DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7154 and dikar

DIOPT Version :9

Sequence 1:	NP_609148.1	Gene:	CG7154 / 34062	FlyBaseID:	FBgn0031947	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_001261480.1	Gene:	dikar / 38747	FlyBaseID:	FBgn0261934	Length:	3261	Species:	Drosophila melanogaster

Alignment Length:	1147	Identity:	200/1147 - (17%)
Similarity:	333/1147 - (29%)	Gaps:	486/1147 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KNKSERREKYEEYSQHQDPAQLQRGLKLILKVGSNATPEYSANSPMVDGGPPTAAEAMMSPVPEE 73
            :.:.::.|:..|..|.|:|.:|         :..:||.: ...||          ||..|..|.|
  Fly   398 EQQRQQEEQPPEEEQRQEPEEL---------LAVSATDD-DFRSP----------EAPKSQTPAE 442

  Fly    74 LQ---DHQGHRERHKKSKKKKKKK---------DREKKHKHHKEKRHR---SRDRHRDAGSDEDM 123
            |:   .|..|...|||.|..||:|         :|:::|.||..:||:   ..|...|..::.:.
  Fly   443 LKSKSSHHHHHHHHKKKKSSKKQKKRHHRDKGRERDREHHHHHRRRHKHASEADEGEDDNNNHNS 507

  Fly   124 MAGADDAACSGFAPSSVAPPA----------ADPDSSQDGFSFMDDD------QSQPLPENILFF 172
            .:.::....|..:.:||.|..          ...::::...|...:|      |.|.|..|   .
  Fly   508 NSNSNSNTNSISSNNSVQPKRRRSGQQQQHHQQAETTEPSTSLSPEDKENFCRQLQLLDTN---S 569

  Fly   173 AGITTDNSPSNCPVTKPIA---PRKLDDILMGSSPNSSSLQSSSLGLIGSSPTKPLPDLLIPSPS 234
            |.|....|.::..:..|:|   ..:.|:.:  ..|.....|..:|    :|...|..::.:|...
  Fly   570 AAIAVATSIADLSLPSPVAHESETEQDEQV--DQPAVVEAQPPAL----TSAMAPAANVKLPGRQ 628

  Fly   235 TPGGANSLNALT-------------PKALEAPKTPSSSSESGREPRSCVLKLKQQKSPLN----- 281
            |   .|||::||             .:..:.|.:.||||:||....:..::.|:||:.||
  Fly   629 T---NNSLSSLTGNIFIPSGSAQQQQQQSQEPPSSSSSSQSGTTTTASTVRSKKQKAVLNSSGSS 690

  Fly   282 ---KLLEHLLRFLEKRD------------------------------------------------ 295
               |:.:...|.|.|.:
  Fly   691 STSKMADKADRNLSKTETTGKSKKSAAGSSASSSSSKAERISGAYSDKSGDDHVNSSNRSTTNNN 755

  Fly   296 ------------PHQFF------------------------------------------------ 300
                        ||...
  Fly   756 SSLNNNNNHKHAPHHSHNNNNNSHSTTTSATTTATTTTSQGYHYNSNLNHNQNHQNSHSHHTHHH 820

  Fly   301 ----------------------------------------------------------------- 300

  Fly   821 HHHHHHTTNNHSNKHKTKSHHSLAHNNNNNNSPTTNPTSTSLLHPVTTNNNSTYNSSNHANILSF 885

  Fly   301 -----------------------AW----PVTDDMAPGYSSIISRPMDFSTMRQKIDDHEYTALT 338
                                   ||    ||.:|:||.|.|||.||||...|..|:|..||...:
  Fly   886 TETEEVLQIGMHKVLVYVKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLKMEDKLDSGEYHKFS 950

  Fly   339 EFTDDFKLMCENAIKYNHVDTVYNKAAKRLLQVGMKHLQPENLMRSLKPLSGYMRELTARELGFE 403
            ||.:||:|:..|...||..:..|.:....|.....|                      |.:..|:
  Fly   951 EFRNDFRLIVNNCRLYNGHNNEYTEMVNNLQDAFEK----------------------ATKKYFD 993

  Fly   404 LSSNDMSRENN---DSADEGASTGAEEPRTPAQLEEEERKRTLRLENAPKTHFEPYVDDLTGEEI 465
            ..|:|...:.|   .:||...:...|:..:....||.|:       :||.   .|.|.  :.||.
  Fly   994 NLSDDEDDDPNLSYPAADSKMNVFREKYFSKKAKEETEK-------DAPG---RPAVS--SAEED 1046

  Fly   466 LAQVQ-NAAQQAKQRVNAKKNAHKMGFLRQMKDGTTTLNLVIKEENEGPERVVTIGDLVGKLQKG 529
            |:::: .|.|:|::|...:|:..:.                                   |..|.
  Fly  1047 LSEIEAEAPQKAQKRKRKEKDKRRK-----------------------------------KKTKS 1076

  Fly   530 SAQLQTRQVDKRNAVRTVKSLNYGAFASFAPTFDSRFSTLSAEETQLVLRTYGDASSAEYAESIL 594
            .|.::|...|..              |...||......|....:|.
  Fly  1077 KADVETDDEDME--------------AEREPTPPPPPPTSKKSKTS------------------- 1108

  Fly   595 QFTKDSNYGTTIANGLLDILTNGEHSKSLDELYNMQLHSYEQREIEKCFEQEEETSS--QQETTA 657
                               .|..|..|.            :::|.:|..|:::||||  :...|.
  Fly  1109 -------------------KTGKEKEKD------------KEKEKDKDKEKDKETSSFKRGRKTK 1142

  Fly   658 QIEQEYEKYKNTHVDFKGLQSLGELGIDVSFLDGMEAEMKSYELNRRMHEHLSQNLTLIEKL--R 720
            ..:...:..|.|....|...:..:...|.|  |..|:|    :.:...|..|::..:|::..  .
  Fly  1143 SDKSASKSSKKTKKGAKKSSADSDPESDPS--DSRESE----DYSDDDHISLAKTKSLVKPTART 1201

  Fly   721 VAQHDRLSQPLPNHLGLVQP----------AGQEEIQTAQQLTQQISDLAKKLPPSAIADPYALR 775
            :|...:.|.|..:.:.:..|          .|::....:....|...::.|:|||:|.|
  Fly  1202 IAAQKKKSVPAESKVKMPTPVKRQVKGKGKGGRKAKDDSLDSDQSDVNVKKQLPPTAAA------ 1260

  Fly   776 KAMGMSYAGL------PPP-----------RPVSP--------------RVQLPELLQQPVALPQ 809
             |:..|.|.|      |||           |.:||              ...|.|||.....:|.
  Fly  1261 -ALAESAAELEEDPDDPPPDEDEDEDSSRSRSMSPFKVDLHKKYSKSALNDDLSELLTTVKKVPT 1324

  Fly   810 LQPV---AMEIDESDEQHGGGDLENELREFLESGSGLHSANP 848
            .:..   |...||:||:....:.:.:.:. |.:..|.....|
  Fly  1325 AETTKLSARHQDEADEERSSRESDGDFKS-LSNSRGSSEERP 1365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7154	NP_609148.1	Bromo_brd7_like	279..376	CDD:99945	39/304 (13%)
CG7154	NP_609148.1	DUF3512	440..687	CDD:288847	37/249 (15%)
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246
dikar	NP_001261480.1	Bromo_gcn5_like	892..991	CDD:99941	32/120 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D439339at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.010