Protein Alignment Uro and uox

DIOPT Version :10

• Sequence 1: NP_476779.1
• Gene: Uro / 34060
• FlyBaseID: FBgn0003961
• Length: 352
• Species: Drosophila melanogaster
• Sequence 2: NP_001002332.1
• Gene: uox / 436604
• ZFINID: ZDB-GENE-030826-24
• Length: 298
• Species: Danio rerio
• Alignment Length: 316
• Identity: 129/316 - (40%)
• Similarity: 178/316 - (56%)
• Gaps: 34/316 - (10%)

  Fly    33 EITDHGYGKDAVKVLHVSRNGPVHAIQEFEVGTHLKLYSKKDYYQGNNSDIVATDSQKNTVYLLA 97
            |....||||:.|||||:.|.|..|.|.|......|.|.::|||..|:||||:.||:.||||:.||
Zfish    10 EFVRTGYGKNMVKVLHIRREGNHHHIIELIANVQLTLKTRKDYLTGDNSDIIPTDTVKNTVHALA 74

  Fly    98 KKHGIESPEKFALLLARHFINKYSHVEEAHVHVEAYPWQRVCQEETRTNVNGKCENGVQGNCDFS 162
            |..||:|.|.|||.:..||:..::||....|:::..||:|:            .:|||:
Zfish    75 KLKGIKSIESFALDICEHFLTAFNHVTRVKVNIDEVPWKRL------------EKNGVE------ 121

  Fly   163 SIDNRSLHNHAFIFTPTALHYCDV--VIRRTDPKQTVITGIKGLRVLKTTQSSFVNFVNDEFRSL 225
                   ||||||..|.||.:|:.  .:.:|   ..|.:|:|.::||||||:.|..|:.|.|.:|
Zfish   122 -------HNHAFIHCPEALRFCEAEQYLSKT---PVVHSGLKDMKVLKTTQTGFEGFLRDRFTTL 176

  Fly   226 PDQYDRIFSTVVDCSWEYSDTENLDFLRAWQTVKNIIIRNFAGDPQVGVSSPSVQHTLYLSERQV 290
            .|..||.|.|.|...|.| :|.|:.|..||:.||:.:|:.|||....|..|||||.|||.::..|
Zfish   177 TDAKDRFFCTSVYARWRY-NTINVAFDAAWKAVKDTVIQKFAGPYDRGEYSPSVQKTLYDTQLLV 240

  Fly   291 LDVLPQVSVISMTMPNKHYFNFDTKPFQKIAPGDNNEVFIPVDKPHGTIYAQLARK 346
            ||.:|:|..|.:.|||:|||..|   ..||...:.:||::|:|.|.|.|...:.||
Zfish   241 LDRIPEVEEIEIIMPNQHYFVID---MTKIGLSNKDEVYLPLDNPSGNITGTVCRK 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uro	NP_476779.1	Uricase	38..345	CDD:238251	126/308 (41%)
uox	NP_001002332.1	urate_oxi	10..292	CDD:274554	127/313 (41%)
		Microbody targeting signal. /evidence=ECO:0000255	296..298