DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanB1 and lam-1

DIOPT Version :9

Sequence 1:	NP_476618.1	Gene:	LanB1 / 34068	FlyBaseID:	FBgn0261800	Length:	1788	Species:	Drosophila melanogaster
Sequence 2:	NP_500734.3	Gene:	lam-1 / 177292	WormBaseID:	WBGene00002247	Length:	1790	Species:	Caenorhabditis elegans

Alignment Length:	1826	Identity:	765/1826 - (41%)
Similarity:	1087/1826 - (59%)	Gaps:	121/1826 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRLIVVIVLALLSWQWDPVDSQRPPQHGRRDRPKYPPNKFIKTHPCERSSCYPATGNLLIGRENR 68
            |.|::.::|..       :::|.|.|. ..||             |:..||||.||||||||:::
Worm     8 LGLLLSLLLVF-------IEAQHPLQQ-NEDR-------------CQDRSCYPITGNLLIGRKSQ 51

  Fly    69 LTASSTCGLHSPERFCILSHLQDK-KCFLCDTREETK--HDPYK-NHRIGQIIYKTKPGTNIPTW 129
            |.|:||||....:||||:|||::: |||.||:|.|.|  .:||: :|||..::.:.....| ..|
Worm    52 LKATSTCGSQGRQRFCIVSHLEEQTKCFYCDSRTEWKPQREPYRLSHRIENVVTEVMDDKN-RNW 115

  Fly   130 WQSENGKENATIQLDLEAEFHFTHLIITFTTFRPAAMYIERSFDFGQTWHIYRYFAYDCKESFPG 194
            :|||||.:|.:|..||||||||||||:||.:||||||.||||.|||:||.:||||||||..||||
Worm   116 YQSENGAQNVSISFDLEAEFHFTHLIMTFKSFRPAAMIIERSADFGKTWQVYRYFAYDCDSSFPG 180

  Fly   195 VPT-VLENITDVMCTSRYSNVEPSRNGEVIFRVLPPNINVTDPYAEHVQNQLKMTNLRIQMTKLH 258
            :|. ..:..|||:|||:||:|.||..||::::|:.|:|...:|||:.:...||:||||...||||
Worm   181 IPEGPPKKHTDVICTSQYSDVAPSTGGEIVYKVISPHIVTENPYADEISTLLKITNLRFNFTKLH 245

  Fly   259 KLGDNLLDSRLENEEKYYYGISNMVVRGSCSCYGHASQCLPLDPAFS------QADNEDGMVHGR 317
            .|||:|||.|.|.:|||||.|..:|||||||||||||:|:|:||..|      :||    :||||
Worm   246 TLGDDLLDYRPEIDEKYYYAIYEIVVRGSCSCYGHASRCIPIDPHVSPNTVMERAD----IVHGR 306

  Fly   318 CECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAVSCHFDEAVFTASGFVSGGVC 382
            |||.|||:|:|||:|:.|:|||||:||.|.:.|.|::|.||.||:.||||.||:.:|||||||||
Worm   307 CECMHNTEGLNCEKCKAFYNDLPWRPAIGDEKNECRQCNCNRHALRCHFDRAVYESSGFVSGGVC 371

  Fly   383 DNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSSDDGICDSLNELEEGAVAGACH 447
            |:|:|||:|::||:|.|:|||||.:.|....||.||:||..||.:.|||:...:.|.|.|||.|:
Worm   372 DDCMHNTQGKNCEQCKPFFYRDPRRTIDDPHVCLPCECDKAGSQNKGICEGEEDAERGLVAGKCY 436

  Fly   448 CKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTLNNSGCVMRTGECKCKKYVTGKDCNQC 512
            ||..|.|.||::||:|||||...|.:||..||||.|||.||.||...||.|.||:.|||::|:||
Worm   437 CKTNVDGNRCDRCKNGYWNLTETNVDGCVACTCNLLGTYNNEGCDKYTGMCTCKRLVTGENCDQC 501

  Fly   513 MPETYGLSESPEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQPKQNYF-IPLLPEVHE 576
            :||.|||||..:||..|:||.||||||.|::.:|||:||...:||.|.....::: ..:...|:|
Worm   502 LPEHYGLSEHVDGCKACDCDIGGSYDNTCEITTGQCKCREGFSGRRCETADSSFYCADITHYVYE 566

  Fly   577 AEVVDECISYGANGNCSLVAETPDGSFTGIGFTRVPENSELVFTVGDIPR-SMPYDAVIRYQ-ST 639
            ||..:  ::.|........::..:.:|||.||.:..|.:  :.||..|.. |..|:.:||:. :.
Worm   567 AEYAN--LTRGEVKTREWPSQPHEQTFTGEGFAQAVEGT--IITVNPIVEVSQKYNVIIRHDGAR 627

  Fly   640 SRGDWENAFITLVRPDQVDPEGGCGELAAATSSETRIPFSLPDRSRQVVALNEVCLEAGKVYKFR 704
            ....|||..||:||| :.:.:|.|.:  |..|.:..|....|. ||.:.....:|||||..|:.|
Worm   628 DPVGWENIQITVVRP-EAEGDGSCSD--APPSDDFLIARIYPG-SRYIEVQPAICLEAGVQYELR 688

  Fly   705 IYFERKR---HDVDSPTATILVDSLTLIPRIDVTPIFQGSVLADIRKKDYEKYNCKSSLYDMNYK 766
            |.|..||   |..:...|.||:||:.|.|......|||||..|:....:|.:|.|:.....::..
Worm   689 IQFNEKRGNSHPQERAAANILIDSILLAPPTSELHIFQGSARAEQHLTEYNRYQCRHLALSLSLF 753

  Fly   767 SDPK---CQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGYCQCKPNVVGRQCDQCAPGTYG 828
            .|.:   |:.....::..:.:..|.|||:.|||:|.:|...||.|:||||||||:|||||.||||
Worm   754 KDQRNEVCERYVCPIAAALLNKTSECNCDATGSVSGICNVQGGQCECKPNVVGRRCDQCAIGTYG 818

  Fly   829 FGPEGCKACDCNSIGSKDKYCDLITGQCQC-VPNTYGRECNQCQPGYWNFPECRVCQCNGHAATC 892
            |||.|||.|||:::||....||..:|||.| ....|||:|||||||:|.|||||.||||.||..|
Worm   819 FGPSGCKKCDCDAVGSLGNDCDKQSGQCVCREKGIYGRQCNQCQPGFWGFPECRTCQCNDHANIC 883

  Fly   893 DPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGSEIGCRPCRCPETVASGLAHADGCSLDTRNNN 957
            |...|.||:|:|.|||:.||.|.|||||:|..|..|.|:||.||....||..|||.|.|....||
Worm   884 DQSSGACIECRDLTTGHYCDRCQDGYYGDPRLGVGIPCKPCPCPGGPTSGYQHADTCYLRNSGNN 948

  Fly   958 ---MLCHCQEGYSGSRCEICADNFFGNP-DNGGTCSKCECSNNVDLYDTGNCDRQTGACLKCLYQ 1018
               ::|:|:.||.|.||..||.|.:|:| :.||||.:|:|:.|:|:...|:||..||.|||||:.
Worm   949 TQDIVCNCKSGYQGERCGECAQNHWGSPREVGGTCERCDCNGNIDMAMEGSCDAATGECLKCLHH 1013

  Fly  1019 TTGDHCELCKDGFFGDALQQNCQQCECDFLGTNNTIAHCDRFTGQCPCLPNVQGVRCDQCAENHW 1083
            |.|..||.|.||::|||..:.||:|.|:.||||:|...|||.:|||||..|:.|::||||||||:
Worm  1014 TEGAQCEHCVDGYYGDAKLKTCQRCVCNELGTNSTKGACDRVSGQCPCHDNIIGMQCDQCAENHF 1078

  Fly  1084 KIASGEGCESCNCDPIGAL-------HEQCNSYTGQCQCKPGFGGRACNQCQAHYWGNPN--EKC 1139
            .:|||.|||:|.||..|.:       |.|||.:.||||||||.|||.|:||:..|||:|.  :.|
Worm  1079 NLASGAGCEACGCDSNGVVLNHEGVPHLQCNIFDGQCQCKPGRGGRKCDQCEDLYWGDPTTPDGC 1143

  Fly  1140 QPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGECFNNWDLILSALE 1204
            ..|||:..|:...||.|..|.|.|..|.||..||||||||.||:|:|:||||||:.||.|:..|:
Worm  1144 HRCECNPTGSKSLQCHRNNGTCECQAGSGGALCNECARGYTGQWPYCNPCGECFHQWDNIMQKLQ 1208

  Fly  1205 DATTATILRAKEIKQVGATGAYTSEFSELDKKLQHIRNLLQNTSVSLVDIEKLDYETQSLRDQLQ 1269
            ....|.|..|..|:..|...||.::|.::::.|:..:..|.:.::|..|||::..:...|:.|:.
Worm  1209 KQVHALIDTANNIEDTGVASAYDADFEKMEETLKETKKALSDANISKEDIEEMSKKLALLKKQVI 1273

  Fly  1270 ASHGRLSETEQNLDDIYNSLSLSGVELESLQNHSRLVQQLSKELKENGIQLQESNIEGALNLTRH 1334
            |...:|...|..:.:|..::..:..:||.||.....|.:.:.||::...:::|:::.||.|:||.
Worm  1274 AGREKLGAIETRISNITQAVDFAQKDLEHLQKEVDKVTKATIELEDKASKIKEADVLGAFNITRE 1338

  Fly  1335 AYERVSNLSTLKDEA-NELASNTDRNCKRVENL-SNKIQAEADDLANNNKLIEDYRAE--LTSLT 1395
            :..:..:.....|.| .:||:..::..:..|.| .||...|...:.|...|.|   ||  |..|.
Worm  1339 SASKSLDAQRRTDAAIGKLAAAENQALRASELLEKNKNDFEKQYVENEEALNE---AETLLGGLE 1400

  Fly  1396 SQIPELNNQVCGKPGDPCDSLCGGAG-CGHCGGFLSCEHGAKTHSEEALKVAKDAETAITSKKDQ 1459
            |.:|:||.||||....|||:||||.| ||.||| .||..||.:.:.:|...|.:|:|.:..|:.:
Worm  1401 SVLPKLNEQVCGASSAPCDALCGGPGSCGFCGG-QSCMEGAVSKANQAKSFATEADTRLDEKQKE 1464

  Fly  1460 ADQTIRAL-------TQAKLNASEAYEKAKRGFEQSERYLNQTNANI-KLAENLFIALNNFQENK 1516
            |::.:..:       |:||..|.:|||.||...:::    |.:.|.: |:||.    :..|...:
Worm  1465 AEEVLSIVRDVLTETTKAKAKAEKAYEVAKNTAQRA----NSSRAELDKIAEE----IGEFLTAQ 1521

  Fly  1517 TASPSESKELAQKTLDLDLKLEPEEIETLGDQINRAVSSLKNVEAIIYRTKPDLDRVNNLQSIAN 1581
            .:||.:.:.||::.|..::.|.|::|..|..:|..:::.:.|::.|:..|:.:.....||:|.|.
Worm  1522 KSSPEQIRNLAEEVLGKEISLTPDQITDLTGKIKESLAKINNIDEILNETRGNKSIAANLESRAV 1586

  Fly  1582 ATKEKADKILDSANSVVESLAAADESQGKAKDAIQQANSNIELAGQDLEKIDEETYSAEA----- 1641
            ...::|:.:..:...:.|:|..||::.......:::.::   :..|..|.||:...|.||
Worm  1587 KANKEAELLQKAMEEIREALQLADQAYNNVTSVLEEIDT---MQVQARELIDKARNSTEAVEGKA 1648

  Fly  1642 -PANNTAQQVEKLAK--KVQKLQNNIMKNDRDAKEITKEAGSVKLEAMRARGEANNLQSATSATN 1703
             .||.|..::|.:..  ||:.||.:     ..||.......:....|..|..:...:|:......
Worm  1649 QAANTTLAELEGVMSGVKVEYLQIS-----ESAKNALTTVDAALAAATNAEQKNKQIQTDLERAT 1708

  Fly  1704 QTLTDR-------ASRSENARERAKQLLQRASKLTVDTNAKLKD-----LNDLQTVYLNKNQQLL 1756
            :.|..|       ..|:|..||||.:||.:|.:...|.:...||     |:|.:|:..:.|.:|.
Worm  1709 ELLEKRMEGNVAPQQRAEKLRERAAKLLYQAQRHNDDIDNLSKDSTEMRLDDYETILADLNSRLE 1773

  Fly  1757 RLQAEI 1762
            |:..:|
Worm  1774 RVTRDI 1779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB1	NP_476618.1	Laminin_N	63..286	CDD:278484	125/227 (55%)
		EGF_Lam	287..343	CDD:238012	37/61 (61%)
		Laminin_EGF	355..415	CDD:278482	36/59 (61%)
		Laminin_EGF	418..475	CDD:278482	28/56 (50%)
		EGF_Lam	477..526	CDD:238012	29/48 (60%)
		EGF_Lam	529..567	CDD:214543	18/37 (49%)
		EGF_Lam	789..834	CDD:214543	31/44 (70%)
		Laminin_EGF	837..885	CDD:278482	28/48 (58%)
		Laminin_EGF	883..930	CDD:278482	27/46 (59%)
		Laminin_EGF	933..988	CDD:278482	26/58 (45%)
		Laminin_EGF	991..1043	CDD:278482	26/51 (51%)
		Laminin_EGF	1043..1091	CDD:278482	28/47 (60%)
		Laminin_EGF	1094..1142	CDD:278482	27/56 (48%)
		Laminin_EGF	1142..1190	CDD:278482	26/47 (55%)
		COG6	1212..>1398	CDD:303003	48/189 (25%)
		TelA	1439..1782	CDD:226371	84/352 (24%)
		ApoLp-III_like	1545..1702	CDD:304399	34/164 (21%)
lam-1	NP_500734.3	LamNT	31..273	CDD:214532	136/255 (53%)
		EGF_Lam	274..332	CDD:238012	37/61 (61%)
		EGF_Lam	344..396	CDD:238012	35/51 (69%)
		Laminin_EGF	407..464	CDD:278482	28/56 (50%)
		EGF_Lam	466..516	CDD:238012	30/49 (61%)
		EGF_Lam	517..>556	CDD:238012	18/38 (47%)
		EGF_Lam	779..824	CDD:214543	31/44 (70%)
		Laminin_EGF	827..876	CDD:278482	28/48 (58%)
		Laminin_EGF	874..913	CDD:278482	24/38 (63%)
		Laminin_EGF	924..983	CDD:278482	26/58 (45%)
		EGF_Lam	985..1030	CDD:238012	22/44 (50%)
		Laminin_EGF	1038..1086	CDD:278482	28/47 (60%)
		EGF_Lam	1088..1144	CDD:238012	26/55 (47%)
		EGF_Lam	1145..1193	CDD:238012	25/47 (53%)
		BAR	1197..>1327	CDD:299863	32/129 (25%)
		DUF1002	<1448..1565	CDD:303039	31/124 (25%)
		BAR	1581..1788	CDD:299863	49/207 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158336
Domainoid	1	1.000	277	1.000	Domainoid score	I908
eggNOG	1	0.900	-	-		E1_KOG0994
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1723
Inparanoid	1	1.050	1473	1.000	Inparanoid score	I44
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49316
OrthoDB	1	1.010	-	-		D42471at33208
OrthoFinder	1	1.000	-	-		FOG0002726
OrthoInspector	1	1.000	-	-		oto20173
orthoMCL	1	0.900	-	-		OOG6_100925
Panther	1	1.100	-	-	LDO	PTHR10574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3531
SonicParanoid	1	1.000	-	-		X1817
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800