DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB1 and Lamb2

DIOPT Version :9

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_037106.1 Gene:Lamb2 / 25473 RGDID:2988 Length:1801 Species:Rattus norvegicus


Alignment Length:1802 Identity:742/1802 - (41%)
Similarity:996/1802 - (55%) Gaps:110/1802 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 CERSSCYPATGNLLIGRENRLTASSTCGLHSPERFCILSHLQD-KKCFLCDTREE-TKHDPYKNH 111
            |.|.|||||||:||:||.:|||||||||||||:.:||:||||| |||||||:|.. :..|...:|
  Rat    45 CSRGSCYPATGDLLVGRADRLTASSTCGLHSPQPYCIVSHLQDEKKCFLCDSRRPFSARDNPNSH 109

  Fly   112 RIGQIIYKTKPGTNIPTWWQSENGKENATIQLDLEAEFHFTHLIITFTTFRPAAMYIERSFDFGQ 176
            ||..::....|... ..|||||||....||||||||||||||||:||.|||||||.:|||.|||:
  Rat   110 RIQNVVTSFAPQRR-TAWWQSENGVPMVTIQLDLEAEFHFTHLIMTFKTFRPAAMLVERSADFGR 173

  Fly   177 TWHIYRYFAYDCKESFPGVPTV-LENITDVMCTSRYSNVEPSRNGEVIFRVLPPNINVTDPYAEH 240
            ||.:||||:|||...|||:|.. .....||:|.||||.:|||..||||:|||.|.|.:.|||:..
  Rat   174 TWRVYRYFSYDCGADFPGIPLAPPRRWDDVVCESRYSEIEPSTEGEVIYRVLDPAIPIPDPYSSR 238

  Fly   241 VQNQLKMTNLRIQMTKLHKLGDNLLDSRLENEEKYYYGISNMVVRGSCSCYGHASQCLPLDPAFS 305
            :||.||:||||:.:|:||.|||||||.|.|..|||||.:..:|:||:|.||||||||.|...|.:
  Rat   239 IQNLLKITNLRVNLTRLHTLGDNLLDPRREIREKYYYALYELVIRGNCFCYGHASQCAPAPGAPA 303

  Fly   306 QADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAVSCHFDEAV 370
            .|   :|||||.|.|.|||:|:|||:|:||:.||||.||....|:||:|||||.|:.|||||.||
  Rat   304 HA---EGMVHGACICKHNTRGLNCEQCQDFYQDLPWHPAEDGHTHACRKCECNGHSHSCHFDMAV 365

  Fly   371 FTASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSSDDGICDSLN 435
            :.|||.|||||||.|.|||.|:|||.|.|:|||||.:|:.....|:||||||.||.|.|.|||.:
  Rat   366 YLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDMRDPAACRPCDCDPMGSQDGGRCDSHD 430

  Fly   436 ELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTL-NNSGCVMRTGECK 499
            :...|.|:|.|.||..|.|.||.||:||::.|.:.||.||:.|.||..||: ..:.|...:|.|.
  Rat   431 DPVLGLVSGQCRCKEHVVGTRCQQCRDGFFGLSASNPRGCQRCQCNSRGTVPGGTPCDSSSGTCF 495

  Fly   500 CKKYVTGKDCNQCMPETYGLSESPEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQPKQ 564
            ||:.|||..|::|:|..:|||....||..|:||.||:.|..||..:|||.|||||.||.|.|.:.
  Rat   496 CKRLVTGDGCDRCLPGHWGLSHDLLGCRPCDCDVGGALDPQCDEATGQCPCRPHMIGRRCEQVQP 560

  Fly   565 NYFIPLLPEV-HEAEVVDECISYGANGNCSLVA-------ETPDGSFTGIGFTRVPENSELVFTV 621
            .||.|.|..: .|||        ||:|....|.       |||  |:||:||.|:.|..|:.|.|
  Rat   561 GYFRPFLDHLTWEAE--------GAHGQVLEVVERLVTNRETP--SWTGVGFVRLREGQEVEFLV 615

  Fly   622 GDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGGCGELAAATSSETRIPFSLPDRSRQ 686
            ..:||:|.||.::|::......|....:.:.||..|.....||.:   ...:.||...|...:|.
  Rat   616 TSLPRAMDYDLLLRWEPQVPEQWAELELVVQRPGPVSAHSPCGHV---LPRDDRIQGMLHPNTRV 677

  Fly   687 VVALNEVCLEAGKVYKFRIYFE----RKRHDVDSPTATILVDSLTLIPRIDVTPIFQGSVLADI- 746
            :|....||||.|..||.::...    |...:.....:.||:|||.|.|.:.:..:|.|...|.: 
  Rat   678 LVFPRPVCLEPGLSYKLKLKLTGTGGRAHPETPYSGSGILIDSLVLQPHVLMLEMFSGGDAAALE 742

  Fly   747 RKKDYEKYNC-KSSLYDMNYKSDPKCQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGYCQC 810
            |:..:|:|.| :..|..........|..|....|..|::||..|.|:|.||||..|..:||.|:|
  Rat   743 RRTTFERYRCHEEGLMPSKTPLSEACVPLLISASSLVYNGALPCQCDPQGSLSSECNPHGGQCRC 807

  Fly   811 KPNVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSKDKYCDLITGQCQCVPNTYGRECNQCQPGYW 875
            ||.||||:||.||.|.|||||.||:||.|:..|:....|:..:|||.|....:|..|:.||.|.|
  Rat   808 KPGVVGRRCDACATGYYGFGPAGCQACQCSPDGALSALCEGTSGQCLCRTGAFGLRCDHCQRGQW 872

  Fly   876 NFPECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPL--FGSEIGCRPCRCPET 938
            .||.||.|.|||.|..||...|.|:.|:|.|.|..|:.|:.|::|:|.  :|.:  ||||.|||.
  Rat   873 GFPNCRPCVCNGRADECDAHTGACLGCRDYTGGEHCERCIAGFHGDPRLPYGGQ--CRPCPCPEG 935

  Fly   939 VASGLAHADGCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNPDN-GGTCSKCECSNNVDLYDT 1002
            ..|....|..|..|..:..::|||:.||:|.|||.||...||:|.. ||.|..||||.|:|..|.
  Rat   936 PGSQRHFATSCHRDGYSQQIVCHCRAGYTGLRCEACAPGHFGDPSKPGGRCQLCECSGNIDPTDP 1000

  Fly  1003 GNCDRQTGACLKCLYQTTGDHCELCKDGFFGDALQQNCQQCECDFLGT------NNTIAHCDRFT 1061
            |.||..||.||:||:.|.|.||..||.||.|.|.:|:|.:|.|:.|||      :..:.|||..|
  Rat  1001 GACDPHTGQCLRCLHHTEGPHCGHCKPGFHGQAARQSCHRCTCNLLGTDPQRCPSTDLCHCDPST 1065

  Fly  1062 GQCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACNQ 1126
            |||||||:|||:.||:||.|.|...||.||:.|.|.|..|....||.:||||.|..|||||.|::
  Rat  1066 GQCPCLPHVQGLSCDRCAPNFWNFTSGRGCQPCACHPSRARGPTCNEFTGQCHCHAGFGGRTCSE 1130

  Fly  1127 CQAHYWGNPNEKCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGE 1191
            ||..:||:|..:|:.|:||..|....||.|.||:|.|..|:.|.:|::||||:.|.||.|.||..
  Rat  1131 CQELHWGDPGLQCRACDCDPRGIDKPQCHRSTGHCSCRPGVSGVRCDQCARGFSGVFPACHPCHA 1195

  Fly  1192 CFNNWDLILSALEDATTATILRAKEIKQVGATGAYTSEFSELDKKLQHIRNLLQNTSVSLVDIEK 1256
            ||.:||.::..|...|......|:|::|.|..||:.|.|..|..||..::.::...:.|.....|
  Rat  1196 CFGDWDRVVQDLAARTRRLEQWAQELQQTGVLGAFESSFLNLQGKLGMVQAIVAARNTSAASTAK 1260

  Fly  1257 LDYETQSLRDQLQASHGRLSETEQNLDDIYN-----SLSLSGVELESLQNHSRLVQQLSKELKEN 1316
            |...|:.||.::..:..||::.|..|.|:.:     :.:|||:|.:.|..:..| :||.:.|.  
  Rat  1261 LVEATEGLRHEIGKTTERLTQLEAELTDVQDENFNANHALSGLERDGLALNLTL-RQLDQHLD-- 1322

  Fly  1317 GIQLQESNIEGALNLTRHAY------ERVSNLSTLKDEANELASNTDRNCKRVENL--SNKIQAE 1373
              .|:.||..||.:..|||:      ||.:|.||....:.  .||:....:|.|.|  :.:....
  Rat  1323 --ILKHSNFLGAYDSIRHAHSQSTEAERRANASTFAIPSP--VSNSADTRRRAEVLMGAQRENFN 1383

  Fly  1374 ADDLANNNKLIEDYRAELTSLTSQIPELNNQVCGKPGD-PC-DSLCGGAGC------GHCGGFLS 1430
            ...|||...|   .|....:.|..:..:|..|||.||| || .|.||||||      ..||| |.
  Rat  1384 RQHLANQQAL---GRLSTHTHTLSLTGVNELVCGAPGDAPCATSPCGGAGCRDEDGQPRCGG-LG 1444

  Fly  1431 CEHGAKT---------HSEEALKVAKDAETAITSKKDQADQTIRALTQAKLNASEAYEK--AKRG 1484
            |...|.|         |::..|:.|......|.|:   ..:|.|...:|:..|..|.:|  |.||
  Rat  1445 CSGAAATADLALGRARHTQAELQRALVEGGGILSR---VSETRRQAEEAQQRAQAALDKANASRG 1506

  Fly  1485 -FEQSERYLNQTNANIKLAENLFIALNNFQENKTASPSESKELAQKTLDLDLKLEPEEIETLGDQ 1548
             .||:.:.|.:...|:|          :|...:.|.|...:.:|.:.||:.:...||:|:.|..:
  Rat  1507 QVEQANQELRELIQNVK----------DFLSQEGADPDSIEMVATRVLDISIPASPEQIQRLASE 1561

  Fly  1549 INRAVSSLKNVEAIIYRTKPDLDRVNNLQSIANATKEKADKILDSANSVVESLAAADESQGKAKD 1613
            |...|.||.:|:.|:..|..|:.|...|...|...:.:|:.....|.:|..:|..|..:||.|:.
  Rat  1562 IAERVRSLADVDTILAHTMGDVRRAEQLLQDAQRARSRAEGERQKAETVQAALEEAQRAQGAAQG 1626

  Fly  1614 AIQQANSNIELAGQDLEKIDEETYSAEAPANNTAQQVEKLAKKVQKLQNNIMKNDRDAKEITKEA 1678
            ||:.|..:.:...|.|:::.|.....|...|:.:::..:|...::.|:.....|...|....:.|
  Rat  1627 AIRGAVVDTKNTEQTLQQVQERMAGTEQSLNSASERARQLHALLEALKLKRAGNSLAASTAEETA 1691

  Fly  1679 GSVKLEAMRARGEANNLQSATSATNQTLTDRASRSEN----ARERAKQLLQRASKLTVDTNAKLK 1739
            ||.:   .|||.....|:.......||:...|.|...    |:.||:||...|..|......||:
  Rat  1692 GSAQ---SRAREAEKQLREQVGDQYQTVRALAERKAEGVLAAQARAEQLRDEARGLLQAAQDKLQ 1753

  Fly  1740 DLNDLQTVYLNKNQQLLRLQAEIGPLNKELNEHLIHIKERGSHYRQC 1786
            .|.:|:..|....::|....|::..|...:...|..|..:...|..|
  Rat  1754 RLQELEGTYEENERELEVKAAQLDGLEARMRSVLQAINLQVQIYNTC 1800

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 63..286 CDD:278484 134/225 (60%)
EGF_Lam 287..343 CDD:238012 33/55 (60%)
Laminin_EGF 355..415 CDD:278482 38/59 (64%)
Laminin_EGF 418..475 CDD:278482 29/56 (52%)
EGF_Lam 477..526 CDD:238012 19/49 (39%)
EGF_Lam 529..567 CDD:214543 20/37 (54%)
EGF_Lam 789..834 CDD:214543 28/44 (64%)
Laminin_EGF 837..885 CDD:278482 19/47 (40%)
Laminin_EGF 883..930 CDD:278482 19/48 (40%)
Laminin_EGF 933..988 CDD:278482 24/55 (44%)
Laminin_EGF 991..1043 CDD:278482 28/51 (55%)
Laminin_EGF 1043..1091 CDD:278482 27/53 (51%)
Laminin_EGF 1094..1142 CDD:278482 23/47 (49%)
Laminin_EGF 1142..1190 CDD:278482 23/47 (49%)
COG6 1212..>1398 CDD:303003 55/198 (28%)
TelA 1439..1782 CDD:226371 87/349 (25%)
ApoLp-III_like 1545..1702 CDD:304399 39/156 (25%)
Lamb2NP_037106.1 Laminin_N 60..284 CDD:278484 134/224 (60%)
EGF_Lam 286..338 CDD:238012 33/54 (61%)
EGF_Lam 350..402 CDD:238012 37/51 (73%)
Laminin_EGF 413..470 CDD:278482 29/56 (52%)
EGF_Lam 472..523 CDD:238012 20/50 (40%)
EGF_Lam 524..565 CDD:238012 22/40 (55%)
EGF_Lam 786..831 CDD:214543 28/44 (64%)
Laminin_EGF 834..882 CDD:278482 19/47 (40%)
Laminin_EGF 880..927 CDD:278482 19/48 (40%)
EGF_Lam 929..987 CDD:238012 25/57 (44%)
Laminin_EGF 989..>1031 CDD:278482 24/41 (59%)
Laminin_EGF 1041..1095 CDD:278482 27/53 (51%)
Laminin_EGF 1098..1146 CDD:278482 23/47 (49%)
Laminin_EGF 1146..>1185 CDD:278482 18/38 (47%)
Domain II 1193..1412 63/228 (28%)
Domain alpha 1413..1445 18/32 (56%)
Domain I 1446..1801 92/371 (25%)
DUF4398 <1446..1516 CDD:291044 18/72 (25%)
flagell_FliJ 1477..1617 CDD:131526 40/152 (26%)
HrpJ 1485..1673 CDD:301626 51/197 (26%)
MscS_porin 1582..1776 CDD:289559 49/196 (25%)
ATP-synt_B <1684..1795 CDD:304375 29/113 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1684..1703 7/21 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 305 1.000 Domainoid score I1319
eggNOG 1 0.900 - - E1_KOG0994
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1723
Inparanoid 1 1.050 1462 1.000 Inparanoid score I103
OMA 1 1.010 - - QHG49316
OrthoDB 1 1.010 - - D42471at33208
OrthoFinder 1 1.000 - - FOG0002726
OrthoInspector 1 1.000 - - otm45315
orthoMCL 1 0.900 - - OOG6_100925
Panther 1 1.100 - - O PTHR10574
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1817
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1413.880

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