DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LKRSDH and aass

DIOPT Version :9

Sequence 1:	NP_001285719.1	Gene:	LKRSDH / 34064	FlyBaseID:	FBgn0286198	Length:	928	Species:	Drosophila melanogaster
Sequence 2:	NP_001167456.1	Gene:	aass / 556229	ZFINID:	ZDB-GENE-061220-8	Length:	935	Species:	Danio rerio

Alignment Length:	906	Identity:	480/906 - (52%)
Similarity:	646/906 - (71%)	Gaps:	10/906 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RQRHSRVIAIRREDQSVWERRAPFGPTHVQKLVKQNVKVIVQPSNRRAYPMQAYMQAGAHIQEDI 81
            :|.|..||||||||.:|||||||..|.||:::.....||:||||||||...:.|.:|||.|||||
Zfish    26 QQNHKSVIAIRREDVNVWERRAPLAPRHVREITAAGHKVLVQPSNRRAIHDRYYEKAGAVIQEDI 90

  Fly    82 SDASVIFGVKQVPIDALIPGKTYCFFSHTIKAQESNMPLLDAILEKKIRLIDYERIIDERGARQV 146
            |:||:|.|||:.|.:.:.|.|||.||||||||||:||.|||.:|:|::||||||:::|..|.|.|
Zfish    91 SEASLIIGVKRPPEEKVYPRKTYAFFSHTIKAQEANMGLLDDLLKKEVRLIDYEKMVDPNGYRIV 155

  Fly   147 AFGKYAGVAGMVNILHGIGLRLLALGHHTPFMHIGPAHNYRNSSMARQAIRDCGYEISLGMMPKS 211
            |||::||||||:|||||:|||.|||||||||||||.||||||.|.|.||:||||||||||:||||
Zfish   156 AFGQWAGVAGMINILHGLGLRFLALGHHTPFMHIGMAHNYRNVSQAIQAVRDCGYEISLGLMPKS 220

  Fly   212 IGPLTFVFTGSGNVSQGAQEVFSELPIEYVPPEMLRKVAEHGNQNKLYGCEVSRSDHLERREGGG 276
            ||||||||||:||||:|||::|:|||.|:|.|..|::|:..|:..|:|...:||..||.||..|.
Zfish   221 IGPLTFVFTGTGNVSKGAQDIFNELPCEFVEPHELKEVSLSGDLTKVYATVISRHHHLMRRSDGL 285

  Fly   277 FDAKEYDEFPERYISTFSTKIAPYASVIVNGIYWAVGSPKLISIPDAKNLLRPANTPWLPTSKGS 341
            :|..||:..||.|.|.|...:|||.:.::|||||...:|:|:...||:.|:||..|.......|.
Zfish   286 YDPLEYENHPELYTSHFRDTVAPYTTCLINGIYWDPHTPRLLRRLDAQRLIRPVVTTSSSADYGC 350

  Fly   342 PALPHRMLAICDISADPGGSIEFMNECTTIDTPFCLYDADRNKDTKSFKGPGVLVCSIDNMPTQL 406
            |||||:.|||||||||.|||||||.|||||:.|||:|||:::.|..|.:|.|:|:|||||:|.||
Zfish   351 PALPHKFLAICDISADTGGSIEFMTECTTIEKPFCMYDANQHIDHDSVEGNGILMCSIDNLPAQL 415

  Fly   407 PRESTDLFGELLAPHVHDIIKSDAKKPLAEENFSYPIQSAIIASNGQLTEGFQYIQELRESQSHR 471
            |.|:|:.||:.|.|:|.:::.|||.|||.||:||..::.|:|.|||:||..|:|||:|||.:...
Zfish   416 PIEATEYFGDRLFPYVMEMLPSDATKPLEEEDFSPQVRDAVITSNGKLTPKFEYIQKLRERRESE 480

  Fly   472 SRHKMEGSSESDKKVLVLGAGMVSAPLVEWLHREKDVSITVCSQVKEEADRLAQQYAGVDSVYLD 536
            ...|..|.    |:||:||||.||.|::|:|.|:....:||.|.:..:|:.:|.:|....:|.||
Zfish   481 QILKKGGM----KRVLLLGAGYVSGPVIEYLTRDAGTQVTVASNLLNQAEEMATRYPNTIAVMLD 541

  Fly   537 VNESTGHLQELCGRADVVVSLLPYSLHGMVARYCVAEGTHMVTASYLNDEISGLHEEAKAKGVTI 601
            :....|||:.|....|:|:|:||||.|..||::|:....:|||||||:..:..|.:.|:..|:||
Zfish   542 ITSQEGHLESLIKDHDIVISMLPYSFHPQVAKHCIKLKVNMVTASYLSPAMKELQKSAEDAGITI 606

  Fly   602 MNEVGLDPGIDHLLALECIHEVQDKGAVVESFVSYCGGLPAPEHSNNALRYKFSWSPRGVLLNTL 666
            :||:||||||||:||:|||.:.:..|..|||:.|:||||||||.|:|.|||||||||.||||||:
Zfish   607 VNEMGLDPGIDHMLAMECIDQAKADGCTVESYSSFCGGLPAPECSDNPLRYKFSWSPYGVLLNTI 671

  Fly   667 SAAKYLSQGQIVEISGGGELMSSPRSLDFLPGFALEGFPNRDSTKYGNLYGLGRDVHTLLRGTIR 731
            |.|.||...|||.:..||.|:...:.:||:|||.||||||||||||...||: ...|||:|||:|
Zfish   672 SPAIYLKDNQIVSVPPGGALLDVTKEMDFMPGFNLEGFPNRDSTKYAEPYGI-ESAHTLIRGTLR 735

  Fly   732 YKGFSESIKPMQLLGLIDPEPHALLHPSGPDVTWRQLVIHLMGMSDSTIFYENLKQKLTERIGDV 796
            ::|||.::.....||||:.||..||..:...|:|::|:...:|:| :|:.....:..:.|:||..
Zfish   736 FRGFSSAMSGFVKLGLINTEPCPLLDHTASPVSWKELLCKQIGLS-ATVSNSVFEDAVYEKIGKD 799

  Fly   797 D----GIESLGLLDDTPVVKLNTPLDTLSHYLSKRLAFERDERDLVVLRHEVGIRWPDGRREERG 857
            |    .::.||||.:.||....|.|..::.:|..:|:|::.|||::::|::||||.|.|..|.:.
Zfish   800 DFRMQSLKWLGLLGEEPVPHAETILAAVAKHLEAKLSFDKGERDMIIMRNDVGIRHPTGELETKH 864

  Fly   858 INFVVYGQPQGHSAMAMTVGKPAAIAAKMILDGEIQERGVLLPFTPDIYRPMLQRLRSEGL 918
            |:.||||.|.|:||||.|||.||||||.|:|:||:..:|:::|....||.|:|:||:.|||
Zfish   865 ISLVVYGDPSGYSAMAKTVGYPAAIAAHMVLNGELTTKGLVVPMVKSIYSPVLKRLQDEGL 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LKRSDH	NP_001285719.1	PLN02819	23..922	CDD:215439	478/900 (53%)
		LKR_SDH_like	23..465	CDD:240665	265/441 (60%)
		Sacchrp_dh_NADP	486..602	CDD:281434	47/115 (41%)
		Sacchrp_dh_C	606..917	CDD:293259	154/314 (49%)
aass	NP_001167456.1	PLN02819	32..930	CDD:215439	478/900 (53%)
		LKR_SDH_like	32..474	CDD:240665	265/441 (60%)
		Sacchrp_dh_NADP	491..607	CDD:281434	47/115 (41%)
		Sacchrp_dh_C	611..924	CDD:293259	154/314 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578480
Domainoid	1	1.000	312	1.000	Domainoid score	I1273
eggNOG	1	0.900	-	-		E1_COG1748
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4212
Inparanoid	1	1.050	962	1.000	Inparanoid score	I313
OMA	1	1.010	-	-		QHG55211
OrthoDB	1	1.010	-	-		D194754at33208
OrthoFinder	1	1.000	-	-		FOG0004455
OrthoInspector	1	1.000	-	-		oto38804
orthoMCL	1	0.900	-	-		OOG6_101775
Panther	1	1.100	-	-	LDO	PTHR11133
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3527
SonicParanoid	1	1.000	-	-		X3157
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840