DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13796 and Slc6a1

DIOPT Version :9

Sequence 1:	NP_001137807.1	Gene:	CG13796 / 34051	FlyBaseID:	FBgn0031939	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_077347.1	Gene:	Slc6a1 / 79212	RGDID:	620533	Length:	599	Species:	Rattus norvegicus

Alignment Length:	572	Identity:	156/572 - (27%)
Similarity:	249/572 - (43%)	Gaps:	85/572 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 RGRWAKSADFYFASCTHAFSSLIFSELSTFGILHG--GWLLFIIAYLMGMLFYSLPIFLIQAFLG 146
            |..|....||..:...:|..   ...:..|..|.|  |...|:|.|.:.::|..:|:||::..||
  Rat    44 RDTWKGRFDFLMSCVGYAIG---LGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLG 105

  Fly   147 QFSSSGTISAFRVAPIFKGIGYAILLLNLGTLTYYSIAAVVPLIYTVNSIHPVIPWMSCNNSWNT 211
            |::|.|.:..:::||:|||:|.|..:|:.....||.:.....:.|..||....:||..|:|.|||
  Rat   106 QYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNT 170

  Fly   212 QECSLHENYDVDDYRVDPHSTVEFF-RSMIASTAKGSTSMSISWSMLIGVLSIWLVVLALLLKPV 275
            ..|  ..||.:.:......:.|||: |:|...|........|.|.:.|.:...|::|...:.|.|
  Rat   171 DRC--FSNYSLVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGV 233

  Fly   276 AFIGKVLRCSCVLMFGFFVAVFLYLLIHEQVTF----DTLHYYWMPQLD--SFDSILATARTALL 334
            .:.|||:..|....:     :.|.:|....||.    :.:.:|..|...  |...:...|.|.:.
  Rat   234 GWTGKVVYFSATYPY-----IMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIF 293

  Fly   335 MAGGALGPGWGSIITLSSYNNFRRDAERLSIWV-CLTHITIGLMGLLCCNVAHDHFEDHVGMMPL 398
            .   :.|.|.||:|.|.|||:|..:..|.||.| |:...|....|.:..::        ||.| .
  Rat   294 F---SYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSI--------VGFM-A 346

  Fly   399 HVDEKHHMQ-------FLYLCFSYLFGRFTTTPNLWAFLFFGMIFLSELCALIIQMMSVITALFD 456
            ||.::....       ..:|.:.....:...:| |||.|||.|:.:..:.:....:...||||.|
  Rat   347 HVTKRSIADVAASGPGLAFLAYPEAVTQLPISP-LWAILFFSMLLMLGIDSQFCTVEGFITALVD 410

  Fly   457 EF-ETLRSRRILVISSLVFCLTASSVYFCTQLGFSQLTQ--LPNLAVFTHLLISGILVLM----- 513
            |: ..||:||.|.|:::  |:.:   |.   :|.|.:||  :....:|.:...||:.:|.
  Rat   411 EYPRLLRNRRELFIAAV--CIVS---YL---IGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFE 467

  Fly   514 ---TTWVYGRVRFQCDLQFMLGKTISSFKIFFIRFATPIFL-GLCLF---QLT------YLFTRD 565
               .:|.||..||..::|.|:|.....:......|.|||.: |:.||   |:|      |:|.:
  Rat   468 CVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPK- 531

  Fly   566 RIHDVLIYVSQGLILLTAIS-------YMVYKVCRTNGDWRQRLQQCLAPHD 610
                    ..||:..|.|:|       ||.|......|..:||||..:.|.:
  Rat   532 --------WGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSE 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13796	NP_001137807.1	SLC5-6-like_sbd	123..610	CDD:294310	147/529 (28%)
Slc6a1	NP_077347.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		SLC6sbd_GAT1	2..599	CDD:212075	156/572 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920