DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herp and tag-353

DIOPT Version :9

Sequence 1:	NP_609151.2	Gene:	Herp / 34065	FlyBaseID:	FBgn0031950	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_492722.2	Gene:	tag-353 / 172916	WormBaseID:	WBGene00009112	Length:	361	Species:	Caenorhabditis elegans

Alignment Length:	461	Identity:	101/461 - (21%)
Similarity:	154/461 - (33%)	Gaps:	135/461 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QKNPETSVRLLIKSSNQQYEDLNVDSDLCWTVQRLKKHLSLIYPGKPLIQDQKLIYSGKLLDDSQ 86
            |.:|...|.|.|:.:.|...||.......||::.:|:|:.......|.:..|:||:||..|::.|
Worm    11 QVSPSDDVELTIRQAYQAESDLKFSCPTSWTIKEVKEHVKNCLNNHPEVVTQRLIFSGASLNNEQ 75

  Fly    87 KISEVIRSYKDVYQQHHIFHLVCASKQVIRPAAKAPTVPQKDAVPAGPEVTGNANELRQRHAPHQ 151
            .:::|:|....|..:...|||:.|.             |.:...|..        ::|:|:..:.
Worm    76 VLADVLRERNHVAGEQIFFHLMIAQ-------------PYQQTTPTA--------DVRRRNVNNT 119

  Fly   152 QQAQQGNAGPHVTGDIGLANPWTHFWQQSQGAAPAANASASPHALFQQQALIYNAWMQQAYAQYM 216
            ...|...:|..:.........|..:|......:|  .|..|.|              |:..|.|
Worm   120 ASNQNSASGSALNEYAQNMVAWQQYWNAYNQLSP--EAQVSEH--------------QRLMAHY- 167

  Fly   217 QQLTLRSTLPGSNQSGLPPPTQPLLPSVPLIAGRNFGEVQQVAGAAAAPAAQVPADPQIN----- 276
              .|..||.|                                    |||..||||:.|:.
Worm   168 --YTYASTTP------------------------------------AAPIYQVPANQQLQQNAVA 194

  Fly   277 --------GAPQNRNFPNIQEEPEMH--DWLDSFFSFTRLAIFVTVLYFNSSALRCLLVVLIAGA 331
                    .||...|.......|...  |.|:..:...::.:..:.:...||..|..||  :..|
Worm   195 WRIRVQGVAAPARANGNQGAAAPRQGRVDILEVGYRIFKVVLLFSAILLYSSFERFALV--LCSA 257

  Fly   332 IYLYHIGVLRRRRERNNNNINRNNNAGDAAAFAAVQQIQRMMDAAVQRENNDPQAANEPGAVPAA 396
            :::|.| .|||...||.                  .|.|....||.|..|.:|...|...
Worm   258 LFIYFI-QLRRNHARNR------------------VQAQAAAAAAQQANNQEPHVNNNNN----- 298

  Fly   397 GPAAAGEQDAIDAPPAGAPVAPASAANPEPTDVSAEAVEP----PNANNSVISVVRTFVITFFTS 457
                 ||.|..:..|......||::..|         |||    |......|:.:.:||.:||.|
Worm   299 -----GENDGDNTAPTTEGETPATSDAP---------VEPPAPQPTGMQVFIATLYSFVTSFFAS 349

  Fly   458 LLPEAP 463
            |:|:.|
Worm   350 LVPDHP 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herp	NP_609151.2	Herp_N	28..110	CDD:176385	24/81 (30%)
Herp	NP_609151.2	UBQ	29..110	CDD:214563	24/80 (30%)
tag-353	NP_492722.2	Ubiquitin_like_fold	18..97	CDD:391949	23/78 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165292
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4583
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	73	1.000	Inparanoid score	I3887
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45891
OrthoDB	1	1.010	-	-		D1251727at2759
OrthoFinder	1	1.000	-	-		FOG0003073
OrthoInspector	1	1.000	-	-		oto20061
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12943
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4127
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.900