DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cdc14 and CDC14B

DIOPT Version :9

Sequence 1:	NP_001285721.1	Gene:	cdc14 / 34067	FlyBaseID:	FBgn0031952	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_016870731.1	Gene:	CDC14B / 8555	HGNCID:	1719	Length:	520	Species:	Homo sapiens

Alignment Length:	511	Identity:	228/511 - (44%)
Similarity:	305/511 - (59%)	Gaps:	73/511 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DRLYFVAFKKNIKPKNTVNTHYFSVDEEFIYENFYNDFGPLNICMLYRYCMKLNTKLNAKCHANK 83
            |||.|.....  :||:..|.||||:|.|..|||||.||||||:.|:||||.|:|.||.:.....|
Human    54 DRLCFAILYS--RPKSASNVHYFSIDNELEYENFYADFGPLNLAMVYRYCCKINKKLKSITMLRK 116

  Fly    84 KIVHYTSMNPAKRLNAAYLIGSYAIIYLNKTPQEAYRPLVAGEIPAYTRFCDASYGPSNFKISLL 148
            ||||:|..:..|:.|||:|:|.|.:|||.:||:||||.|:.|| .:|..|.||:||..||.|:||
Human   117 KIVHFTGSDQRKQANAAFLVGCYMVIYLGRTPEEAYRILIFGE-TSYIPFRDAAYGSCNFYITLL 180

  Fly   149 DCLNAVHKGLQAGFFNFNDFDAEEYEYFERVENGDFNWIVPQKFIAFCGPHQKSKTLPNGYPCHA 213
            ||.:||.|.:|.||.|||.|:.:|||::|:.||||.|||:|.:||||||||.::: |.:||..|:
Human   181 DCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFIAFCGPHSRAR-LESGYHQHS 244

  Fly   214 PERYFSYFRDNNVTTVIRLNAKVYHASSFENAGFDHKDLFFIDGSTPSDAIMKKFLSICETTKGA 278
            ||.|..||:::||||:||||.::|.|..|.:|||||.||||.|||||:|||:|:||.|||..:||
Human   245 PETYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDICENAEGA 309

  Fly   279 IAVHCKAGLGRTGSLIGAYIMKHYGFTALEAIAWLRLCRPGSVIGHQQQWMEDKQSWLWSEGERM 343
            |||||||||||||:||..||||||..||.|.|||:|:||||||||.|||::..||:.||.||:..
Human   310 IAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGSVIGPQQQFLVMKQTNLWLEGDYF 374

  Fly   344 RRRTSLPILQHTYGINSLELKKKLASAAADSTEHVDLLLTRVKGISQRVDTMHLNDQDNLDAACT 408
            |::                ||      ..::.:|.......:.|    ||.:.:|..:|.|....
Human   375 RQK----------------LK------GQENGQHRAAFSKLLSG----VDDISINGVENQDQQEP 413

  Fly   409 D--QTDEELS-----EQLRLERDER-----------ALYQSVEDPNCNNSDDNDTDTISAPADPP 455
            :  ..|:|::     ::||..:..|           .|..||:  :|..|:.|    ||..|
Human   414 EPYSDDDEINGVTQGDRLRALKSRRQSKTNAIPLTVILQSSVQ--SCKTSEPN----ISGSA--- 469

  Fly   456 PTSSYTISTRRRKSPSGANKPTVIATSLRRLVNPNANRSGLSTASGVYPTPELASC 511
                   ...:|.:.|.:.|     :|::.||.....|    |.|.:...|..|||
Human   470 -------GITKRTTRSASRK-----SSVKSLVPQRKGR----TRSALQHVPLAASC 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdc14	NP_001285721.1	DSPn	19..156	CDD:291343	73/136 (54%)
		PTPc	217..331	CDD:304379	78/113 (69%)
		CDC14	<229..330	CDD:225297	71/100 (71%)
CDC14B	XP_016870731.1	CDC14_N	52..190	CDD:350495	74/138 (54%)
CDC14B	XP_016870731.1	CDC14_C	199..372	CDD:350349	110/173 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	176	1.000	Domainoid score	I3621
eggNOG	1	0.900	-	-		E2759_KOG1720
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	497	1.000	Inparanoid score	I1391
Isobase	1	0.950	-	0	Normalized mean entropy	S1763
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001645
OrthoInspector	1	1.000	-	-		otm40353
orthoMCL	1	0.900	-	-		OOG6_100917
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R450
SonicParanoid	1	1.000	-	-		X1202
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.700