DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment r2d2 and Prkra

DIOPT Version :9

Sequence 1:	NP_001162903.1	Gene:	r2d2 / 34066	FlyBaseID:	FBgn0031951	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_001019951.1	Gene:	Prkra / 311130	RGDID:	1306707	Length:	313	Species:	Rattus norvegicus

Alignment Length:	182	Identity:	46/182 - (25%)
Similarity:	80/182 - (43%)	Gaps:	30/182 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KSAVSALQEF-----------CART--QINLPTYSFIPGEDGGYVCKVELLEIEALGNGRSKRDA 55
            |:.:..|.|:           |.|:  |:::||::|          :|.:.:|...|.|.||:.|
  Rat    33 KTPIQVLHEYGTKTKNIPVYECERSDVQVHVPTFTF----------RVTVGDITCTGEGTSKKLA 87

  Fly    56 KHLAASNILRKIQLLPGIHGLMKDSTVGDLDEELTN-LNRDMVKELRDYCVRREMPLPCIEVVQQ 119
            ||.||...:..::....|...:.|..:.|..::..| ||  .:..|::..:.....||...:.|:
  Rat    88 KHRAAEAAINILKANASICFAVPDPLMPDPSKQPKNQLN--PIGSLQELAIHHGWRLPEYTLSQE 150

  Fly   120 SGTPSAPEFVACCSVASIVRYGKSDKKKDARQRAAIEMLALISSNSDNLRPD 171
            .|.....|:...|.:.|.:..||...||.|::.||.:.||..|    |:.|:
  Rat   151 GGPAHKREYTTICRLESFMETGKGASKKQAKRNAAEKFLAKFS----NISPE 198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
r2d2	NP_001162903.1	DSRM	6..67	CDD:238007	19/73 (26%)
r2d2	NP_001162903.1	DSRM	95..158	CDD:238007	15/62 (24%)
Prkra	NP_001019951.1	Sufficient for self-association and interaction with TARBP2. /evidence=ECO:0000250	1..103		20/79 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		DSRM	35..100	CDD:214634	19/74 (26%)
		Sufficient for self-association and interaction with TARBP2. /evidence=ECO:0000250	102..195		24/98 (24%)
		DSRM	126..192	CDD:238007	18/67 (27%)
		Sufficient for self-association and interaction with TARBP2. /evidence=ECO:0000250	195..313		1/4 (25%)
		DSRM	241..307	CDD:214634
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3732
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1093169at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46205
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920