DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LanB1 and SPAC4H3.14c

DIOPT Version :9

Sequence 1:	NP_476618.1	Gene:	LanB1 / 34068	FlyBaseID:	FBgn0261800	Length:	1788	Species:	Drosophila melanogaster
Sequence 2:	NP_594350.1	Gene:	SPAC4H3.14c / 2543546	PomBaseID:	SPAC4H3.14c	Length:	345	Species:	Schizosaccharomyces pombe

Alignment Length:	420	Identity:	85/420 - (20%)
Similarity:	159/420 - (37%)	Gaps:	102/420 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1312 ELKENGIQLQESNIEGALNLTRHAYERVSNLSTLKDEANELASNTDRNCKRVENLSNKIQAE--- 1373
            |..|:.|:....|||          .|...:|||:|.||:|           |.|::.|:|.
pombe     7 EKLEHEIEQVHDNIE----------NRKEEVSTLQDMANDL-----------EKLTDHIEATYIG 50

  Fly  1374 ---ADDLANNNKLIEDYRAELTSLTSQIPELNNQVCGKPGDPCDSLCGGAGCGHCGGFLSCEHGA 1435
               ..|.|............:.::.::|..|.     |.||....|            |..|...
pombe    51 RGVPHDHAKTGSRKPSSGQLIATMQNEIDRLK-----KEGDKVSIL------------LMQERKK 98

  Fly  1436 KTHSEEA----------LKVAKDAETAITSKKDQA---DQTIRALTQAKL-NASEAYEKAKRGFE 1486
            :...|.|          ||:.|.:.:::.::|.:|   :|.|:...:.:: :..|..::.|...|
pombe    99 RKELESAKNNLLNVYDSLKMQKASVSSMVNRKQRAAKEEQKIQEEFERQITDLLEEQQQLKLEIE 163

  Fly  1487 QSERYLNQTNANIKLAENLFIALNNFQENKTASPSESKELAQKTLDLDLKLEPEEIETLGDQINR 1551
            :.|....:.|:..:          .:::.|.|...|.:||..:.|..|.:|: .||.||.|....
pombe   164 RLEAETERANSETE----------QYEKQKEALEEEYEELRNECLKHDPQLD-AEIRTLQDTFEE 217

  Fly  1552 AVSSL-KNVEAIIYRTKPDLDRVNNLQSIANATKEKADKILDSANSVVESLAAADESQGKAKDAI 1615
            ...:| |.|.......||..|.:.|    :|:.|||          ::.:|..|::......:.|
pombe   218 VERTLTKQVSDAKIADKPLKDSMFN----SNSEKEK----------IMHALEKAEKDADIYSEFI 268

  Fly  1616 QQANSNIELAGQDLEKIDEETYSAEAPANNTAQQVEKLAKKVQKLQNNIMKNDRDAKEITKEAGS 1680
            ||....:|      ..:::.:.:.|...|..|:....||      :::...||.|...|..|. .
pombe   269 QQYMEQLE------SSLEKSSTAIENAQNRLAEMTAHLA------ESSDYDNDDDTDGIINET-D 320

  Fly  1681 VKLEAMRARGEANNLQSATSATNQTLTDRA 1710
            .:|:..:     :...:.|:::|:::.:.:
pombe   321 YELDTSQ-----SEFATLTTSSNKSILNES 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB1	NP_476618.1	Laminin_N	63..286	CDD:278484
		EGF_Lam	287..343	CDD:238012
		Laminin_EGF	355..415	CDD:278482
		Laminin_EGF	418..475	CDD:278482
		EGF_Lam	477..526	CDD:238012
		EGF_Lam	529..567	CDD:214543
		EGF_Lam	789..834	CDD:214543
		Laminin_EGF	837..885	CDD:278482
		Laminin_EGF	883..930	CDD:278482
		Laminin_EGF	933..988	CDD:278482
		Laminin_EGF	991..1043	CDD:278482
		Laminin_EGF	1043..1091	CDD:278482
		Laminin_EGF	1094..1142	CDD:278482
		Laminin_EGF	1142..1190	CDD:278482
		COG6	1212..>1398	CDD:303003	20/91 (22%)
		TelA	1439..1782	CDD:226371	57/287 (20%)
		ApoLp-III_like	1545..1702	CDD:304399	31/157 (20%)
SPAC4H3.14c	NP_594350.1	SMC_prok_A	<61..>302	CDD:274009	57/294 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100925
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900