DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LanB1 and LAMB4

DIOPT Version :9

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:XP_011514277.1 Gene:LAMB4 / 22798 HGNCID:6491 Length:1772 Species:Homo sapiens


Alignment Length:1772 Identity:668/1772 - (37%)
Similarity:962/1772 - (54%) Gaps:155/1772 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 CERSSCYPATGNLLIGRENRLTASSTCGLHSPERFCILSHLQ-DKKCFLCDTREETKHDPY---K 109
            |.|.:|:|.||:||:||..:|.|||||||...:::||||:|: ::|||:||:|  ..:|||   .
Human    23 CNRGACHPTTGDLLVGRNTQLMASSTCGLSRAQKYCILSYLEGEQKCFICDSR--FPYDPYDQPN 85

  Fly   110 NHRIGQIIYKTKPGTNIPTWWQSENGKENATIQLDLEAEFHFTHLIITFTTFRPAAMYIERSFDF 174
            :|.|..:|...:|... ..|||||||.::.:|:|||||.|.|:|||:||.|||||||.:|||.|:
Human    86 SHTIENVIVSFEPDRE-KKWWQSENGLDHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERSTDY 149

  Fly   175 GQTWHIYRYFAYDCKESFPGVPT-VLENITDVMCTSRYSNVEPSRNGEVIFRVLPPNINVTDPYA 238
            |..|.:::|||.||..|||.:.: ..:.:.|::|.|:||::|||..|||:.:||.|:..:.:||:
Human   150 GHNWKVFKYFAKDCATSFPNITSGQAQGVGDIVCDSKYSDIEPSTGGEVVLKVLDPSFEIENPYS 214

  Fly   239 EHVQNQLKMTNLRIQMTKLHKLGDNLLDSRLENE--EKYYYGISNMVVRGSCSCYGHASQCLPLD 301
            .::|:.:.:|||||..||||.|||.|| .|.:|:  :||||.:..|:|||||.|.||||:|.|:.
Human   215 PYIQDLVTLTNLRINFTKLHTLGDALL-GRRQNDSLDKYYYALYEMIVRGSCFCNGHASECRPMQ 278

  Fly   302 PAFSQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAVSCHF 366
            .......:..|||||:|.|.|||.|.|||.|:|||.|.||:||...:.|||:.|.||.|:..|||
Human   279 KMRGDVFSPPGMVHGQCVCQHNTDGPNCERCKDFFQDAPWRPAADLQDNACRSCSCNSHSSRCHF 343

  Fly   367 DEAVFTASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSSDDGIC 431
            |...:.|||.:|||||::|.|||.||||:.|.|.|||||.:.|:....|.||:|||.|:...|||
Human   344 DMTTYLASGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPDGTISGGIC 408

  Fly   432 DSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTLNNSGCVMRTG 496
            .|.::...|:|||.|.||..|.|.:|:|||..::.|.:.:|.||:||.|||||:|....|.:.||
Human   409 VSHSDPALGSVAGQCLCKENVEGAKCDQCKPNHYGLSATDPLGCQPCDCNPLGSLPFLTCDVDTG 473

  Fly   497 ECKCKKYVTGKDCNQCMPETYGLSESPEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQ 561
            :|.|..||||..|.:|....:||.....|||.|:||.||:|.|.|...:|||.||||:||||||:
Human   474 QCLCLSYVTGAHCEECTVGYWGLGNHLHGCSPCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSE 538

  Fly   562 PKQNYFI-PL---LPEVHEAEVVDECISYGAN--GNCSLV----AETPDG---SFTGIGFTRVPE 613
            |...||. ||   |.|..||..:......|:.  |....|    .|...|   ::||.||.||..
Human   539 PAPGYFFAPLNFYLYEAEEATTLQGLAPLGSETFGQSPAVHVVLGEPVPGNPVTWTGPGFARVLP 603

  Fly   614 NSELVFTVGDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGGCGELAAATSSETRIPF 678
            .:.|.|.|.:||..:.:...|.|::.|..||....:       |:|.||.......|.......|
Human   604 GAGLRFAVNNIPFPVDFTIAIHYETQSAADWTVQIV-------VNPPGGSEHCIPKTLQSKPQSF 661

  Fly   679 SLPDRSRQVVALNEVCLEAGKVYKFRIYFERKRHDVDSPTATILVDSLTLIPRIDVTPIFQGSVL 743
            :||..:|.::....:|||....|...:||.:.........:.:|||||.|||:|:....|.....
Human   662 ALPAATRIMLLPTPICLEPDVQYSIDVYFSQPLQGESHAHSHVLVDSLGLIPQINSLENFCSKQD 726

  Fly   744 ADIRKKDYEKYNCKSSLYDMNYKSDP-KCQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGY 807
            .|    :|:.:||......|..:..| .|:.|...:|..:||||..|.|:|.||:...|...||.
Human   727 LD----EYQLHNCVEIASAMGPQVLPGACERLIISMSAKLHDGAVACKCHPQGSVGSSCSRLGGQ 787

  Fly   808 CQCKPNVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSKDKYCDLITGQCQCVPNTYGRECNQCQP 872
            |||||.||||.||:|:.|:|..|..||..|.|:..||||..||.:||||.|.....||.|::|..
Human   788 CQCKPLVVGRCCDRCSTGSYDLGHHGCHPCHCHPQGSKDTVCDQVTGQCPCHGEVSGRRCDRCLA 852

  Fly   873 GYWNFPECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGSEIGCRPCRCPE 937
            ||:.||.|..|.||..|..|||..|:|.:|...|||.:|:.|:|||||||..|..  ||||.||:
Human   853 GYFGFPSCHPCPCNRFAELCDPETGSCFNCGGFTTGRNCERCIDGYYGNPSSGQP--CRPCLCPD 915

  Fly   938 TVASGLAHADGCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNPD-NGGTCSKCECSNNVDLYD 1001
            ..:|....|..|..:..:::::|:|.:||:|::|..|:..|:|||. :|..|..|.|:||:|:.|
Human   916 DPSSNQYFAHSCYQNLWSSDVICNCLQGYTGTQCGECSTGFYGNPRISGAPCQPCACNNNIDVTD 980

  Fly  1002 TGNCDRQTGACLKCLYQTTGDHCELCKDGFFGDALQQNCQQCECDFLGTN-------NTIAHCDR 1059
            ..:|.|.||.||:||:.|.|.:|:|||.|.:|.||.|.|::|.|...|.:       .....||.
Human   981 PESCSRVTGECLRCLHNTQGANCQLCKPGHYGSALNQTCRRCSCHASGVSPMECPPGGGACLCDP 1045

  Fly  1060 FTGQCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRAC 1124
            .||.|||||||.|:.||:||:.:|.:..|.||:||:|||..:....|:..||||.||.|:||:.|
Human  1046 VTGACPCLPNVTGLACDRCADGYWNLVPGRGCQSCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRC 1110

  Fly  1125 NQCQAHYWGNPNEKCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPC 1189
            ::||.:|:|:|..:|.||:|::.|.....||.:||.|.|.||:.|.:|:.||||:..:||.|..|
Human  1111 SECQENYYGDPPGRCIPCDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGHSQEFPTCLQC 1175

  Fly  1190 GECFNNWDLILSALEDATTATILRAKEIKQVGAT-GAYTSEFSELDKKLQHIRNLLQN---TSVS 1250
            ..||:.||..:|:|..|....:..|..::....| ....::|.:|...:..|..:|::   .|..
Human  1176 HLCFDQWDHTISSLSKAVQGLMRLAANMEDKRETLPVCEADFKDLRGNVSEIERILKHPVFPSGK 1240

  Fly  1251 LVDIEKLDYETQSLRDQLQASHGRLSETEQNLDDIYNSLSLSGVELESLQNHSRLVQQLSKELKE 1315
            .:.::  ||. .|:|.|:.       :..:.|..:|....|... :|..:|.:.|   |.::|:|
Human  1241 FLKVK--DYH-DSVRRQIM-------QLNEQLKAVYEFQDLKDT-IERAKNEADL---LLEDLQE 1291

  Fly  1316 NGIQLQESNIEGAL-----NLTRHAYERVSNLSTLKDEANELAS--NTDRNCKRVENLSNKIQAE 1373
            . |.||.|.:..::     |:.:  |..:|  |:.:.:.||.:|  ||..|.:      |.:...
Human  1292 E-IDLQSSVLNASIADSSENIKK--YYHIS--SSAEKKINETSSTINTSANTR------NDLLTI 1345

  Fly  1374 ADDLANNNKLIEDYRAELTSLTSQIPE---LNNQVCGKPGD-PCDSL-CGGAGCGHCGGFLSCE- 1432
            .|.|.:...|..:...::     :||:   ||.:|||.||: ||..| ||||.|....|...|. 
Human  1346 LDTLTSKGNLSLERLKQI-----KIPDIQILNEKVCGDPGNVPCVPLPCGGALCTGRKGHRKCRG 1405

  Fly  1433 ---HGAKTHSEEALKVAKDAETAITSKKDQADQTIRALTQAKLNASEAYEKAKRGFEQSERYL-- 1492
               ||:.|.|..||:.|::|::.|.:    .|:.:|.|.....:.||..|.:|....|....|  
Human  1406 PGCHGSLTLSTNALQKAQEAKSIIRN----LDKQVRGLKNQIESISEQAEVSKNNALQLREKLGN 1466

  Fly  1493 --NQTNA---NIKLAENLFI-ALNNFQENKTASPSESKELAQKTLDLDLKLEPEEIETLGDQINR 1551
              ||:::   ||    |||| .:.||...:...|.:.:::|...||:.|   |...:.|.|::.:
Human  1467 IRNQSDSEEENI----NLFIKKVKNFLLEENVPPEDIEKVANGVLDIHL---PIPSQNLTDELVK 1524

  Fly  1552 AVSSLKNVEAIIYRTKPDLDRVN----NLQSIANATK--EKADKILDSANSVVESLAAADESQGK 1610
            ....::..|.  |||  |.:|:|    ..|.:....|  |||..||.:.:..:..|..|..:||:
Human  1525 IQKHMQLCED--YRT--DENRLNEEADGAQKLLVKAKAAEKAANILLNLDKTLNQLQQAQITQGR 1585

  Fly  1611 AKDAIQQANSNIELAGQDLEKIDEETYSAEAPANNTAQQVEKLAK--------------KVQKLQ 1661
            |...|.|..:||       .||.:....||........::| |||              |:|:.|
Human  1586 ANSTITQLTANI-------TKIKKNVLQAENQTREMKSELE-LAKQRSGLEDGLSLLQTKLQRHQ 1642

  Fly  1662 NNIMKNDRDAKEITKEAGSVKLEAMRARGEANNLQSATSATNQTLTDRASRSENARERAKQLLQR 1726
            ::.:.....|:....:|||::.|.:..:.:...||..||.|..|        :....:.|||...
Human  1643 DHAVNAKVQAESAQHQAGSLEKEFVELKKQYAILQRKTSTTGLT--------KETLGKVKQLKDA 1699

  Fly  1727 ASKLTVDTNAKLKDLND 1743
            |.||..||.||::.:.|
Human  1700 AEKLAGDTEAKIRRITD 1716

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 63..286 CDD:278484 108/229 (47%)
EGF_Lam 287..343 CDD:238012 30/55 (55%)
Laminin_EGF 355..415 CDD:278482 32/59 (54%)
Laminin_EGF 418..475 CDD:278482 24/56 (43%)
EGF_Lam 477..526 CDD:238012 21/48 (44%)
EGF_Lam 529..567 CDD:214543 22/37 (59%)
EGF_Lam 789..834 CDD:214543 23/44 (52%)
Laminin_EGF 837..885 CDD:278482 23/47 (49%)
Laminin_EGF 883..930 CDD:278482 23/46 (50%)
Laminin_EGF 933..988 CDD:278482 18/55 (33%)
Laminin_EGF 991..1043 CDD:278482 26/51 (51%)
Laminin_EGF 1043..1091 CDD:278482 21/54 (39%)
Laminin_EGF 1094..1142 CDD:278482 21/47 (45%)
Laminin_EGF 1142..1190 CDD:278482 20/47 (43%)
COG6 1212..>1398 CDD:303003 39/196 (20%)
TelA 1439..1782 CDD:226371 89/333 (27%)
ApoLp-III_like 1545..1702 CDD:304399 45/176 (26%)
LAMB4XP_011514277.1 Laminin_N 38..263 CDD:278484 108/228 (47%)
EGF_Lam 264..320 CDD:238012 30/55 (55%)
Laminin_EGF 332..382 CDD:278482 29/49 (59%)
Laminin_EGF 395..452 CDD:278482 24/56 (43%)
EGF_Lam 454..503 CDD:238012 21/48 (44%)
EGF_Lam 505..549 CDD:238012 25/43 (58%)
EGF_Lam 768..809 CDD:238012 22/40 (55%)
Laminin_EGF 822..865 CDD:278482 21/42 (50%)
EGF_Lam 862..909 CDD:238012 23/48 (48%)
EGF_CA <938..967 CDD:304395 12/28 (43%)
Laminin_EGF 970..>1012 CDD:278482 21/41 (51%)
Laminin_EGF 1033..1077 CDD:278482 18/43 (42%)
Laminin_EGF 1080..1128 CDD:278482 21/47 (45%)
EGF_Lam 1127..>1165 CDD:238012 17/37 (46%)
Mplasa_alph_rch 1254..>1714 CDD:275316 138/517 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 71 1.000 Domainoid score I9432
eggNOG 1 0.900 - - E1_KOG0994
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D42471at33208
OrthoFinder 1 1.000 - - FOG0002726
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100925
Panther 1 1.100 - - O PTHR10574
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
87.780

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