Protein Alignment CG7154 and BRD7

DIOPT Version :9

• Sequence 1: NP_609148.1
• Gene: CG7154 / 34062
• FlyBaseID: FBgn0031947
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: XP_011521348.1
• Gene: BRD7 / 29117
• HGNCID: 14310
• Length: 669
• Species: Homo sapiens
• Alignment Length: 846
• Identity: 240/846 - (28%)
• Similarity: 375/846 - (44%)
• Gaps: 232/846 - (27%)

  Fly     1 MGSSKKHKKNKSERREKYEEYSQHQDPAQLQRGLKLILKVGSNATPEYSANSPMVDGGPPTAAEA 65
            ||  |||||:||: :..||||        :::.|||:||||.|...|.|..|...|
Human     1 MG--KKHKKHKSD-KHLYEEY--------VEKPLKLVLKVGGNEVTELSTGSSGHD--------- 45

  Fly    66 MMSPVPEELQDHQGHRERHKKSKKKKKKK--DREKKHKHHKEK-----------RH-------RS 110
              |.:.|:..||..|::|.:|.:||.:|:  ..||..|..:.|           ||       :.
Human    46 --SSLFEDKNDHDKHKDRKRKKRKKGEKQIPGEEKGRKRRRVKVQVVTLLWLCGRHCLFQEDKKK 108

  Fly   111 RDRHRDAGSDEDMMAGADDAACSGFAPSSVAPPAADPDSSQDGFSFMDDDQSQPLPENILFFAGI 175
            |||.|.....|      .|..|.
Human   109 RDRDRVENEAE------KDLQCH------------------------------------------ 125

  Fly   176 TTDNSPSNCPVTKPIAPRKLDDILMGSSPNSSSLQSSSLGLIGSSPTKPLPDLLIPSPSTPGGAN 240
                           ||.:||                            ||
Human   126 ---------------APVRLD----------------------------LP-------------- 133

  Fly   241 SLNALTPKALEAPKTPSSSSESGREPRSCVLKLKQQKSPLNKLLEHLLRFLEKRDPHQFFAWPVT 305
                        |:.|.:||.:.:|        :.:::||.:.|..|:|.|:::||..||::|||
Human   134 ------------PEKPLTSSLAKQE--------EVEQTPLQEALNQLMRQLQRKDPSAFFSFPVT 178

  Fly   306 DDMAPGYSSIISRPMDFSTMRQKIDDHEYTALTEFTDDFKLMCENAIKYNHVDTVYNKAAKRLLQ 370
            |.:|||||.||..|||||||::||.:::|.::.|..|:|||||.||:.||..:|:|.||||:||.
Human   179 DFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYYKAAKKLLH 243

  Fly   371 VGMKHLQPENLMRSLKPLSGYMREL--TAREL-GFELSSND-----MSRENNDSADEGASTGAEE 427
            .|||.|..|.: :|||....:|.:|  |.::. |.:.|.:.     ..||..||.|      ||.
Human   244 SGMKILSQERI-QSLKQSIDFMADLQKTRKQKDGTDTSQSGEDGGCWQREREDSGD------AEA 301

  Fly   428 PRTPAQLEEEERKRTLRLENAPKTHFEPYVDDLTGEEILAQVQNAAQQAKQRVNAKKNAHKMGFL 492
            ....:..:|.::|....||:..|:      ::|..|:  .|:....:::..::..:....:..|.
Human   302 HAFKSPSKENKKKDKDMLEDKFKS------NNLEREQ--EQLDRIVKESGGKLTRRLVNSQCEFE 358

  Fly   493 RQMKDGTTTLNL------VIKEENEGPERVVTIGDLVGKLQKGSAQLQTRQVDKRNAVRTVKSLN 551
            |:..||||||.|      ::.|....|   |.:|...|:||.|...||..:.||||.|..|..||
Human   359 RRKPDGTTTLGLLHPVDPIVGEPGYCP---VRLGMTTGRLQSGVNTLQGFKEDKRNKVTPVLYLN 420

  Fly   552 YGAFASFAPTFDSRFSTLSAEETQLVLRTYGDASSAEYAESILQFTKD-SNYGTTIANGLLDILT 615
            ||.::|:||.:||.|:.:|.:::.|:..|||:.|......||.:|... .:|...:|:.|||:||
Human   421 YGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPSDFSIHEFLATCQDYPYVMADSLLDVLT 485

  Fly   616 NGEHSKSLDELYNMQLHSYEQREIEKCFEQEE------ETSSQQETTAQIEQEYEKYKNTHVDFK 674
            .|.||::|             :|:|....::|      :|:.:.|...::|.......:|.....
Human   486 KGGHSRTL-------------QEMEMSLPEDEGHTRTLDTAKEMEQITEVEPPGRLDSSTQDRLI 537

  Fly   675 GLQSLGELGIDVSFLDGMEAEMKSYELNRRMHEHLSQNLTLIEKLRVAQHDRLS-QPLPNHLGLV 738
            .|:::...|:.|...|..|||:        ..:.|.:...|:.:|:.||::||| :|.||.:.|:
Human   538 ALKAVTNFGVPVEVFDSEEAEI--------FQKKLDETTRLLRELQEAQNERLSTRPPPNMICLL 594

  Fly   739 QPAGQEEIQTAQQLTQQISDLAKKLPPSAIADPYALRKAMGMSYAGLPPPRPVSPRVQLPELLQQ 803
            .|: ..|:..|:|:|..:.:||:::.|..|...|.:|||||:|   :|.|...:..|.|.|..::
Human   595 GPS-YREMHLAEQVTNNLKELAQQVTPGDIVSTYGVRKAMGIS---IPSPVMENNFVDLTEDTEE 655

  Fly   804 P 804
            |
Human   656 P 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7154	NP_609148.1	Bromo_brd7_like	279..376	CDD:99945	53/96 (55%)
		DUF3512	440..687	CDD:288847	71/259 (27%)
BRD7	XP_011521348.1	Bromo_brd7_like	152..249	CDD:99945	53/96 (55%)
		DUF3512	304..550	CDD:288847	72/269 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159923
Domainoid	1	1.000	112	1.000	Domainoid score	I6205
eggNOG	1	0.900	-	-		E1_KOG1828
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	251	1.000	Inparanoid score	I3229
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210550at33208
OrthoFinder	1	1.000	-	-		FOG0002091
OrthoInspector	1	1.000	-	-		otm42254
orthoMCL	1	0.900	-	-		OOG6_106537
Panther	1	1.100	-	-	LDO	PTHR22881
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2976
SonicParanoid	1	1.000	-	-		X833
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790