DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7154 and swsn-9

DIOPT Version :9

Sequence 1:	NP_609148.1	Gene:	CG7154 / 34062	FlyBaseID:	FBgn0031947	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_001366778.1	Gene:	swsn-9 / 172461	WormBaseID:	WBGene00007256	Length:	636	Species:	Caenorhabditis elegans

Alignment Length:	782	Identity:	207/782 - (26%)
Similarity:	322/782 - (41%)	Gaps:	209/782 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PEYSANSPMVDGGPPT-AAEAMMSP------VPEELQDHQGHRERHKKSKK-KKKKKDREKKHKH 102
            ||..:...|| |.||| .|....:|      ||         |...:.:|: ||::.:.|:.:|:
Worm     2 PEGESRRSMV-GIPPTRRARGGNTPSTATPVVP---------RTSARAAKRVKKEEPEEEEDYKN 56

  Fly   103 HKEKRHRSRDRHRDAGSDEDMMAGADDAACSGFAPSSVAPPAADPDSSQDGFSFMDDDQSQPLPE 167
            :.....:|.:...:...||                 ...|....|.....|    ...:..||.:
Worm    57 NNSDPEKSEEDESEESGDE-----------------MTTPSRKTPGGGAGG----RKKKRAPLTD 100

  Fly   168 NILFFAGITTDNSPSNCPVTKPIAPRKLDDILMGSSPNSSSLQSSSLGLIGSSPTKPLPDLLIPS 232
            ..|....|....:..:....|.:.|...:::                      |.:|.|    |.
Worm   101 YHLKKKKILARKAARDAEKEKEVEPEVQEEV----------------------PKEPTP----PP 139

  Fly   233 PSTPGGANSLNALTPKALEAPKTPSSSSESGREPRSCVLKLKQQKSPLNKLLEHLLRFLEKRDPH 297
            |.                   |.||.||                ..|:..:.:|:||.|.::||.
Worm   140 PR-------------------KAPSFSS----------------YLPIQLMQDHILRKLVEKDPE 169

  Fly   298 QFFAWPVTDDMAPGYSSIISRPMDFSTMRQKIDDHEYTALTEFTDDFKLMCENAIKYNHVDTVYN 362
            |:||:|||..|||.|..||..|||..|:|:.|:|.:|.:|....:|.:|:..||.:||..:||:.
Worm   170 QYFAFPVTPSMAPDYRDIIKTPMDLQTIRENIEDGKYASLPAMKEDCELIVSNAFQYNQPNTVFY 234

  Fly   363 KAAKRLLQV-----GMKHLQPENLMRSLKPLSGYMRELTARELGFELSSNDMSRENNDSADEGAS 422
            .|||||..:     |.::|:  .|..|| |:        |.::.||:
Worm   235 LAAKRLSNLIAYYFGEQYLR--FLFHSL-PM--------ANKIPFEI------------------ 270

  Fly   423 TGAEEPRTPAQLEEEERKRTLRLENAPKTHFEPYVDDLTGEEILAQVQNAAQQAKQRVNAK---- 483
            .|. .|..|...|....||...::           |.:|.|:.|   |.|..:.::|::||
Worm   271 VGI-RPLAPVPKERTMNKRKAVVK-----------DGMTSEDCL---QVADPKVRERLSAKLPEA 320

  Fly   484 -----KNAHKMGFLRQMKDGTTTLNLVI------KEENEGPERVVTIGDLVGKLQKGSAQLQTRQ 537
                 |...|:|||.: ||||..||:|.      |.||..|.| |||||:||.|::|:..:....
Worm   321 NNPKNKKMGKLGFLSE-KDGTVVLNVVAGDSEDGKLENNAPRR-VTIGDIVGPLEEGTPGMIQMA 383

  Fly   538 VDKRNAVRTVKSLNYGAFASFAPTFDSRFSTLSAEETQLVLRTYGDASSAEYAESILQFTKDSNY 602
            ..:..:...|..||||.::||||.:||.::|::.|:|.|.||||||.|:|....|:.:|..|...
Worm   384 DHRLFSQAPVNYLNYGPYSSFAPMYDSTWATMTKEDTDLFLRTYGDKSNASDVMSMRRFVGDCPE 448

  Fly   603 GTTIANGLLDILTNGEHSKSLDELYNMQLHSYEQREIEKCFEQEEETSSQQETTAQIEQEYEKYK 667
            .:.|...|||.||:|||||::.||.|      ..:|:::                  |.:.::||
Worm   449 FSEIIGSLLDTLTDGEHSKTMKELEN------AGKEVKE------------------EVDNDEYK 489

  Fly   668 NTHV--DFKGLQSLGELGIDVSFLDGMEAEM------KSYE------LNRRMHEHLSQNLT---- 714
            |..|  ....:.|:..|||:..||:.:..::      .:.|      :|...|.::.|.|.
Worm   490 NETVLSLIDDVSSISNLGIETGFLNDIRQQVLVPAVESNIENNIPEFMNEVNHMNVQQQLNHSGQ 554

  Fly   715 LIEKLRVAQHDRLSQPLPNHLGLVQPAGQEEIQTAQQLTQQIS-DLAKKLPPSAIADPYALRKAM 778
            .::.|...|..||.|..|..:..||.|||.|.:.|:.|.|.:: .:.....|.|..:...:..|:
Worm   555 KVKDLAHIQEHRLVQQPPPMIMSVQGAGQIEQKLAENLQQHLAHQMTTHAAPEAFVNDTMIHDAI 619

  Fly   779 GM 780
            |:
Worm   620 GV 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7154	NP_609148.1	Bromo_brd7_like	279..376	CDD:99945	42/101 (42%)
CG7154	NP_609148.1	DUF3512	440..687	CDD:288847	87/263 (33%)
swsn-9	NP_001366778.1	Bromodomain	151..240	CDD:413371	39/88 (44%)
swsn-9	NP_001366778.1	DUF3512	288..478	CDD:403296	76/211 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167437
Domainoid	1	1.000	116	1.000	Domainoid score	I3736
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	198	1.000	Inparanoid score	I2489
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210550at33208
OrthoFinder	1	1.000	-	-		FOG0002091
OrthoInspector	1	1.000	-	-		oto19117
orthoMCL	1	0.900	-	-		OOG6_106537
Panther	1	1.100	-	-	LDO	PTHR22881
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2976
SonicParanoid	1	1.000	-	-		X833
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.930