Protein Alignment Uro and Uox

DIOPT Version :10

• Sequence 1: NP_476779.1
• Gene: Uro / 34060
• FlyBaseID: FBgn0003961
• Length: 352
• Species: Drosophila melanogaster
• Sequence 2: NP_033500.1
• Gene: Uox / 22262
• MGIID: 98907
• Length: 303
• Species: Mus musculus
• Alignment Length: 325
• Identity: 136/325 - (41%)
• Similarity: 190/325 - (58%)
• Gaps: 34/325 - (10%)

  Fly    24 DEHGKPYQYEITDHGYGKDAVKVLHVSRNGPVHAIQEFEVGTHLKLYSKKDYYQGNNSDIVATDS 88
            |.:||..:.|....|||||.|||||:.|:|..|:|:|......|.|.|||||..|:||||:.||:
Mouse     6 DNYGKNDEVEFVRTGYGKDMVKVLHIQRDGKYHSIKEVATSVQLTLRSKKDYLHGDNSDIIPTDT 70

  Fly    89 QKNTVYLLAKKHGIESPEKFALLLARHFINKYSHVEEAHVHVEAYPWQRVCQEETRTNVNGKCEN 153
            .||||::|||..||.:.|.||:.:..||::.::||..|||:||..||:|.            .:|
Mouse    71 IKNTVHVLAKLRGIRNIETFAMNICEHFLSSFNHVTRAHVYVEEVPWKRF------------EKN 123

  Fly   154 GVQGNCDFSSIDNRSLHNHAFIFTPTALHYCDVVIRRTDPKQTVITGIKGLRVLKTTQSSFVNFV 218
            |::             |.||||.|||..|:|:|...|..| ..:.:|||.|:|||||||.|..|:
Mouse   124 GIK-------------HVHAFIHTPTGTHFCEVEQMRNGP-PVIHSGIKDLKVLKTTQSGFEGFL 174

  Fly   219 NDEFRSLPDQYDRIFSTVVDCSWEYSDTENLDFLRAWQTVKNIIIRNFAGDPQVGVSSPSVQHTL 283
            .|:|.:||:..||.|:|.|.|.|.| ...::||...|..|::|:::.|||....|..|||||.||
Mouse   175 KDQFTTLPEVKDRCFATQVYCKWRY-QRRDVDFEAIWGAVRDIVLQKFAGPYDKGEYSPSVQKTL 238

  Fly   284 YLSERQVLDV--LPQVSVISMTMPNKHYFNFDTKPFQKIAPGDNNEVFIPVDKPHGTIYAQLARK 346
            |  :.|||.:  ||::..:.:::||.||||.|   ..|:...:..||.:|:|.|:|.|...:.||
Mouse   239 Y--DIQVLSLSQLPEIEDMEISLPNIHYFNID---MSKMGLINKEEVLLPLDNPYGKITGTVKRK 298

  Fly   347  346
            Mouse   299  298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uro	NP_476779.1	Uricase	38..345	CDD:238251	130/308 (42%)
Uox	NP_033500.1	urate_oxi	15..297	CDD:274554	131/313 (42%)
		Microbody targeting signal. /evidence=ECO:0000255	301..303