DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13796 and SLC6A8

DIOPT Version :9

Sequence 1:	NP_001137807.1	Gene:	CG13796 / 34051	FlyBaseID:	FBgn0031939	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_005620.1	Gene:	SLC6A8 / 6535	HGNCID:	11055	Length:	635	Species:	Homo sapiens

Alignment Length:	685	Identity:	153/685 - (22%)
Similarity:	260/685 - (37%)	Gaps:	168/685 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SEHGTELPGDFI-----GEPVETESGGGM---GGSLALAARRIRSRQVH------SMAVRTGSAY 71
            |..|.|..|..|     |.|.:.:...|:   ||.||:..|...:||:.      ..||..|:.:
Human    12 SVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVW 76

  Fly    72 DTLERPYRHDKCRGRWAKSADFYFASCTHAFSSLIFSELSTFGILHGGWLLFIIAYLMGMLFYSL 136
                                         .|..|.:.        :||. :|:|.|::..|...:
Human    77 -----------------------------RFPYLCYK--------NGGG-VFLIPYVLIALVGGI 103

  Fly   137 PIFLIQAFLGQFSSSGTISAFRVAPIFKGIGYAILLLNLGTLTYYSIAAVVPLIYTVNSIHPVIP 201
            |||.::..||||..:|:|:.:.:.|:|||:|||.:::.....|||.:.......|.|.|....:|
Human   104 PIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLP 168

  Fly   202 WMSCNNSWNTQEC---SLHE--------NYDVDDYRVDPHSTVEFFRSMIASTAKG-STSMSISW 254
            |.:|.::|||.:|   ..||        |...|.........:||:.:.:...:.| ....:::|
Human   169 WATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNW 233

  Fly   255 SMLIGVLSIWLVVLALLLKPVAFIGKVLRCSCVLMFGFFVAVFLY-----LLIHEQV---TFDTL 311
            .:.:.:|:.|::|...:.|.|...||::         :|.|.|.|     ||:...:   ..|.:
Human   234 EVTLCLLACWVLVYFCVWKGVKSTGKIV---------YFTATFPYVVLVVLLVRGVLLPGALDGI 289

  Fly   312 HYYWMPQLDSFDS--ILATARTALLMAGGALGPGWGSIITLSSYNNFRRDAERLSIWVCLTH--- 371
            .||..|......|  :...|.|.:..   :...|.|::..|.|||.|..:..:.:|.:.|.:
Human   290 IYYLKPDWSKLGSPQVWIDAGTQIFF---SYAIGLGALTALGSYNRFNNNCYKDAIILALINSGT 351

  Fly   372 ------ITIGLMGLLCCNVAHDHFEDHVGMMPLHVDE--KHHMQFLYLCFSYLFGRFTTTPNLWA 428
                  :...::|.:...            ..:|:.:  :......::.:..........| |||
Human   352 SFFAGFVVFSILGFMAAE------------QGVHISKVAESGPGLAFIAYPRAVTLMPVAP-LWA 403

  Fly   429 FLFFGMIFLSELCALIIQMMSVITALFD------EFETLRSRRILVISSLVFCLTASSVYFCTQL 487
            .|||.|:.|..|.:..:.:...||.|.|      .|...|...:.:..:|.|.:..|.|   |.
Human   404 ALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMV---TD- 464

  Fly   488 GFSQLTQLPNLAVFTHLLISGILVL--------MTTWVYGRVRFQCDLQFMLGKTISSFKIFFIR 544
            |...:.||     |.:...||..:|        :..||||..||..|:..|:|.....:..:...
Human   465 GGMYVFQL-----FDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWS 524

  Fly   545 FATP-IFLGLCLFQLTYLFTRDRIHDVLIYVS--------QGLILLTAISYMVYKVC-------- 592
            |.|| :.:|:.:|.:.|       ::.|:|.:        :.:....|:|.|   :|
Human   525 FFTPLVCMGIFIFNVVY-------YEPLVYNNTYVYPWWGEAMGWAFALSSM---LCVPLHLLGC 579

  Fly   593 --RTNGDWRQRLQQCLAP-----H-DWHPVDADNR 619
              |..|...:|.|....|     | ::...|||.|
Human   580 LLRAKGTMAERWQHLTQPIWGLHHLEYRAQDADVR 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13796	NP_001137807.1	SLC5-6-like_sbd	123..610	CDD:294310	127/558 (23%)
SLC6A8	NP_005620.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		5/15 (33%)
SLC6A8	NP_005620.1	SLC6sbd_CT1	52..621	CDD:271397	141/645 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920