Protein Alignment LKRSDH and Aass

DIOPT Version :10

• Sequence 1: NP_609150.2
• Gene: LKRSDH / 34064
• FlyBaseID: FBgn0286198
• Length: 928
• Species: Drosophila melanogaster
• Sequence 2: NP_038958.2
• Gene: Aass / 30956
• MGIID: 1353573
• Length: 926
• Species: Mus musculus
• Alignment Length: 921
• Identity: 470/921 - (51%)
• Similarity: 663/921 - (71%)
• Gaps: 17/921 - (1%)

  Fly     3 RVIQLRATIAHPFTRQRHSRVIAIRREDQSVWERRAPFGPTHVQKLVKQNVKVIVQPSNRRAYPM 67
            |:.:|||.::...   .|..|:|:||||.:.||||||..|.|::.:.|...||::|||||||...
Mouse     8 RLARLRACLSRGL---HHKPVMALRREDVNAWERRAPLAPKHIKGITKLGYKVLIQPSNRRAIHD 69

  Fly    68 QAYMQAGAHIQEDISDASVIFGVKQVPIDALIPGKTYCFFSHTIKAQESNMPLLDAILEKKIRLI 132
            :.|::||..:||||::|.:|.|||:.|.:.|:..|||.||||||||||:||.|||.:|:::||||
Mouse    70 KEYVRAGGILQEDITEACLILGVKRPPEEKLMSKKTYAFFSHTIKAQEANMNLLDEVLKQEIRLI 134

  Fly   133 DYERIIDERGARQVAFGKYAGVAGMVNILHGIGLRLLALGHHTPFMHIGPAHNYRNSSMARQAIR 197
            |||:::|.||:|.||||::||||||:|||||:|||||||||||||||:|.||||||||.|.||:|
Mouse   135 DYEKMVDHRGSRIVAFGQWAGVAGMINILHGMGLRLLALGHHTPFMHLGMAHNYRNSSQAVQAVR 199

  Fly   198 DCGYEISLGMMPKSIGPLTFVFTGSGNVSQGAQEVFSELPIEYVPPEMLRKVAEHGNQNKLYGCE 262
            |.|||||||:||||||||||||||:||||:||||||:|||.|||.|..||:|::.|:..|:||..
Mouse   200 DAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQEVFNELPCEYVEPHELREVSKTGDLRKVYGTV 264

  Fly   263 VSRSDHLERREGGGFDAKEYDEFPERYISTFSTKIAPYASVIVNGIYWAVGSPKLISIPDAKNLL 327
            :||..||.|:..|.:|..||:::||||.|.|:|.||||.:.::|||||...:|:|::..||::||
Mouse   265 LSRHHHLVRKTDGVYDPVEYEKYPERYTSRFNTDIAPYTTCLINGIYWEQNTPRLLTRQDAQSLL 329

  Fly   328 RPANTPWLPTSKGSPALPHRMLAICDISADPGGSIEFMNECTTIDTPFCLYDADRNKDTKSFKGP 392
            .|..:..:|. :|.|.|||:::||||||||.||||:||.|||||:.|||:||||:.....|.:|.
Mouse   330 VPVKSSVVPV-EGCPELPHKLVAICDISADTGGSIDFMTECTTIERPFCMYDADQQIIHDSVEGS 393

  Fly   393 GVLVCSIDNMPTQLPRESTDLFGELLAPHVHDIIKSDAKKPLAEENFSYPIQSAIIASNGQLTEG 457
            |:|:|||||:|.|||.|:|:.||::|.|:|.:::.|||.:||..:|||..::.|:|.|||.||:.
Mouse   394 GILMCSIDNLPAQLPIEATEYFGDMLYPYVEEMLLSDASQPLESQNFSPVVRDAVITSNGLLTDK 458

  Fly   458 FQYIQELRESQSHRSRHKMEG-SSESDKKVLVLGAGMVSAPLVEWLHREKDVSITVCSQVKEEAD 521
            ::|||:|||     ||.:::. |..:.|||||||:|.||.|::|:|.|:.::.||:.|.:..:..
Mouse   459 YKYIQKLRE-----SRERIQFLSMSTKKKVLVLGSGYVSGPVLEYLSRDNNIEITLGSDMTNQMQ 518

  Fly   522 RLAQQYAGVDSVYLDVNESTGHLQELCGRADVVVSLLPYSLHGMVARYCVAEGTHMVTASYLNDE 586
            :|:::| .::.|.|.|.:....||.|....|:|:|||||.||.:||:.|:....:||||||:...
Mouse   519 QLSKKY-NINPVSLTVGKQEAKLQSLVESQDLVISLLPYVLHPVVAKACIESRVNMVTASYITPA 582

  Fly   587 ISGLHEEAKAKGVTIMNEVGLDPGIDHLLALECIHEVQDKGAVVESFVSYCGGLPAPEHSNNALR 651
            :..|.:.....|:|::.|:|||||:||:||:|.|...::.||.|||:|||||||||||||:|.||
Mouse   583 MKELEKSVDDAGITVIGELGLDPGLDHMLAMETIDTAKELGATVESYVSYCGGLPAPEHSDNPLR 647

  Fly   652 YKFSWSPRGVLLNTLSAAKYLSQGQIVEISGGGELMSSPRSLDFLPGFALEGFPNRDSTKYGNLY 716
            |||||||.|||:|.:..|.||..|::|.::||...::|...:|:.||..|||:|||||.||..:|
Mouse   648 YKFSWSPVGVLMNIMQPASYLLNGKVVNVTGGVSFLNSVTPMDYFPGLNLEGYPNRDSIKYAEIY 712

  Fly   717 GLGRDVHTLLRGTIRYKGFSESIKPMQLLGLIDPEPHALLHPSGPDVTWRQLVIHLMGMSDSTIF 781
            |:. ..|||||||:||||:|:::.....||||:.|.:..|.|....:||:||:..|:|:|.|:.
Mouse   713 GIS-SAHTLLRGTLRYKGYSKALNGFVKLGLINREAYPALRPEANPLTWKQLLCDLVGISRSSP- 775

  Fly   782 YENLKQKLTERIG----DVDGIESLGLLDDTPVVKLNTPLDTLSHYLSKRLAFERDERDLVVLRH 842
            .|.||:.:..::|    .::..|.||||.|..|.:..:.:|..|.:|..:|::..:|:|::|:|.
Mouse   776 CEKLKEVVFTKLGGDNTQLEAAEWLGLLGDEQVPQAESIVDAFSKHLVSKLSYGPEEKDMIVMRD 840

  Fly   843 EVGIRWPDGRREERGINFVVYGQPQGHSAMAMTVGKPAAIAAKMILDGEIQERGVLLPFTPDIYR 907
            ..|||.|.|..|.:.|:.||||...|.||||.|||.|.|:||||:|||||:.:|::.|||.:||.
Mouse   841 SFGIRHPSGHLENKTIDLVVYGDFNGFSAMAKTVGLPTAMAAKMLLDGEIEAKGLMGPFTKEIYG 905

  Fly   908 PMLQRLRSEGL 918
            |:|:|:::||:
Mouse   906 PILERIKAEGI 916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LKRSDH	NP_609150.2	PLN02819	23..922	CDD:215439	465/901 (52%)
		LKR_SDH_like	23..465	CDD:240665	259/441 (59%)
Aass	NP_038958.2	PLN02819	25..916	CDD:215439	464/899 (52%)
		LKR_SDH_like	25..466	CDD:240665	259/441 (59%)
		Lysine-ketoglutarate reductase. /evidence=ECO:0000303|PubMed:10567240	28..455		252/427 (59%)
		Saccharopine dehydrogenase. /evidence=ECO:0000303|PubMed:10567240	477..926		200/443 (45%)