DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB1 and Lama2

DIOPT Version :10

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_032507.2 Gene:Lama2 / 16773 MGIID:99912 Length:3118 Species:Mus musculus


Alignment Length:2343 Identity:550/2343 - (23%)
Similarity:858/2343 - (36%) Gaps:796/2343 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 IVLALLSWQWDPVDSQRPPQHGRRDRPKYPPNKFIKTHPCERSSCYPATGNLLIGRENRL-TASS 73
            |:|.||....:...:||......:.|                 ..:||..||   ..|.| |.::
Mouse     8 ILLLLLLGTLEGSQTQRRQSQAHQQR-----------------GLFPAVLNL---ASNALITTNA 52

  Fly    74 TCGLHSPERFC-ILSH-----LQDKKCFLCDTREETKHDPYKNHRIGQIIYKTKPGTNIPTWWQS 132
            |||...||.:| ::.|     :::.:|.:|:   :...:||:.|.|...|    .|.|  |||||
Mouse    53 TCGEKGPEMYCKLVEHVPGQPVRNPQCRICN---QNSSNPYQRHPITNAI----DGKN--TWWQS 108

  Fly   133 ---ENGKE--NATIQLDLEAEFHFTHLII-TFTTFRPAAMYIERSFDFGQ--TWHIYRYFAYDCK 189
               :||.|  ..||.|||:..|...::|: ...:.||....:|||.|..:  .|..:.....:|.
Mouse   109 PSIKNGVEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDTECL 173

  Fly   190 ESF-----PGVPTVLENITDVMCTSRYSNVEPSRNGEVIFRVLPPNINVTDPYAEHVQNQLKMTN 249
            ..:     .|.|:..:: .:|:|||.||.:.|..|||:...::....:..||..|    .|:.|:
Mouse   174 TLYNIYPRTGPPSYAKD-DEVICTSFYSKIHPLENGEIHISLINGRPSADDPSPE----LLEFTS 233

  Fly   250 ---LRIQMTKLHKLGDNLL-----DSRLEN---EEKYYYGISNMVVRGSCSCYGHASQCLPLDPA 303
               :|::..::..|..:|:     |.|..:   ..:|||.:.::.|.|.|.|||||..| |||||
Mouse   234 ARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARAC-PLDPA 297

  Fly   304 FSQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAVSCHFDE 368
            .:::         ||||.|||.|.:|:.|...|:..||:.......:.|:.|.|:..|..|::||
Mouse   298 TNKS---------RCECEHNTCGESCDRCCPGFHQKPWRAGTFLTKSECEACNCHGKAEECYYDE 353

  Fly   369 AVFTAS-------GFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSS 426
            .|.:.:       .::.||||.||.|||.|.:||.|:..|:|.........|.||||.|||.||.
Mouse   354 TVASRNLSLNIHGKYIGGGVCINCTHNTAGINCETCVDGFFRPKGVSPNYPRPCQPCHCDPTGSL 418

  Fly   427 DDGICDSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTLNNSGC 491
            .:.........:.|...|:||||....|..|::|..||...    |: |:||.|:.||:.|...|
Mouse   419 SEVCVKDEKYAQRGLKPGSCHCKTGFGGVNCDRCVRGYHGY----PD-CQPCNCSGLGSTNEDPC 478

  Fly   492 VMRTGECKCKKYVTGKDCNQCMPETYGLSE-SPEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMT 555
            |   |.|.||:.|.|:||::|....:.|.| :.:||..|          :|..:|.:|:......
Mouse   479 V---GPCSCKENVEGEDCSRCKSGFFNLQEDNQKGCEEC----------FCSGVSNRCQSSYWTY 530

  Fly   556 GRSCSQPKQNYF-------IPLLPEVHEAEVVDECISYGANGNCSLVAETPDGSFTG-----IGF 608
            |.  .|..:.::       |.:.|::...:...:.....:....||:    ||.:..     :| 
Mouse   531 GN--IQDMRGWYLTDLSGRIRMAPQLDNPDSPQQISISNSEARKSLL----DGYYWSAPPPYLG- 588

  Fly   609 TRVPE-NSELVFTVGDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGGCGELAAATSS 672
            .|:|. ..:|.||:.       ||                    :..::.|.|.....:.....:
Mouse   589 NRLPAVGGQLSFTIS-------YD--------------------LEEEEDDTEKILQLMIIFEGN 626

  Fly   673 ETRIPFSLPDRSRQVVALNEVCLEAGKVYKFRIYFERKRHDVDSPTATILVDSLTLIPRIDVTPI 737
            :.||                     ...|| .:|.|.....::.  .::..::.|:         
Mouse   627 DLRI---------------------STAYK-EVYLEPSEEHIEE--VSLKEEAFTI--------- 658

  Fly   738 FQGSVLADIRKKDY--EKYNCKSSLYDMNYKSDPKCQNLDNILSVFVHDGASMCNCNPTGSLSKV 800
             .|:.| .:.:||:  ...|.:..|..:.|       || .:.::|.....::.:..|..:..::
Mouse   659 -HGTNL-PVTRKDFMIVLTNLERVLMQITY-------NL-GMDAIFRLSSVNLESAVPYPTDRRI 713

  Fly   801 CESNGGYCQCKPNVVGRQCDQCAP------GTYGFGPEGCKACDCNSIGSKDKYCDLITGQCQCV 859
            . ::...|||.|...|..|:.|.|      ||. ||                             
Mouse   714 A-TDVEVCQCPPGYSGSSCETCWPRHRRVNGTI-FG----------------------------- 747

  Fly   860 PNTYGRECNQCQPGYWNFPECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLF 924
                    ..|:|          |||..||..||.|.|.|::|:|.|.|..|:.||.|:||:|..
Mouse   748 --------GICEP----------CQCFAHAEACDDITGECLNCKDHTGGPYCNECLPGFYGDPTR 794

  Fly   925 GSEIGCRPCRCPETVASGLAHADGCSLDTRNNNMLC-HCQEGYSGSRCEICADNFFGNPD-NGGT 987
            ||...|:||.||..:.|. ..:..|.|| |:..::| .|..||:|.|||.||:.:||.|. .||:
Mouse   795 GSPEDCQPCACPLNIPSN-NFSPTCHLD-RSLGLICDECPIGYTGPRCERCAEGYFGQPSIPGGS 857

  Fly   988 CSKCECSNNVDLYDTGNCDRQTGACLKCLYQTTGDHCELCKDGFFGDALQ-QNCQQCECDFLGTN 1051
            |..|:|::|:|....|:||..:|:||.|...|||.:||||.||:||||:. :|||.|.|:..|:.
Mouse   858 CQPCQCNDNLDYSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVNAKNCQPCRCNINGSF 922

  Fly  1052 NTIAHCDRFTGQCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCK 1116
            :.|.|..  ||||.|.|||||..||:|....:.:..|.||..|||:..|:....|.: :|||.|:
Mouse   923 SEICHTR--TGQCECRPNVQGRHCDECKPETFGLQLGRGCLPCNCNSFGSKSFDCEA-SGQCWCQ 984

  Fly  1117 PGFGGRACNQCQAHYW---------------GN------------PN---EK------------- 1138
            ||..|:.|::|...|:               ||            ||   ||             
Mouse   985 PGVAGKKCDRCAHGYFNFQEGGCIACDCSHLGNNCDPKTGQCICPPNTTGEKCSECLPNTWGHSI 1049

  Fly  1139 ---CQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPC----------- 1189
               |:.|.|...|:...||:..||.|.||....|.||:||:||: ..:|.|:.|           
Mouse  1050 VTGCKVCNCSTVGSLASQCNVNTGQCSCHPKFSGMKCSECSRGH-WNYPLCTLCDCFLPGTDATT 1113

  Fly  1190 --------------GEC-----------------------------------------------F 1193
                          |:|                                               .
Mouse  1114 CDLETRKCSCSDQTGQCSCKVNVEGVHCDRCRPGKFGLDAKNPLGCSSCYCFGVTSQCSEAKGLI 1178

  Fly  1194 NNW----------DLILSALEDATTATI------------------------------LRAKEIK 1218
            ..|          .|:..||:..||..|                              ...|::.
Mouse  1179 RTWVTLSDEQTILPLVDEALQHTTTKGIAFQKPEIVAKMDEVRQELHLEPFYWKLPQQFEGKKLM 1243

  Fly  1219 QVGATGAYTSEFSELDK------KLQ---------HIRNLLQNTSVSLV------DIEKLDYETQ 1262
            ..|....|...|...|:      |.|         |.|.:.::.:..|:      :||..:.|.:
Mouse  1244 AYGGKLKYAIYFEARDETGFATYKPQVIIRGGTPTHARIITRHMAAPLIGQLTRHEIEMTEKEWK 1308

  Fly  1263 SLRDQLQASHGRLSET---EQNLDDIYN-SLSLSGVELESLQNHSRLVQQLSKELKENGIQLQES 1323
            ...|.     .|:|.|   |..||.:|: ...|......::...|| :.::|.|:.|.|..|..|
Mouse  1309 YYGDD-----PRISRTVTREDFLDILYDIHYILIKATYGNVVRQSR-ISEISMEVAEPGHVLAGS 1367

  Fly  1324 NIEGALNLTRHAYER------VSNLS---------TLKDE-----------------ANELASNT 1356
            .       ..|..||      .|.||         .|:.|                 .|..:|..
Mouse  1368 P-------PAHLIERCDCPPGYSGLSCETCAPGFYRLRSEPGGRTPGPTLGTCVPCQCNGHSSQC 1425

  Fly  1357 D------RNCKR-----------------VENLSNKIQAEADDL--ANNN-------KLIEDYRA 1389
            |      :||:.                 |..|.|..|..|..|  .:||       :.:||||.
Mouse  1426 DPETSVCQNCQHHTAGDFCERCALGYYGIVRGLPNDCQPCACPLISPSNNFSPSCVLEGLEDYRC 1490

  Fly  1390 ELTSLTSQIPELNNQVC--------GKPGD------------------PCDSLCG------GA-- 1420
                 |:.......|.|        |.|..                  |||.:.|      ||  
Mouse  1491 -----TACPRGYEGQYCERCAPGYTGSPSSPGGSCQECECDPYGSLPVPCDRVTGLCTCRPGATG 1550

  Fly  1421 ----GCGH---------------CGGFLSCE------------------------HGAKTHSEE- 1441
                ||.|               |.|.|..:                        :|.:..::| 
Mouse  1551 RKCDGCEHWHAREGAECVFCGDECTGLLLGDLARLEQMTMNINLTGPLPAPYKILYGLENTTQEL 1615

  Fly  1442 ----------------------------------ALKVAKDAETA------ITSKKDQADQTIRA 1466
                                              |.||..|.|..      ..|:.:..::.|:.
Mouse  1616 KHLLSPQRAPERLIQLAEGNVNTLVMETNELLTRATKVTADGEQTGQDAERTNSRAESLEEFIKG 1680

  Fly  1467 LTQAKLNASEAYEK--------------AKRGFEQSERYLN-----------QTNANIK-----L 1501
            |.|   :|....||              |:|..|:.::.::           ||...:.     .
Mouse  1681 LVQ---DAEAINEKAVQLNETLGNQDKTAERNLEELQKEIDRMLKELRSKDLQTQKEVAEDELVA 1742

  Fly  1502 AENLFIALNN-FQENKTASPSESKELAQKTLDLDLKLEP------EEIETLGDQINRAVSSLKNV 1559
            ||.|...:|. |.|.:..:....|:|.||..:...||:.      |..:...|....:.::.||:
Mouse  1743 AEGLLKRVNKLFGEPRAQNEDMEKDLQQKLAEYKNKLDDAWDLLREATDKTRDANRLSAANQKNM 1807

  Fly  1560 EAIIYRTKPDLDRVNNLQSIANATKE------KADKILDSANSVVESLAAADESQGKAKDAIQQA 1618
              .|..||.:....:..| |.|..||      :|:::|...|||::.:   |:.:.|.....::.
Mouse  1808 --TILETKKEAIEGSKRQ-IENTLKEGNDILDEANRLLGEINSVIDYV---DDIKTKLPPMSEEL 1866

  Fly  1619 NSNIELAGQDLE--KIDEETYSAEAPA----------------------NNTA------------ 1647
            :..|:...|:::  ::.|:.:.||:.|                      |.||            
Mouse  1867 SDKIDDLAQEIKDRRLAEKVFQAESHAAQLNDSSAVLDGILDEAKNISFNATAAFRAYSNIKDYI 1931

  Fly  1648 QQVEKLAKKVQKL-------------------QNNIMKNDRDAKEITKEAGSVK-----LEAMRA 1688
            .:.||:|::.::|                   :.::.|:.|...|..|.|..||     |..::.
Mouse  1932 DEAEKVAREAKELAQGATKLATSPQGLLKEDAKGSLQKSFRILNEAKKLANDVKGNHNDLNDLKT 1996

  Fly  1689 RGEANNLQSA--TSATNQTL-------TDRASRSENARERAKQ---------------------L 1723
            |.|..:|:::  ..|.|.|:       .|.|::.:..:|:|::                     |
Mouse  1997 RLETADLRNSGLLGALNDTMDKLSAITNDTAAKLQAVKEKAREANDTAKAVLAQVKDLHQNLDGL 2061

  Fly  1724 LQRASKL---TVDTNAKLKD------LNDLQTVYLNKNQQLLRLQAEIGPLNKELNEHL----IH 1775
            .|..:||   ...|||.:||      :.|..|...|..|:..||..::.|: |||.::|    ..
Mouse  2062 KQNYNKLADSVAKTNAVVKDPSKNKIIADAGTSVRNLEQEADRLIDKLKPI-KELEDNLKKNISE 2125

  Fly  1776 IKE 1778
            |||
Mouse  2126 IKE 2128

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 54..286 CDD:459653 72/262 (27%)
EGF_Lam 287..343 CDD:238012 25/55 (45%)
Laminin_EGF 355..415 CDD:395007 23/66 (35%)
Laminin_EGF 418..475 CDD:395007 18/56 (32%)
EGF_Lam 477..526 CDD:238012 19/49 (39%)
EGF_Lam 529..567 CDD:214543 6/37 (16%)
EGF_Lam 789..834 CDD:214543 13/50 (26%)
Laminin_EGF 837..885 CDD:395007 3/47 (6%)
Laminin_EGF 883..930 CDD:395007 23/46 (50%)
Laminin_EGF 933..988 CDD:395007 23/56 (41%)
Laminin_EGF 991..1035 CDD:395007 22/43 (51%)
Laminin_EGF 1043..1091 CDD:395007 19/47 (40%)
Laminin_EGF 1094..1142 CDD:395007 22/93 (24%)
Laminin_EGF 1142..1190 CDD:395007 20/72 (28%)
Mplasa_alph_rch 1228..>1771 CDD:275316 169/891 (19%)
cc_DmLAMB1-like_C 1717..1786 CDD:411973 25/96 (26%)
Lama2NP_032507.2 LamNT 29..281 CDD:214532 73/285 (26%)
EGF_Lam 283..330 CDD:238012 25/56 (45%)
Laminin_EGF 410..467 CDD:395007 21/61 (34%)
Laminin_EGF 465..511 CDD:395007 18/48 (38%)
Laminin_B 579..718 CDD:459652 28/210 (13%)
EGF_Lam 752..801 CDD:238012 24/58 (41%)
EGF_Lam 802..859 CDD:238012 24/58 (41%)
EGF_Lam 860..912 CDD:238012 25/51 (49%)
EGF_Lam 913..960 CDD:238012 19/48 (40%)
EGF_Lam 963..1007 CDD:214543 15/44 (34%)
EGF_Lam 1009..1054 CDD:238012 6/44 (14%)
Laminin_EGF 1056..1104 CDD:395007 20/48 (42%)
Laminin_EGF 1102..1159 CDD:395007 3/56 (5%)
LamB 1225..1360 CDD:214597 26/140 (19%)
EGF_Lam <1375..1403 CDD:238012 6/27 (22%)
Laminin_EGF 1416..1462 CDD:395007 8/45 (18%)
Laminin_EGF 1465..1520 CDD:395007 13/59 (22%)
EGF_Lam 1523..1566 CDD:214543 9/42 (21%)
Domain II and I 1570..2140 107/569 (19%)
Laminin_I 1589..1848 CDD:310534 46/264 (17%)
COG4372 1694..2054 CDD:443500 67/365 (18%)
Laminin_II 2033..2168 CDD:368703 25/97 (26%)
Laminin_G_1 2170..2310 CDD:395008
Laminin_G_1 2364..2503 CDD:395008
LamG 2524..2686 CDD:238058
Laminin_G_1 2789..2917 CDD:395008
LamG 2937..3089 CDD:238058
Blue background indicates that the domain is not in the aligned region.

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