Protein Alignment CG13796 and SLC6A6

DIOPT Version :10

• Sequence 1: NP_609140.2
• Gene: CG13796 / 34051
• FlyBaseID: FBgn0031939
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_001127839.2
• Gene: SLC6A6 / 6533
• HGNCID: 11052
• Length: 721
• Species: Homo sapiens
• Alignment Length: 693
• Identity: 161/693 - (23%)
• Similarity: 264/693 - (38%)
• Gaps: 199/693 - (28%)

  Fly    42 GGMGGSLALAARR-------------IRSRQVHSMAVR-----------------TGSAYDTLER 76
            ||...|.|...||             :||.|...||.:                 .|.:..|  |
Human    68 GGTRHSRAERGRRRSHPRSRTRTTALLRSSQTKEMATKEKLQCLKDFHKDILKPSPGKSPGT--R 130

  Fly    77 PYRHDKCRG------RWAKSADFYFASCTHAFSSLIFSELSTFGIL---HGGWLLFIIAYLMGML 132
            |  .|:..|      :|:...||.. |....|..|  ..:..|..|   :||. .|:|.|.:.:.
Human   131 P--EDEAEGKPPQREKWSSKIDFVL-SVAGGFVGL--GNVWRFPYLCYKNGGG-AFLIPYFIFLF 189

  Fly   133 FYSLPIFLIQAFLGQFSSSGTISAF-RVAPIFKGIGYA----ILLLNLGTLTYYSIAAVVPLIYT 192
            ...||:|.::..:||::|.|.|:.: ::.|:|.|||||    :.|||:    ||.:.......|.
Human   190 GSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNV----YYIVILAWATYYL 250

  Fly   193 VNSIHPVIPWMSCNNSWNTQEC---SLHENYDVDDYRVDPHST------VEFFRSMIASTAKG-S 247
            ..|....:||..||:||||..|   ::.:|..|   .:...||      :||:...:.|.:.| .
Human   251 FQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSV---WITISSTNFTSPVIEFWERNVLSLSPGID 312

  Fly   248 TSMSISWSMLIGVLSIWLVVLALLLKPVAFIGKVLRCSCVLMFGFFVAVF----LYLLIHEQVTF 308
            ...|:.|.:.:.:|.:|||....:.|.|...|||:         :|.|.|    |.:|:...:|.
Human   313 HPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVV---------YFTATFPFAMLLVLLVRGLTL 368

  Fly   309 D----TLHYYWMPQLDSFD--SILATARTALLMAGGALGPGWGSIITLSSYNNFR----RDAERL 363
            .    .:.:|..|.:...:  .:...|.|.:..:....   .|::.:|.|||.::    ||...|
Human   369 PGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAIC---LGAMTSLGSYNKYKYNSYRDCMLL 430

  Fly   364 SIWVCLTHIT-----------IGLM----GLLCCNVAHD-------HFEDHVGMMPLHVDEKHHM 406
            .   ||...|           :|.|    |:...:||..       .:...|.||||
Human   431 G---CLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPL-------- 484

  Fly   407 QFLYLCFSYLFGRFTTTPNLWAFLFFGMIFLSELCALIIQMMSVITALFDEFET-LRS--RRILV 468
                             |..|:.|||.|:.|..|.:..:::...||:|.|.:.: ||.  ||.:.
Human   485 -----------------PTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIF 532

  Fly   469 ISSLVFCLTASSVYFCT---QLGFSQLTQ--LPNLAVFTHLLISGILVL--------MTTWVYGR 520
            |:           :.|:   .||.:.:|:  :....:|.:...||:.:|        :..|:||.
Human   533 IA-----------FVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGG 586

  Fly   521 VRFQCDLQFMLGKTISSFKIFFIRFATPIF-LGLCLFQL----------TYLFTRDRIHDVLIYV 574
            ......::.|:|.....:..:.....||:. :|..:|.|          ||::....|
Human   587 DNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAI------- 644

  Fly   575 SQGLILLTAISYM-------VYKVCRTNGDWRQRLQQCLAPHD 610
              ||....|:|.|       |.::|:|.|.:..|::..|.|.:
Human   645 --GLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPRE 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13796	NP_609140.2	SLC5-6-like_sbd	123..610	CDD:444915	134/571 (23%)
SLC6A6	NP_001127839.2	SLC6sbd_TauT	142..683	CDD:271398	143/611 (23%)