DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanB1 and lamb1

DIOPT Version :9

Sequence 1:	NP_476618.1	Gene:	LanB1 / 34068	FlyBaseID:	FBgn0261800	Length:	1788	Species:	Drosophila melanogaster
Sequence 2:	XP_002933140.2	Gene:	lamb1 / 100495516	XenbaseID:	XB-GENE-1011014	Length:	1782	Species:	Xenopus tropicalis

Alignment Length:	1830	Identity:	756/1830 - (41%)
Similarity:	1073/1830 - (58%)	Gaps:	161/1830 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 THPCERSSCYPATGNLLIGRENRLTASSTCGLHSPERFCILSHLQ-DKKCFLCDTREETKHDPY- 108
            :|.|...|||||||:|||||.::||||||||:..||.|||:|||| :||||:||:.     |||
Frog    26 SHGCAEGSCYPATGDLLIGRSDQLTASSTCGIQKPESFCIVSHLQEEKKCFICDSL-----DPYN 85

  Fly   109 -----KNHRIGQIIYKTKPGTNIPTWWQSENGKENATIQLDLEAEFHFTHLIITFTTFRPAAMYI 168
                 ::|||..::....| ..:..|||||||.||.||||||||||||||||:||.|||||||.|
Frog    86 EQNNTESHRIENVVTTFAP-NRLNLWWQSENGLENVTIQLDLEAEFHFTHLIMTFKTFRPAAMLI 149

  Fly   169 ERSFDFGQTWHIYRYFAYDCKESFPGVPT-VLENITDVMCTSRYSNVEPSRNGEVIFRVLPPNIN 232
            |||.|||:||.|||||||||:.||||:.| .::.:.|::|.||||::|||..||||:|||.|...
Frog   150 ERSSDFGKTWKIYRYFAYDCETSFPGISTGPMKKVDDIICDSRYSDIEPSTEGEVIYRVLDPAFR 214

  Fly   233 VTDPYAEHVQNQLKMTNLRIQMTKLHKLGDNLLDSRLENEEKYYYGISNMVVRGSCSCYGHASQC 297
            :.|||:..:::.|::|||||:..|||.|||||||||:|.:|||||.|.:|||||:|.||||||:|
Frog   215 IDDPYSLRIKSMLRITNLRIKFLKLHTLGDNLLDSRVEIKEKYYYAIYDMVVRGNCFCYGHASEC 279

  Fly   298 LPLDPAFSQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAV 362
            .|:.   ..:||.:|||||||.|.|||||:|||:|.||::||||:||.|:.:||||||.||:|:.
Frog   280 APVK---GYSDNVEGMVHGRCVCRHNTKGLNCEQCLDFYHDLPWRPAEGRSSNACKKCNCNEHST 341

  Fly   363 SCHFDEAVFTASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSSD 427
            .||||.||:.::|..||||||:|.|||.|::||:|.|:||:.|::||....:||||:|||.||.|
Frog   342 HCHFDMAVYMSTGNTSGGVCDDCQHNTMGRNCEQCKPFFYQHPDKDIRDPNICQPCNCDPAGSQD 406

  Fly   428 DGICDSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTL-NNSGC 491
            .||||..::...|.:||.|.||..|.|.||:|||:|:::|.:::||||:.|.||||||: ..:.|
Frog   407 GGICDRYSDFSVGLIAGQCRCKLNVEGERCDQCKEGFYDLNAEDPEGCQFCGCNPLGTIPGGNSC 471

  Fly   492 VMRTGECKCKKYVTGKDCNQCMPETYGLSESPEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTG 556
            ..|.|.|.||::|||:.|:||.||.:|||...:||..|:||.|||.||.|...||||||||||.|
Frog   472 DSRNGNCFCKRFVTGRKCDQCAPEFWGLSNDLDGCRPCDCDHGGSEDNNCSPESGQCRCRPHMIG 536

  Fly   557 RSCSQPKQN-YFIPLLPEVHEAEVVDECISYGANGNCSLVAETP-----DGSFTGIGFTRVPENS 615
            |.|::.:.. |||.|....:|||       |...|....:.|.|     ..|:|||||.||||.:
Frog   537 RQCNEVESGFYFISLDHYTYEAE-------YANFGPDVRIVERPLPHDRTPSWTGIGFARVPEGA 594

  Fly   616 ELVFTVGDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGGCGELAAATSSETRIPFSL 680
            .|.|.:.|||.||.||.:|||:......||.|.||::||.::.....||....:..:::   .:|
Frog   595 YLEFHINDIPTSMEYDLLIRYEPQLPEQWEEAVITVIRPGKIPTSSRCGNTVPSDDNQS---VAL 656

  Fly   681 PDRSRQVVALNEVCLEAGKVYKFRIYFERKRHDVDSPTAT--ILVDSLTLIPRIDVTPIFQ--GS 741
            |..||.:.....:|.|.|..|..|:  |..|:.|:|....  .|:||:.|:|.:....||.  ||
Frog   657 PPGSRYITLPRPICFEKGLNYTIRL--ELPRYSVNSNVENPYTLIDSIVLLPHVKSLDIFSMGGS 719

  Fly   742 ---VLADIRKKDYEKYNC--------KSSLYDMNYKSDPKCQNLDNILSVFVHDGASMCNCNPTG 795
               |..:...:.:::|.|        |:.|.|:       |:|....:|..:|..|..|.|:|.|
Frog   720 GDDVTTNTAWQTFQRYRCLENSQSVVKTPLTDV-------CKNFLFTISALLHKSALECQCDPQG 777

  Fly   796 SLSKVCESNGGYCQCKPNVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSKDKYCDLITGQCQCVP 860
            |||.||:.|||.|||:|||:||.|::|||||:||||.|||.|:|:..||...:|...||||.|:.
Frog   778 SLSSVCDPNGGQCQCRPNVIGRNCNKCAPGTFGFGPNGCKPCECDVRGSSHPFCHTETGQCPCIH 842

  Fly   861 NTYGRECNQCQPGYWNFPECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFG 925
            ..:||:|:.|.||||.||.||.|||||||..|:.:.|.|.:|:|.:.||||:.||.||||:|..|
Frog   843 GAFGRQCDVCLPGYWGFPSCRQCQCNGHAEDCNALTGECTNCKDHSEGYSCERCLSGYYGDPRLG 907

  Fly   926 SEIGCRPCRCPETVASGLAHADGCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNPDN-GGTCS 989
            |...||||.||:...|....|.||..|.....::|.|..||:|.||:.||..:||||:. ||.|.
Frog   908 SGDHCRPCPCPDGPGSERQFASGCYKDPTTLQVVCSCNMGYTGIRCDGCASGYFGNPEEIGGVCQ 972

  Fly   990 KCECSNNVDLYDTGNCDRQTGACLKCLYQTTGDHCELCKDGFFGDALQQNCQQCECDFLGT---- 1050
            .|.|:||:|:.|:..|.:|:|.||||||.|.|.:|:.|:.|::|:|:||:|::|.|::|||
Frog   973 PCHCNNNIDMSDSLACHKQSGLCLKCLYHTEGINCQECQLGYYGNAIQQDCRRCVCNYLGTEQEN 1037

  Fly  1051 --NNTIAHCDRFTGQCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQC 1113
              .....||:|..|||||||||.|..||:||.|.|.:|||.|||.|.||...:|...||.:||||
Frog  1038 CSGEIDCHCNRTNGQCPCLPNVIGQSCDRCAANTWNLASGTGCEPCACDTNRSLGLSCNEFTGQC 1102

  Fly  1114 QCKPGFGGRACNQCQAHYWGNPNEKCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARG 1178
            ||.||||||.|::||..:||||:.:|:.|:||..|....||:|.||:|:|.||:.|.:|::||||
Frog  1103 QCMPGFGGRDCSECQELFWGNPDIECRACDCDSRGIQTSQCNRATGHCICKEGVEGVRCDKCARG 1167

  Fly  1179 YIGQFPHCSPCGECFNNWDLILSALEDATTATILRAKEIKQVGATGAYTSEFSELDKKLQHIRNL 1243
            |.|.||:|:||.:||..||:|:..|.:.|...:.||.::|..|..|.|.....::.:||:.||::
Frog  1168 YSGAFPYCTPCHKCFALWDIIIQELSNRTKQLLNRANDLKISGVIGPYQQTVDKVQEKLEEIRSI 1232

  Fly  1244 LQNTSVS--LVDIEKLDYETQSLRDQLQASHGRLSETEQNLDDIYNSLSLSGVELESLQNHSRL- 1305
            |.:...:  |.:||.|..|.:.|:          ||..|.:|::  .:.|:.:::...:....|
Frog  1233 LAHNPAAQPLKNIENLFEEAEKLK----------SEVSQKVDEV--EMKLAEIKINDTEKLDALQ 1285

  Fly  1306 --VQQLSKELKENGIQLQ---ESNIEGALNLTRHAYERVSNLSTLKDEANEL----ASNTD---- 1357
              .:...|.|||.|.||:   .||::||:       :.::....:..||.|:    .||.|
Frog  1286 ADAESFGKALKELGDQLEFMKISNVQGAM-------DSINKYFQMSLEAEEMVNASVSNPDSIIE 1343

  Fly  1358 ---RNCKRVENLSN-------KIQAE----ADDLANNNKLIEDYRAELTSLTSQIPELNNQVCG- 1407
               ...:.||||.|       |.|.|    .|:||.|.:.::            :..|:.:.||
Frog  1344 HSAATRQEVENLINENLSQFKKEQEEQTRLLDELAGNGQSLD------------LSSLSEKTCGN 1396

  Fly  1408 KPGDPC-DSLCGGAGC-----------GHCGGFLSCEHGAKTHSEEALKVAKDAETAITSKKDQA 1460
            .||..| ||.|||..|           ..|||.::..|       .|.|.|...:|.|.:...:.
Frog  1397 SPGLLCEDSECGGLNCKTDDGKRKCGGPGCGGLVTVAH-------SAWKTASSFDTEIQNALAEV 1454

  Fly  1461 DQTIRALTQAKLNASEAYEKAKRGFEQ---SERYLNQTNANIKLAENLFIALNNFQENKTASPSE 1522
            ::..:.:.::||.|.||.:.|:....:   ::..:||:|.:::   ||...:..|.....|....
Frog  1455 EELSKMVAESKLRAEEAKQSAQDVLTKANATKEKVNQSNEDLR---NLIKQIREFLMQDGADLDS 1516

  Fly  1523 SKELAQKTLDLDLKLEPEEIETLGDQINRAVSSLKNVEAIIYRTKPDLDRVNNLQSIANATKEKA 1587
            .:.:|.:.|.:|:...||:::.|.::|...|.||..|:.|:.::..|:.|...|...|..:.:.|
Frog  1517 IEAVASEVLKMDMPTTPEQLQKLTEEIRERVESLSGVDTILKQSAGDIARAEALLDEAKESSKSA 1581

  Fly  1588 DKILDSANSVVESLAAADESQGKAKDAIQQANSNIELAGQDLEKIDEETYSAEAPANNTAQQVEK 1652
            ..|..:.::|.|:|..|.::|..|:.||::|:.:|:.....|..|:.|...:|...||..:::.:
Frog  1582 ADIKATVDAVKEALMEAGKAQSAAEKAIKRADDDIKGTNDLLTSIESEAAVSEETLNNATKRLVQ 1646

  Fly  1653 LAKKVQKLQNNIMKNDRDAKEITKEAGSVKLEAMRAR----GEANNLQSATSATNQTLTDRASRS 1713
            |...:..|......|.:.|.::.|....||..|..|:    ||..|   ........:..:|..|
Frog  1647 LENNIDDLMKKSAANSQTANQVEKSVHEVKANANGAKKVLDGELTN---KYKTVEDLIAKKAEDS 1708

  Fly  1714 ENARERAKQLLQRASKLTVDTNAKLKDLNDLQTVYLNKNQQLLRLQA-EIGPLNKELNEHLIHIK 1777
            |.||.:|::|.:.|..|....|.||..:.||:..| ..|:::|..:| ::..|.:.:...|..|.
Frog  1709 EEARRKAQELQKEAKGLLEQANKKLDTIKDLEKTY-EGNERILEEKAKQLVQLEETVRALLQAIS 1772

  Fly  1778 ERGSHYRQCY 1787
            ::.:.|..|:
Frog  1773 QKAAVYSTCF 1782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB1	NP_476618.1	Laminin_N	63..286	CDD:278484	138/230 (60%)
		EGF_Lam	287..343	CDD:238012	34/55 (62%)
		Laminin_EGF	355..415	CDD:278482	31/59 (53%)
		Laminin_EGF	418..475	CDD:278482	28/56 (50%)
		EGF_Lam	477..526	CDD:238012	24/49 (49%)
		EGF_Lam	529..567	CDD:214543	22/38 (58%)
		EGF_Lam	789..834	CDD:214543	30/44 (68%)
		Laminin_EGF	837..885	CDD:278482	23/47 (49%)
		Laminin_EGF	883..930	CDD:278482	25/46 (54%)
		Laminin_EGF	933..988	CDD:278482	23/55 (42%)
		Laminin_EGF	991..1043	CDD:278482	25/51 (49%)
		Laminin_EGF	1043..1091	CDD:278482	27/53 (51%)
		Laminin_EGF	1094..1142	CDD:278482	26/47 (55%)
		Laminin_EGF	1142..1190	CDD:278482	25/47 (53%)
		COG6	1212..>1398	CDD:303003	52/215 (24%)
		TelA	1439..1782	CDD:226371	85/350 (24%)
		ApoLp-III_like	1545..1702	CDD:304399	41/160 (26%)
lamb1	XP_002933140.2	Laminin_N	43..268	CDD:365840	138/230 (60%)
		EGF_Lam	270..322	CDD:238012	34/54 (63%)
		EGF_Lam	334..386	CDD:238012	29/51 (57%)
		Laminin_EGF	397..454	CDD:365839	28/56 (50%)
		EGF_Lam	457..507	CDD:238012	25/49 (51%)
		EGF_Lam	508..>547	CDD:238012	22/38 (58%)
		EGF_Lam	771..816	CDD:214543	30/44 (68%)
		Laminin_EGF	819..867	CDD:365839	23/47 (49%)
		EGF_Lam	865..909	CDD:238012	24/43 (56%)
		EGF_Lam	914..972	CDD:238012	24/57 (42%)
		EGF_Lam	973..1024	CDD:238012	24/50 (48%)
		Laminin_EGF	1026..1080	CDD:365839	27/53 (51%)
		Laminin_EGF	1083..1131	CDD:365839	26/47 (55%)
		Laminin_EGF	1131..>1170	CDD:365839	20/38 (53%)
		Smc	<1189..1772	CDD:224117	154/627 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	303	1.000	Domainoid score	I1381
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1476	1.000	Inparanoid score	I109
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42471at33208
OrthoFinder	1	1.000	-	-		FOG0002726
OrthoInspector	1	1.000	-	-		oto103527
Panther	1	1.100	-	-	O	PTHR10574
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1817
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160