTYGRECNQC 870
            .:|:|.....|..|:.|..|.|                   :...::.|             ..|
Human   707 EHCECPQGYTGTSCESCLSGYY-------------------RVDGILFG-------------GIC 739

  Fly   871 QPGYWNFPECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGSEIGCRPCRC 935
            ||          |:|:||||.|: :.|.||.|..:|||..|:.||.|:||.|..|:...|:||.|
Human   740 QP----------CECHGHAAECN-VHGVCIACAHNTTGVHCEQCLPGFYGEPSRGTPGDCQPCAC 793

  Fly   936 PETVASGLAHADGCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNPD-NGGTCSKCECSNNVDL 999
            |.|:||. ..:..|.|:..:..:...|..||||:.||.|||.::|||. .|.:|..|:||.|||.
Human   794 PLTIASN-NFSPTCHLNDGDEVVCDWCAPGYSGAWCERCADGYYGNPTVPGESCVPCDCSGNVDP 857

  Fly  1000 YDTGNCDRQTGACLKCLYQTTGDHCELCKDGFFGDAL-QQNCQQCECDFLGTNNTIAH------- 1056
            .:.|:||..||.|||||..|.|.|||.|.|||:|||: .:||:.|||...|:::.:.|       
Human   858 SEAGHCDSVTGECLKCLGNTDGAHCERCADGFYGDAVTAKNCRACECHVKGSHSAVCHLETGLCD 922

  Fly  1057 ----------------------------------------------------------------- 1056
                                                                             
Human   923 CKPNVTGQQCDQCLHGYYGLDSGHGCRPCNCSVAGSVSDGCTDEGQCHCVPGVAGKRCDRCAHGF 987

  Fly  1057 -------------------CDRFTGQCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGAL 1102
                               ||..||:|.|.|:.|||:|::|.:.||...:..||::|||..:|:.
Human   988 YAYQDGSCTPCDCPHTQNTCDPETGECVCPPHTQGVKCEECEDGHWGYDAEVGCQACNCSLVGST 1052

  Fly  1103 HEQCNSYTGQCQCKPGFGGRACNQCQAHYWGNPNEKCQPCECDQFGAADFQCD---------RET 1158
            |.:|:..||.||||..||||||:||...|...|:  |.||:||..|.:...|:         .||
Human  1053 HHRCDVVTGHCQCKSKFGGRACDQCSLGYRDFPD--CVPCDCDLRGTSGDACNLEQGLCGCVEET 1115

  Fly  1159 GNCVCHEGIGGYKCNECARGY--------IGQFPHCSPCGECFNNWDLILSALED--ATTATILR 1213
            |.|.|.|.:.|.:||||..|.        :|    |||| .| :....:.|.|||  .|..|:..
Human  1116 GACPCKENVFGPQCNECREGTFALRADNPLG----CSPC-FC-SGLSHLCSELEDYVRTPVTLGS 1174

  Fly  1214 AKEIKQV-------GAT-GAY--TSEFSELDKKL--QHIRNLLQNTSVSLVDIE----KLDYETQ 1262
            .:.:.:|       |.| |.|  ..:|. ||...  ||||            .|    :|..:.|
Human  1175 DQPLLRVVSQSNLRGTTEGVYYQAPDFL-LDAATVRQHIR------------AEPFYWRLPQQFQ 1226

  Fly  1263 SLRDQLQASHGRL--SETEQNLDDIYNSLSLSGVELESLQNHSRLVQQ---LSKELKENGIQLQE 1322
            .  |||.|..|:|  |....:||.:    ..|..|.:.|....|:.:|   :.....|||:: ||
Human  1227 G--DQLMAYGGKLKYSVAFYSLDGV----GTSNFEPQVLIKGGRIRKQVIYMDAPAPENGVR-QE 1284

  Fly  1323 SNIEGALNLTRHAYERVSNLSTLKDEANELASNTD-----------RNCKRVENLSNKIQAEADD 1376
            ..:....|..:: :..||.....:::...:.|:.:           ....|:.::|.::..:|:.
Human  1285 QEVAMRENFWKY-FNSVSEKPVTREDFMSVLSDIEYILIKASYGQGLQQSRISDISMEVGRKAEK 1348

  Fly  1377 LANNNK---LIED-------------------YRAELTSLTSQIP----------ELNNQV---- 1405
            |....:   |:|:                   :|.:|.:.:.:.|          ..||..    
Human  1349 LHPEEEVASLLENCVCPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSDTCD 1413

  Fly  1406 --------CG--KPGDPCD-----------------SLCG------------------------- 1418
                    ||  ..||.||                 :||.                         
Human  1414 PNTGKCLNCGDNTAGDHCDVCTSGYYGKVTGSASDCALCACPHSPPASFSPTCVLEGDHDFRCDA 1478

  Fly  1419 ------GAGCGHC-----------GG--------------------------------------- 1427
                  |..|..|           ||                                       
Human  1479 CLLGYEGKHCERCSSSYYGNPQTPGGSCQKCDCNPHGSVHGDCDRTSGQCVCRLGASGLRCDECE 1543

  Fly  1428 ---------FLSCE------------------------------HGAKTHSEEALKVAKDAETAI 1453
                     .:||:                              :|..::.|...|..:::....
Human  1544 PRHILMETDCVSCDDECVGVLLNDLDEIGDAVLSLNLTGIIPVPYGILSNLENTTKYLQESLLKE 1608

  Fly  1454 TSKKD-----------QADQTIRALTQAKLNASEAYEKAKRGFEQSE--------------RYLN 1493
            ..:||           :.|...:.||:...:..:.....:|.|::|:              ..:.
Human  1609 NMQKDLGKIKLEGVAEETDNLQKKLTRMLASTQKVNRATERIFKESQDLAIAIERLQMSITEIME 1673

  Fly  1494 QTNANIKLAENLFI---ALNNFQENKTA--SPSESKELAQ--KTLDLDLKL-------------E 1538
            :|..|..|.|:..:   .|.|.|:|.|:  ...:.::..|  :...|:||.             :
Human  1674 KTTLNQTLDEDFLLPNSTLQNMQQNGTSLLEIMQIRDFTQLHQNATLELKAAEDLLSQIQENYQK 1738

  Fly  1539 P-EEIETLGDQINRAVS----SLKNVEAIIYRTKPDLDRVNNLQSIANAT-KEKADK-------- 1589
            | ||:|.|.:..:..:|    .||..||::...:..:...|:|..:.||. :|.:||        
Human  1739 PLEELEVLKEAASHVLSKHNNELKAAEALVREAEAKMQESNHLLLMVNANLREFSDKKLHVQEEQ 1803

  Fly  1590 ------------ILDSANSVVESLAAADE---------------------------SQGKAKDAI 1615
                        ::|:|.:..:::..|.|                           ||..|.|.:
Human  1804 NLTSELIVQGRGLIDAAAAQTDAVQDALEHLEDHQDKLLLWSAKIRHHIDDLVMHMSQRNAVDLV 1868

  Fly  1616 QQANSN-------IELAGQDLEKIDEETYSAEAPA------NNTAQQVEKLAKKVQK-------L 1660
            .:|..:       .::....||.|...:.:|.:.|      .:..::.|:||:...:       |
Human  1869 YRAEDHAAEFQRLADVLYSGLENIRNVSLNATSAAYVHYNIQSLIEESEELARDAHRTVTETSLL 1933

  Fly  1661 QNNIMKNDRDA--------KE---ITKEAGSVKLEAMRARGEANNLQ----SATSATNQTLTDRA 1710
            ..:::.|.:.|        ||   ::::...:.||....|.:.|..|    ..|..||::|....
Human  1934 SESLVSNGKAAVQRSSRFLKEGNNLSRKLPGIALELSELRNKTNRFQENAVEITRQTNESLLILR 1998

  Fly  1711 SRSENARE---RAKQLLQRASKLTVDTNAKLKDLNDLQTVYLNKNQQLLRLQAEIGPLNKELNE 1771
            :..:..|:   :.|:|...||:..|.|   |:|:..|       :|:||...|.:..:|..|.|
Human  1999 AIPKGIRDKGAKTKELATSASQSAVST---LRDVAGL-------SQELLNTSASLSRVNTTLRE 2052

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 63..286 CDD:278484 71/255 (28%)
EGF_Lam 287..343 CDD:238012 20/55 (36%)
Laminin_EGF 355..415 CDD:278482 25/66 (38%)
Laminin_EGF 418..475 CDD:278482 22/59 (37%)
EGF_Lam 477..526 CDD:238012 21/49 (43%)
EGF_Lam 529..567 CDD:214543 0/37 (0%)
EGF_Lam 789..834 CDD:214543 8/53 (15%)
Laminin_EGF 837..885 CDD:278482 5/47 (11%)
Laminin_EGF 883..930 CDD:278482 22/46 (48%)
Laminin_EGF 933..988 CDD:278482 22/55 (40%)
Laminin_EGF 991..1043 CDD:278482 30/52 (58%)
Laminin_EGF 1043..1091 CDD:278482 19/138 (14%)
Laminin_EGF 1094..1142 CDD:278482 23/47 (49%)
Laminin_EGF 1142..1190 CDD:278482 21/64 (33%)
COG6 1212..>1398 CDD:303003 46/239 (19%)
TelA 1439..1782 CDD:226371 88/469 (19%)
ApoLp-III_like 1545..1702 CDD:304399 41/243 (17%)
LAMA1NP_005550.2 LamNT 16..268 CDD:214532 76/269 (28%)
EGF_Lam 270..317 CDD:238012 21/56 (38%)
Laminin_EGF 397..456 CDD:278482 24/64 (38%)
Laminin_EGF 454..500 CDD:278482 21/48 (44%)
Laminin_B 568..696 CDD:278481 24/132 (18%)
EGF_Lam 741..789 CDD:238012 23/58 (40%)
Laminin_EGF 791..846 CDD:278482 22/55 (40%)
EGF_Lam 848..900 CDD:238012 29/51 (57%)
Laminin_EGF 902..948 CDD:278482 5/45 (11%)
Laminin_EGF 951..998 CDD:278482 0/46 (0%)
Laminin_EGF 998..1041 CDD:278482 14/42 (33%)
Laminin_EGF 1044..1092 CDD:278482 25/49 (51%)
Laminin_EGF 1090..1147 CDD:278482 18/60 (30%)
LamB 1213..1344 CDD:214597 29/150 (19%)
Laminin_EGF 1403..1449 CDD:278482 8/45 (18%)
Laminin_EGF 1452..1506 CDD:278482 6/53 (11%)
Laminin_EGF 1509..1556 CDD:278482 0/46 (0%)
Laminin_I 1567..1830 CDD:283627 43/262 (16%)
BAR 1609..1841 CDD:299863 42/231 (18%)
Laminin_II 2011..2145 CDD:283628 16/52 (31%)
LamG 2141..2280 CDD:214598
LamG 2307..2463 CDD:238058
Laminin_G_1 2514..2658 CDD:278483
Laminin_G_1 2743..2872 CDD:278483
LamG 2892..3043 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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