DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13796 and SLC6A4

DIOPT Version :9

Sequence 1:	NP_001137807.1	Gene:	CG13796 / 34051	FlyBaseID:	FBgn0031939	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001036.1	Gene:	SLC6A4 / 6532	HGNCID:	11050	Length:	630	Species:	Homo sapiens

Alignment Length:	658	Identity:	167/658 - (25%)
Similarity:	275/658 - (41%)	Gaps:	107/658 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LNNCMLLGDCENSEHGTE---------LPGDFIGEPVETESGGGMGGSLALAARRIRSRQVHSMA 64
            ||:...|..||:.|...|         .|||      :.|||....|..|:.:........||:.
Human     6 LNSQKQLSACEDGEDCQENGVLQKVVPTPGD------KVESGQISNGYSAVPSPGAGDDTRHSIP 64

  Fly    65 VRTGSAYDTLERPYRHDKCRGRWAKSADFYFASCTHA--------FSSLIFSELSTFGILHGGWL 121
            ..|.:....|     |...|..|.|..||..:...:|        |..:.:.        :||.
Human    65 ATTTTLVAEL-----HQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQ--------NGGG- 115

  Fly   122 LFIIAYLMGMLFYSLPIFLIQAFLGQFSSSGTISAFR-VAPIFKGIGYAILLLNLGTLTYYSIAA 185
            .|::.|.:..:|..:|:|.::..|||:..:|.||.:| :.||||||||||.::.....:||:...
Human   116 AFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM 180

  Fly   186 VVPLIYTVNSIHPVIPWMSCNNSWNTQECSLHENY-DVDDYRVDPHST---VEFFRSMIAS--TA 244
            ...|.|.::|....:||.||.|||||..|:   || ..|:.....|||   .||:...:..  .:
Human   181 AWALYYLISSFTDQLPWTSCKNSWNTGNCT---NYFSEDNITWTLHSTSPAEEFYTRHVLQIHRS 242

  Fly   245 KGSTSM-SISWSMLIGVLSIWLVVLALLLKPVAFIGKVLRCSCVLMFGFFVAVFLYLLIHEQVTF 308
            ||...: .|||.:.:.::.|:.|:...:.|.|...|||     |.:...|..:.|.:|:....|.
Human   243 KGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKV-----VWVTATFPYIILSVLLVRGATL 302

  Fly   309 -----DTLHYY---WMPQLDSFDSILATARTALLMAGGALGPGWGSIITLSSYNNFR----RDAE 361
                 ..|.|.   |...|::...|.|.|:...     :||||:|.::..:|||.|.    :||.
Human   303 PGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFF-----SLGPGFGVLLAFASYNKFNNNCYQDAL 362

  Fly   362 RLSIWVCLTHITIGLMGLLCCNVAHDHFEDHVGMMPLHVDEKHHMQFLYLCFSYLFGRFTTTPNL 426
            ..|:..|:|....|.:.........:...:.|.    .|.:......|::.::........: ..
Human   363 VTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVS----EVAKDAGPSLLFITYAEAIANMPAS-TF 422

  Fly   427 WAFLFFGMIFLSELCALIIQMMSVITALFDEFETL--RSRRILVISSLVFCLTASSVYFCTQLGF 489
            :|.:||.|:....|.:....:..||||:.|||..:  :.|...|::.::.|...|.|  ....|.
Human   423 FAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLV--TLTFGG 485

  Fly   490 SQLTQL-----PNLAVFTHLLISGILVLMTTWVYGRVRFQCDLQFMLGKTISSF-KIFFIRFATP 548
            :.:.:|     ...||.|..||..:.|   :|.||..:|..|::.|||.:...| :|.::.. :|
Human   486 AYVVKLLEEYATGPAVLTVALIEAVAV---SWFYGITQFCRDVKEMLGFSPGWFWRICWVAI-SP 546

  Fly   549 IFL------------GLCLFQLTYLFTRDRIHDVLIYVSQGLILLTAI-SYMVYKVCRTNGDWRQ 600
            :||            .|.|||..|.:     ..:::....|......| :|:.|::..|.|.:::
Human   547 LFLLFIICSFLMSPPQLRLFQYNYPY-----WSIILGYCIGTSSFICIPTYIAYRLIITPGTFKE 606

  Fly   601 RLQQCLAP 608
            |:.:.:.|
Human   607 RIIKSITP 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13796	NP_001137807.1	SLC5-6-like_sbd	123..610	CDD:294310	138/527 (26%)
SLC6A4	NP_001036.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59		15/58 (26%)
		5HT_transport_N	24..64	CDD:397524	10/45 (22%)
		SLC6sbd_SERT	79..615	CDD:271399	147/574 (26%)
		Interaction with RAB4A	616..624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920