DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cdc14 and CDC14A

DIOPT Version :9

Sequence 1:	NP_001285721.1	Gene:	cdc14 / 34067	FlyBaseID:	FBgn0031952	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_201569.1	Gene:	CDC14A / 8556	HGNCID:	1718	Length:	623	Species:	Homo sapiens

Alignment Length:	791	Identity:	289/791 - (36%)
Similarity:	385/791 - (48%)	Gaps:	216/791 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LVCASEMQEDRLYFVAFKKNIKPKNTVNTHYFSVDEEFIYENFYNDFGPLNICMLYRYCMKLNTK 74
            |:.|.|..:|||||...:.  :||:||||||||:|||.:|||||.||||||:.|:||||.|||.|
Human     8 LIGACEFMKDRLYFATLRN--RPKSTVNTHYFSIDEELVYENFYADFGPLNLAMVYRYCCKLNKK 70

  Fly    75 LNAKCHANKKIVHYTSMNPAKRLNAAYLIGSYAIIYLNKTPQEAYRPLVAGEIPAYTRFCDASYG 139
            |.:...:.|||||||..:..||.|||:|||:||:|||.|||:||||.|::|..|.|..|.|||:|
Human    71 LKSYSLSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFG 135

  Fly   140 PSNFKISLLDCLNAVHKGLQAGFFNFNDFDAEEYEYFERVENGDFNWIVPQKFIAFCGPHQKSKT 204
            ...:.:::||||..:.||||.|||:|..||.:|||::|||||||||||||.||:||.|||.|||
Human   136 NCTYNLTILDCLQGIRKGLQHGFFDFETFDVDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSK- 199

  Fly   205 LPNGYPCHAPERYFSYFRDNNVTTVIRLNAKVYHASSFENAGFDHKDLFFIDGSTPSDAIMKKFL 269
            :.||||.||||.||.||:.:|||.|:|||.|:|.|..|.:|||:|.||||||||||||.|:::||
Human   200 IENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFL 264

  Fly   270 SICETTKGAIAVHCKAGLGRTGSLIGAYIMKHYGFTALEAIAWLRLCRPGSVIGHQQQWMEDKQS 334
            :|||.|:|||||||||||||||:||..|:||||.||..|.|||:|:|||||:||.||.::|:||:
Human   265 NICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQA 329

  Fly   335 WLWSEGERMRRRTSLPILQHTYGINSLELKKKLASAAADSTEHVDLLLTRVKGISQRVDTMHLND 399
            .||.:|:..|.:                ||.:.:|..:            :..|...:|.|.:..
Human   330 SLWVQGDIFRSK----------------LKNRPSSEGS------------INKILSGLDDMSIGG 366

  Fly   400 QDNLDAACTDQTDEELSEQLRLERDERALYQSVEDPNCNNSDDNDTDTISAPADPPPTSSYTIST 464
                          .||:...:||       ..||    |.:|:|
Human   367 --------------NLSKTQNMER-------FGED----NLEDDD-------------------- 386

  Fly   465 RRRKSPSGANKPTVIATSLRRLVNPNANRSGLSTASGVYPTPELASCTEKKLRKPSANVFEAARH 529

Human   387 ----------------------------------------------------------------- 386

  Fly   530 TIASTVRMTQTALEKKQAQTQGDKLNQIKALRRHHSRSVNVNSNSSEQESNVRHTRARSQPFRNN 594
                        :|.|...||||||..:|:.|:..:..    |.:...:....|.||.|||||.:
Human   387 ------------VEMKNGITQGDKLRALKSQRQPRTSP----SCAFRSDDTKGHPRAVSQPFRLS 435

  Fly   595 NNGVGG----NTAMAALKPTSSCLPTGTGTAALLANNLNNNNDCGIGTSGSSNNNHNNNNNNSNL 655
            ::..|.    .|:..||.|:::            |..:|.       ||.||.....:.:.||.|
Human   436 SSLQGSAVTLKTSKMALSPSAT------------AKRINR-------TSLSSGATVRSFSINSRL 481

  Fly   656 SNSLNNYNNNNNTTNNILASSGSSRTRSLALYSKRMELKHLRKAEQQQQQQVQQEQPLLPVEKQL 720
            ::||.|.|...:...|...||.|....:.:.::..:.               ...||       .
Human   482 ASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLN---------------GSSQP-------T 524

  Fly   721 LRQYATINESKIPVVSGGGGGAGSSATIPPTRGSAARTSHHHMTLR------GRSRIRYQRPNAG 779
            .|.|..:|.::....|...||..:|   ||...| |:|..|...||      ..|..|:    ..
Human   525 TRNYPELNNNQYNRSSNSNGGNLNS---PPGPHS-AKTEEHTTILRPSYTGLSSSSARF----LS 581

  Fly   780 ETAPAAAQTQP 790
            .:.|.:|||.|
Human   582 RSIPVSAQTPP 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdc14	NP_001285721.1	DSPn	19..156	CDD:291343	79/136 (58%)
		PTPc	217..331	CDD:304379	76/113 (67%)
		CDC14	<229..330	CDD:225297	69/100 (69%)
CDC14A	NP_201569.1	A	7..162		89/155 (57%)
		DSPn	17..152	CDD:291343	79/136 (58%)
		Linker	163..176		7/12 (58%)
		CDC14	175..329	CDD:225297	107/154 (69%)
		B	177..343		110/182 (60%)
		PTPc	187..326	CDD:304379	94/139 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..435		15/42 (36%)
		SOBP	<413..613	CDD:291927	55/229 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	487..560		20/98 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	176	1.000	Domainoid score	I3621
eggNOG	1	0.900	-	-		E2759_KOG1720
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	497	1.000	Inparanoid score	I1391
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001645
OrthoInspector	1	1.000	-	-		otm40353
orthoMCL	1	0.900	-	-		OOG6_100917
Panther	1	1.100	-	-	LDO	PTHR23339
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R450
SonicParanoid	1	1.000	-	-		X1202
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.850