DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LKRSDH and aass-1

DIOPT Version :9

Sequence 1:	NP_001285719.1	Gene:	LKRSDH / 34064	FlyBaseID:	FBgn0286198	Length:	928	Species:	Drosophila melanogaster
Sequence 2:	NP_001294658.1	Gene:	aass-1 / 176842	WormBaseID:	WBGene00019819	Length:	952	Species:	Caenorhabditis elegans

Alignment Length:	949	Identity:	473/949 - (49%)
Similarity:	639/949 - (67%)	Gaps:	36/949 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWRVIQLRATIAHPFTRQRHSR---VIAIRREDQSVWERRAPFGPTHVQKLVKQNVKVIVQPSNR 62
            |.|.|..|...:..|    |.:   .|.||||..:.||||||..||||::|.|..|.|::|||||
Worm    10 MMRQISQRFQSSKVF----HGKGTPTIGIRRETVNSWERRAPLAPTHVKRLTKSGVNVLIQPSNR 70

  Fly    63 RAYPMQAYMQAGAHIQEDISDASVIFGVKQVPIDALIPGKTYCFFSHTIKAQESNMPLLDAILEK 127
            ||||:|.|:.|||.::||:|:|.:|..||.||||.|||.|||.|||||||||:.||.:||.||::
Worm    71 RAYPIQDYISAGAIVREDLSEAHIIMSVKSVPIDQLIPNKTYAFFSHTIKAQQDNMEMLDTILQR 135

  Fly   128 KIRLIDYERIIDERGARQVAFGKYAGVAGMVNILHGIGLRLLALGHHTPFMHIGPAHNYRNSSMA 192
            .|||:|||:|.|::|.|.|.|||:||.||.::||||||||||||||:|||:|:|.||||.:|.||
Worm   136 NIRLLDYEKICDDKGKRLVMFGKWAGNAGFIDILHGIGLRLLALGHNTPFLHMGLAHNYNDSHMA 200

  Fly   193 RQAIRDCGYEISLGMMPKSIGPLTFVFTGSGNVSQGAQEVFSELPIEYVPPEMLRKVAEHGNQNK 257
            ..|:||.||||:|..||:|:|||.|||||||||||||:|:|..||.|||....|.|||:.|..||
Worm   201 INALRDIGYEIALDRMPRSLGPLIFVFTGSGNVSQGARELFEHLPHEYVDVATLPKVAQKGQLNK 265

  Fly   258 LYGCEVSRSDHLERREGGGFDAKEYDEFPERYISTFSTKIAPYASVIVNGIYWAVGSPKLISIPD 322
            :|||.|:|.||...:.||.||.||:::||:||.|.|:|:||||||||:||:||...||:||:|||
Worm   266 VYGCVVTRKDHFVPKHGGPFDKKEFEQFPDRYTSKFATEIAPYASVIINGVYWDAQSPRLITIPD 330

  Fly   323 AKNLLRPANTPWLPTSK---------------GSPALPHRMLAICDISADPGGSIEFMNECTTID 372
            |||||.|.......|::               |.|.|||.::|:||||||||||:|||.||||||
Worm   331 AKNLLTPVQRKKKKTNQTSRASTKSGGLYDTPGCPTLPHHLIALCDISADPGGSVEFMRECTTID 395

  Fly   373 TPFCLYDADRNKDTKSF-KGPGVLVCSIDNMPTQLPRESTDLFGELLAPHVHDIIKSDAKKPLAE 436
            .||.:||||.|..:.|| ...|.|||||||||.|:|.|:|:.||.||.|.:.|::.:...:....
Worm   396 KPFAIYDADFNTSSDSFDAASGCLVCSIDNMPAQMPIEATEQFGNLLYPWLWDLLNTSNDQHFDR 460

  Fly   437 ENFSYPIQSAIIASNGQLTEGFQYIQELRE----SQSHRSRHKMEGSSESDKKVLVLGAGMVSAP 497
            ......|::|||...|:||..|:||.:||:    |.|..|| .|.|:  :||:||:|||||||.|
Worm   461 LQCRTEIKNAIITDQGKLTPNFEYIAQLRKDKAASASANSR-VMGGT--TDKRVLLLGAGMVSGP 522

  Fly   498 LVEWLHREKDVSITVCSQVKEEADRLAQQYAGVDSVYLDVNESTGHLQELCGRADVVVSLLPYSL 562
            ..::..::|||::||.::.:.:..||... ..:.||.:|:...:..::.|....|:||||||::.
Worm   523 FADFYSKQKDVNLTVATESQRDGQRLCTS-PNIQSVVVDIARESHTMERLIREHDLVVSLLPFNF 586

  Fly   563 HGMVARYCVAEGTHMVTASYLNDEISGLHEEAKAKGVTIMNEVGLDPGIDHLLALECIHEVQDKG 627
            |.:||:.|::....|||:||::.|:..|.:.||...||||||.||||||||:||:||..::::.|
Worm   587 HPLVAKMCISNQRDMVTSSYVSPELEALDKAAKDADVTIMNEAGLDPGIDHMLAMECFDDIKEHG 651

  Fly   628 AVVESFVSYCGGLPAPEHSNNALRYKFSWSPRGVLLNTLSAAKYLSQGQIVEISGGGELMSSPRS 692
            ..:.||.|:||||||||.|:|.|||||||||:|||...::.||||..|:|||:. .|.::.:...
Worm   652 GRITSFESFCGGLPAPEWSDNPLRYKFSWSPKGVLTALMNPAKYLKNGKIVEVP-SGSVVDNLID 715

  Fly   693 LDFLPGFALEGFPNRDSTKYGNLYGLGRDVHTLLRGTIRYKGFSESIKPMQLLGLIDPEP-HALL 756
            :||:||..|.||||||||||.::||||.|..|::|||:||:||.:::|.:..:||:..:. .:..
Worm   716 IDFMPGLNLIGFPNRDSTKYSDVYGLGNDCKTIIRGTLRYQGFVDTVKALHSVGLLSGDNIDSFT 780

  Fly   757 HPSGPDVTWRQLVIHLMGMSDSTIFYENLKQKLTERIG--DVDGIESLGLLDDTPVVKLNTPLDT 819
            ...|||:||::|:..|.... ..||.::|:..:.|::|  .:..:|:|||..|..|.:..||:||
Worm   781 SNIGPDLTWKELIASLSNQK-LDIFPDSLRHIIEEKVGGKGLSALENLGLFSDKVVDRHGTPIDT 844

  Fly   820 LSHYLSKRLAFERDERDLVVLRHEVGIRWPDGRREERGINFVVYGQPQGHSAMAMTVGKPAAIAA 884
            |:.||:|.|||:..|.|||||.|::|.:.|.|..|...|:.|.||.|.|.||||.|||...||.:
Worm   845 LAQYLAKILAFKDHESDLVVLNHDIGAQLPGGNSERHRISLVQYGNPNGFSAMARTVGYTTAIVS 909

  Fly   885 KMILDGEIQERGVLLPFTPDIYRPMLQRLRSEGLTATET 923
            .|:|:.|||..|:..|...::|||.|:|||..|:..|.|
Worm   910 HMVLNNEIQRAGIQRPILKEVYRPALKRLRDFGIVPTHT 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LKRSDH	NP_001285719.1	PLN02819	23..922	CDD:215439	465/921 (50%)
		LKR_SDH_like	23..465	CDD:240665	260/457 (57%)
		Sacchrp_dh_NADP	486..602	CDD:281434	43/115 (37%)
		Sacchrp_dh_C	606..917	CDD:293259	147/313 (47%)
aass-1	NP_001294658.1	PLN02819	28..943	CDD:215439	464/920 (50%)
		LKR_SDH_like	31..489	CDD:240665	260/457 (57%)
		Sacchrp_dh_NADP	511..626	CDD:281434	43/115 (37%)
		Sacchrp_dh_C	630..942	CDD:293259	147/313 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158531
Domainoid	1	1.000	364	1.000	Domainoid score	I494
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4212
Inparanoid	1	1.050	916	1.000	Inparanoid score	I182
Isobase	1	0.950	-	0	Normalized mean entropy	S1121
OMA	1	1.010	-	-		QHG55211
OrthoDB	1	1.010	-	-		D194754at33208
OrthoFinder	1	1.000	-	-		FOG0004455
OrthoInspector	1	1.000	-	-		oto18860
orthoMCL	1	0.900	-	-		OOG6_101775
Panther	1	1.100	-	-	LDO	PTHR11133
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3527
SonicParanoid	1	1.000	-	-		X3157
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.850