Protein Alignment LanB1 and lam-2

DIOPT Version :10

• Sequence 1: NP_476618.1
• Gene: LanB1 / 34068
• FlyBaseID: FBgn0261800
• Length: 1788
• Species: Drosophila melanogaster
• Sequence 2: NP_509204.3
• Gene: lam-2 / 180980
• WormBaseID: WBGene00016913
• Length: 1633
• Species: Caenorhabditis elegans
• Alignment Length: 1854
• Identity: 478/1854 - (25%)
• Similarity: 786/1854 - (42%)
• Gaps: 429/1854 - (23%)

  Fly    36 PKYPPNKF-IKTHPC-ERSS-----CYPATGNLLIGRENRLTASSTCGLHSPERFCILS-HL-QD 91
            |...||.| ...:|| :|::     |.|...|.....|.::|  :|||...|.:||:.| |. |.
 Worm    26 PSVDPNHFGADGNPCYDRATRQPQRCVPDFVNAAFNLEVQVT--NTCGTKRPTKFCVQSGHTGQR 88

  Fly    92 KKCFLCDTREETKHDPYK---NHRIGQIIYKTKPGTNIPTWWQSENGKE------NATIQLDLEA 147
            ..|..||.|.|....|.|   :..:|          |..|||||:..:|      ...:.|.|..
 Worm    89 SVCETCDDRHEGFSHPAKYLTDFNVG----------NNETWWQSDTMQEGQQYPTTTNLTLVLGK 143

  Fly   148 EFHFTHLIITFTTFRPAAMYIERSFDFGQTWHIYRYFAYDCKESF---PGVPTVLENITDVMCTS 209
            .|..|::.:.|.:.||.:..|.:.......|..:::::..|:.::   ...|.:..|.....||.
 Worm   144 SFDITYVRLKFISPRPESFTIYKKTHTDSEWEPWQFYSGSCRATYGLSDRAPILPGNEATAQCTK 208

  Fly   210 RYSNVEPSRNGEVIFRVLP--PNINVTDPYAEHVQNQLKMTNLRIQMTKLHKLGDNLL-DSRLEN 271
            .:|::.|...|.:.|..|.  |:.:..:. :|.:|..:..:.:||.:.:::..||.:. |.::
 Worm   209 EFSDISPITGGNIAFSTLEGRPSAHAFEE-SEVLQKWVTASAIRISLNRMNTFGDEVFKDPQV-- 270

  Fly   272 EEKYYYGISNMVVRGSCSCYGHASQCLPLDPAFSQADNEDGMVHGRCECTHNTKGMNCEECEDFF 336
            ...|||.||:..|.|.|.|.||||:|:    ..|..|.|:.:|   |.|.|||:|.:|.||..|:
 Worm   271 LRSYYYAISDFAVGGRCKCNGHASECV----GSSSVDGENRLV---CRCEHNTQGADCNECLPFY 328

  Fly   337 NDLPWKPAFGKKTNACKKCECNDHAVSCHFDEAVFTASGFVSGGVCDNCLHNTRGQHCEECMPYF 401
            ||.||:.....:.|.|..|.|:..:..|:||:.:|..:|  .||.|.:|..||:|.|||:|:...
 Worm   329 NDRPWRSGTSVEANECIACNCSQLSNRCYFDQQLFEETG--HGGHCIDCQGNTQGVHCEQCIANH 391

  Fly   402 YRDPEQDITSERVCQPCDCDPQGSSDDGICDSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWN 466
            :|.|     .|..|..|.|:..||.... ||  ||       |.|.||..||||.|:||.||:::
 Worm   392 WRRP-----GENYCVACGCNEIGSLSTQ-CD--NE-------GKCQCKPGVTGRFCDQCLDGFYD 441

  Fly   467 LQSDNPEGCEPCTCNPLGTLNNS-GCVMRTGECKCKKYVTGKDCNQCMPETYGLS-ESPEGCSLC 529
            ..::   ||:.|.|...|:|||. .|...:|.|.||..|.|:.|::|.|..:.|| |:..||:.|
 Worm   442 FSTN---GCKNCGCETSGSLNNQPRCDSSSGSCSCKLNVEGRQCDKCKPGYFDLSTENQFGCTPC 503

  Fly   530 NCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQPKQNYFIPL---LPEVHEAEVVDECISYGANGN 591
            .|   ..:.:.|:...|.....   ......|.||.:....   |.:...|| :|:.::.....|
 Worm   504 FC---FGHSSICNTADGYFAMN---VSSVFDQDKQKWAGQNRIGLQDTQWAE-LDKAVAVSDTDN 561

  Fly   592 CSLVAETPDGSFTGIGFTRVPENSELVFTVGDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQ 656
            ..:....|: .|  :|..|...|.:||||:          .|.::  .:..|.::  |.:|..|:
 Worm   562 SPVYFVAPE-QF--LGDQRSSYNQDLVFTL----------KVAKH--VTNQDVKD--IIIVGADR 609

  Fly   657 VDPEGGCGELAAATSSETRIPFSLPDRSRQVVALNEVCLEAGKVYKFRIYFERKRHDVDSPTATI 721
                   .||:.:.:::.. ||...:               .:.|:||::.:
 Worm   610 -------QELSTSITAQGN-PFPTTE---------------AQTYRFRVHAD------------- 638

  Fly   722 LVDSLTLIPRIDVTPIFQGSVLADIRKKDYEKYNCKSSLYDMNYKSDPKCQNLD------NILSV 780
                          |.|                    ..|       |:...||      ||.::
 Worm   639 --------------PYF--------------------GWY-------PRINELDFIGILSNITAI 662

  Fly   781 FVHDGASMCNCNPTGSLSKVCESNGGYCQCKPNVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSK 845
            .:....|.   ...|.||.|            |:          ||.|..|..........|
 Worm   663 KIRGTYSY---KDIGYLSNV------------NL----------GTAGVAPSAANPKQATWI--- 699

  Fly   846 DKYCDLITGQCQCVPNTYGRECNQCQPGYWN-------FPECRVCQCNGHAATCDPIQGTCIDCQ 903
                    ..|:|:|...|:.|..|:.|:..       |..|..|.|:.|:.:|:...|:|| |:
 Worm   700 --------EHCECLPGFVGQFCESCESGFRRETKFGGPFNHCIKCDCHNHSNSCEAESGSCI-CE 755

  Fly   904 DSTTGYSCDSCLDGYYGNPLFGSEIGCRPCRCPETVASGLAHADGCSLDTRNNNMLC-HCQEGYS 967
            .:|.|.:|:.|..||||:.|.|:|..|:.|.||.. ...:.||||        :::| .|..||:
 Worm   756 HNTAGDTCERCARGYYGDALQGTEEDCQKCPCPND-GPCILHADG--------DVICTECPNGYT 811

  Fly   968 GSRCEICADNFFGNPDNGGTCSKCECSNNVDLYDTGNCDRQTGACLKCLYQTTGDHCELCKDGFF 1032
            |.||:.|:|.:||||.:|..|.:|.||.|.|....||||:.||.|.||::.|.|.:||.||.|::
 Worm   812 GRRCDECSDGYFGNPKDGTECVECACSGNTDPNSIGNCDKITGECKKCIFNTHGFNCENCKPGYW 876

  Fly  1033 GDAL---QQNCQQCECDFLGT---NN--TIAHCDRFTGQCPCLPNVQGVRCDQCAENHWKIASGE 1089
            ||||   :.|||.|.|...||   ||  |:..|::..|||.|||||.|::|||||...:.|.||.
 Worm   877 GDALIEPKGNCQSCGCFAAGTRRPNNDYTLLECNQQDGQCDCLPNVIGIQCDQCAHGFYNITSGL 941

  Fly  1090 GCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACNQCQAHYWGNPNEKCQPCECDQFGAADFQC 1154
            ||:.|||||:|:....|:..|||||||||..|:.|::|..:::|.....||||:|:..|:.:.||
 Worm   942 GCQECNCDPLGSEGNTCDVNTGQCQCKPGVTGQRCDRCADYHFGFSANGCQPCDCEYIGSENQQC 1006

  Fly  1155 DRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGECFNNWDLILSALEDATTATILRAKEIKQ 1219
            |..:|.|:|.|.:.|.:|::||....|....|.||.:|:                |:::::
 Worm  1007 DVNSGQCLCKENVEGRRCDQCAENRYGITQGCLPCDDCY----------------TLIQSR---- 1051

  Fly  1220 VGATGAYTSEFSELDKKLQHIRNLLQNTSVSLVDIEKLDYETQSLRDQLQASHGRLSETEQNLDD 1284
               ...:..:...||..||.|   ::|.:.  |:..|.|              .::.||.:...:
 Worm  1052 ---VNVFREKVKSLDNTLQEI---IENPAP--VNDTKFD--------------EKVKETSRAASE 1094

  Fly  1285 IYNSLSLSGVELESLQNHSRLVQQLSKELKENGIQLQESNIEGALNLTRHAYERVSNLSTLKDEA 1349
            ::.::.      :..:.....::..||.:|:..:.               |.|:::::.....:|
 Worm  1095 VWEAVK------QKTKEGGGTIKTKSKAIKDEIVA---------------ALEKLTSIDESVAQA 1138

  Fly  1350 NELASNTDRNCKRVENLSNKIQAEADDLANNNKLIEDYRAELTSLTSQIPELNNQVCGKPGDPCD 1414
            ...|...:.:.||.|.:....:.|.:::.:..:...:.||::....||          |.|:...
 Worm  1139 KVGADAAENDMKRWEIIIENARREIENVLHYLETEGEERAQIAYNASQ----------KYGEQSK 1193

  Fly  1415 SLCGGAGCGHCGGFLSCEHGAKTHSEEALKVAKDAETAITSKKDQADQTIRALTQAKLNASEAY- 1478
            .:...|.            |.:..:|:.||.|.:.|       ..::|.|...|||...||:|.
 Worm  1194 RMSELAS------------GTREEAEKHLKQASEIE-------QLSEQAIANATQANKEASDAIY 1239

  Fly  1479 --EKAKRGFEQSERYLNQTNANI----KLAE----------NL-FIALNNFQENKTAS--PSESK 1524
              |:..:...:.:...||.|.:|    .|||          || .::|.|.:..|..|  |.|.:
 Worm  1240 GGEQISKQIAELKEKQNQLNESIHRTLDLAEEQKKSADEANNLAAVSLTNVEAVKIPSVDPKELR 1304

  Fly  1525 -------ELAQKTLDLDLKLEPEEIETLGDQINRAVSSLKNVEAIIYRTKPDLDRVNNLQSIANA 1582
                   |.::..:|..:| |....:.|.|::||:|:..:|          :|....:.|.:::.
 Worm  1305 NDVAGVLEESENLVDSSVK-ENSANDELFDEVNRSVADARN----------ELQSSQDQQRVSDQ 1358

  Fly  1583 TKEKADKILDSANSVVESLAAADESQGKAKDAIQQANSNIELAGQDLEKIDEETYSAEAPANNTA 1647
            ...:.:|   |...:|:|::.||::...|:.|:|.    :|..|..:||...:..:..|......
 Worm  1359 LMLELEK---SRERIVDSVSTADKTLKDAEAALQV----LEEFGAKIEKSRNDAVAEFAGVEGIN 1416

  Fly  1648 QQVEKLAKKVQKLQN-------------------------------NIMKNDRDAKEITKEAGSV 1681
            |:::.:.....|.:|                               :|:.:|.|.::.| ||...
 Worm  1417 QRLDDIIDAQDKRRNSLPIDKQFVIDYRKSADVLLNETHALADRYKDIIHSDVDTRDST-EAVQY 1480

  Fly  1682 KLEAMRARGEANNLQSATSATNQTLTDRASRSENARERAKQLLQRAS---KLTVDTNAKL----- 1738
            .:|         .|....:.:|:.|.....::|:.::.|.:.:::|:   ...::.||.:
 Worm  1481 DIE---------QLMEELTDSNENLQYYKKQAEDDKQMATEAVRKATLAKNSAIEANATILAEED 1536

  Fly  1739 ---KDLNDLQTVYLNKNQQLLRLQAEIGPLNKEL 1769
               |.:|.|.|:....|.:|..|:.||..|::.|
 Worm  1537 EIKKIINSLDTMEEVNNAELDELEEEIDRLDQLL 1570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LanB1	NP_476618.1	Laminin_N	54..286	CDD:459653	62/248 (25%)
		EGF_Lam	287..343	CDD:238012	25/55 (45%)
		Laminin_EGF	355..415	CDD:395007	21/59 (36%)
		Laminin_EGF	418..475	CDD:395007	21/56 (38%)
		EGF_Lam	477..526	CDD:238012	19/50 (38%)
		EGF_Lam	529..567	CDD:214543	7/37 (19%)
		EGF_Lam	789..834	CDD:214543	9/44 (20%)
		Laminin_EGF	837..885	CDD:395007	11/54 (20%)
		Laminin_EGF	883..930	CDD:395007	19/46 (41%)
		Laminin_EGF	933..988	CDD:395007	21/55 (38%)
		Laminin_EGF	991..1035	CDD:395007	22/43 (51%)
		Laminin_EGF	1043..1091	CDD:395007	25/52 (48%)
		Laminin_EGF	1094..1142	CDD:395007	22/47 (47%)
		Laminin_EGF	1142..1190	CDD:395007	17/47 (36%)
		Mplasa_alph_rch	1228..>1771	CDD:275316	114/611 (19%)
		cc_DmLAMB1-like_C	1717..1786	CDD:411973	15/64 (23%)
lam-2	NP_509204.3	LamNT	45..285	CDD:214532	62/254 (24%)
		EGF_Lam	286..337	CDD:238012	25/57 (44%)
		Laminin_EGF	347..405	CDD:395007	23/64 (36%)
		EGF_Lam	403..447	CDD:214543	21/56 (38%)
		LamB	560..684	CDD:214597	37/242 (15%)
		EGF_Lam	736..783	CDD:238012	19/47 (40%)
		EGF_Lam	785..833	CDD:238012	21/56 (38%)
		Laminin_EGF	835..890	CDD:395007	28/54 (52%)
		EGF_Lam	889..944	CDD:238012	26/54 (48%)
		EGF_Lam	946..991	CDD:214543	20/44 (45%)
		EGF_Lam	993..1041	CDD:238012	17/47 (36%)
		Smc	<1087..>1617	CDD:440809	105/562 (19%)