DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB1 and lam-3

DIOPT Version :10

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_492775.2 Gene:lam-3 / 172952 WormBaseID:WBGene00002248 Length:3102 Species:Caenorhabditis elegans


Alignment Length:2365 Identity:536/2365 - (22%)
Similarity:832/2365 - (35%) Gaps:829/2365 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 LELRLIVVIVLALLSWQ-------WDPV--DSQRPPQHGRRDRPKYPPNKFIKTHPCERSSCYPA 57
            |.|.|:.|..:||..|.       |:..  ||..              ::||.:. .|| ..:|.
 Worm     3 LWLGLLAVSNIALGGWNTSEDASIWENYVEDSNY--------------HEFISSE-SER-GLFPN 51

  Fly    58 TGNLLIGRENRLTASSTCGLHSPERFC-ILSHL--------QDKKCFLCDTREETKHDPYKNHRI 113
            ..||  ...:.:||:.|||.::.|.:| ::.|:        |..:|.:||.     ::.:|.|.|
 Worm    52 IFNL--ATNSLITATDTCGQYTAEEYCKLVEHVLLRKTTNTQSPQCDICDA-----NNVHKRHPI 109

  Fly   114 GQIIYKTKPGTNIPTWWQS---ENGK--ENATIQLDLEAEFHFTHLIITF-TTFRPAAMYIERSF 172
            ...|..|:      .||||   .||.  |...|.:||..|:...::|:.. .:.||....:|:|.
 Worm   110 EYAIDGTR------RWWQSPSLANGLRFEKVNITIDLRQEYQVAYIILKMGNSPRPGTWVLEKSL 168

  Fly   173 DFGQTWHIYRYFAY---DCKESFPGVPTV-----LENITDVMCTSRYSNVEPSRNGEVIFRVLPP 229
            | |:.:..::|:|.   :|...| |:|..     .:...:|.|||.||.:.|..|||:...::..
 Worm   169 D-GEYYEPWQYYAMQDAECMRQF-GIPATTGVPRFQKEDEVHCTSEYSKITPLENGEIHTSLVNG 231

  Fly   230 NINVTDPYAEHVQNQL-KMTN---LRIQMTKLHKLGDNLLDSRLENEE-------KYYYGISNMV 283
            .     |.||:...:| |.|.   :|:::.....|..:|:....:::.       :|:|.||::.
 Worm   232 R-----PGAENTSLELQKFTRARFVRLRLISPRTLNADLMIINKKSDSLDKSVTMRYFYSISDIS 291

  Fly   284 VRGSCSCYGHASQCLPLDPAFSQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKK 348
            :.|.|.|||||..| |.||...|.         :|||.|||.|.:|..|...||.|||||.....
 Worm   292 IGGQCICYGHAESC-PSDPVTGQF---------KCECRHNTCGESCNRCCPLFNQLPWKPGTNSH 346

  Fly   349 TNACKKCECNDHAVSCHFDEAV------FTASG-FVSGGVCDNCLHNTRGQHCEECMPYFYRDPE 406
            .|.|::|:|.:||.||.:|:.:      .|..| :..||.|..|.|||.|.:||.|...:||...
 Worm   347 PNVCQQCQCFNHAHSCVYDDELDRNKWSITPEGVYEGGGRCLECAHNTEGFNCERCKDGYYRPSG 411

  Fly   407 QDITSERVCQPCDCDPQGSSDDGICDSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDN 471
            .....|..|:.|:|||.||..|.........|.|...|.|.||....||||.:|..||.|    :
 Worm   412 LSHYREDACRTCECDPVGSVSDACVRDDQSAENGQKPGDCICKPGFGGRRCERCAPGYRN----H 472

  Fly   472 PEGCEPCTCNPLGTLNNSGCVMRTGECKCKKYVTGKDCNQCMPETYGLSES-PEGCSLCNCDAGG 535
            |. ||||.||..|::|...|  ....|:||..|.|..|::|...|..||.| |.||..|.|....
 Worm   473 PT-CEPCPCNRAGSVNFDTC--DGASCQCKANVEGIYCDRCKAGTIHLSASNPLGCQPCFCFGHS 534

  Fly   536 SYDNYCDVISGQCRCRPHMTGRSCSQPKQN----------YFIPLL------PEVHEAEVVDECI 584
            |                     :|:|.|.|          :...|.      |||...||    :
 Worm   535 S---------------------TCTQGKWNKAQIINNIGWHLTDLTGGKDVKPEVENGEV----L 574

  Fly   585 SYGANGNCSLVAETPDGSFTGIGFTRVPENSELVFTVGDIPRS----MPYDAVIRYQSTSRGDWE 645
            .:.||.|       .|.|   :.:.:.|::.:     |::..|    :.||  :.|..|.:|  .
 Worm   575 MFNANQN-------QDRS---LYYWKAPDSFK-----GNMLNSYGGYLHYD--VYYVPTEQG--A 620

  Fly   646 NAFITLVRPDQVDPEGGCGELAAATSSETRIPFSLPDRSRQVVALNEVCLEAGKVYKFRIYFERK 710
            ..|:.     .|..||.    .......:||.| || |.:..||:....|...       |....
 Worm   621 TVFVA-----DVAIEGN----GIKIEYHSRIEF-LP-REKMTVAIPMSELSGW-------YNAEA 667

  Fly   711 RHDVDSPTATILVDSLTLIPRIDVTPIFQGSVLADIRKKDYEKYNCKSSLYDMNYKS-----DPK 770
            |..||.      .|.:..:..:|...:          :..|.:...:||::.::..:     |..
 Worm   668 RSPVDK------ADMMRALANVDRFTV----------RATYHQPQLQSSIFGLSLDTAVPAPDEI 716

  Fly   771 CQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGG--YCQCKPNVVGRQCDQCAPGTYGFGPEG 833
            .:...::.::..|...::.               ||  .|:|..|..|..|:.|.||        
 Worm   717 VEEDTSLKALAYHTQDTLM---------------GGVEVCECPENFAGNSCESCVPG-------- 758

  Fly   834 CKACDCNSIGSKDKYCDLITGQCQCVPNTYGRECNQCQPGYWNFPECRVCQCNGHAATCDPIQGT 898
                                         |.|..||...|     .|..|.|:|::..|||..|.
 Worm   759 -----------------------------YRRVNNQLYGG-----RCEKCDCHGNSEECDPFTGE 789

  Fly   899 CIDCQDSTTGYSCDSCLDGYYGNPLFGSEIG-CRPCRC--------PETVASGLAHADGCSLDTR 954
            |::|:.:|||..|:.|..|:.|||..|.|:| |..|.|        ||.:::.||...  |:.:.
 Worm   790 CLNCRHNTTGSRCELCKPGHVGNPSRGGELGACEQCECPSLDLNPNPECISTELAVLG--SVASN 852

  Fly   955 NNNMLC-HCQEGYSGSRCEICADNFFGNPDNGGTCSKCECSNNVDLYDTGNCDRQTGACLKCLYQ 1018
            .:|.:| :|..||.|::||.|:|.||.:|.. |.|.:|.|:.|:|....||||.:||.||||:..
 Worm   853 EDNYVCINCPLGYEGNKCEYCSDGFFEDPLT-GKCIECTCNGNIDPMGIGNCDSETGKCLKCIGH 916

  Fly  1019 TTGDHCELCKDGFFGDALQQNCQ-------------------QCEC--DFLGT------------ 1050
            ||||.||.||:..:|:|....|:                   :|||  :::|.            
 Worm   917 TTGDSCESCKEHHWGNAQLHTCKPCGCHTQGAVNPQCSEENGECECKENYIGAQCDRCKENHGDV 981

  Fly  1051 ---------NNT-----------------------------------------IAH--------- 1056
                     |:|                                         ..|         
 Worm   982 ENGCPACDCNDTGSIGSDCDQVSGQCNCKQGVFGKQCDQCRPSYFNFTDAGCQFCHCNIYGSIED 1046

  Fly  1057 --CDRFTGQCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGF 1119
              ||:.||:|.|..||:|..|::||:.::.|.||:|||.|.|||.|:....||..||||.||||.
 Worm  1047 GKCDQTTGKCECRENVEGTMCEKCADGYFNITSGDGCEDCGCDPTGSEDVSCNLVTGQCVCKPGV 1111

  Fly  1120 GGRACNQCQAHYWG-------------NPNEKCQP------------------------------ 1141
            .|..|:.|..:::|             .|.:.|.|                              
 Worm  1112 TGLKCDSCLPNFYGLTSEGCTECEPCPAPGQVCDPIDGSCVCPPNTVGEMCENCTTNAWDYHPLN 1176

  Fly  1142 ----CECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCG------------ 1190
                |:|...|:....|:..||.|.|.....|.||:.|..|:. .||.|.|||            
 Worm  1177 GCKLCDCSDIGSDGGMCNTFTGQCKCKAAYVGLKCDLCTHGFF-NFPTCEPCGCNAAGTDPLQCK 1240

  Fly  1191 --------------------------------------------ECFNN---------------- 1195
                                                        .|||.                
 Worm  1241 DGQCLCNEIGECPCKKNVHGTKCDQCGEGTFSLDSSNLKGCTECFCFNRTSNCEQSDLVWQQMYA 1305

  Fly  1196 -----------------------------------------WDLILSALEDATTA--TILRAK-- 1215
                                                     |.|..:.|.|.|.:  ..||.|  
 Worm  1306 EDRRAVFQEPWEFYTKKHNINLLREKPSHFNSYPTDATPLYWPLPSTMLGDRTASYNGFLRFKIW 1370

  Fly  1216 -EIKQVGATG-----AYTSEFSEL------DKKLQHIRNLLQNTSVSLVDIEKLDYETQSLRDQL 1268
             |..:.|..|     .|...|.::      ..:|:||...:.:..:..:.:.:.::..:. ..:|
 Worm  1371 NEDNRRGLHGIRPDQQYFRHFPQVIIFGNNRIELEHIPMEINDDGIYKIRLHESEWRVRH-SPEL 1434

  Fly  1269 QASHGRLSETEQNLDDIY-----------NSLSLSGVELESLQNHSRLVQQLSKELKENGIQ--- 1319
            ..:..::....|:...||           :::::..|.|:.....|::|..|| ..|..|::   
 Worm  1435 TLTRKQMMVALQDTQGIYIRGTYTYPARGDAINIQEVSLDVAVPESKIVAGLS-TTKAIGVEKCL 1498

  Fly  1320 --------LQESNIEGA---------LN-------------LTRHAYERVSN----------LST 1344
                    |...|.|..         ||             .:.|.:.:..|          .:|
 Worm  1499 GCPQGYTGLSCQNPEVGYYRKKHREYLNQADDIALIGWSEPCSCHGHSQTCNPDTSVCTDCEHNT 1563

  Fly  1345 LKD-----------EANELASN--TDRNCKRVENLSNKIQAEADD----LANNNKLIEDYRAELT 1392
            ..|           :|.|..:|  |...|..|||..:......|.    :.|:.|          
 Worm  1564 FGDFCEHCLPGYIGDAREGGANACTKCACPLVENSFSDSCVAVDHGRGYVCNSCK---------- 1618

  Fly  1393 SLTSQIPELNNQVC-----GKPGDP---------------------CDSLCG---------GAGC 1422
                  |....|.|     |..|||                     |:.|.|         |..|
 Worm  1619 ------PGYTGQYCETCVAGYYGDPQHIGGTCSPCDCHPDGSLHGACNPLSGQCECKPGVTGRTC 1677

  Fly  1423 GHC---GGFL-----SCEHGAKTHSEEAL------------------------------------ 1443
            ..|   ..|:     ||:.|......|.:                                    
 Worm  1678 SMCQERHAFINRVCTSCDQGCYLPLMETMDTMEEHLGRQNFSGLKPIPWKRVWRIGNESQDLSTF 1742

  Fly  1444 --------------KVAKDA---------------ETAITSKK--DQADQTIRALTQAKLNASEA 1477
                          |.||||               ::|::.|:  ..|:|.|   ..|:::.:.|
 Worm  1743 VGGIDKDGEIVKDSKWAKDAFALLDEVNFQMGRSNKSAVSIKQFTGIAEQLI---LDAQIHYANA 1804

  Fly  1478 YEK-------AKRG------------FEQSERYLNQTNANIKLAENLFIALNNF-QENKTASPSE 1522
            :..       |:.|            ..::|.:|   ||.::..|.:...||.. ||:|.|....
 Worm  1805 FNTTNFLKMFAEHGATTVGGAALDGMLMEAEAHL---NATVERGEYVEKRLNRAQQEHKKAEELL 1866

  Fly  1523 SKELAQK---TLDLDLKLEPEEI--------ETLGDQINRAVSSLKNVEAIIYRTKPDLDRVNNL 1576
            ....|||   |:..|||...:.:        ||:.|...:..:..:.:..::.:      |:|..
 Worm  1867 KMVTAQKLNETIFEDLKNRIDVLEQWMNDYRETIYDVSKKDTADAERMSLVVGK------RINRY 1925

  Fly  1577 QSIANATK----EKADKILDSANSV----VESLAAADESQGKAK-------DAIQQANSNIELAG 1626
            :.::|..:    |..|:|..|.||:    .|.|....|.:.|..       |.::|..:...|..
 Worm  1926 KEVSNEIEKLRVEAEDQIAYSRNSIEKARSEELMNMFEDKEKINMTLAELPDLVEQCQNITLLYS 1990

  Fly  1627 QDLEKIDEETYSAEAPANNTAQQVEKLAKKVQKLQNNIMKNDRDAKEITKEAGSVK--LEAMRAR 1689
            |.:::.|||.      .....:..|||..:.||:.:..:....:.:...|.:.:.:  :||::..
 Worm  1991 QLIDEYDEEY------VQTAGRHAEKLEVQAQKIVDRFVDTRTETENPLKASHAYENIVEALKNA 2049

  Fly  1690 GEA-NNLQSATSATNQTLTDRASRSENARERAKQLLQRASKLTVDTNAKLKDLNDLQTVYLNKNQ 1753
            .|| ::...|:.|.::.|....|.|.:|.|.:.:     |:|     .|||:.:.|..|   .|.
 Worm  2050 TEAVDSAAEASEAVSKMLGSEGSESGDANEESLR-----SQL-----EKLKNESSLSNV---DNS 2101

  Fly  1754 QLLRLQAEIGPLNKELNEHLIHIKE 1778
            ..:::..|:....|:|.:.|.|:.|
 Worm  2102 NAVKIVEELKKEKKDLTDRLGHLNE 2126

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 54..286 CDD:459653 67/265 (25%)
EGF_Lam 287..343 CDD:238012 25/55 (45%)
Laminin_EGF 355..415 CDD:395007 23/66 (35%)
Laminin_EGF 418..475 CDD:395007 22/56 (39%)
EGF_Lam 477..526 CDD:238012 19/49 (39%)
EGF_Lam 529..567 CDD:214543 7/47 (15%)
EGF_Lam 789..834 CDD:214543 10/46 (22%)
Laminin_EGF 837..885 CDD:395007 7/47 (15%)
Laminin_EGF 883..930 CDD:395007 21/47 (45%)
Laminin_EGF 933..988 CDD:395007 21/63 (33%)
Laminin_EGF 991..1035 CDD:395007 23/43 (53%)
Laminin_EGF 1043..1091 CDD:395007 22/122 (18%)
Laminin_EGF 1094..1142 CDD:395007 22/94 (23%)
Laminin_EGF 1142..1190 CDD:395007 17/47 (36%)
Mplasa_alph_rch 1228..>1771 CDD:275316 137/778 (18%)
cc_DmLAMB1-like_C 1717..1786 CDD:411973 15/62 (24%)
lam-3NP_492775.2 LamNT 42..294 CDD:214532 69/273 (25%)
EGF_Lam 296..343 CDD:238012 27/56 (48%)
EGF_Lam <384..411 CDD:214543 13/26 (50%)
Laminin_EGF 423..480 CDD:395007 26/61 (43%)
EGF_Lam 477..526 CDD:238012 20/50 (40%)
LamB 583..711 CDD:214597 32/173 (18%)
EGF_Lam 774..818 CDD:238012 19/43 (44%)
Laminin_EGF 889..943 CDD:395007 25/53 (47%)
EGF_Lam 941..985 CDD:214543 4/43 (9%)
EGF_Lam 988..1033 CDD:214543 2/44 (5%)
EGF_Lam 1036..1083 CDD:214543 16/46 (35%)
EGF_Lam 1086..1131 CDD:214543 19/44 (43%)
EGF_Lam 1133..1179 CDD:238012 3/45 (7%)
Laminin_EGF 1181..1229 CDD:395007 18/48 (38%)
Laminin_EGF 1227..1281 CDD:395007 2/53 (4%)
LamB 1341..1478 CDD:214597 22/137 (16%)
EGF_Lam 1539..1583 CDD:238012 6/43 (14%)
Laminin_EGF 1590..1644 CDD:395007 14/69 (20%)
EGF_Lam 1646..1694 CDD:238012 7/47 (15%)
PRK03918 <1831..2226 CDD:235175 72/324 (22%)
LamG 2285..2443 CDD:214598
LamG 2471..2622 CDD:238058
LamG 2655..2821 CDD:238058
LamG 2919..3065 CDD:238058
Blue background indicates that the domain is not in the aligned region.

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