DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LanB1 and Lama1

DIOPT Version :9

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_032506.2 Gene:Lama1 / 16772 MGIID:99892 Length:3083 Species:Mus musculus


Alignment Length:2224 Identity:543/2224 - (24%)
Similarity:846/2224 - (38%) Gaps:668/2224 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 IVLALLSWQWDPVDSQRPPQHGRRDRPKYPPNKFIKTHPCERSSCYPATGNLLIGRENRLTASST 74
            :::.|.|..|..|.||   |.|                      .:||..||  .....::|::|
Mouse    10 LLVLLASVLWVTVRSQ---QRG----------------------LFPAILNL--ATNAHISANAT 47

  Fly    75 CGLHSPERFC-ILSHLQDK-----KCFLCDTREETKHDPYKNHRIGQIIYKTKPGTNIPTWWQS- 132
            ||...||.|| ::.|:..:     :|.:||....   :|.:.|.|...|    .|||  .|||| 
Mouse    48 CGEKGPEMFCKLVEHVPGRPVRHAQCRVCDGNST---NPRERHPISHAI----DGTN--NWWQSP 103

  Fly   133 --ENGKEN--ATIQLDLEAEFHFTHLIITFTTF-RPAAMYIERSFDFGQTWHIYRYFAY---DCK 189
              :||:|.  .|:.|||...|...::||..... ||....:|||.| |..:..::|:|.   :|.
Mouse   104 SIQNGREYHWVTVTLDLRQVFQVAYIIIKAANAPRPGNWILERSVD-GVKFKPWQYYAVSDTECL 167

  Fly   190 ESFP-----GVPTVLENITDVMCTSRYSNVEPSRNGEVIFRVLPPNINVTDPYAEHVQ-NQLKMT 248
            ..:.     |.||...: .:|:|||.||.:.|..:||:...::....:..||..:.:: ...:..
Mouse   168 TRYKITPRRGPPTYRAD-NEVICTSYYSKLVPLEHGEIHTSLINGRPSADDPSPQLLEFTSARYI 231

  Fly   249 NLRIQ---------MTKLHKLGDNLLDSRLENEEKYYYGISNMVVRGSCSCYGHASQCLPLDPAF 304
            .||:|         ||..|:   :|.|.......:|||.|.::.|.|.|.||||||.| |.|...
Mouse   232 RLRLQRIRTLNADLMTLSHR---DLRDLDPIVTRRYYYSIKDISVGGMCICYGHASSC-PWDEEA 292

  Fly   305 SQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAVSCHFDEA 369
            .|.         :|:|.|||.|.:|:.|...::..||:|......|.|::|.|::.|..|::|.:
Mouse   293 KQL---------QCQCEHNTCGESCDRCCPGYHQQPWRPGTISSGNECEECNCHNKAKDCYYDSS 348

  Fly   370 VF-------TASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSSD 427
            |.       ||..:..||||.||..||.|.:||.|:..:||..:.....:..|:||:|||.||. 
Mouse   349 VAKERRSLNTAGQYSGGGVCVNCSQNTTGINCETCIDQYYRPHKVSPYDDHPCRPCNCDPVGSL- 412

  Fly   428 DGIC---DSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTLNNS 489
            ..:|   |...:|..|...|.|.|:....|.:|::|:.||....:     |.||.|..:|:||..
Mouse   413 SSVCIKDDRHADLANGKWPGQCPCRKGYAGDKCDRCQFGYRGFPN-----CIPCDCRTVGSLNED 472

  Fly   490 GCVMRTGECKCKKYVTGKDCNQCMPETYGLSE-SPEGCSLCNCDAGGSYDNYCDVISGQCRCRPH 553
            .|:   ..|.|||.|.||:|::|.|..|.|.| :|||||.|.|   ......||.::.......:
Mouse   473 PCI---EPCLCKKNVEGKNCDRCKPGFYNLKERNPEGCSECFC---FGVSGVCDSLTWSISQVTN 531

  Fly   554 MTGRSCSQPKQNYFIPLLPEVHEAEVVDECISYGANGNCSLVAETPDGSFTGIGFTRVPE---NS 615
            |:|         :.:..|...::.....:.:  |.:...|:.........|...:...||   .:
Mouse   532 MSG---------WLVTDLMSTNKIRSQQDVL--GGHRQISINNTAVMQRLTSTYYWAAPEAYLGN 585

  Fly   616 ELVFTVGDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGGCGELAAATSSE--TRIPF 678
            :|....|.:..::.||..:   .|...|..:....:::        |.| |..:|.:|  :..|:
Mouse   586 KLTAFGGFLKYTVSYDIPV---ETVDSDLMSHADIIIK--------GNG-LTISTRAEGLSLQPY 638

  Fly   679 SLPDRSRQVVALNEVCLEAGKVYKFRIYFERKRHDVDSPTATILVDSLTLIPRIDVTPIFQGSVL 743
            .......::|..|           ||.:..|:..|.|. ..|:|.:...|:.|.:          
Mouse   639 EEYFNVVRLVPEN-----------FRDFDTRREIDRDQ-LMTVLANVTHLLIRAN---------- 681

  Fly   744 ADIRKKDYEKYN-CKSSLYDMNYKSDPKCQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGY 807
                      || .|.:||.:                    |..|:...:| .::.....::..:
Mouse   682 ----------YNSAKMALYRL--------------------DSVSLDIASP-NAIDLAVAADVEH 715

  Fly   808 CQCKPNVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSKDKYCDLITGQCQCVPNTYGRECNQCQP 872
            |:|.....|..|:.|.||.|                   :...::.|             ..|||
Mouse   716 CECPQGYTGTSCEACLPGYY-------------------RVDGILFG-------------GICQP 748

  Fly   873 GYWNFPECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGSEIGCRPCRCPE 937
                      |:|:|||:.|| |.|.|..|..:|||..|:.||.|:||.|..|:...|:||.|| 
Mouse   749 ----------CECHGHASECD-IHGICSVCTHNTTGDHCEQCLPGFYGTPSRGTPGDCQPCACP- 801

  Fly   938 TVASGLAHADGCSLDTRNNNMLCH-----------CQEGYSGSRCEICADNFFGNPD-NGGTCSK 990
                       .|:|:.|.:..||           |..|||||.||.|||.::|||. .||||..
Mouse   802 -----------LSIDSNNFSPTCHLTDGEEVVCDQCAPGYSGSWCERCADGYYGNPTVPGGTCVP 855

  Fly   991 CECSNNVDLYDTGNCDRQTGACLKCLYQTTGDHCELCKDGFFGDAL-QQNCQQCECDFLGTNNTI 1054
            |.||.|||..:.|:||..||.|||||:.|.|.|||.|.|||:|||: .:||:.|:|...|:.:.|
Mouse   856 CNCSGNVDPLEAGHCDSVTGECLKCLWNTDGAHCERCADGFYGDAVTAKNCRACDCHENGSLSGI 920

  Fly  1055 AHCDRFTGQCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGF 1119
            .|.:  ||.|.|.|:|.|.:||||...::.:.:|.||..|||...|::.:.|.. .|||.|.||.
Mouse   921 CHLE--TGLCDCKPHVTGQQCDQCLSGYYGLDTGLGCVPCNCSVEGSVSDNCTE-EGQCHCGPGV 982

  Fly  1120 GGRACNQCQ----------------AH-----------------------------YWG-NPNEK 1138
            .|:.|::|.                ||                             ||| :|.:.
Mouse   983 SGKQCDRCSHGFYAFQDGGCTPCDCAHTQNNCDPASGECLCPPHTQGLKCEECEEAYWGLDPEQG 1047

  Fly  1139 CQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGECF------NNWD 1197
            ||.|.|...|:...|||..:|:|.|.:|.||..|::|:.|| ..||.|.||| |.      :..|
Mouse  1048 CQACNCSAVGSTSAQCDVLSGHCPCKKGFGGQSCHQCSLGY-RSFPDCVPCG-CDLRGTLPDTCD 1110

  Fly  1198 L---ILSALEDATTAT------------------ILRAKEIKQVGATGAYTSEFSELDKKLQ-HI 1240
            |   :.|..||..|.:                  .||....:  |.:..:....|:|..:|: ::
Mouse  1111 LEQGLCSCSEDGGTCSCKENAVGPQCSKCQAGTFALRGDNPQ--GCSPCFCFGLSQLCSELEGYV 1173

  Fly  1241 RNLLQNTS-------VS------------------LVDIE-------------KLDYETQSLRDQ 1267
            |.|:...|       ||                  |:|.|             :|..:.|.  ||
Mouse  1174 RTLITLASDQPLLHVVSQSNLKGTIEGVHFQPPDTLLDAEAVRQHIYAEPFYWRLPKQFQG--DQ 1236

  Fly  1268 LQASHGRLSETEQNLDDIYNSL--SLSGVELESLQNHSRL---VQQLSKELKENGIQLQESNIEG 1327
            |.|..|:|    |.....|::|  ..|..|.:.|....|.   |..:.....|||:: |:..:..
Mouse  1237 LLAYGGKL----QYSVAFYSTLGTGTSNYEPQVLIKGGRARKHVIYMDAPAPENGVR-QDYEVRM 1296

  Fly  1328 ALNLTRHAYERVSNLSTLKDEANELASNTD-----------RNCKRVENLSNKIQAEADDLANNN 1381
            .....:: :..||.......:...:.||.|           ....|:.|:|.::..:|.:|....
Mouse  1297 KEEFWKY-FNSVSEKHVTHSDFMSVLSNIDYILIKASYGQGLQQSRIANISMEVGRKAVELPAEG 1360

  Fly  1382 K---LIE-------------------DYRAELTS---------LTSQIP-ELNN----------- 1403
            :   |:|                   .||.:|..         |...:| ..||           
Mouse  1361 EAALLLELCVCPPGTAGHSCQDCAPGYYREKLPESGGRGPRPLLAPCVPCNCNNHSDVCDPETGK 1425

  Fly  1404 ----------------------QVCGKPGD--PC--------------------DSLC------- 1417
                                  :|.|.|||  ||                    |..|       
Mouse  1426 CLSCRDHTSGDHCELCASGYYGKVTGLPGDCTPCTCPHHPPFSFSPTCVVEGDSDFRCNACLPGY 1490

  Fly  1418 -------------------GG--------------AGCGHCGGFLSCEHGAK-THSEEAL----- 1443
                               ||              :.|....|...|:.||. .|.|:.|     
Mouse  1491 EGQYCERCSAGYHGNPRAAGGSCQTCDCNPQGSVHSDCDRASGQCVCKPGATGLHCEKCLPRHIL 1555

  Fly  1444 ------KVAKDAETAITSKKDQADQTIRAL-----TQAKLNASEAYEKAKRGFEQSERYLNQTN- 1496
                  ....|....:.:..|.....:.:|     :.|.....|..|...:.|   :|||.:.| 
Mouse  1556 MESDCVSCDDDCVGPLLNDLDSVGDAVLSLNLTGVSPAPYGILENLENTTKYF---QRYLIKENA 1617

  Fly  1497 ----ANIKL------AENLFIALN---------NFQENKTASPSESKELAQKTLDLDLKLEPEEI 1542
                |.|:|      .|||...|.         |.:..:|::.:::.....:.|..::|...|::
Mouse  1618 KKIRAEIQLEGIAEQTENLQKELTRVLARHQKVNAEMERTSNGTQALATFIEQLHANIKEITEKV 1682

  Fly  1543 ETLGDQINR----AVSSL----KNVEAII----------------YRTKPDLDRVNNLQSIANAT 1583
            .||.....:    .||:|    :|:.:::                ...|...|.::.:|......
Mouse  1683 ATLNQTARKDFQPPVSALQSMHQNISSLLGLIKERNFTEMQQNATLELKAAKDLLSRIQKRFQKP 1747

  Fly  1584 KEKADKILDSANSVV----ESLAAADESQGKAKDAIQQANSNIELAGQDLEKIDEETYSAEAPAN 1644
            :||. |.|..|||::    |.|.||:|...:|....|::|..:.|...:|::..|:....:...|
Mouse  1748 QEKL-KALKEANSLLSNHSEKLQAAEELLKEAGSKTQESNLLLLLVKANLKEFQEKKLRVQEEQN 1811

  Fly  1645 NTAQQVEK-------------------------------LAKKV-------------QKLQNNIM 1665
            .|::.:.|                               .|:|:             ::.::.:.
Mouse  1812 VTSELIAKGREWVDAAGTHTAAAQDTLTQLEHHRDELLLWARKIRSHVDDLVMQMSKRRARDLVH 1876

  Fly  1666 KNDRDAKEITKEAGSVKLEAMRARGEANNLQSATSATN-----QTLTDRASR------------- 1712
            :.::.|.|:...||::..:....|..:.|   ||||.:     ||||:.|..             
Mouse  1877 RAEQHASELQSRAGALDRDLENVRNVSLN---ATSAAHVHSNIQTLTEEAEMLAADAHKTANKTD 1938

  Fly  1713 --SENARERAKQLLQRAS---KLTVDTNAKLKDLNDLQTVYLNKNQQLL-RLQAEIGPLNKELNE 1771
              ||:...|.|.:|||:|   |.:|.|..|.:.:    |:.|::.:.|. :.|..:..:.|:.|:
Mouse  1939 LISESLASRGKAVLQRSSRFLKESVSTRRKQQGI----TMKLDELKNLTSQFQESMDNIMKQAND 1999

  Fly  1772 HLIHIKERGSHYRQ 1785
            .|..::|.....|:
Mouse  2000 SLAMLRESPGGMRE 2013

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 63..286 CDD:278484 70/252 (28%)
EGF_Lam 287..343 CDD:238012 21/55 (38%)
Laminin_EGF 355..415 CDD:278482 22/66 (33%)
Laminin_EGF 418..475 CDD:278482 18/59 (31%)
EGF_Lam 477..526 CDD:238012 22/49 (45%)
EGF_Lam 529..567 CDD:214543 6/37 (16%)
EGF_Lam 789..834 CDD:214543 9/44 (20%)
Laminin_EGF 837..885 CDD:278482 5/47 (11%)
Laminin_EGF 883..930 CDD:278482 22/46 (48%)
Laminin_EGF 933..988 CDD:278482 24/66 (36%)
Laminin_EGF 991..1043 CDD:278482 30/52 (58%)
Laminin_EGF 1043..1091 CDD:278482 17/47 (36%)
Laminin_EGF 1094..1142 CDD:278482 22/93 (24%)
Laminin_EGF 1142..1190 CDD:278482 20/47 (43%)
COG6 1212..>1398 CDD:303003 50/271 (18%)
TelA 1439..1782 CDD:226371 92/474 (19%)
ApoLp-III_like 1545..1702 CDD:304399 40/228 (18%)
Lama1NP_032506.2 LamNT 25..275 CDD:214532 77/290 (27%)
EGF_Lam 277..324 CDD:238012 22/56 (39%)
Laminin_EGF 404..463 CDD:278482 21/64 (33%)
Laminin_EGF 461..507 CDD:278482 21/48 (44%)
Laminin_B 575..714 CDD:306547 33/203 (16%)
EGF_Lam 748..796 CDD:238012 23/58 (40%)
Laminin_EGF 798..853 CDD:278482 24/66 (36%)
EGF_Lam 855..907 CDD:238012 29/51 (57%)
Laminin_EGF 909..955 CDD:278482 17/47 (36%)
EGF_Lam 958..1002 CDD:214543 14/44 (32%)
EGF_Lam 1004..1049 CDD:238012 6/44 (14%)
Laminin_EGF 1051..1099 CDD:278482 22/49 (45%)
Laminin_EGF 1097..1154 CDD:278482 11/59 (19%)
Cell attachment site 1147..1149 1/1 (100%)
Laminin_B 1225..1367 CDD:306547 31/149 (21%)
Laminin_EGF 1410..1456 CDD:278482 6/45 (13%)
Laminin_EGF 1459..1513 CDD:278482 5/53 (9%)
EGF_Lam 1516..>1553 CDD:238012 8/36 (22%)
Domain II and I 1564..2123 91/461 (20%)
Laminin_I 1582..1837 CDD:310534 51/258 (20%)
DUF390 <1827..>2064 CDD:330463 38/194 (20%)
Laminin_II 2018..2152 CDD:283628
LamG 2136..2285 CDD:238058
LamG 2314..2470 CDD:238058
LamG 2495..2659 CDD:238058
Laminin_G_1 2751..2880 CDD:278483
LamG 2900..3053 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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