DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VSIG1 and vsig1

DIOPT Version :9

Sequence 1:	XP_005262184.1	Gene:	VSIG1 / 340547	HGNCID:	28675	Length:	449	Species:	Homo sapiens
Sequence 2:	XP_031762727.1	Gene:	vsig1 / 100127183	XenbaseID:	XB-GENE-484207	Length:	356	Species:	Xenopus tropicalis

Alignment Length:	387	Identity:	146/387 - (37%)
Similarity:	205/387 - (52%)	Gaps:	61/387 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     9 FLILSCLAGQVSV----VQVTIPDGFVNVTVGSNVTLICIYT-TTVASREQLSIQWSFFHKKEME 68
            ||:...|...::.    ||||:...:||||.|.|.||.|.|. ....|.:.|.|||:.|..|...
Frog     3 FLLFVALGLSLTALSHCVQVTVRSPYVNVTSGQNATLYCTYALNNPQSTKNLVIQWNVFQAKSQN 67

Human    69 PISHSSCLSTEGMEEKAVSQCLKMTHARDARGRCSWTSESPWEEGKWPDVEAVKGTLDGQQAELQ 133
            ..:.|.|.|.   :|.:::||||..:.|||||||:|.:                          |
Frog    68 QETLSPCFSP---DEGSLNQCLKTAYGRDARGRCNWKN--------------------------Q 103

Human   134 IYFSQGGQAVAIGQFKDRITGSNDPGNASITISHMQPADSGIYICDVNNPPDFLGQNQGILNVSV 198
            ::|.|.||..:...:|:|:|.:..||||:||||:|||.|:|:|.|::.|.|:..|  :|.:.|:|
Frog   104 VFFYQNGQPFSGPGYKNRVTAALTPGNATITISNMQPEDTGVYTCEILNLPESSG--EGKIIVTV 166

Human   199 LVKPSKPLCSVQGRPETGHTISLSCLSALGTPSPVYYWHKLEGRDIVPVKENFNPTTGILVIGNL 263
            ||.||.|.|:::|..||||.|||.|.|..|.|.|:|.|:::|...:.......|...|.|:||||
Frog   167 LVPPSNPHCTIRGAVETGHFISLMCYSEEGMPRPLYTWNRVENGVLKSTPPQMNQQKGSLIIGNL 231

Human   264 TNFEQGYYQCTAINRLGNSSCEIDLTSSHPEVGIIVGALIGSLVGAAIIISVVCFARNKAKAKAK 328
            |:||:|||:|||.|.|||::||::|.:. .|.|:|..|:||.|:.|||||::|.|...|.|.|
Frog   232 TDFEEGYYRCTASNALGNATCELNLHTG-GEAGVIAAAVIGGLLAAAIIIAIVWFLIVKRKQK-- 293

Human   329 ERNSKTIAELEPMTKINPRGESEAMPREDATQLEVTLPSSIHETGPDTIQEPDYEPKPTQEP 390
                |.|...:.| |.:|.||:.          |.|..|.       ...||:.|...:.||
Frog   294 ----KQIPPTKEM-KTSPSGETH----------EYTAVSG-------EANEPNKETLGSSEP 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VSIG1	XP_005262184.1	Ig	97..189	CDD:299845	32/91 (35%)
		IG_like	127..198	CDD:214653	28/70 (40%)
		IG_like	216..289	CDD:214653	35/72 (49%)
		Ig	219..286	CDD:143165	32/66 (48%)
vsig1	XP_031762727.1	V-set	26..167	CDD:400157	61/171 (36%)
		Ig strand C'	110..115	CDD:409353	2/4 (50%)
		FR3	118..150	CDD:409353	18/31 (58%)
		Ig strand D	121..127	CDD:409353	2/5 (40%)
		Ig strand E	130..137	CDD:409353	5/6 (83%)
		Ig strand F	144..151	CDD:409353	3/6 (50%)
		CDR3	152..157	CDD:409353	2/4 (50%)
		FR4	158..166	CDD:409353	3/9 (33%)
		Ig strand G	158..166	CDD:409353	3/9 (33%)
		Ig	<195..251	CDD:416386	26/55 (47%)
		Ig strand C	201..205	CDD:409353	1/3 (33%)
		Ig strand E	224..228	CDD:409353	2/3 (67%)
		Ig strand F	238..243	CDD:409353	3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	78	1.000	Domainoid score	I34437
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H12703
Inparanoid	1	1.050	200	1.000	Inparanoid score	I12019
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221829at32523
OrthoFinder	1	1.000	-	-		FOG0013483
OrthoInspector	1	1.000	-	-		oto148277
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R18397
SonicParanoid	1	1.000	-	-		X11000
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.090