DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB1 and lama2

DIOPT Version :9

Sequence 1:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster
Sequence 2:NP_001265728.1 Gene:lama2 / 100049705 ZFINID:ZDB-GENE-060119-1 Length:3078 Species:Danio rerio


Alignment Length:2262 Identity:511/2262 - (22%)
Similarity:799/2262 - (35%) Gaps:736/2262 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 VLALLSWQWDPVDSQRPPQHGRRDRPKYPPNKFIKTHPCERSSCYPATGNLLIGRENRLTASSTC 75
            ::|||...|....:   ||.|                      .:||..||....|  :..::||
Zfish     6 LVALLGLLWRCCGA---PQRG----------------------LFPAVLNLASMAE--IKTNATC 43

  Fly    76 GLHSPERFC-ILSH-----LQDKKCFLCDTREETKHDPYKNHRIGQIIYKTKPGTNIPTWWQSE- 133
            |...||.:| ::.|     :::.:|..||...:  :| |:.|.|...|    .|||  .||||. 
Zfish    44 GETGPEMYCKLVEHVPGRPVKNPQCRTCDLNSD--YD-YERHPIEFAI----DGTN--RWWQSPS 99

  Fly   134 --NGKE--NATIQLDLEAEFHFTHLII-TFTTFRPAAMYIERSFDFGQTWHIYRYFAY---DCKE 190
              ||.:  :.|:.|||:..|...::|: ...:.||....:|||.| |:|:..::|:|.   :|..
Zfish   100 IMNGMDLHHVTVTLDLQQVFQIAYVILKAANSPRPGNWILERSLD-GETFMPWQYYAITDTECIT 163

  Fly   191 SFPGVPTV----LENITDVMCTSRYSNVEPSRNGEVIFRVLPPNINVTDPYAEHVQNQLKMTNLR 251
            .:..:|..    ..:..:|:|||.||.:.|..|||:...::....:..|| :..:.|......:|
Zfish   164 RYDIIPRTGPPSYTHDDEVICTSFYSKIHPLENGEIHTSLINGRPSADDP-SPTLLNFTSARFIR 227

  Fly   252 IQMTKLHKLGDNLLDSRLEN--------EEKYYYGISNMVVRGSCSCYGHASQCLPLDPAFSQAD 308
            :|..::..|..:|:...|.:        ..:|||.|.::.|.|.|.|||||..| ||:       
Zfish   228 LQFQRIRTLNADLMTLALHDPRDIDPIVTRRYYYSIKDISVGGMCICYGHAKAC-PLN------- 284

  Fly   309 NEDGMVHGR---CECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAVSCHFDEAV 370
                 .|.:   |||.|||.|.:|:.|...:|..||........:.|:||.|::.:..|::::.|
Zfish   285 -----THTKKFSCECEHNTCGESCDRCCPAYNQKPWMAGTFLTRHVCEKCNCHNKSEECYYNQTV 344

  Fly   371 FTA-------SGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSSDD 428
            ..|       ..:..||||..|..||.|.:|:.|:..|||...........|.||.||.:|:...
Zfish   345 ADAKLSLNIHGEYEGGGVCLGCSENTGGINCQSCIDGFYRPSGVSPLEPWPCTPCTCDLRGALHS 409

  Fly   429 GICDSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTLNNSGCVM 493
            ......::.......|:|.||....|.||::|..||    :..|: ||.|.|:..|::|...|  
Zfish   410 TCVPDESQATTDLPVGSCICKPGYAGERCDRCVFGY----AGFPQ-CERCRCSSDGSVNQDPC-- 467

  Fly   494 RTGECKCKKYVTGKDCNQCMPETYGLSES-PEGCSLCNCDAGGS--------YDNYCDV----IS 545
             ...|.||::|.|:||::|....|.||.. ..||..|.|....|        |.|..|:    ::
Zfish   468 -QPPCVCKEHVEGRDCDRCKQGFYHLSGGRVRGCDKCYCSGVASLCAESQWDYTNVTDMSGWYLT 531

  Fly   546 G----------QCRCRPHMTGRSCSQPKQNYFIPLLPEVHEAEVVDECISYGANGNCSLVAETPD 600
            |          ..|...|....|.|..:.:...|.......|.:..:.::||.....|:..:|  
Zfish   532 GADGEGLVWAEPSRETAHQVTVSQSDAQTHLTAPYYWSAPSAYLGKKLLAYGGRLVYSISHDT-- 594

  Fly   601 GSFTGIGFTRVPENSELVFTVGDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGGC-- 663
                        |:.|.|.|:|                              .||.:...||.  
Zfish   595 ------------ESLEAVHTLG------------------------------APDVIIEGGGLRL 617

  Fly   664 ----GE--LAAATSSETRIPFSLPD-----RSRQVVALNEVCLEAGKVYKFRIYFERKRHDVDSP 717
                .|  |.:.:|||..:.. ||:     .|.|.|:..:.......:.:..:   |..|.:...
Zfish   618 VHRWSEVLLKSPSSSERGVDL-LPELFQHQASGQSVSRRDFHSVLQHIQRLML---RAEHSLQEH 678

  Fly   718 TATILVDSLTLIPRIDVTPIFQGSVLADIRKKDYEKYNCKSSLYDMNYKSDPKCQNLDNILSVFV 782
            |..|                             |...:.::|:.|.:.:|.             :
Zfish   679 THAI-----------------------------YRLGSVRTSVADEDSRSG-------------I 701

  Fly   783 HDGASMCNCNPTGSLSKVCESNGGYCQCKPNVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSKDK 847
            ..||.                  ..|||.|...|..|:.||.|                      
Zfish   702 QAGAV------------------EVCQCPPGYDGTSCEMCALG---------------------- 726

  Fly   848 YCDLITGQCQCVPNTYGRECNQCQPGYWNFPECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCD 912
                           |.|.......|.     |.:|||:||...||.:.|.|:.|:|.|.|.:|.
Zfish   727 ---------------YRRVNGTIYQGV-----CELCQCHGHTERCDDLTGHCLGCRDHTVGPNCG 771

  Fly   913 SCLDGYYGNPLFGSEIGCRPCRCPETVASGLAHADGCSLDTRNNNMLCHCQEGYSGSRCEICADN 977
            .|..||||:...|:...|:||.|| .::.....:..|.:|.|...:...|..||:||||:.|::.
Zfish   772 QCAPGYYGDATRGTADDCQPCACP-LLSPANNFSPTCRVDGRGEVICDRCPPGYTGSRCDRCSNG 835

  Fly   978 FFGNPD-NGGTCSKCECSNNVDLYDTGNCDRQTGACLKCLYQTTGDHCELCKDGFFGDAL-QQNC 1040
            :||.|: .||:|..|.||.|:|.....:||..|||||:|.....|..||.|.||:||||| .:||
Zfish   836 YFGRPNIPGGSCQPCVCSGNLDQTAPLSCDPLTGACLRCRKGYGGADCERCADGYFGDALIAKNC 900

  Fly  1041 QQCECDFLGTNNTI------------------------------------AHCDRF--------- 1060
            |.|:|...|:.:.:                                    .||:.|         
Zfish   901 QACQCHSNGSVSELCHQETGQCQCRQHVIGRQCDECMAGSHLQGALGCVPCHCNSFGSKSFDCDE 965

  Fly  1061 TGQCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACN 1125
            :|||.|.|.|.|.:||:||..|:....| ||..|.|..:|   ..|::.||||.|.|...|..|:
Zfish   966 SGQCRCQPGVTGQKCDRCAAGHFSFQEG-GCTPCQCAHVG---NNCDASTGQCICPPNTVGERCD 1026

  Fly  1126 QCQAHYWGNP-NEKCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPC 1189
            :|..::||:. :..|:||.|:..|:...||:..||.|:|.|...|.||:||..|| ..||.|..|
Zfish  1027 KCAPNHWGHDISTGCKPCGCNALGSVAQQCNLNTGCCMCREQFRGEKCDECKLGY-RDFPQCISC 1090

  Fly  1190 -----GECFNNWDLI--LSALEDATTATILRAKEIKQ-----------------VGATGAY---- 1226
                 |...:..|..  |.|..|.:.....:|....|                 :|.:..|    
Zfish  1091 QCSAAGSSLDTCDSESGLCACADRSGQCSCKANVEGQKCERCKSGSFGLSHRNPLGCSRCYCFGL 1155

  Fly  1227 TSEFSELDKKLQHIRNLL-QNTSVSLVD------------------------------------- 1253
            :|..:|....::....|: :.|.:.|||                                     
Zfish  1156 SSSCTEATGLIRMRLTLMPEQTVLPLVDRSGHQETTAGITFQHPDIIATADVVQQQLSEPYYWRL 1220

  Fly  1254 ---------------------------IEKLDYETQSL------RDQLQASH------GRLSETE 1279
                                       ..:..||.|.:      :|::...|      |:|:..|
Zfish  1221 PKQFKRSMITAYGGKLRYAIYYEAREETGRTSYEPQVIIKGGPNKDKIMVRHMPALQIGQLTRHE 1285

  Fly  1280 --------QNLDD------------IYNSLSLSGVELESLQNHSRLVQQLSKELKENGIQLQESN 1324
                    ::.||            .:....|......::..||| :.:::.|:.|.|...|:|.
Zfish  1286 IDITEHEWKHKDDRPMSREDFMDVLFHVEYILIKASHGNVMRHSR-ISEITLEVAEVGRASQDSE 1349

  Fly  1325 I----------EGALNLT----RHAYERVSNL---------------------STLKDEANELAS 1354
            |          :|...|:    ...:.|:|.|                     |...|....:..
Zfish  1350 IAHQIEKCVCPQGYAGLSCEECAAGFYRLSVLAGGSASRAGFGSCVRCQCNGHSDSCDPETSICQ 1414

  Fly  1355 NTDRN-----CKR--------VENLSNKIQAEADDLAN--NNKLIEDYRAELTSLTSQIPELNNQ 1404
            |...|     |:|        |...::..:..|..|.|  ||          .|.|.|....|..
Zfish  1415 NCQHNTVGDKCERCAAGFYGVVRGFTDDCKPCACPLLNPENN----------FSPTCQTEGFNEY 1469

  Fly  1405 VC-----------------GKPGDP------CDSLCGGAGCGHCGGFL----------------- 1429
            .|                 |..|||      |:..|.    ..|.|.|                 
Zfish  1470 RCTACPEGYEGKHCERCAPGFHGDPGVLGGRCEESCD----DDCAGLLIRDMERLLRLIGSVNLT 1530

  Fly  1430 ------------------SCEH--------------------GAKTHSEE----ALKVAKDAE-T 1451
                              ..:|                    ...|..:|    |.||:.|.| |
Zfish  1531 LPLPLPYKVLYRFENVTEELKHMLSPQRAPERLMQLADSNLGSLVTEMDELLNRATKVSADGEQT 1595

  Fly  1452 AITSKKD-QADQTIRALTQAKLNASEAYEKAKRGFEQS--------ERYLNQTNANIK------- 1500
            |..:::. :|.:.:....:..|.|:||.....|....:        |:.:|:.|..|:       
Zfish  1596 AADAERSRKAAEELELYVRNTLLAAEALRDKARDLNATLGLRDGTLEKSVNEMNDEIQEMLAELR 1660

  Fly  1501 ----------------LAENLFIALNN-FQENKTASPSESKELAQKTLDLDLKL-EPEEIETLGD 1547
                            .||.|...:.. |.:.:.|:....:|:.||..|..||| |.:|:     
Zfish  1661 KRQLTGKKHMADEELGAAEALLSRVKRLFGDPQQATADLKQEVGQKMSDHKLKLQEAQEL----- 1720

  Fly  1548 QINRAVSSLKNVEAIIYRTKPDLDRVNNLQSIANATKE-------KADKILDSANSVVESLAAAD 1605
             :..|::..:..|.:....:..|..:...:..|...||       :.:|.||.||::.:::....
Zfish  1721 -LEEALTHTRQAEDLTLNNQLKLQHLQGKRDAAVKQKEQTEGVLLEGEKSLDEANALSDAITRGK 1784

  Fly  1606 E-------SQGKAKDAIQQANSNIELAGQDLEKIDEETYSAE---APANNTAQQVEKLAKKVQKL 1660
            |       ..|..:|.::...|::. .|.| |.:.|....||   |..|::|..::.:..:.:.|
Zfish  1785 EELEEMAGELGPLRDQLRDKESDLS-RGLD-ESVPELLLRAEDHAAQLNHSAAILDSILAEAKNL 1847

  Fly  1661 --------------QNNIMKNDR---DAKEITKEA--------GSVKLEAMRA-------RGEAN 1693
                          :|.|.:.||   |||:.:.||        ||:|.:|..:       ..||.
Zfish  1848 SFNATAAFSAYTNIKNYIEEADRVAKDAKKTSAEALQLASGPKGSLKDQAKGSLQKSHDLLNEAK 1912

  Fly  1694 NLQSATSATNQTLTDRASRSENARERAKQLLQR--------------------ASKL-------- 1730
            :||...:...:.|.....|.:.|.::.|.|.:|                    |:||        
Zfish  1913 DLQKDVTENGENLGALQLRLKGANKQNKDLQKRLNDTVEKLNSIPDDMALKIQATKLKAAEANDT 1977

  Fly  1731 TVDTNAKLKDLNDLQTVYLNKNQQLLRLQAEIGPLNKELNEHLIHIKERGSH 1782
            .:|...:|||:| |..:.|.||..  :|:.::...|     :||...|:..|
Zfish  1978 ALDVLNRLKDMN-LNLMGLKKNYD--KLEDDVRKTN-----NLIKDPEKNIH 2021

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB1NP_476618.1 Laminin_N 63..286 CDD:278484 66/249 (27%)
EGF_Lam 287..343 CDD:238012 22/58 (38%)
Laminin_EGF 355..415 CDD:278482 18/66 (27%)
Laminin_EGF 418..475 CDD:278482 15/56 (27%)
EGF_Lam 477..526 CDD:238012 16/49 (33%)
EGF_Lam 529..567 CDD:214543 11/59 (19%)
EGF_Lam 789..834 CDD:214543 9/44 (20%)
Laminin_EGF 837..885 CDD:278482 5/47 (11%)
Laminin_EGF 883..930 CDD:278482 20/46 (43%)
Laminin_EGF 933..988 CDD:278482 19/55 (35%)
Laminin_EGF 991..1043 CDD:278482 27/52 (52%)
Laminin_EGF 1043..1091 CDD:278482 19/92 (21%)
Laminin_EGF 1094..1142 CDD:278482 16/48 (33%)
Laminin_EGF 1142..1190 CDD:278482 21/52 (40%)
COG6 1212..>1398 CDD:303003 50/353 (14%)
TelA 1439..1782 CDD:226371 97/458 (21%)
ApoLp-III_like 1545..1702 CDD:304399 42/205 (20%)
lama2NP_001265728.1 LamNT 21..270 CDD:214532 72/283 (25%)
EGF_Lam 272..319 CDD:238012 22/59 (37%)
Laminin_EGF 399..456 CDD:278482 18/61 (30%)
Laminin_EGF 454..500 CDD:278482 16/48 (33%)
Laminin_B 567..695 CDD:278481 30/204 (15%)
EGF_Lam 742..790 CDD:238012 20/47 (43%)
Laminin_EGF 792..847 CDD:278482 19/55 (35%)
EGF_Lam 849..901 CDD:238012 25/51 (49%)
EGF_Lam 903..948 CDD:214543 3/44 (7%)
EGF_Lam 951..995 CDD:214543 16/44 (36%)
EGF_Lam 997..1042 CDD:238012 15/47 (32%)
Laminin_EGF 1044..1092 CDD:278482 21/48 (44%)
Laminin_EGF 1090..1147 CDD:278482 8/56 (14%)
LamB 1212..1340 CDD:214597 15/128 (12%)
Laminin_EGF 1397..1443 CDD:278482 7/45 (16%)
EGF_Lam 1446..1495 CDD:214543 13/58 (22%)
Laminin_I 1526..1780 CDD:283627 45/259 (17%)
zf-C4H2 1698..>1808 CDD:287156 24/115 (21%)
Tropomyosin_1 1892..2053 CDD:289488 31/138 (22%)
Laminin_II 1967..2100 CDD:283628 17/63 (27%)
Laminin_G_1 2103..2242 CDD:278483
LamG 2268..2425 CDD:238058
LamG 2452..2627 CDD:238058
Laminin_G_1 2750..2878 CDD:278483
LamG 2898..3050 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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