Protein Alignment r2d2 and TARBP2

DIOPT Version :10

• Sequence 1: NP_609152.1
• Gene: r2d2 / 34066
• FlyBaseID: FBgn0031951
• Length: 311
• Species: Drosophila melanogaster
• Sequence 2: NP_599150.1
• Gene: TARBP2 / 6895
• HGNCID: 11569
• Length: 366
• Species: Homo sapiens
• Alignment Length: 217
• Identity: 53/217 - (24%)
• Similarity: 80/217 - (36%)
• Gaps: 53/217 - (24%)

  Fly     4 KSAVSALQEFCARTQINLPTYSFIPGE----DGGYVCKVELLEIEALGNGRSKRDAKHLAASNIL 64
            |:.:|.|||:..|.. ..|.|..:..|    ...:..:|.:.:....|.|.||:.|||.||...|
Human    29 KTPISLLQEYGTRIG-KTPVYDLLKAEGQAHQPNFTFRVTVGDTSCTGQGPSKKAAKHKAAEVAL 92

  Fly    65 RKIQ----LLPGIHGLMKDSTVGDLDEELTN------------------LNR------------- 94
            :.::    |.|   .|...|:...||..|..                  |.|
Human    93 KHLKGGSMLEP---ALEDSSSFSPLDSSLPEDIPVFTAAAAATPVPSVVLTRSPPMELQPPVSPQ 154

  Fly    95 ----DMVKELRDYCVRREMPLPCIEVVQQSGTPSAPEFVACCSVASIVRYGKSDKKKDARQRAAI 155
                :.|..|::..|::...||...|.|:||.....||...|.|...:..|....||.|::.||.
Human   155 QSECNPVGALQELVVQKGWRLPEYTVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAAA 219

  Fly   156 EML------ALISSNSDNLRPD 171
            :||      .|.:.:.:.:.||
Human   220 KMLLRVHTVPLDARDGNEVEPD 241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
r2d2	NP_609152.1	DSRM	6..68	CDD:214634	19/65 (29%)
		DSRM_SF	102..158	CDD:380679	17/55 (31%)
TARBP2	NP_599150.1	Sufficient for interaction with PRKRA	22..105		22/79 (28%)
		DSRM_TARBP2_rpt1	27..98	CDD:380719	20/69 (29%)
		Sufficient for interaction with PRKRA	152..234		22/81 (27%)
		DSRM_TARBP2_rpt2	159..225	CDD:380681	21/65 (32%)
		Sufficient for interaction with DICER1	228..366		3/14 (21%)
		Sufficient for interaction with PRKRA	287..366
		DSRM_TARBP2_rpt3	292..363	CDD:380722