DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herp and Herpud2

DIOPT Version :9

Sequence 1:	NP_609151.2	Gene:	Herp / 34065	FlyBaseID:	FBgn0031950	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_065611.1	Gene:	Herpud2 / 80517	MGIID:	1915393	Length:	404	Species:	Mus musculus

Alignment Length:	490	Identity:	140/490 - (28%)
Similarity:	205/490 - (41%)	Gaps:	141/490 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QKNPETSVRLLIKSSNQQYEDLNVDSDLCWTVQRLKKHLSLIYPGKPLIQDQKLIYSGKLLDDSQ 86
            |...|..|.|:||:.||:|.|..:...|.|||.:||.|||.:||.|||.:||:|:|||:||.|..
Mouse     3 QSGMEIPVTLIIKAPNQKYSDQTISCFLNWTVGKLKTHLSNVYPSKPLTKDQRLVYSGRLLPDHL 67

  Fly    87 KISEVIRSYKDVYQQHHIFHLVCASKQVIRPAAKAPTVPQ---------------------KDAV 130
            ::.:::|.    ..::|:.||||||:       ..|:.|:                     .|:.
Mouse    68 QLKDILRK----QDEYHMVHLVCASR-------SPPSSPKSSTDRGSHEALASSTSSNSDHSDST 121

  Fly   131 PAGPE------VTGNANELRQRHAPHQQQAQQGNAGPH-----VTGDIGLANPWTHFWQQSQGAA 184
            ...|.      |||::..||||..   .|||...|..|     :.|::....|       .||..
Mouse   122 TPSPSQESLSLVTGSSEGLRQRTL---SQAQTDPAQSHQFPYVIQGNVDHQFP-------GQGVP 176

  Fly   185 PA--ANASASPHALFQQQALIYNAWMQQAYAQ--YMQ-QLTLRSTLPGSNQSGLPPPTQPLLPSV 244
            ||  ...:.||         :...|.||.||.  ||| |..:.:....|..|.....:.||
Mouse   177 PAFPVYPALSP---------LQMLWWQQMYAHQYYMQYQAAVSAQATSSAGSAQRAASSPL---- 228

  Fly   245 PLIAGRNFGEVQQVAGAAAAPAAQVPADPQINGAPQNRNF-------PNIQEEPEMHDWLDSFFS 302
                     .:..|.|....||..:.|  |.|| |.|.|.       |.:.||....||||..::
Mouse   229 ---------NLAHVPGEEPPPAPNLVA--QENG-PMNENVQMNAQGGPVLNEEDLNRDWLDWVYT 281

  Fly   303 FTRLAIFVTVLYFNSSALRCLLVVLIAGAIYLYHIGVLRRRRERNN----NNINRNNNAGDAAAF 363
            |:|.|:.::::||.||..|.::|:.....:||:..|....|:|...    ||::.||: |..|..
Mouse   282 FSRAAVLLSIVYFYSSFSRFIMVMGAMLLVYLHQAGWFPFRQEGGQQQAPNNVDANND-GHNANN 345

  Fly   364 AAVQQIQRMMDAAVQRENNDPQAANEPGAVPAAGPAAAGEQDAIDAPPAGAPVAPASAANPEPTD 428
            ..:::::|:||..::.|:.:.                |||    ||..|..|...|||
Mouse   346 LELEEMERLMDDGLEDESGED----------------AGE----DASAAQRPGLMASA------- 383

  Fly   429 VSAEAVEPPNANNSVISVVRTFVITFFTSLLPEAP 463
                               .:|:.||||||:||.|
Mouse   384 -------------------WSFITTFFTSLIPEGP 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herp	NP_609151.2	Herp_N	28..110	CDD:176385	36/81 (44%)
Herp	NP_609151.2	UBQ	29..110	CDD:214563	36/80 (45%)
Herpud2	NP_065611.1	Herp_N	9..87	CDD:176385	36/81 (44%)
		UBQ	10..87	CDD:214563	36/80 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	86..153		17/76 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847516
Domainoid	1	1.000	73	1.000	Domainoid score	I9203
eggNOG	1	0.900	-	-		E1_KOG4583
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10756
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4472
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45891
OrthoDB	1	1.010	-	-		D1251727at2759
OrthoFinder	1	1.000	-	-		FOG0003073
OrthoInspector	1	1.000	-	-		otm44080
orthoMCL	1	0.900	-	-		OOG6_108340
Panther	1	1.100	-	-	O	PTHR12943
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4127
SonicParanoid	1	1.000	-	-		X2439
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800