Protein Alignment Uro and Uox

DIOPT Version :10

• Sequence 1: NP_476779.1
• Gene: Uro / 34060
• FlyBaseID: FBgn0003961
• Length: 352
• Species: Drosophila melanogaster
• Sequence 2: NP_446220.2
• Gene: Uox / 114768
• RGDID: 621369
• Length: 303
• Species: Rattus norvegicus
• Alignment Length: 323
• Identity: 138/323 - (42%)
• Similarity: 190/323 - (58%)
• Gaps: 30/323 - (9%)

  Fly    24 DEHGKPYQYEITDHGYGKDAVKVLHVSRNGPVHAIQEFEVGTHLKLYSKKDYYQGNNSDIVATDS 88
            |::||..:.|....|||||.|||||:.|:|..|:|:|......|.|.|||||..|:||||:.||:
  Rat     6 DDYGKNDEVEFVRTGYGKDMVKVLHIQRDGKYHSIKEVATSVQLTLRSKKDYLHGDNSDIIPTDT 70

  Fly    89 QKNTVYLLAKKHGIESPEKFALLLARHFINKYSHVEEAHVHVEAYPWQRVCQEETRTNVNGKCEN 153
            .||||::|||..||:|.|.||:.:..||::.:|||..|||:||..||:|.            .:|
  Rat    71 IKNTVHVLAKFKGIKSIETFAMNICEHFLSSFSHVTRAHVYVEEVPWKRF------------EKN 123

  Fly   154 GVQGNCDFSSIDNRSLHNHAFIFTPTALHYCDVVIRRTDPKQTVITGIKGLRVLKTTQSSFVNFV 218
            ||:             |.||||.|||..|:|||...|..| ..:.:|||.|:|||||||.|..|:
  Rat   124 GVK-------------HVHAFIHTPTGTHFCDVEQVRNGP-PIIHSGIKDLKVLKTTQSGFEGFI 174

  Fly   219 NDEFRSLPDQYDRIFSTVVDCSWEYSDTENLDFLRAWQTVKNIIIRNFAGDPQVGVSSPSVQHTL 283
            .|:|.:||:..||.|:|.|.|.|.|.: .::||...|..|::|:::.|||....|..|||||.||
  Rat   175 KDQFTTLPEVKDRCFATQVYCKWRYQN-RDVDFEATWGAVRDIVLKKFAGPYDRGEYSPSVQKTL 238

  Fly   284 YLSERQVLDVLPQVSVISMTMPNKHYFNFDTKPFQKIAPGDNNEVFIPVDKPHGTIYAQLARK 346
            |..:...|..||::..:.:::||.||||.|   ..|:...:..||.:|:|.|:|.|...:.||
  Rat   239 YDIQVLTLSQLPEIEDMEISLPNIHYFNID---MSKMGLINKEEVLLPLDNPYGKITGTVRRK 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uro	NP_476779.1	Uricase	38..345	CDD:238251	132/306 (43%)
Uox	NP_446220.2	urate_oxi	15..297	CDD:274554	133/311 (43%)
		Microbody targeting signal. /evidence=ECO:0000255	301..303