DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7154 and BRD9

DIOPT Version :9

Sequence 1:	NP_609148.1	Gene:	CG7154 / 34062	FlyBaseID:	FBgn0031947	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_001362790.1	Gene:	BRD9 / 65980	HGNCID:	25818	Length:	647	Species:	Homo sapiens

Alignment Length:	836	Identity:	217/836 - (25%)
Similarity:	344/836 - (41%)	Gaps:	237/836 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSSKKHKKNKSERREKYEEYSQHQDPAQLQRGLKLILKVGSNATPEYSANSPMVDGGPPTAAEA 65
            ||  |||||:|:|.|..||:|:.    ..|::.|||:||||.:...|.|.:             .
Human     1 MG--KKHKKHKAEWRSSYEDYAD----KPLEKPLKLVLKVGGSEVTELSGS-------------G 46

  Fly    66 MMSPVPEELQDHQGHRERHKKSKKKKKKKDREKKHKHHKEKRHRSRDRHRDAGSDE-DMMAGADD 129
            ..|...::..||:  |||||:.|||||||..::||...:|:|.|..::.|....:. |....|||
Human    47 HDSSYYDDRSDHE--RERHKEKKKKKKKKSEKEKHLDDEERRKRKEEKKRKREREHCDTEGEADD 109

  Fly   130 AACSGFAPSSVAPPAADPDSSQDGFSFMDDDQSQPLPENILFFAGITTDNSPSNCPVTKPIAPRK 194
                 |.|.                                                      :|
Human   110 -----FDPG------------------------------------------------------KK 115

  Fly   195 LDDILMGSSPNSSSLQSSSLGLIGSSPTKPLPDLLIPSPSTPGGANSLNALTPKALEAPKTPSSS 259
            ::                         .:|.||                    :.:.|.:|..:.
Human   116 VE-------------------------VEPPPD--------------------RPVRACRTQPAE 135

  Fly   260 SESGREPRSCVLKLKQQKSPLNKLLEHLLRFLEKRDPHQFFAWPVTDDMAPGYSSIISRPMDFST 324
            :||               :|:.:||||.||.|:::|||.|||:||||.:|||||.||..||||.|
Human   136 NES---------------TPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGT 185

  Fly   325 MRQKIDDHEYTALTEFTDDFKLMCENAIKYNHVDTVYNKAAKRLLQVGMKHLQPENLMRSLKPLS 389
            |:.||..:||.::|||..||||||:||:.||..||||.|.||::|..|.|.:..|.|: :||...
Human   186 MKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKERLL-ALKRSM 249

  Fly   390 GYMRELTARELGFELSSNDMSRENNDSADEGASTGAEEP---RTPAQLEEEERKRTLRLENAPKT 451
            .:|:::...:....|.:.|              |..|||   ..|.|:|..::.:....| ....
Human   250 SFMQDMDFSQQAALLGNED--------------TAVEEPVPEVVPVQVETAKKSKKPSRE-VISC 299

  Fly   452 HFEP-----YVDDLTGEE-ILAQVQNAAQQAKQRVN-----AKKNAH------------------ 487
            .|||     .:.|.|.|| :||.|::||.:|:.|:|     .|...|
Human   300 MFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKGPGHPVGSETLHGSAVGSCPHT 364

  Fly   488 -------KMGFLRQMKDGTTTLNLVIKEENEGPE---RVVTIGDLVGKLQKGSAQLQTRQVDKRN 542
                   :||:|::..||:...::|...|.:..|   ..|.:..|..||..|...|..:. ::||
Human   365 NVRLFSGQMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKD-ERRN 428

  Fly   543 AVRTVKSLNYGAFASFAPTFDSRFSTLSAEETQLVLRTYGDASSAEYAESILQFTKDS-NYGTTI 606
            .|..:.|    |..:.:...:|.|..|.::|.:|:...|||.:..:.|.|:.:|.||: :|...:
Human   429 KVTFLSS----ATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKV 489

  Fly   607 ANGLLDILTNGEHSKSLDELYNMQLHSYEQREIEKCFEQEEETSSQQETTAQIEQEYEKYKNTHV 671
            .:.|||.:|.|:||::|.:|                 :|......:....|::........::.:
Human   490 VDDLLDQITGGDHSRTLFQL-----------------KQRRNVPMKPPDEAKVGDTLGDSSSSVL 537

  Fly   672 DFKGLQSLGELGIDVSFLDGMEAEMKSYELNRRMHEHLSQNLTLIEKLRVAQHDRLSQPLPNHLG 736
            :|..::|..::.:|:|.|..:....|..:.: ..|.:|.:...|::.|..||.:|......::|.
Human   538 EFMSMKSYPDVSVDISMLSSLGKVKKELDPD-DSHLNLDETTKLLQDLHEAQAERGGSRPSSNLS 601

  Fly   737 LVQPAGQEEIQTAQQLTQQISDLAKKLPPSAIADPYALRKAMGMSYAGLPPPRPVS 792
            .:..|.:.:    |......|.|:....|....|||..          |..|.|.:
Human   602 SLSNASERD----QHHLGSPSRLSVGEQPDVTHDPYEF----------LQSPEPAA 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7154	NP_609148.1	Bromo_brd7_like	279..376	CDD:99945	58/96 (60%)
CG7154	NP_609148.1	DUF3512	440..687	CDD:288847	65/286 (23%)
BRD9	NP_001362790.1	Bromo_brd7_like	140..237	CDD:99945	58/96 (60%)
BRD9	NP_001362790.1	DUF3512	294..553	CDD:371853	65/281 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159924
Domainoid	1	1.000	112	1.000	Domainoid score	I6205
eggNOG	1	0.900	-	-		E1_KOG1828
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	251	1.000	Inparanoid score	I3229
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210550at33208
OrthoFinder	1	1.000	-	-		FOG0002091
OrthoInspector	1	1.000	-	-		otm42254
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22881
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2976
SonicParanoid	1	1.000	-	-		X833
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.890