DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanB1 and XB5969698

DIOPT Version :9

Sequence 1:	NP_476618.1	Gene:	LanB1 / 34068	FlyBaseID:	FBgn0261800	Length:	1788	Species:	Drosophila melanogaster
Sequence 2:	NP_001123798.1	Gene:	XB5969698 / 100170549	XenbaseID:	XB-GENE-5969699	Length:	1853	Species:	Xenopus tropicalis

Alignment Length:	1911	Identity:	714/1911 - (37%)
Similarity:	1010/1911 - (52%)	Gaps:	274/1911 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 HPCERSSCYPATGNLLIGRENRLTASSTCGLHSPERFCILSHLQD-KKCFLCDTREETKHDPY-- 108
            |.|....||||||||||||...|:|:||||:...:.:||:||||| :|||.||:|.     ||
Frog    46 HGCTEGGCYPATGNLLIGRAQSLSATSTCGMEEAQEYCIVSHLQDSEKCFACDSRV-----PYQK 105

  Fly   109 KNHRIGQIIYKTKPGTNIPTWWQSENGKENATIQLDLEAEFHFTHLIITFTTFRPAAMYIERSFD 173
            ::|||..:||.|:.... .||||||||.|:.:|:|||||||||||||:.|.|||||||.||||.|
Frog   106 ESHRIENVIYLTEEDEE-KTWWQSENGVESVSIRLDLEAEFHFTHLIMKFKTFRPAAMLIERSAD 169

  Fly   174 FGQTWHIYRYFAYDCKESFPGVPT-VLENITDVMCTSRYSNVEPSRNGEVIFRVLPPNINVTDPY 237
            :|:||.:||||:|:|.:.|||||. .|:.|.|::|..|||::|||..||||::||.|.|.|.|||
Frog   170 YGRTWKVYRYFSYNCTKMFPGVPIHALQQIDDIICDQRYSDIEPSSEGEVIYKVLDPAITVEDPY 234

  Fly   238 AEHVQNQLKMTNLRIQMTKLHKLGDNLLDSRLENEEKYYYGISNMVVRGSCSCYGHASQCLPLDP 302
            :..:|..|::|||||..||||.|||||||.|.|..:||||.:..:||||||.||||||:|.|::.
Frog   235 SAEIQELLQITNLRINFTKLHTLGDNLLDQRPEVLQKYYYSVYELVVRGSCFCYGHASECSPVEG 299

  Fly   303 AFSQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAVSCHFD 367
            ..:   ..:||:||||.|.|:|||:|||:|:||::||||:||.....:.||:|.||:|:..||||
Frog   300 IEA---GVEGMIHGRCVCKHHTKGLNCEQCQDFYHDLPWRPAEANDPHTCKRCNCNNHSRKCHFD 361

  Fly   368 EAVFTASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSSDDGICD 432
            .||:.|:|..||||||:|.|||.|::||.|.|::|:||..||.::..|..|||||.||.|.|:||
Frog   362 MAVYLATGKESGGVCDDCQHNTMGRNCELCKPFYYQDPRADIRADNACISCDCDPVGSLDGGVCD 426

  Fly   433 SLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTL-NNSGCVMRTG 496
            |...:..|.:||.|.||..|.|.||:.||:.::.|..::|.||:||:|:|.|.: .|:.|...:|
Frog   427 SHTNVNLGMIAGQCRCKGNVKGERCDSCKESFYGLSMNDPVGCQPCSCDPRGIITGNTPCDQISG 491

  Fly   497 ECKCKKYVTGKDCNQCMPETYGLSESPEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQ 561
            :|.||::|||:.||||:||.:|||....||..|:||.||:|:|.|.:..|||.||.::.||.|..
Frog   492 DCYCKRFVTGRYCNQCLPEYWGLSNDITGCRPCDCDFGGAYNNKCSLGDGQCDCRSNIIGRQCGD 556

  Fly   562 PKQNYFI--------------------PLLPEVHEAEVVDECISYGANG---------------- 590
            .:..||.                    |.||...:.|...:|:.| .||
Frog   557 VQLGYFCMPLDYYTYEAENAKGLSPTDPQLPGSPKPEAQTDCLEY-FNGIQNGKKVRLRRQRRTA 620

  Fly   591 ----------NCSLVAETPDG-------------SFTGIGFTRVPENSELVFTVGDIPRSMPYDA 632
                      ....:.:.||.             ::||.||.||.:.:.|:|.:.::|..|.||.
Frog   621 RVLQQRASQRRARQLQQKPDTEVIRREHNSGHMVTWTGQGFVRVRDGAGLLFQIDNVPYPMDYDI 685

  Fly   633 VIRYQSTSRGDWENAFITLVRPDQVDPEGGCGELAAATSSETRIPFSLPDRSRQVVALNEVCLEA 697
            :|||:..|..|||.......|...:.|.  ||.:   ..||......||...|.:|.....|.|:
Frog   686 MIRYEPESAEDWEATVSVTSRILPMSPR--CGNV---LPSEQMYKEKLPHTERYLVLPKPFCFES 745

  Fly   698 GKVYKFRIYFER----KRHDVDSPTATILVDSLTLIPRIDVTPIFQGSVLADI-RKKDYEKYNCK 757
            ...|:..|.|:|    .||    |.|.||:|||.|:|:|...|.|.|:....: .:::.|:|.|.
Frog   746 NNQYEISIRFQRWGAANRH----PAAFILIDSLVLLPKIYELPGFHGNDPVSVHHREEMERYMCL 806

  Fly   758 SSLYDMNYKSD--PKCQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGYCQCKPNVVGRQCD 820
            .| :.|....|  ..|..|...:|..:||||..|.|:..||||.||:..||.|:|||||:|::||
Frog   807 DS-FKMATMPDLAEMCIKLLCSISAIIHDGALPCLCDLQGSLSAVCDKIGGQCKCKPNVIGQRCD 870

  Fly   821 QCAPGTYGFGPEGCKACDCNSIGSKDKYCDLITGQCQCVPNTYGRECNQCQPGYWNFPECRVCQC 885
            |||||||||||.||..|||:..||..:.|:..||||.|..|..||:|:||.||.|.:|.||.|.|
Frog   871 QCAPGTYGFGPYGCSKCDCHPQGSTSRLCNPFTGQCPCQSNVAGRQCDQCLPGQWGYPHCRPCVC 935

  Fly   886 NGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGSEIGCRPCRCPETVASGLAHADGCS 950
            |||:..||...|.||.|:|||||..|:.|||||||:|:.||...||||.||....|...|...|.
Frog   936 NGHSDECDSKTGACIRCRDSTTGRHCEKCLDGYYGDPILGSGQQCRPCPCPGYPGSRNYHGSSCY 1000

  Fly   951 LDTRNNNMLCHCQEGYSGSRCEICADNFFGNPD-NGGTCSKCECSNNVDLYDTGNCDRQTGACLK 1014
            .|..::.::|.|..||:|:||:.|:..:||||: .||.|..|:|:||:|..|..:||..:|.|:|
Frog  1001 ADKDSHQIVCLCAPGYTGTRCDRCSPGYFGNPEQEGGECRPCQCNNNIDPTDPESCDSHSGMCMK 1065

  Fly  1015 CLYQTTGDHCELCKDGFFGDALQQNCQQCECDFLGT-----NNTIAHCDRFTGQCPCLPNVQGVR 1074
            |||.|.|.|||.||.||:|.|:|:||::|.|:..||     ...:.:|||.||.|||..||.|..
Frog  1066 CLYNTDGAHCEECKAGFYGSAMQRNCRRCTCNEQGTLQSHCTRDVCYCDRVTGHCPCRANVLGKS 1130

  Fly  1075 CDQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACNQCQAHYWGNPNEKC 1139
            |||||.|.|......|||.|.|||..:|.:.||.:||||.|:||||||.|:.||.:|||:|..||
Frog  1131 CDQCASNFWNFGGDLGCEPCTCDPAHSLRQDCNVFTGQCHCQPGFGGRVCSHCQENYWGDPQIKC 1195

  Fly  1140 QPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGECFNNWDLILSALE 1204
            :.|:||.:|:...|||..||.|.|.:|..|.:|::||||:...:|.|.||.|||..||:|:|.|.
Frog  1196 EVCDCDAYGSETAQCDPLTGKCFCRKGFTGQRCDQCARGFQNNYPRCLPCHECFAQWDMIISQLR 1260

  Fly  1205 DATTATILRAKEIKQVGATGAYTSEFSELDKKLQHIRNLLQNTSVSLVDIEKLDYETQSLRDQLQ 1269
            |                              :||.::..|            ||::..::..::
Frog  1261 D------------------------------RLQGVQQKL------------LDFQEGAVAPEI- 1282

  Fly  1270 ASHGRLSETEQNLDDIYNSLSLSGVE-LESLQNHSRLVQQLSKELKENGIQLQESNIEGALNLTR 1333
             ||.::.|.:..|..|...:...|.: :..|:..::||.::|.|:.:...||
Frog  1283 -SHSQIKELDNKLRTIEELIKDGGADGMRMLEQMTKLVNKISSEVAQLSFQL------------- 1333

  Fly  1334 HAYERVSNLSTLKD-----EANELASNTDRNCKRVENLSNKIQA--------------------- 1372
            |..|:..|.:..||     :.::|..:.....:.|.:|..:|:|
Frog  1334 HTQEKQMNGTEAKDRWQRGKLDQLTLDITVVNETVYDLKVQIEAIVAAGFNESYNSIVKSYLEST 1398

  Fly  1373 EADDLANNN-----------------------KLIEDYRAELTSLTSQIPEL------------N 1402
            ||:.:||.:                       :.::.|:..:|:..|.:.||            |
Frog  1399 EAEKIANGSVYGPGSPVFQSQQTREETERLLKEKLDTYKRNMTAQKSSLKELQKKVQGLNVSKIN 1463

  Fly  1403 NQVCGKPGD-PC-DSLCGGAGC------GHCGGFLSCEHGAKTHSEEALKVAK----DAETAITS 1455
            .::||.||| .| ||.||||.|      ..|||. .| :||...|.:||..|:    :.|.....
Frog  1464 EKICGAPGDQECEDSPCGGANCRDEDGKRKCGGD-DC-NGALPVSAKALSTAQNITLELENMANR 1526

  Fly  1456 KKDQAD---------QTIRALTQAKL-NASEAYEKAKRGFEQSERYLNQTNANIKLAENLFIALN 1510
            .||.|.         |..:..|:|.| ||.|    :||..|.|...|.:....||
Frog  1527 LKDIAQKIQDIQGIAQDAKVQTEATLANAKE----SKRRIEDSTEKLREFIKKIK---------- 1577

  Fly  1511 NFQENKTASPSESKELAQKTLDLDLKLEPEEIETLGDQINRAVSSLKNVEAIIYRTKPDLDRVNN 1575
            :|...:.|.|...:.:|::.|::.|...|.:||.|.::|..::.:|...:.|:..|...|....|
Frog  1578 DFLTEEGADPESIELVARQVLNISLPASPGDIEALVNKIKESIGNLSCTDEILTNTSEILATAKN 1642

  Fly  1576 LQSIANATKEKADKILDSANSVVESLAAADESQGKAKD---AIQQANSNIELAGQDLEKIDEETY 1637
            |...|...:.||:.:  ||| :.::.|...|::.|||.   |:::|..:|:.....:|:..:...
Frog  1643 LHKEAVEAQAKAEAV--SAN-ISDAQALLQEAEAKAKSAEKALKKAKQSIKDVKSKVEQTMQTLT 1704

  Fly  1638 SAEAPANNTAQQVEKLAKKVQKLQNNIMKNDR---DAKE----ITKEAGSVKLEAMRARGEANNL 1695
            ..|....:..:::..|::||..|.:....|.:   ||||    :....|.::.|....:.:.::|
Frog  1705 GVEQKEMDIMERIGNLSEKVDDLLDKTESNRQIASDAKERANLVLNSTGELRKEMDDVQRKYDDL 1769

  Fly  1696 QSATSATNQTLTDRASRSENARERAKQLLQRASKLTVDTNAKLKDLNDLQTVYLNKNQQLLRLQA 1760
            :......|.:......|.|..:|.||.|..:|       |...|:|..|:..:......:.....
Frog  1770 KEKVGGYNSSSGTALDRIEKIKEEAKALYDKA-------NTAKKELAKLEAQFRANEANMTAKIL 1827

  Fly  1761 EIGPLNKELNEHLIHIKERGSHYRQC 1786
            .|..|..:..:.|..|:|:.:.|..|
Frog  1828 TIEQLENQTTQLLNDIREKSNIYSTC 1853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB1	NP_476618.1	Laminin_N	63..286	CDD:278484	128/226 (57%)
		EGF_Lam	287..343	CDD:238012	31/55 (56%)
		Laminin_EGF	355..415	CDD:278482	32/59 (54%)
		Laminin_EGF	418..475	CDD:278482	26/56 (46%)
		EGF_Lam	477..526	CDD:238012	23/49 (47%)
		EGF_Lam	529..567	CDD:214543	16/37 (43%)
		EGF_Lam	789..834	CDD:214543	30/44 (68%)
		Laminin_EGF	837..885	CDD:278482	24/47 (51%)
		Laminin_EGF	883..930	CDD:278482	27/46 (59%)
		Laminin_EGF	933..988	CDD:278482	21/55 (38%)
		Laminin_EGF	991..1043	CDD:278482	28/51 (55%)
		Laminin_EGF	1043..1091	CDD:278482	22/52 (42%)
		Laminin_EGF	1094..1142	CDD:278482	27/47 (57%)
		Laminin_EGF	1142..1190	CDD:278482	21/47 (45%)
		COG6	1212..>1398	CDD:303003	35/235 (15%)
		TelA	1439..1782	CDD:226371	84/366 (23%)
		ApoLp-III_like	1545..1702	CDD:304399	36/166 (22%)
XB5969698	NP_001123798.1	Laminin_N	62..283	CDD:278484	128/226 (57%)
		EGF_Lam	284..337	CDD:238012	31/55 (56%)
		Laminin_EGF	349..399	CDD:278482	28/49 (57%)
		Laminin_EGF	412..469	CDD:278482	26/56 (46%)
		EGF_Lam	471..522	CDD:238012	24/50 (48%)
		EGF_Lam	523..>562	CDD:238012	16/38 (42%)
		EGF_Lam	839..884	CDD:214543	30/44 (68%)
		Laminin_EGF	887..935	CDD:278482	24/47 (51%)
		Laminin_EGF	933..980	CDD:278482	27/46 (59%)
		Laminin_EGF	983..1039	CDD:278482	21/55 (38%)
		Laminin_EGF	1042..>1084	CDD:278482	23/41 (56%)
		Laminin_EGF	1094..1147	CDD:278482	22/52 (42%)
		Laminin_EGF	1150..1198	CDD:278482	27/47 (57%)
		EGF_Lam	1198..1246	CDD:238012	21/47 (45%)
		P-loop_NTPase	<1253..1328	CDD:304359	21/118 (18%)
		SCP-1	<1283..1695	CDD:114219	105/443 (24%)
		OspD	1542..1749	CDD:281234	56/223 (25%)
		COG1340	1563..1846	CDD:224259	66/302 (22%)
		BAR	1668..1853	CDD:299863	39/191 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	303	1.000	Domainoid score	I1381
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1476	1.000	Inparanoid score	I109
OMA	1	1.010	-	-		QHG49316
OrthoDB	1	1.010	-	-		D42471at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1817
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.080