DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herp and herpud2

DIOPT Version :9

Sequence 1:	NP_609151.2	Gene:	Herp / 34065	FlyBaseID:	FBgn0031950	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_001016818.1	Gene:	herpud2 / 549572	XenbaseID:	XB-GENE-5806725	Length:	399	Species:	Xenopus tropicalis

Alignment Length:	472	Identity:	124/472 - (26%)
Similarity:	204/472 - (43%)	Gaps:	124/472 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VRLLIKSSNQQYEDLNVDSDLCWTVQRLKKHLSLIYPGKPLIQDQKLIYSGKLLDDSQKISEVIR 93
            |.|:||:.||:|:|..::..|.|||::||.|||.:||.|||.:||:|:||||||.|...:.:|:|
Frog    10 VTLVIKAPNQKYDDQTINCFLDWTVEKLKSHLSKVYPSKPLAKDQRLVYSGKLLLDHLLLKDVLR 74

  Fly    94 SYKDVYQQHHIFHLVCASKQVIRPAAKAPTVPQKDAVPA-----GPEVTGNAN--ELRQRHAPHQ 151
            .    ..::|:.||||||:  ..|::...:...|....|     ..|.:|:|:  .:||..:...
Frog    75 K----QDEYHMVHLVCASR--TPPSSPKASTSNKSMGTASISRSSSEHSGSASPASIRQDTSSTY 133

  Fly   152 QQAQQGNAGPH-----VTGDIGLANPWTHFWQQSQGAAPAANASASPHALFQQQALIYNAWMQQA 211
            ...:.|::..|     :..::..::|:::..|:.....|...||.|....:.....:...|.||.
Frog   134 PDPRPGDSIRHRHTSLMYNNLVHSHPFSYLRQEYALNPPPGQASPSTFPAYSAFTPLQMMWWQQL 198

  Fly   212 YA-QY--MQQLTLRSTLPGSNQSGLPPPTQPLLPSVPLIAGRNFGEVQQVAGAAAAPAAQVPADP 273
            || ||  ..|.|..:..|.:.::..|.| :|::.|                   .:|....|..|
Frog   199 YARQYYIYSQATASNQSPSNGENAQPVP-RPVINS-------------------ESPPPNPPRAP 243

  Fly   274 QINGAPQNRNFPNIQ----------EEPEMHDWLDSFFSFTRLAIFVTVLYFNSSALRCLLVVLI 328
            . |.||:..  ||||          ||....||||..::.:|.||.::::||.||..|.::|:..
Frog   244 P-NVAPEMN--PNIQMNAQGGPVMNEEDINRDWLDWMYTVSRAAILLSIVYFYSSFSRFVMVMGA 305

  Fly   329 AGAIYLYHIG---VLR---------RRRERNNNNINRNNNAGDAAAFAAVQQIQRMMDAAVQREN 381
            ...:|::..|   :|:         ...|.|.:::|.|:          .|:::..||..:|.|:
Frog   306 MILVYMHQAGWFPLLQDEGQQHARDNAAEVNPDHVNNND----------PQELEHRMDEGLQEEH 360

  Fly   382 NDPQAANEPGAVPAAGPAAAGEQDAIDAPPAGAPVAPASAANPEPTDVSAEAVEPPNANNSVISV 446
            |:                           .||..|.                     |...|::.
Frog   361 NN---------------------------NAGGNVV---------------------ARRGVLAS 377

  Fly   447 VRTFVITFFTSLLPEAP 463
            ..:|:.||||||:||.|
Frog   378 AWSFITTFFTSLIPEGP 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herp	NP_609151.2	Herp_N	28..110	CDD:176385	38/80 (48%)
Herp	NP_609151.2	UBQ	29..110	CDD:214563	38/80 (48%)
herpud2	NP_001016818.1	Herp_N	9..87	CDD:176385	38/80 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	88..144		10/57 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..250		11/59 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9776
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10756
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4519
OMA	1	1.010	-	-		QHG45891
OrthoDB	1	1.010	-	-		D1251727at2759
OrthoFinder	1	1.000	-	-		FOG0003073
OrthoInspector	1	1.000	-	-		oto105042
Panther	1	1.100	-	-	O	PTHR12943
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4127
SonicParanoid	1	1.000	-	-		X2439
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110