DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herp and Herpud1

DIOPT Version :9

Sequence 1:	NP_609151.2	Gene:	Herp / 34065	FlyBaseID:	FBgn0031950	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	XP_006255195.3	Gene:	Herpud1 / 85430	RGDID:	620818	Length:	488	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	135/492 - (27%)
Similarity:	196/492 - (39%)	Gaps:	150/492 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AATRQKNPETS-VRLLIKSSNQQYEDLNVDSDLCWTVQRLKKHLSLIYPGKPLIQDQKLIYSGKL 81
            ||..:..|:.. |.||:||.||::.||.:..|..|:|.|||.|||.:||.:|..:||:|||||||
  Rat    96 AADMEPEPQPEPVTLLVKSPNQRHRDLELSGDRGWSVSRLKAHLSRVYPERPRPEDQRLIYSGKL 160

  Fly    82 LDDSQKISEVIRSYKDVYQQHHIFHLVCASKQVIRPAAKAPTVPQKDAVPA-GPEVTGNA----- 140
            |.|.|.:.:::..     ::.|:.||||.    :|..:|.|....|.|... .|:.|..|
  Rat   161 LLDHQCLQDLLPK-----EKRHVLHLVCN----VRSPSKKPEASTKGAESTEQPDNTSQAQYPGD 216

  Fly   141 ---NELRQRHAPHQ---------------QQAQQGNAGPHVTGDIGLANPWTHFWQQSQGAAPAA 187
               :.||:|.....               ||..|| .||      |.:...|:.|.|.
  Rat   217 SSSDGLREREVLRNLPPSGWENVSRPEAVQQTFQG-LGP------GFSGYTTYGWLQL------- 267

  Fly   188 NASASPHALFQQQALIYNAWMQQAYAQ--YMQQLTLRSTLPGSNQSGLPPPTQPLLPSVPLIA-- 248
                              :|.||.||:  |||.|...:.      ||...|| |....:|:::
  Rat   268 ------------------SWFQQIYARQYYMQYLAATAA------SGAFGPT-PSAQEIPVVSTP 307

  Fly   249 -----GRNFGEVQQVAGAAAAPAAQVPADPQINGAPQN-----RNFPNIQEEPEMH-DWLDSFFS 302
                 ...|....|.|...|  |||...:|   ||.||     :..|.::|:.|:: ||||..:|
  Rat   308 APAPIHNQFPAENQPANQNA--AAQAVVNP---GANQNLRMNAQGGPLVEEDDEINRDWLDWTYS 367

  Fly   303 FTRLAIFVTVLYFNSSALRCLLVVLIAGAIYLYHIGVLRRRRERNNNNINRNNNAGDAAAFAAVQ 367
            ....::|:::|||.||..|.|:|:.....:||:|:|....|:                      :
  Rat   368 AATFSVFLSILYFYSSLSRFLMVMGATVVMYLHHVGWFPFRQ----------------------R 410

  Fly   368 QIQRMMD------AAVQRENNDPQAANEPGAVPAAGPAAAGEQDAIDAPPAGAPVAPASAANPEP 426
            .:|...|      ||.|..||:.|...:|                             ...:|..
  Rat   411 PVQNFPDDGPPQEAANQDPNNNLQGGLDP-----------------------------EMEDPNR 446

  Fly   427 TDVSAEAVEPPNANNSVISVVRTFVITFFTSLLPEAP 463
            ..|..|.::|.:.:.|.:|.......|||.|||||.|
  Rat   447 LPVGREVLDPEHTSPSFMSTAWLVFKTFFASLLPEGP 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herp	NP_609151.2	Herp_N	28..110	CDD:176385	37/82 (45%)
Herp	NP_609151.2	UBQ	29..110	CDD:214563	37/80 (46%)
Herpud1	XP_006255195.3	Ubl_HERP1	107..183	CDD:340638	36/80 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351069
Domainoid	1	1.000	66	1.000	Domainoid score	I9698
eggNOG	1	0.900	-	-		E1_KOG4583
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I4486
OMA	1	1.010	-	-		QHG45891
OrthoDB	1	1.010	-	-		D1251727at2759
OrthoFinder	1	1.000	-	-		FOG0003073
OrthoInspector	1	1.000	-	-		otm46173
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12943
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2439
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.870