DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LKRSDH and AT4G33150

DIOPT Version :9

Sequence 1:	NP_001285719.1	Gene:	LKRSDH / 34064	FlyBaseID:	FBgn0286198	Length:	928	Species:	Drosophila melanogaster
Sequence 2:	NP_001328161.1	Gene:	AT4G33150 / 829452	AraportID:	AT4G33150	Length:	1064	Species:	Arabidopsis thaliana

Alignment Length:	1079	Identity:	356/1079 - (32%)
Similarity:	547/1079 - (50%)	Gaps:	192/1079 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 HPFTRQRHSRVIAIRREDQSVWERRAPFGPTHVQKLV---KQNV---KVIVQPSNRRAYPMQAYM 71
            |...::..:.|:.|..|..:.||||.|..|:|..:|:   |...   :::||||.:|.:....|.
plant     6 HEEEKKLGNGVVGILAETVNKWERRTPLTPSHCARLLHGGKDRTGISRIVVQPSAKRIHHDALYE 70

  Fly    72 QAGAHIQEDISDASVIFGVKQVPIDALIPGKTYCFFSHTIKAQESNMPLLDAILEKKIRLIDYER 136
            ..|..|.:|:||..:|.|:||..::.::|.:.|.|||||.|||:.||||||.||.:::.|.|||.
plant    71 DVGCEISDDLSDCGLILGIKQPELEMILPERAYAFFSHTHKAQKENMPLLDKILSERVTLCDYEL 135

  Fly   137 IIDERGARQVAFGKYAGVAGMVNILHGIGLRLLALGHHTPFMHIGPAHNYRNSSMARQAIRDCGY 201
            |:.:.|.|.:|||||||.||:|:.|||:|.|.|:||:.|||:.:|.::.|.:.:.|:.|:...|.
plant   136 IVGDHGKRLLAFGKYAGRAGLVDFLHGLGQRYLSLGYSTPFLSLGASYMYSSLAAAKAAVISVGE 200

  Fly   202 EISLGMMPKSIGPLTFVFTGSGNVSQGAQEVFSELPIEYVPPEML-------RKVAEHGNQNK-- 257
            ||:...:|..|.||.|||||:||||.||||:|..||..:|.|..|       :.::::|...|
plant   201 EIASQGLPLGICPLVFVFTGTGNVSLGAQEIFKLLPHTFVEPSKLPELFVKDKGISQNGISTKRV 265

  Fly   258 --LYGCEVSRSDHLERRE-GGGFDAKEYDEFPERYISTFSTKIAPYASVIVNGIYWAVGSPKLIS 319
              :|||.::..|.:|.:: ...||..:|...||.|...|..||:||.||:||.:||....|.|:|
plant   266 YQVYGCIITSQDMVEHKDPSKSFDKADYYAHPEHYNPVFHEKISPYTSVLVNCMYWEKRFPCLLS 330

  Fly   320 IPDAKNLLRPANTPWLPTSKGSPALPHRMLAICDISADPGGSIEFMNECTTIDTPFCLYDADRNK 384
            ....::|          |.||.|     ::.||||:.|.||||||:|..|.||:||..::...|.
plant   331 TKQLQDL----------TKKGLP-----LVGICDITCDIGGSIEFVNRATLIDSPFFRFNPSNNS 380

  Fly   385 DTKSFKGPGVLVCSIDNMPTQLPRESTDLFGELLAPHVHDIIKSDAKKPLAEENFSYPIQSAIIA 449
            ......|.|||..::|.:||:..:|::..||::|:..|..:........|...     ::.|.|:
plant   381 YYDDMDGDGVLCMAVDILPTEFAKEASQHFGDILSGFVGSLASMTEISDLPAH-----LKRACIS 440

  Fly   450 SNGQLTEGFQYIQELRES----------------------------------------------- 467
            ..|:||..::||..:|:|
plant   441 YRGELTSLYEYIPRMRKSNPEEAQDNIIANGVSSQRTFNILVSLSGHLFDKFLINEALDMIEAAG 505

  Fly   468 -----------QS---------------------------------------HRSRHK------- 475
                       ||                                       ||..:|
plant   506 GSFHLAKCELGQSADAESYSELEVGADDKRVLDQIIDSLTRLANPNEDYISPHREANKISLKIGK 570

  Fly   476 ------MEGSSESDKK--VLVLGAGMVSAPLVEWL--------------------HREKDVSITV 512
                  ::...|..||  ||:||||.|..|..::|                    ..:.||.:.|
plant   571 VQQENEIKEKPEMTKKSGVLILGAGRVCRPAADFLASVRTISSQQWYKTYFGADSEEKTDVHVIV 635

  Fly   513 CSQVKEEADRLAQQYAGVDSVYLDVNESTGHLQELCGRADVVVSLLPYSLHGMVARYCVAEGTHM 577
            .|...::|....:..:.|::|.|||::|.. |.:...:.|||:||||.|.|.:||:.|:....|:
plant   636 ASLYLKDAKETVEGISDVEAVRLDVSDSES-LLKYVSQVDVVLSLLPASCHAVVAKTCIELKKHL 699

  Fly   578 VTASYLNDEISGLHEEAKAKGVTIMNEVGLDPGIDHLLALECIHEVQDKGAVVESFVSYCGGLPA 642
            |||||::||.|.|||:||:.|:||:.|:||||||||::|::.|::...|...|:||.|||||||:
plant   700 VTASYVDDETSMLHEKAKSAGITILGEMGLDPGIDHMMAMKMINDAHIKKGKVKSFTSYCGGLPS 764

  Fly   643 PEHSNNALRYKFSWSPRGVLLNTLSAAKYLSQGQIVEISGGGELMSSPR-SLDFLPGFALEGFPN 706
            |..:||.|.|||||:|.|.:....:.|||.|.|.|:.:.|.....|:.| .:..||.||||.|||
plant   765 PAAANNPLAYKFSWNPAGAIRAGQNPAKYKSNGDIIHVDGKNLYDSAARFRVPNLPAFALECFPN 829

  Fly   707 RDSTKYGNLYGLGRDVHTLLRGTIRYKGFSESIKPMQLLGLIDPEPHALLHPSGPDVTWRQLVIH 771
            |||..||..||:..:..|:.|||:||:|||..:..:..||..|.|.:.:| .:|..:|:..|:.:
plant   830 RDSLVYGEHYGIESEATTIFRGTLRYEGFSMIMATLSKLGFFDSEANQVL-STGKRITFGALLSN 893

  Fly   772 LMGMSDSTIFYENL--KQKLTERI-----------GDVDGIESLGLLDDTPVVKL-NTPLDTLSH 822
            ::. .|:....|.|  ::::::||           .....|..||..::..|..| .:..|...:
plant   894 ILN-KDADNESEPLAGEEEISKRIIKLGHSKETAAKAAKTIVFLGFNEEREVPSLCKSVFDATCY 957

  Fly   823 YLSKRLAFERDERDLVVLRHEVGIRWPDGRR-EERGINFVVYG---QPQGHSAMAMTVGKPAAIA 883
            .:.::||:..:|:|:|:|.|||.:.:.:.:| |:.....:.:|   ..|..:|||.|||.||||.
plant   958 LMEEKLAYSGNEQDMVLLHHEVEVEFLESKRIEKHTATLLEFGDIKNGQTTTAMAKTVGIPAAIG 1022

  Fly   884 AKMILDGEIQERGVLLPFTPDIYRPMLQRLRSEGLTATE 922
            |.::::.:|:.||||.|...::|.|.|..|::.|:...|
plant  1023 ALLLIEDKIKTRGVLRPLEAEVYLPALDILQAYGIKLME 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LKRSDH	NP_001285719.1	PLN02819	23..922	CDD:215439	354/1067 (33%)
		LKR_SDH_like	23..465	CDD:240665	173/459 (38%)
		Sacchrp_dh_NADP	486..602	CDD:281434	49/135 (36%)
		Sacchrp_dh_C	606..917	CDD:293259	119/329 (36%)
AT4G33150	NP_001328161.1	PLN02819	10..1064	CDD:215439	355/1075 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	196	1.000	Domainoid score	I905
eggNOG	1	0.900	-	-		E1_COG1748
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4212
Inparanoid	1	1.050	589	1.000	Inparanoid score	I230
OMA	1	1.010	-	-		QHG55211
OrthoDB	1	1.010	-	-		D498994at2759
OrthoFinder	1	1.000	-	-		FOG0004455
OrthoInspector	1	1.000	-	-		oto4170
orthoMCL	1	0.900	-	-		OOG6_101775
Panther	1	1.100	-	-	LDO	PTHR11133
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3157
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840