DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cdc14 and Cdc14b

DIOPT Version :9

Sequence 1:	NP_001285721.1	Gene:	cdc14 / 34067	FlyBaseID:	FBgn0031952	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001101874.1	Gene:	Cdc14b / 361195	RGDID:	1311163	Length:	520	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	222/542 - (40%)
Similarity:	308/542 - (56%)	Gaps:	94/542 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DRLYFVAFKKNIKPKNTVNTHYFSVDEEFIYENFYNDFGPLNICMLYRYCMKLNTKLNAKCHANK 83
            |||.|.....  :||:..|.||||:|.|..|||||.||||||:.|:||||.|:|.||.:.....|
  Rat    54 DRLCFAILYS--RPKSASNEHYFSIDNELEYENFYADFGPLNLAMVYRYCCKINKKLKSITMLRK 116

  Fly    84 KIVHYTSMNPAKRLNAAYLIGSYAIIYLNKTPQEAYRPLVAGEIPAYTRFCDASYGPSNFKISLL 148
            ||:|:|..:..|:.|||:|||.|.:|||.:.|::|||.|:.|: .||..|.||:||..:|.|:||
  Rat   117 KIIHFTGTDQRKQANAAFLIGCYMVIYLGRAPEDAYRTLIFGD-TAYIPFRDAAYGSCSFYITLL 180

  Fly   149 DCLNAVHKGLQAGFFNFNDFDAEEYEYFERVENGDFNWIVPQKFIAFCGPHQKSKTLPNGYPCHA 213
            ||.:||.|.:|.||.|||.|:.:|||::|:.||||||||:|::|:||||||.:|: |.:||..|:
  Rat   181 DCFHAVKKAIQYGFLNFNSFNLDEYEHYEKAENGDFNWIIPERFLAFCGPHSRSR-LESGYHQHS 244

  Fly   214 PERYFSYFRDNNVTTVIRLNAKVYHASSFENAGFDHKDLFFIDGSTPSDAIMKKFLSICETTKGA 278
            ||.|..||:::||||:||||.::|.|..|.:|||||.||||.|||||::||:::||.|||..:||
  Rat   245 PETYIPYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFPDGSTPAEAIVQEFLDICENVEGA 309

  Fly   279 IAVHCKAGLGRTGSLIGAYIMKHYGFTALEAIAWLRLCRPGSVIGHQQQWMEDKQSWLWSEGERM 343
            |||||||||||||:|||.|:||||..||.|:|||||:||||||||.|||::..|||.||.||:..
  Rat   310 IAVHCKAGLGRTGTLIGCYLMKHYRMTAAESIAWLRICRPGSVIGPQQQFLVMKQSSLWLEGDYF 374

  Fly   344 RRRTSLPILQHTYGINSLELKKKLASAAADSTEHVDLLLTRVKGISQRVDTMHLNDQDNLDAACT 408
            |::                                  |..:..|..:...:.||:|.|::.....
  Rat   375 RQK----------------------------------LRGQENGALREAFSKHLSDVDDISINGL 405

  Fly   409 DQTDEELSEQLRLERDERALYQSVEDPNCNNSDDNDT------DTISAPADPPPTSSYTISTRRR 467
            :..|.:..|..                    |||::.      |.:.|           :.:||:
  Rat   406 ENQDSQEPEPY--------------------SDDDEVSGVTQGDRLRA-----------LKSRRQ 439

  Fly   468 KSPSGANKPTVIATSLRRLVNPNANRSGLS--------TASGVYPTPELASCTEKKLRKPSANVF 524
            ...:......::.:|::....|..|.||.:        :|||......||...|::.|
  Rat   440 PKTNAIPLTVILQSSVQSSKTPEPNLSGSAGITKRTTRSASGKSSLKSLAPWRERRRR------- 497

  Fly   525 EAARH----TIASTVRMTQTAL 542
            .|.:|    .:...:..|:|.|
  Rat   498 SALQHMPMLALCPAISRTKTVL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdc14	NP_001285721.1	DSPn	19..156	CDD:291343	70/136 (51%)
		PTPc	217..331	CDD:304379	77/113 (68%)
		CDC14	<229..330	CDD:225297	70/100 (70%)
Cdc14b	NP_001101874.1	DSPn	54..188	CDD:291343	70/136 (51%)
Cdc14b	NP_001101874.1	PTPc	246..360	CDD:304379	78/113 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3552
eggNOG	1	0.900	-	-		E2759_KOG1720
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	461	1.000	Inparanoid score	I1499
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001645
OrthoInspector	1	1.000	-	-		otm44483
orthoMCL	1	0.900	-	-		OOG6_100917
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1202
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.720