DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LKRSDH and lys3

DIOPT Version :9

Sequence 1:	NP_001285719.1	Gene:	LKRSDH / 34064	FlyBaseID:	FBgn0286198	Length:	928	Species:	Drosophila melanogaster
Sequence 2:	NP_592972.1	Gene:	lys3 / 2541500	PomBaseID:	SPAC227.18	Length:	368	Species:	Schizosaccharomyces pombe

Alignment Length:	417	Identity:	102/417 - (24%)
Similarity:	158/417 - (37%)	Gaps:	109/417 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 REDQSVWERRAPFGPTHVQKLVKQNVKVIVQPSNRRAYPMQAYMQAG---------AHIQEDISD 83
            |.:....|.|:...|...:.|.....::.::.|::||:..:.:.:.|         .|..:|
pombe     9 RAETKPLEERSALTPRTAKILADAGFQITIERSSQRAFKDKEFERLGFPMVPEGSWRHAPKD--- 70

  Fly    84 ASVIFGVKQVPIDALIPGK-TYCFFSHTIKAQESNMPLLDAILEKKIRLIDYERIIDERGARQVA 147
             :.|.|:|::|.:...|.| |:..|:|..|.||....:|.........|.|.|.:.|:.|.|..|
pombe    71 -AYIIGLKELPENDNSPLKHTHIQFAHCYKNQEGWREVLSRFPAGNGLLYDLEFLQDDNGRRVAA 134

  Fly   148 FGKYAGVAGMVNILHGIGLRLLALGH-----HTPFMHIGPAHNYRNSSMARQAIRDCGYEISLGM 207
            ||.:||.||.       .:..|...|     :..|..|.|..|  ..|:.|...|    ::.|.:
pombe   135 FGYHAGFAGS-------AISCLVWAHQLLHPNKQFPAIRPFPN--EKSLVRHVAR----QVRLAL 186

  Fly   208 MPKSIG-PLTFVFTGSGNVSQGAQEVFSELPIEYVPPEMLRKVAEHGNQNKLYGCEVSRSDHLER 271
            ...:.. |...|....|....||.::.|::.|.:                    ..:.|.|..|.
pombe   187 KKNNNQYPRILVIGALGRCGTGACDLASKIGIPF--------------------DNILRWDINET 231

  Fly   272 REGGGFDAKEYDEFPERYISTFSTKIAPYASVIVNGIYWAVGSPKLISIPDAKNLLRPANTPWLP 336
            ::||.|                 |:|.. :.:.||.||.::..||..::.
pombe   232 KKGGPF-----------------TEITE-SDIFVNCIYLSMPIPKFCTVE--------------- 263

  Fly   337 TSKGSPALPHRML-AICDISAD---PGGSIEFMNECTTIDTPFCLYDADRNKDTKSFKG----PG 393
                |..:|:|.| .:||:|.|   |...|...|..||.|.|           |...||    |.
pombe   264 ----SLNVPNRKLRVVCDVSCDTTNPNNPIPIYNVNTTFDHP-----------TVEVKGVTTPPP 313

  Fly   394 VLVCSIDNMPTQLPRESTDLFGELLAP 420
            :.|.|||::||.|||||::.|.|.|.|
pombe   314 LEVISIDHLPTLLPRESSEAFSEALIP 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LKRSDH	NP_001285719.1	PLN02819	23..922	CDD:215439	102/417 (24%)
		LKR_SDH_like	23..465	CDD:240665	102/417 (24%)
		Sacchrp_dh_NADP	486..602	CDD:281434
		Sacchrp_dh_C	606..917	CDD:293259
lys3	NP_592972.1	SDH	4..366	CDD:240664	102/417 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	43	1.000	Domainoid score	I3662
eggNOG	1	0.900	-	-		E1_COG1748
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3527
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840