DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7154 and brd9

DIOPT Version :9

Sequence 1:	NP_609148.1	Gene:	CG7154 / 34062	FlyBaseID:	FBgn0031947	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	XP_005170179.1	Gene:	brd9 / 393245	ZFINID:	ZDB-GENE-060502-1	Length:	651	Species:	Danio rerio

Alignment Length:	816	Identity:	203/816 - (24%)
Similarity:	346/816 - (42%)	Gaps:	193/816 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSSKKHKKNKSERREKYEEYSQHQDPAQLQRGLKLILKVGSNATPEYSANSPMVDGGPPTAAEA 65
            ||  |||||.:.|.|....:|    :...|::.|||:||||.:...|.|.:             .
Zfish     1 MG--KKHKKYRPEWRAVEGDY----EDKPLEKPLKLVLKVGGSEVTELSGS-------------G 46

  Fly    66 MMSPVPEELQDHQGHRERHKKSKKKKKKKDREKKHKHHKEKRHRSRDRHRDAGSDEDMMAGADDA 130
            ..|...::..||:.  ||||:.|||||||..::|:....|:|.|..::.:.
Zfish    47 HDSSYYDDRSDHEW--ERHKEKKKKKKKKSEKEKYADDDERRRRKEEKKKK-------------- 95

  Fly   131 ACSGFAPSSVAPPAADPDSSQDGFSFMDDDQSQPLPENILFFAGITTDNSPSNCPVTKPIAPRKL 195
                                      .:.:||:                :.|..||.....|:.:
Zfish    96 --------------------------REREQSE----------------TASTAPVEPFTLPKPV 118

  Fly   196 DDILMGSSPNSSSLQSSSLGLIGSSPTKPLPDLLIPSPSTPGGANSLNALTPKALEAPKTPSSSS 260
            :.::..........:|.|                        .|:..:......:|.|
Zfish   119 EVVVEEKKRKRDKFESES------------------------EADEFHPAVKVEVEQP------- 152

  Fly   261 ESGREPRSCVLKLKQQKSPLNKLLEHLLRFLEKRDPHQFFAWPVTDDMAPGYSSIISRPMDFSTM 325
             :.|..|:|..:.:.:.:|..:||||.||.|:::|.|.|||:||||.:|||||.||..|||||||
Zfish   153 -ADRPVRACRTQQENEATPRQQLLEHFLRLLQRKDAHGFFAFPVTDAIAPGYSMIIKHPMDFSTM 216

  Fly   326 RQKIDDHEYTALTEFTDDFKLMCENAIKYNHVDTVYNKAAKRLLQVGMKHLQPENLMRSLKPLSG 390
            :.||..:||..:|||..||||||:||:.||..:|||.||||:||..|.|.:..|.|: :||....
Zfish   217 KDKIAANEYKTITEFKADFKLMCDNAMVYNRPETVYYKAAKKLLHTGFKMMSKERLL-ALKRSMS 280

  Fly   391 YMRELTARELGFELSSNDMSRENNDSADEGASTGAEEPRT---PAQLE--EEERKRTLRLENAPK 450
            :|:::...:....|..:|::              .|||.|   |...|  ::.:|:.::
Zfish   281 FMQDMDFSQQAAILGDDDIA--------------PEEPVTEMMPIHTEYPKKSKKQPVK------ 325

  Fly   451 THFEPYVDDL-------------TGEE-ILAQVQNAAQQAKQRVNAKKNAHKMGFLRQMKDGTTT 501
               ||.:.|:             |.|| :||.|::||.:|:.|:|......|:|:|::..:| :.
Zfish   326 ---EPIISDMYELEGNACSLTDSTAEEHVLALVEHAADEARDRINRFMPNSKIGYLKKDTEG-SL 386

  Fly   502 LNLVIKEENEGPE---RVVTIGDLVGKLQKGSAQLQTRQVDKRNAVRTVKSLNYGAFASFAPTFD 563
            :.:|:.::.||.|   ..|.:..|..||..|...|..:. |:|:.|..:.|    |:.:.....:
Zfish   387 MYVVVNQDPEGEEEETHPVDLSSLANKLIPGLTSLGFKD-DRRHKVTFLSS----AYNTQTLQNN 446

  Fly   564 SRFSTLSAEETQLVLRTYGDASSAEYAESILQFTKD-SNYGTTIANGLLDILTNGEHSKSLDELY 627
            |.:..|..||..::...|||.:..:.|.|:.:|.|. ..:...:.:.|||.:|.|:|||::.::.
Zfish   447 SIYPDLHPEEMDMLYSAYGDETGVQCALSLQEFVKGCGGFTKRLVDDLLDKMTAGDHSKAVVQIR 511

  Fly   628 NMQLHSYEQREIEKCFEQEEETSSQQETTAQIEQEYEKYKNTHVDFKGLQSLGELGIDVSFLDGM 692
            ..:....::.:...|.....:....:..:.             :||..::|..::.:|:  |:.:
Zfish   512 QKRNLPIDEAKSSLCDMPGTDGGGMEAGSV-------------LDFMSMKSYPDMSLDM--LNTL 561

  Fly   693 EAEMKSYELNRRMHEHLSQNLTLIEKLRVAQHDRL-SQPLPNHLGLVQPAGQEEIQTAQQLTQQI 756
            ...:|....:...|:|......|:::.:.|..||: |:|..|...|...:.:::..........:
Zfish   562 GKCVKKEPEHEDGHQHFDDPTKLLQEFQDASVDRVGSRPSSNLSSLSNASERDQHHLGSSPHLGV 626

  Fly   757 SDLAKKLPPSAIADPYALRKAMGMSYAGLPPPRPVS 792
            .|.|:     .:.|||..          |..|.|.|
Zfish   627 GDQAE-----MVQDPYEF----------LQSPEPGS 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7154	NP_609148.1	Bromo_brd7_like	279..376	CDD:99945	59/96 (61%)
CG7154	NP_609148.1	DUF3512	440..687	CDD:288847	58/264 (22%)
brd9	XP_005170179.1	Bromo_brd7_like	170..267	CDD:99945	59/96 (61%)
brd9	XP_005170179.1	DUF3512	326..557	CDD:288847	56/249 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596204
Domainoid	1	1.000	106	1.000	Domainoid score	I6513
eggNOG	1	0.900	-	-		E1_KOG1828
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210550at33208
OrthoFinder	1	1.000	-	-		FOG0002091
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22881
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2976
SonicParanoid	1	1.000	-	-		X833
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.840