DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB1 and Lamb3

DIOPT Version :9

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_001264857.1 Gene:Lamb3 / 16780 MGIID:99915 Length:1168 Species:Mus musculus


Alignment Length:1795 Identity:389/1795 - (21%)
Similarity:590/1795 - (32%) Gaps:705/1795 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 CERSSCYPATGNLLIGRENRLTASSTCGLHSPERFCILSHLQDKKCFLCDTREETKHDPYKNHRI 113
            |.|.:|||..|:|||||...|.|||||||..||.:|........||..||:|....   |.:||:
Mouse    21 CSRGACYPPVGDLLIGRTQLLRASSTCGLTKPETYCTQYGQWQMKCCKCDSRLPRN---YNSHRV 82

  Fly   114 GQIIYKTKPGTNIPTWWQSENGKENATIQLDLEAEFHFTHLIITFTTFRPAAMYIERSFDFGQTW 178
            ..:...:.|    ..||||:|.....::||||:.......:::.|....||.|.||||.|||:||
Mouse    83 ENVASSSGP----MRWWQSQNDVSPVSLQLDLDKRMQLQDIMMDFKGLTPAGMLIERSSDFGKTW 143

  Fly   179 HIYRYFAYDCKESFP----GVPTVLENITDVMCTSRYSNVEPS---RNGEVIFRVLPPNINVTDP 236
            .:|:|.|.||..:||    |.|   :|..||.|  |..:..|:   ..|:|...::.....:...
Mouse   144 RVYQYLATDCASTFPQVHQGQP---KNWQDVRC--RPLSQRPNGHLTGGKVQLNLMDLASAIPAS 203

  Fly   237 YAEHVQNQLKMTNLRIQMTKLHKLGDNLLDSRLENEEKYYYGISNMVVRGSCSCYGHASQCLPLD 301
            .::.:|....:||||:..|||..     :..|.......|:.:|.:.::|||.|:|||.:|.|  
Mouse   204 QSKKIQELGDITNLRVNFTKLAP-----VPQRGSYPPSAYFAVSQLRLQGSCFCHGHADRCAP-- 261

  Fly   302 PAFSQADNEDG-----MVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHA 361
                   |..|     .|:..|.|.|||.|.||:.|..|:|:.||:||.|:.|:.|::|:||.|:
Mouse   262 -------NPGGSTTAVQVNNVCVCQHNTAGPNCDRCAPFYNNRPWRPAEGQDTHECQRCDCNGHS 319

  Fly   362 VSCHFDEAVFTASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSS 426
            .:||||.|||.||...:|||||||..:|.|::||.|..:::|:..........|.||:|||.|:.
Mouse   320 ETCHFDPAVFAASQGTNGGVCDNCRDHTEGKNCERCQLHYFRNRRPSAPIHETCIPCECDPDGAV 384

  Fly   427 DDGICDSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTLNNSGC 491
            ....||.|                                                         
Mouse   385 QGAPCDRL--------------------------------------------------------- 392

  Fly   492 VMRTGECKCKKYVTGKDCNQCMPETYGLSESPEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTG 556
               ||:|.||:||.|:.|:.|.|                                          
Mouse   393 ---TGQCVCKEYVQGERCDLCKP------------------------------------------ 412

  Fly   557 RSCSQPKQNYFIPLLPEVHEAEVVDECISYGANGNCSLVAETPDGSFTGIGFTRVPENSELVFTV 621
                                                         .|||:.|.            
Mouse   413 ---------------------------------------------GFTGLTFA------------ 420

  Fly   622 GDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGGCGELAAATSSETRIPFSLPDRSRQ 686
                                                                             
Mouse   421 ----------------------------------------------------------------- 420

  Fly   687 VVALNEVCLEAGKVYKFRIYFERKRHDVDSPTATILVDSLTLIPRIDVTPIFQGSVLADIRKKDY 751
                                                                             
Mouse   421 ----------------------------------------------------------------- 420

  Fly   752 EKYNCKSSLYDMNYKSDPKCQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGYCQCKPNVVG 816
                                                                             
Mouse   421 ----------------------------------------------------------------- 420

  Fly   817 RQCDQCAPGTYGFGPEGCKACDCNSIGSKDKYCDLITGQCQCVPNTYGRECNQCQPGYWNFPECR 881
                         .|:||.||||:.:|::                                    
Mouse   421 -------------NPKGCHACDCSILGAR------------------------------------ 436

  Fly   882 VCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGSEIGCRPCRCPETVASGLAHA 946
                                                                             
Mouse   437 ----------------------------------------------------------------- 436

  Fly   947 DGCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNPDNGGTCSKCECSNNVDLYDTGNCDRQTGA 1011
                                                                             
Mouse   437 ----------------------------------------------------------------- 436

  Fly  1012 CLKCLYQTTGDHCELCKDGFFGDALQQNCQQCECDFLGTNNTIAHCDRFTGQCPCLPNVQGVRCD 1076
                            ||                         ..|:..||:|.|||||.|.:||
Mouse   437 ----------------KD-------------------------MPCEEETGRCLCLPNVVGPKCD 460

  Fly  1077 QCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACN-----QCQAHYWGNPN 1136
            |||.:|||:|||.|||.|.|||..:|..|||.:||||.|:.||||..|:     ||....:|:..
Mouse   461 QCAPSHWKLASGLGCEPCACDPRNSLSSQCNQFTGQCPCREGFGGLTCSSAAIRQCPDQTYGHVA 525

  Fly  1137 EKCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGECFNNWDLILS 1201
            ..|:.|:||..|.....||:.:|.|:|..|..|.:|::|.||:..::|.|..|..||..:|..|.
Mouse   526 TGCRACDCDFRGTEGPGCDKASGRCLCRPGFTGPRCDQCQRGHCDRYPVCVACHSCFQAYDTDLQ 590

  Fly  1202 ALEDATTATILR-AKEIKQVGATG----AYTSEFSELDKKLQHIRNLLQNTSVSLVDIEKLDYET 1261
              |.|.....|| |.|....| ||    ...|...:...|::.||.:|:.|||:..|:.::....
Mouse   591 --EQARRLHSLRNATEGLWTG-TGLEDHGLASRLLDAKSKIEQIRQILEGTSVTEQDVAQVANGI 652

  Fly  1262 QSLRDQLQASHGRLSETEQNLDDIYNSLSLSGVELESL-QNHSRLVQQLSKELKENGIQLQESNI 1325
            .|:|..||.....| ..|:.::      |.|| :|.:| ::.|||: .:.:..||...:|...:.
Mouse   653 LSIRRTLQGLPLDL-PLEEEME------SFSG-DLGNLDRSFSRLL-LMYRSKKEQFEKLSSEDP 708

  Fly  1326 EGALNLTRHAYERVSNLSTLKDEANELASNTDRNCKRVENLSNKIQAEADDLANNNKLIEDYRAE 1390
            .||..:...|||:.|..:....:::.|.|....:.:..|.|    :.:|.........:...|.|
Mouse   709 SGAFRMLTMAYEQSSRAAQQVSDSSSLLSQLRDSRREAEGL----ERQAGGGGTGGAQLMALRLE 769

  Fly  1391 LTSLTSQIPELNNQVCGK-------PGDPCDSLC---GGAGCG-HCGGFLSCEHGAKTHSEEALK 1444
            :.||....|.: |::||:       |||....||   .|..|| ||.|.|....||   ...|.:
Mouse   770 MASLPDLTPTI-NKLCGRSRQTACTPGDCPGELCPQDNGTACGSHCRGALPRAKGA---FHMAGR 830

  Fly  1445 VAKDAETAITSKKDQADQTIRALTQAKLNASEAYEKAKRGFEQSERYLNQTNANIKLAEN----- 1504
            ||:.... ..::..|..|.|||          |.|.|.|....::|...|.:.:..|.|.     
Mouse   831 VAEQLRN-FNTQLQQTRQMIRA----------AEEAASRVQADAQRLETQVSTSRLLMEEDVQRT 884

  Fly  1505 --LFIALNNFQENKTASPSESKELAQKTLDLDLKLEPEEIETLGDQINRAVSSLKNVEAIIYRTK 1567
              |...:..|..:.....:..:::::..|.|.|..:...:.....:|....:.|.||::::.:||
Mouse   885 RLLIQQVRGFLTDPDTDAATIQQVSEAVLALWLPTDSATVLRKMKEIQAIAARLPNVDSVLSQTK 949

  Fly  1568 PDLDRVNNLQSIANATKEKADKILDSANSVVESLAAADESQGKAKDAIQQANSNIELAGQDLEKI 1632
            .|:.|...||:.|...:.:|..:....:.||.:|     .||..  |:|:|...::..|:.|..|
Mouse   950 QDIARARRLQAEAEQARSRAHAVEGQVDDVVGNL-----RQGTV--ALQEAQDTMQGTGRSLRLI 1007

  Fly  1633 DE---ETYSAEAPANNTAQQVEKLAKKVQKLQNNIMKNDRDAKEITKEAGSVKLEAMRAR----- 1689
            .|   |......||       |:|.|.:::..:.....   .||:.::|...:.:||:||     
Mouse  1008 QERVGEVQQVLVPA-------ERLVKGMKEQMSGFWAR---MKELRRQAQEEQAQAMQARQLAEG 1062

  Fly  1690 --GEANNLQSATSATNQTLT---DRASRSENARERAKQLL---QRASKLTVDTNAKLKDLNDLQT 1746
              .:|.|.|.......|..|   ||..:|....|:..::|   ..|.:|..:|...:..:.|:::
Mouse  1063 ASQQAMNAQEGFKRLKQKYTELKDRLGQSPVLGEQGNRILSIKMEAEELFGETMEMMDKMKDMES 1127

  Fly  1747 VYLNKNQQLLRLQAEIGPLNKELNEHLIHIKERGSHYRQC 1786
            ..|..:|.::...|::..|.|.:.:...:|..|..:|..|
Mouse  1128 ELLRGSQAIMLRSADLSGLEKRVEQIRSYINGRVLYYATC 1167

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 63..286 CDD:278484 73/229 (32%)
EGF_Lam 287..343 CDD:238012 24/60 (40%)
Laminin_EGF 355..415 CDD:278482 26/59 (44%)
Laminin_EGF 418..475 CDD:278482 8/56 (14%)
EGF_Lam 477..526 CDD:238012 11/48 (23%)
EGF_Lam 529..567 CDD:214543 0/37 (0%)
EGF_Lam 789..834 CDD:214543 1/44 (2%)
Laminin_EGF 837..885 CDD:278482 4/47 (9%)
Laminin_EGF 883..930 CDD:278482 0/46 (0%)
Laminin_EGF 933..988 CDD:278482 0/54 (0%)
Laminin_EGF 991..1043 CDD:278482 2/51 (4%)
Laminin_EGF 1043..1091 CDD:278482 21/47 (45%)
Laminin_EGF 1094..1142 CDD:278482 22/52 (42%)
Laminin_EGF 1142..1190 CDD:278482 17/47 (36%)
COG6 1212..>1398 CDD:303003 48/191 (25%)
TelA 1439..1782 CDD:226371 79/365 (22%)
ApoLp-III_like 1545..1702 CDD:304399 40/166 (24%)
Lamb3NP_001264857.1 Laminin_N 20..248 CDD:383136 81/243 (33%)
EGF_Lam 249..301 CDD:238012 24/60 (40%)
EGF_Lam 312..362 CDD:238012 25/49 (51%)
Laminin_EGF 376..425 CDD:365839 24/415 (6%)
EGF_Lam 427..476 CDD:238012 29/255 (11%)
EGF_Lam 478..528 CDD:214543 21/49 (43%)
EGF_Lam 530..579 CDD:238012 17/48 (35%)
Domain II 576..781 56/221 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 723..760 6/40 (15%)
Domain alpha 782..812 9/29 (31%)
Domain I 813..1168 87/386 (23%)
SMC_prok_B <830..1161 CDD:274008 77/358 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0994
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10574
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.910

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